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Black cumin (Nigella sativa) seeds: Chemistry, Technology, Functionality and Applications

Authors:
Mohamed FawzyRamadan
Editor
Black cumin (Nigella sativa)
seeds: Chemistry,
Technology, Functionality,
and Applications
ISSN 2661-8958 ISSN 2661-8966 (electronic)
Food Bioactive Ingredients
ISBN 978-3-030-48797-3 ISBN 978-3-030-48798-0 (eBook)
https://doi.org/10.1007/978-3-030-48798-0
© Springer Nature Switzerland AG 2021
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of
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Editor
Mohamed FawzyRamadan
Deanship of Scientic Research
Umm Al-Qura University
Makkah, KSA
Agricultural Biochemistry Department
Faculty of Agriculture
Zagazig University
Zagazig, Egypt
Dedicated to my beloved family
vii
Preface
Nigella sativa (black cumin) is one of the most admired medicinal plants in history.
Recently, black cumin has become an important topic for scientic research world-
wide. Nigella sativa seeds are rich in bioactive phytochemicals (i.e., thymoquinone,
tocols, sterols, polar lipids, and amino acids) with diverse biological and health-
promoting traits. Extracts, essential oils, and xed oils from Nigella sativa seeds
have been used in pharmaceuticals, functional foods, and nutraceuticals. Nigella
sativa is evident to promote health and it might serve to be a novel source for mod-
ern phytomedicine. This book project aims to build a multidisciplinary discussion
on the advances in Nigella sativa chemistry, technology, cultivation practices, func-
tional properties, health-promoting activities, as well as food and non-food
applications.
Upon kind invitation from the Springer Nature, this book was edited. The book
contains chapters that describe cultivation, composition, and applications of
N. sativa seeds as well as the chemistry, technology, functionality, and applications
of its extracts, xed oil, and essential oil. Aiming to provide a major reference work
for those involved in pharmaceuticals, nutraceuticals, and oil industry as well as
undergraduate and graduate students, this volume presents a comprehensive review
of the results that have led to the advancements in Nigella sativa chemistry, technol-
ogy, and applications. I hope this book will be a valuable source for people involved
in medicinal plants and functional foods.
I sincerely thank all authors for their valuable contributions and for their coop-
eration during book preparation. I highly acknowledge the support from Deanship
of Scientic Research (Umm Al-Qura University, KSA). The help and support
given to me by the Springer Nature staff, especially Daniel Falatko and Arjun
Narayanan, was essential for the completion of my task and is appreciated.
“Let food be your medicine and medicine be your food” (Hippocrates)
Makkah, Saudi Arabia MohamedFawzyRamadan
ix
Description
Nigella sativa seeds have an increasing number of applications in food and pharma-
ceutical industries. Black cumin is used worldwide in traditional medicine for treat-
ment of several diseases. Bioactive phytochemicals with pharmacological properties
have been identied in black cumin, including thymoquinone, t-anethol, alkaloids,
and saponins.
Black Cumin (Nigella sativa) Seeds: Chemistry, Technology, Functionality, and
Applications covers several specic topics with a focus on cultivation, composition,
and applications of Nigella sativa seeds as well as the chemistry, technology, func-
tionality, and applications of Nigella sativa extracts, xed oil, and essential oil.
Edited by a team of experts, Black Cumin (Nigella sativa) Seeds: Chemistry,
Technology, Functionality, and Applications brings together diverse developments
in food science to chemists, nutritionists, and students of food science, nutrition,
lipids chemistry and technology, agricultural science, pharmaceuticals, cosmetics,
and nutraceuticals.
Black Cumin (Nigella sativa) Seeds: Chemistry, Technology, Functionality, and
Applications is a key textbook for pharmaceutical and functional food developers as
well as research and development (R&D) managers working in all sector using
medicinal plants and vegetable oils. It is a useful reference work for companies
reformulating their products or developing new products.
