Mk Atiku

Bayero University, Kano · Department of Biochemistry

Background and aims. Diabetes mellitus (DM) is a significant global health concern and a leading contributor to mortality. It is characterized by both macrovascular and microvascular complications. Preventing the onset of diabetes and managing its associated complications are of utmost importance. In recent times, there has been a growing inclinati...

Momordica charantia (bitter melon) has been used extensively in herbal medicine as a remedy for many diseases. The present study evaluated sub chronic toxicological indices of the liver following 4 weeks administration of Momordica charantia (MC) aqueous leaf extract to alloxan-induced diabetic rat. The extract was administered orally at the dose o...

This study was aimed at studying the effect of solvents (n-hexane, chloroform and methanol) fractions of Cucurbita maxima (pumpkin) cuticular lipids on metabolic biomarkers of cardiovascular disease using L-NAME induced hypertensive rats. A total of thirty-six (120-150 g) albino rats were randomly selected and placed into twelve groups of three rat...

Shisha Smoking is a risk factor for coronary heart diseases. The smoke contains large amount of chemicals which are capable of generating reactive oxygen species which play an important role in oxidative stress which in turn leads to the development and progression of many disorders such as hypertension, cancer, diabetes mellitus and cardiovascular...

Cabbage and lettuce were collected from three locations each along the irrigation farms of Rivers Jakara and Getsi. Domestic and industrial waste are freely discharge into these rivers. Thirty Nine Albino Rats were divided into Thirteen (13) groups where Animals in groups 1-12 were fed with diet containing 10% cabbage or lettuce. The 13th group wer...

Three samples of soil, lettuce and cabbage were collected from three sites along River Jakara (Zungeru, Airport Road and P.R.P) and River Getsi (Gama, Gayawa and Getsi) and were analyzed for Fe, Pb, Zn, Cu, Mn, Cr, As, Ni, Cd, Co, and Hg content using Atomic Absorption Spectrophotometer and the toxicological indices of the soils and vegetables were...

Background and aims: Amino acids composition of local and regional dietary proteins determines the protein quality. The study was aimed at evaluating amino acid profiles of some selected traditional diets commonly consumed in Jigawa (JG), Kano (KN) and Katsina (KT) States, Northwest Zone-Nigeria. Methods: The selected prepared diets (four per state...

Hypercholesterolemia is characterized by high blood cholesterol. It is a leading cause of disease burden accounting for one-third of ischemic heart diseases and one-fifth of stroke and reports reveal a rising prevalence across many low-income countries including Nigeria. While the quest for a therapeutic remedy is ongoing, this study investigated t