Key Features
Broad coverage encompasses chemistry, technology, functionality, and applica-
tions of Nigella sativa
Authored by international academics and industry experts
Addresses growing application areas including pharmaceuticals, functional
foods, nutraceuticals, and cosmetics
x
Readership
Academics and students with a research interest in the area (pharmacologists,
food chemists, lipid scientists, food scientists, and agronomists)
Pharmaceutics, functional food developers, and R&D managers working in all
sectors using medicinal plants and specialty oils
Description
xi
Contents
1 Introduction to Black Cumin (Nigella sativa): Chemistry,
Technology, Functionality and Applications . . . . . . . . . . . . . . . . . . . . . 1
Mohamed Fawzy Ramadan
Part I Nigella sativa Seeds: Cultivation, Composition and Applications
2 Effect of Cultivation, Ferfztilization and Irrigation Practices
on Nigella sativa Yield and Quality . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
Enas Mohamed Wagdi Abdel-Hamed
3 Morphological Characters of Nigella sativa . . . . . . . . . . . . . . . . . . . . . 23
Mohamed Helmy El-Morsy and Hanan El-Sayed Osman
4 Micro and Macroscopic Characterization of Traded
Nigella sativa Seeds Using Applied Systematics Techniques . . . . . . . . 31
Soa Rashid, Muhammad Zafar, Mushtaq Ahmad, Shazia Sultana,
Sidra Nisar Ahmed, and Omer Kilic
5 Composition of Nigella sativa Seeds . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Hamid Mukhtar, Muhammad Waseem Mumtaz, Tooba Tauqeer,
and Syed Ali Raza
6 Nigella sativa Seed Peptides (Thionins) . . . . . . . . . . . . . . . . . . . . . . . . . 59
Ali Osman
7 Black Cumin Polysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Ines Trigui, Salma Cheikh-Rouhou, Hamadi Attia,
and Mohamed Ali Ayadi
8 Thymoquinone: Chemistry and Functionality . . . . . . . . . . . . . . . . . . . 81
Amr E. Edris
xii
9 Novel Prospective of N. sativa Essential Oil Analysis, Culinary
and Medicinal Uses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Doaa M. Abo-Atya, Mohamed F. El-Mallah, Hesham R. El-Seedi,
and Mohamed A. Farag
10 Rediscovering Nigella Seeds Bioactives Chemical Composition
Using Metabolomics Technologies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
Mohamed A. Farag, Hamada H. Saad, and Nesrine M. Hegazi
11 Health Promoting Activities of Nigella sativa Seeds . . . . . . . . . . . . . . . 153
Ebru Aydin and Arzu Kart
12 Nigella sativa Seed Extract in Green Synthesis
and Nanocomposite . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Raya Soltane, Dalila Mtat, Amani Chrouda, Noof Alzahrani,
Youssef O. Al-Ghamdi, Hussam El-Desouky, and Khaled Elbanna
13 Food Applications of Nigella sativa Seeds . . . . . . . . . . . . . . . . . . . . . . . 191
Omar Bashir, Nusrat Jan, Gousia Gani, H. R. Naik,
Syed Zameer Hussain, Monika Reshi, and Tawheed Amin
14 Nutraceutical Importance and Applications of Nigella sativa
Seed Flour . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
Jasmeet Kour, Adil Gani, Vishal Sharma, and Sajad Ahmad So
15 Nigella sativa Seed Cake: Nutraceutical Significance
and Applications in the Food and Cosmetic Industry . . . . . . . . . . . . . 223
Jasmeet Kour and Adil Gani
16 Nigella sativa Seeds in Cosmetic Products: Shedding the Light
on the Cosmeceutical Potential of Nigella sativa and its Utilization
as a Natural Beauty Care Ingredient . . . . . . . . . . . . . . . . . . . . . . . . . . 231
Fadia S. Youssef
17 Nigella sativa Supplementation in Ruminant Diets:
Production, Health, and Environmental Perspectives . . . . . . . . . . . . . 245
Yasmina M. Abd El-Hakim, Adham A. Al-Sagheer,
Asmaa F. Khafaga, Gaber E. Batiha, Muhammad Arif,
and Mohamed E. Abd El-Hack
18 Nigella sativa Seeds and Its Derivatives in Poultry Feed . . . . . . . . . . . 265
Mohamed E. Abd El-Hack, Abdel-Moneim E. Abdel-Moneim,
Noura M. Mesalam, Khalid M. Mahrose, Asmaa F. Khafaga, Ayman
E. Taha, and Ayman A. Swelum
19 Nigella sativa Seeds and Its Derivatives in Fish Feed . . . . . . . . . . . . . . 297
Mohamed E. Abd El-Hack, Sameh A. Abdelnour, Asmaa F. Khafaga,
Ayman E. Taha, and Hany M. R. Abdel-Latif
Contents
xiii
Part II Nigella sativa Fixed Oil: Chemistry, Technology, Functionality
and Applications
20 Composition and Functionality of Nigella sativa Fixed Oil . . . . . . . . . 319
Mustafa Kiralan, Sündüz Sezer Kiralan, Gulcan Ozkan,
and Mohamed Fawzy Ramadan
21 Effect of Processing on the Composition and Quality
of Nigella sativa Fixed Oil . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 335
Yeganeh Mazaheri, Mohammadali Torbati,
and Sodeif Azadmard-Damirchi
22 Food Applications of Nigella sativa Fixed Oil . . . . . . . . . . . . . . . . . . . . 349
Mustafa Kiralan, Sündüz Sezer Kiralan, Gulcan Ozkan,
and Mohamed Fawzy Ramadan
23 Health-Promoting Activities of Nigella sativa Fixed Oil . . . . . . . . . . . 361
Mahmoud Balbaa, Marwa El-Zeftawy, Shaymaa A. Abdulmalek,
and Yasmin R. Shahin
24 Micro- and Nano-encapsulation of Nigella sativa Oil . . . . . . . . . . . . . 381
Amr E. Edris
25 Biodiesel Production Potential of Nigella sativa Oil . . . . . . . . . . . . . . . 389
Muhammad Sajjad Iqbal
Part III Nigella sativa Essential Oil: Chemistry, Technology,
Functionality and Applications
26 Composition and Functionality of Nigella sativa Essential Oil . . . . . . 409
Mehmet Aksu, Gulcan Ozkan, Sündüz Sezer Kiralan,
Mustafa Kiralan, and Mohamed Fawzy Ramadan
27 Effect of Processing on the Composition and Quality
of Nigella sativa Essential Oil . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 421
Faten M. Ibrahim and S. F. El Habbasha
28 Food Applications of Nigella sativa Essential Oil . . . . . . . . . . . . . . . . . 433
Wei Liao, Waisudin Badri, Amani H. Alhibshi, Emilie Dumas,
Sami Ghnimi, Adem Gharsallaoui, Abdelhamid Errachid,
and Abdelhamid Elaissari
29 Health-Promoting Activities of Nigella sativa Essential Oil . . . . . . . . 457
Mahmoud Alagawany, Shabaan S. Elnesr, Mayada R. Farag,
Mohamed E. Abd El-Hack, Asmaa F. Khafaga, Khan Sharun,
Gopi Marappan, and Kuldeep Dhama
Contents
xiv
Part IV Nigella sativa Seed Extracts: Chemistry, Technology,
Functionality and Applications
30 Composition and Functionality of Nigella sativa Seed Extracts . . . . . 481
Songul Kesen
31 Nigella sativa Seed Extracts in Functional Foods
and Nutraceutical Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 501
Ranga Rao Ambati and Mohamed Fawzy Ramadan
32 Health Promoting Activities of Nigella sativa Seed Extracts . . . . . . . . 521
Arzu Kart and Ebru Aydın
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 539
Contents
xv
Contributors
Mohamed E. Abd El-Hack Department of Poultry, Faculty of Agriculture,
Zagazig University, Zagazig, Egypt
YasminaM.Abd El-Hakim Department of Forensic Medicine and Toxicology,
Zagazig University, Zagazig, Egypt
Enas Mohamed Wagdi Abdel-Hamed Soil Science Department, Faculty of
Agriculture, Zagazig University, Zagazig, Egypt
Hany M. R. Abdel-Latif Department of Poultry and Fish Diseases, Faculty of
Veterinary Medicine, Alexandria University, Edna, Behera, Egypt
Abdel-Moneim E. Abdel-Moneim Biological Application Department, Nuclear
Research Center, Atomic Energy Authority, Abu-Zaabal, Egypt
SamehA.Abdelnour Department of Animal Production, Faculty of Agriculture,
Zagazig University, Zagazig, Egypt
Shaymaa A. Abdulmalek Biochemistry Department, Faculty of Science,
Alexandria University, Alexandria, Egypt
Doaa M. Abo-Atya Department of Chemistry, Faculty of Science, Menoua
University, Shebin El-Koom, Egypt
Mushtaq Ahmad Department of Plant Sciences, Quaid-i-Azam University,
Islamabad, Pakistan
Sidra Nisar Ahmed Department of Plant Sciences, Quaid-i-Azam University,
Islamabad, Pakistan
Department of Botany, The Women University Multan, Multan, Pakistan
Mehmet Aksu Isparta Provincial Coordination Unit, Agriculture and Rural
Development Support Institution, Isparta, Turkey
Mahmoud Alagawany Department of Poultry, Faculty of Agriculture, Zagazig
University, Zagazig, Egypt
xvi
Youssef O.Al-Ghamdi Department of Chemistry, College of Al-Zul, Majmaah
University, Al-Majmaah, Saudi Arabia
AmaniH.Alhibshi Department of Neuroscience Research, Institute of Research
and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University,
Dammam, Saudi Arabia
AdhamA.Al-Sagheer Department of Animal Production, Faculty of Agriculture,
Zagazig University, Zagazig, Egypt
NoofAlzahrani Department of Basic Sciences, Adham University College, Umm
Al-Qura University, Adham, Saudi Arabia
Ranga Rao Ambati Department of Biotechnology, Vignan’s Foundation for
Science, Technology and Research University (VFSTRU) (Deemed to Be
University), Guntur, Andhra Pradesh, India
Tawheed Amin Division of Food Science and Technology, SKUAST-Kashmir,
Srinagar, Jammu and Kashmir, India
Muhammad Arif Department of Animal Sciences, College of Agriculture,
University of Sargodha, Sargodha, Pakistan
Hamadi Attia Valuation, Security, and Food Analysis Laboratory, National
Engineering School of Sfax, Sfax, Tunisia
MohamedAliAyadi Valuation, Security, and Food Analysis Laboratory, National
Engineering School of Sfax, Sfax, Tunisia
EbruAydin Faculty of Engineering, Department of Food Engineering, Suleyman
Demirel University, Isparta, Turkey
Sodeif Azadmard-Damirchi Department of Food Science and Technology,
Faculty of Agriculture, University of Tabriz, Tabriz, Iran
WaisudinBadri Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-
UMR 5007, Lyon, France
Mahmoud Balbaa Biochemistry Department, Faculty of Science, Alexandria
University, Alexandria, Egypt
Omar Bashir Division of Food Science and Technology, SKUAST-Kashmir,
Srinagar, Jammu and Kashmir, India
Gaber E. Batiha National Research Center for Protozoan Diseases, Obihiro
University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine,
Damanhour University, Damanhour, AlBeheira, Egypt
Salma Cheikh-Rouhou Valuation, Security, and Food Analysis Laboratory,
National Engineering School of Sfax, Sfax, Tunisia
Contributors
xvii
Amani Chrouda Department of Chemistry, College of Al-Zul, Majmaah
University, Al-Majmaah, Saudi Arabia
Laboratory of Interfaces and Advanced Materials, Faculty of Sciences, University
of Monastir, Monastir, Tunisia
Laboratory of Analytical Sciences UMR CNRS-UCBL-ENS 5280, Villeurbanne
Cedex, France
Kuldeep Dhama Division of Pathology, ICAR-Indian Veterinary Research
Institute, Bareilly, Uttar Pradesh, India
EmilieDumas Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-
UMR 5007, Lyon, France
AmrE.Edris Aroma & Flavor Chemistry Department, Food Industries & Nutrition
Division, National Research Center, Cairo, Egypt
Abdelhamid Elaissari Univ Lyon, University Claude Bernard Lyon-1, CNRS,
LAGEP-UMR 5007, Lyon, France
KhaledElbanna Department of Agricultural Microbiology, Faculty of Agriculture,
Fayoum University, Fayoum, Egypt
Department of Biology, Faculty of Applied Science, Umm Al-Qura University,
Makkah, Saudi Arabia
Hussam El-Desouky Chemistry Department, Faculty of Science, Helwan
University, Helwan, Egypt
Chemistry Department, Jamoum University College, Umm Al-Qura University,
Makkah, Saudi Arabia
S.F.El Habbasha Field Crops Research Department, National Research Centre,
Dokki, Giza, Egypt
MohamedF.El-Mallah Department of Chemistry, Faculty of Science, Menoua
University, Shebin El-Koom, Egypt
Mohamed Helmy El-Morsy Deanship of Scientic Research, Umm Al-Qura
University, Makkah, Saudi Arabia
Range Management Unit, Desert Research Center, Cairo, Egypt
Shabaan S. Elnesr Department of Poultry Production, Faculty of Agriculture,
Fayoum University, Fayoum, Egypt
Hesham R. El-Seedi Department of Chemistry, Faculty of Science, Menoua
University, Shebin El-Koom, Egypt
Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala
University, Uppsala, Sweden
Marwa El-Zeftawy Biochemistry Department, Faculty of Veterinary Medicine,
The New Valley University, New Valley, Egypt
Contributors
xviii
Abdelhamid Errachid Univ Lyon, University Claude Bernard Lyon-1, CNRS,
ISA- UMR 5280, CNRS, Villeurbanne, France
Mayada R. Farag Forensic Medicine and Toxicology Department, Faculty of
Veterinary Medicine, Zagazig University, Zagazig, Egypt
Mohamed A. Farag Pharmacognosy Department, College of Pharmacy, Cairo
University, Cairo, Egypt
Department of Chemistry, School of Sciences & Engineering, The American
University in Cairo, New Cairo, Egypt
AdilGani Department of Food Science and Technology, University of Kashmir,
Srinagar, Jammu and Kashmir, India
Gousia Gani Division of Food Science and Technology, SKUAST-Kashmir,
Srinagar, Jammu and Kashmir, India
Adem Gharsallaoui Univ Lyon, University Claude Bernard Lyon-1, CNRS,
LAGEP-UMR 5007, Lyon, France
Sami Ghnimi Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-
UMR 5007, Lyon, France
Nesrine M. Hegazi Department of Pharmaceutical Biology, Pharmaceutical
Institute, Eberhard Karls University of Tübingen, Tübingen, Germany
Syed Zameer Hussain Division of Food Science and Technology, SKUAST-
Kashmir, Srinagar, Jammu and Kashmir, India
FatenM.Ibrahim Medicinal and Aromatic Plants Research Department, National
Research Centre, Dokki, Giza, Egypt
Muhammad Sajjad Iqbal Department of Botany, University of Gujrat, Gujrat,
Pakistan
Nusrat Jan Division of Food Science and Technology, SKUAST-Kashmir,
Srinagar, Jammu and Kashmir, India
ArzuKart Faculty of Engineering, Department of Food Engineering, Suleyman
Demirel University, Isparta, Turkey
Songul Kesen Naci Topcuoglu Vocational High School, Gaziantep University,
Gaziantep, Turkey
Asmaa F. Khafaga Department of Pathology, Faculty of Veterinary Medicine,
Alexandria University, Edna, Egypt
Omer Kilic Department of Basic Science of Pharmacy, Adıyaman University,
Adıyaman, Turkey
Mustafa Kiralan Faculty of Engineering, Department of Food Engineering,
Balıkesir University, Balikesir, Turkey
Contributors
xix
SündüzSezerKiralan Faculty of Engineering, Department of Food Engineering,
Balıkesir University, Balikesir, Turkey
JasmeetKour Department of Food Engineering and Technology, Sant Longowal
Institute of Engineering and Technology, Longowal, Punjab, India
WeiLiao Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR
5007, Lyon, France
Khalid M. Mahrose Animal and Poultry Production Department, Faculty of
Technology and Development, Zagazig University, Zagazig, Egypt
GopiMarappan Division of Avian Physiology and Reproduction, ICAR-Central
Avian Research Institute, Bareilly, Uttar Pradesh, India
Yeganeh Mazaheri Department of Food Science and Technology, Faculty of
Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
NouraM.Mesalam Biological Application Department, Nuclear Research Center,
Atomic Energy Authority, Abu-Zaabal, Egypt
Dalila Mtat Laboratory of Asymmetric Organic Synthesis and Homogeneous
Catalysis (UR11ES56), Faculty of Sciences of Monastir Avenue of the Environment,
Monastir, Tunisia
Hamid Mukhtar Institute of Industrial Biotechnology, Government College
University, Lahore, Pakistan
MuhammadWaseemMumtaz Department of Chemistry, University of Gujrat,
Gujrat, Pakistan
H.R.Naik Division of Food Science and Technology, SKUAST-Kashmir, Srinagar,
Jammu and Kashmir, India
AliOsman Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig
University, Zagazig, Egypt
HananEl-SayedOsman Biology Department, Faculty of Applied Science, Umm
Al-Qura University, Makkah, Saudi Arabia
Botany and Microbiology Department, Faculty of Science, Al-Azhar University,
Cairo, Egypt
Gulcan Ozkan Faculty of Engineering, Department of Food Engineering,
Suleyman Demirel University, Isparta, Turkey
Mohamed Fawzy Ramadan Deanship of Scientic Research, Umm Al-Qura
University, Makkah, KSA
Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University,
Zagazig, Egypt
SoaRashid Department of Plant Sciences, Quaid-i-Azam University, Islamabad,
Pakistan
Department of Bio Sciences, Comsats University Islamabad, Islamabad, Pakistan
Contributors
xx
SyedAliRaza Department of Chemistry, Government College University, Lahore,
Pakistan
Monika Reshi Division of Food Science and Technology, SKUAST-Kashmir,
Srinagar, Jammu and Kashmir, India
HamadaH.Saad Phytochemistry and Plant Systematics Department, Division of
Pharmaceutical Industries, National Research Centre, Cairo, Egypt
Department of Pharmaceutical Biology, Pharmaceutical Institute, Eberhard Karls
University of Tübingen, Tübingen, Germany
Yasmin R. Shahina Biochemistry Department, Faculty of Science, Alexandria
University, Alexandria, Egypt
Vishal Sharma Department of Industries and Commerce, District Industries
Centre, Kathua, Jammu and Kashmir, India
Khan Sharun Division of Surgery, ICAR-Indian Veterinary Research Institute,
Bareilly, Uttar Pradesh, India
Sajad Ahmad So Division of Food Science and Technology, Sher-e-Kashmir
University of Agricultural Science & Technology, Srinagar, Jammu and Kashmir,
India
Raya Soltane Department of Basic Sciences, Adham University College, Umm
Al-Qura University, Adham, Saudi Arabia
Department of Biology, Faculty of Sciences, Tunis El Manar University, El Manar,
Tunis, Tunisia
Shazia Sultana Department of Plant Sciences, Quaid-i-Azam University,
Islamabad, Pakistan
Ayman A. Swelum Department of Theriogenology, Faculty of Veterinary
Medicine, Zagazig University, Zagazig, Egypt
Ayman E. Taha Department of Animal Husbandry and Animal Wealth
Development, Faculty of Veterinary Medicine, Alexandria University, Edna, Egypt
ToobaTauqeer Department of Chemistry, University of Gujrat, Gujrat, Pakistan
MohammadaliTorbati Department of Food Science and Technology, Faculty of
Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
Ines Trigui Valuation, Security, and Food Analysis Laboratory, National
Engineering School of Sfax, Sfax, Tunisia
FadiaS.Youssef Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams
University, Cairo, Egypt
Muhammad Zafar Department of Plant Sciences, Quaid-i-Azam University,
Islamabad, Pakistan
Contributors
xxi
About the Editor
Mohamed Fawzy Ramadan is a Professor in the
Department of Agricultural Biochemistry, Faculty of
Agriculture, at Zagazig University, Zagazig, Egypt.
Since 2013, Prof. Ramadan has also been a Professor
of Biochemistry and Consultant of International
Publishing at the Deanship of Scientic Research,
Umm Al-Qura University, Makkah, Saudi Arabia.
Prof. Ramadan obtained his Ph.D. (Dr.rer.nat.) in
Food Chemistry from Berlin University of Technology
(Germany, 2004). He continued his postdoctoral
research at ranked universities in different countries,
such as the University of Helsinki (Finland), Max-
Rubner Institute (Germany), Berlin University of
Technology (Germany), and the University of Maryland
(USA). In 2010, he was appointed as Visiting Professor
(100% research) at King Saud University in Saudi
Arabia. In 2012, Prof. Ramadan was appointed as
Visiting Professor (100% teaching) in the School of
Biomedicine at Far Eastern Federal University in
Vladivostok, Russian Federation.
Prof. Ramadan has published more than 250
research papers and reviews in international peer-
reviewed journals as well as several books and book
chapters (Scopus h-index is 40 and more than 4300
citations). He was an invited speaker at several interna-
tional conferences. Since 2003, Prof. Ramadan has
been a reviewer and editor of several highly cited inter-
national journals such as Journal of Medicinal Food
and Journal of Advanced Research.
xxii
Prof. Ramadan received Abdul Hamid Shoman
Prize for Arab Researcher in Agricultural Sciences
(2006), Egyptian State Prize for Encouragement in
Agricultural Sciences (2009), European Young Lipid
Scientist Award (2009), AU-TWAS Young Scientist
National Awards (Egypt) in Basic Sciences, Technology
and Innovation (2012), TWAS-ARO Young Arab
Scientist (YAS) Prize in Scientic and Technological
Achievement (2013), and Atta-ur- Rahman Prize in
Chemistry (2014).
About the Editor
... and steric acid (C18:0, 2.0-5.5%) [21][22][23][24]. The minor Nigella seed oil constituents include different terpenoids (monoterpenoids, sterols, tocols, carotenoids) and phenolic compounds [23]. ...
... [21][22][23][24]. The minor Nigella seed oil constituents include different terpenoids (monoterpenoids, sterols, tocols, carotenoids) and phenolic compounds [23]. ...
... The most common approach for extracting oil is cold-press extraction. This method avoids the use of heat and chemicals but results in lower yields [23,25]. The extracted also known as crude oil, is composed mainly of fixed oil, which is a non-volatile oil with the same lipid composition as that described above. ...
Article
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Nigella sativa oil (NSO) and its essential oil (NSEO) have long been used in traditional treatment for various ailments. However, in practice, these substances are limited by their limited solubility in water, instability, and low bioavailability. Encapsulation has emerged as a promising solution for addressing these issues. This review is dedicated to the chemical composition of Nigella crude and essential oils, the exploration of their encapsulation system preparation methods, and a comprehensive examination of their potential applications across the food, cosmetics, and pharmaceutical industries. This exhaustive survey serves as an invaluable resource for researchers, professionals, and students with a keen interest in the encapsulation of N. sativa using cyclodextrins and liposomes.
... ecological allows CO 2 absorption at night, which minimizes water loss during the photosynthesis. Numerous colors of Opuntia spp., including red, violet, green, and yellow, result from genetic variation [10,11]. ...
... Several Opuntia spp. are known to be renowned weeds in various regions worldwide, while some species, like Opuntia ficus-indica, are professionally farmed for edible and feed uses [7,8,[10][11][12]. Although Opuntia spp. ...
... The Opuntia fruit is made up of a thick skin (40-60% of the fruit weight) that surrounds a pulp (30-60% of the fruit weight) that contains smaller seeds (2-10% of the fruit weight). Opuntia fruit pulp is the starting point for many manufactured food items like juices and jams [10,11]. Opuntia ficus-indica seed oil is usually utilized in various meals, cosmetics, and pharmaceuticals, but fruit seeds contain significant lipid content. ...
Article
Full-text available
This review was conducted to fully comprehend the nutritional value of the Opuntia spp., alongside the impact of the bioactive components on health and how well they combat disease. Opuntia ficus-indica fruit is plentiful with the amino acid taurine, a therapeutic compound, alongside vitamins C, E, and K. Opuntia plants are renowned for having a high level of phenolic acids, antioxidants, and pigments like betalains in all of their parts (pulp, roots, cladodes, seeds, and juice). Bioactives content enables Opuntia ficus-indica fruit to generate significant antidepressant effects, an anticancer impact, and the ability to prevent fatty liver disease or hepatic steatosis. Opuntia ficus-indica fruit has a desirable technique of consumption that may be applied as a nutritious component in several edible and value-added items. Fruits and stems may be eaten, making them a great natural energy source and supplement antioxidants and nutritional components that may be added to the diet. Traditionally, Opuntia ficus-indica seed oil is used in various foods, cosmetic products, and medications, mainly for treating chronic disorders, wound healing, and urinary tract infections in traditional folk medicine. In addition, Opuntia fruits could be utilized successfully in various food and nonfood applications.
... Average life expectancy and a healthy diet are strongly associated [1]. Food product adulterations, the effect of pesticides (organophosphates, carbamates, organochlorines, etc.) on fruits and vegetables, improper plastic usage, and side effects of medicines all have a negative influence on human health, thereby contributing to a number of ailments (leukemia, lymphoma, cancers of the breast, brain, prostate, testes, and ovaries). ...
Article
Full-text available
Background: Black cumin/Nigella sativa is traditionally used for its wide range of medicinal effects. Clove/Syzygium aromaticum is well known as a natural antibiotic with antiviral, antibacterial, and antifungal properties, and onion/Allium cepa for its antibacterial properties. The combination of these extracts can effectively have many therapeutic applications. Aim: The aim of the present study is to prepare the formulation of N. sativa, S. aromaticum, A. cepa and to assess the antimicrobial activity and cytotoxic effect of the prepared formulation. Materials and Methods: Antimicrobial activity was carried out by agar well diffusion method and cytotoxic activity was carried out using the brine shrimp lethality assay method. Results: The antimicrobial activity showed the zone of inhibition was highest with Staphylococcus aureus showing 22 mm of zone of inhibition at 100 µl. The cytotoxicity test showed there are about 90% live nauplii in the lowest concentration at 5 µl. Conclusion: The study concluded that the combination extract of N. sativa, S. aromaticum, and A. cepa could be used as an antimicrobial agent. Further research with pathogenic oral microorganisms can validate this formulation as an antimicrobial gel or mouthwash for various pathologies.
... Nigella sativa, commonly known as black cumin or black seed, is a culinary spice and an age-old medicinal herb with a wide range of health-beneficial pharmacological effects to attenuate oxidative stress, inflammation, immunity, energy metabolism, and cell survival (6,7). Black cumin oil composed of both volatile and fixed oil fractions was identified as the major bioactive component of black cumin, in which thymoquinone (TQ) is considered the most active molecule (8). Black cumin has been reported to have antioxidant, anti-inflammatory, and neuroprotective effects as a function of its TQ content (6,(9)(10)(11). ...
Article
Full-text available
Objective Stress, sleep, and immunity are important interdependent factors that play critical roles in the maintenance of health. It has been established that stress can affect sleep, and the quality and duration of sleep significantly impact immunity. However, single drugs capable of targeting these factors are limited because of their multi-targeting mechanisms. The present study investigated the influence of a proprietary thymoquinone-rich black cumin oil extract (BCO-5) in modulating stress, sleep, and immunity. Methods A randomized double-blinded placebo-controlled study was carried out on healthy volunteers with self-reported non-refreshing sleep issues (n = 72), followed by supplementation with BCO-5/placebo at 200 mg/day for 90 days. Validated questionnaires, PSQI and PSS, were employed for monitoring sleep and stress respectively, along with the measurement of cortisol and melatonin levels. Immunity markers were analyzed at the end of the study. Results In the BCO-5 group, 70% of the participants reported satisfaction with their sleep pattern on day 7 and 79% on day 14. Additionally, both inter- and intra- group analyses of the total PSQI scores and component scores (sleep latency, duration, efficiency, quality, and daytime dysfunction) on days 45 and 90 showed the effectiveness of BCO-5 in the improvement of sleep (p < 0.05). PSS-14 analysis revealed a significant reduction in stress, upon both intra (p < 0.001) and inter-group (p < 0.001) comparisons. The observed reduction in stress among the BCO-5 group, with respect to the placebo, was significant with an effect size of 1.19 by the end of the study (p < 0.001). A significant correlation was also observed between improved sleep and reduced stress as evident from PSQI and PSS. Furthermore, there was a significant modulation in melatonin, cortisol, and orexin levels. Hematological/immunological parameters further revealed the immunomodulatory effects of BCO-5. Conclusion BCO-5 significantly modulated the stress-sleep-immunity axis with no side effects and restored restful sleep.
... The SDG target 12.3 aims to halve global food biowaste per capita and reduce food biowaste along the processing and supply chains [15][16][17]. A significant link between people and a sustainable circular economy in the food sector is the value-added chain, which includes how plants are farmed, transported, marketed, processed, and consumed [19]. Therefore, biowastes from edible oil and oilseed processing could be inexpensive, efficient, and environmentally benign, reducing environmental consequences. ...
Article
Full-text available
Obesity has become a worldwide epidemic and its prevalence continues to increase at an alarming rate. It is considered a major risk factor for the development of several comorbidities, including type 2 diabetes, stroke, other cardiovascular diseases and even cancer. Conventional treatments for obesity, such as dietary interventions, exercise and pharmacotherapy, have proven to have limited effectiveness and are often associated with undesirable side effects. Therefore, there is a growing interest in exploring alternative therapeutic approaches. Nigella sativa (NS), a medicinal plant with multiple pharmacological properties, has gained attention due to its potential role in the treatment of obesity and its associated complications. The aim of this review is therefore to assess the effects of NS on obesity and its complications and to provide insights into the underlying mechanisms. From this review, NS appears to play a complementary or supportive role in the treatment of obesity and its complications. However, future studies are needed to verify the efficacy of NS in the treatment of obesity and its complications and to prove its safety so that it can be introduced in patients with obesity.
Article
Full-text available
Climate change could negatively impact black cumin (Nigella sativa) cultivation, changing the crop's characteristics. Thus, the farming of new expanses was necessary. As a result, this research was carried out in Egypt to determine the effect of newly reclaimed regions on production. The study was conducted in four desert locations: El-Hammam, Matrouh Governorate; Oraby Association, Al-Eubour, Qalyubia Governorate; Tour Sinai, South Sinai Governorate; and the western desert hinterland, Minya Governorate. The results revealed that all ecosystems significantly affected growth and yield traits. The highest plant height, fresh and dry weights per plant, capsule numbers per plant, seed yield, and fixed oil per unit area were from the governorates of Minya, followed by South Sinai, Qalyubia, and Matrouh, respectively. The highest content of unsaturated fatty acids and the lowest concentration of saturated fatty acids were from the governorates of Matrouh, followed by Minya, Qalyubia, and South Sinai, in that order. Based on the quantity and quality characteristics, the study recommended cultivating black cumin in newly reclaimed lands in the western desert hinterland of Minya Governorate, then South Sinai Governorate, as new areas for this crop's production.
Chapter
Full-text available
Nigella sativa (black cumin) is an annual flowering plant grown in the Middle East, Asia, and Mediterranean regions. Black cumin seeds are well known in history with their therapeutic effects in various cultures and also are used for culinary applications. Oil extraction is possible with different methods, but nowadays, the cold press method is gaining importance with the modern customers’ healthy product preferences and its by-products rich in bioactive phytochemicals. The main compounds of seedcakes are carbohydrates, proteins, minerals, fibers, flavonoids, phenolics, and vitamins. Even though the seedcakes are used only as fodder for animals, recent studies have shown the seedcakes’ potential as a value-added raw material or additives for functional food, supplements, cosmeceuticals, and pharmaceuticals with their antioxidant, antimicrobial, and nutritional effects. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
Chapter
Nigella sativa L. belongs to Ranunculaceae family and is native to southwest Asia and the Mediterranean. The seed of the plant is reported to be high in fixed and essential oils, proteins, alkaloids, and saponin. In folk medicine, the seeds of N. sativa, often known as “black seed” or “black cumin,” are used to cure and prevent a variety of ailments. Much of its biological activity has been linked to thymoquinone, which has been shown to have anticancer properties. Essential oils, usually referred to as volatile or ethereal oils, are fragrant oily liquids derived from plant material. The main volatile components of the N. sativa essential oil are p-cymene, γ-terpinene, α-thujene, carvacrol, α-pinene, and β-pinene. This chapter focuses on an in-depth discussion of the volatile components of N. sativa as well as its extraction processes. The chapter also discusses its aroma quality in detail.
Egyptian State Prize for Encouragement in Agricultural Sciences
Prof. Ramadan received Abdul Hamid Shoman Prize for Arab Researcher in Agricultural Sciences (2006), Egyptian State Prize for Encouragement in Agricultural Sciences (2009), European Young Lipid Scientist Award (2009), AU-TWAS Young Scientist National Awards (Egypt) in Basic Sciences, Technology and Innovation (2012), TWAS-ARO Young Arab Scientist (YAS) Prize in Scientific and Technological Achievement (2013), and Atta-ur-Rahman Prize in Chemistry (2014).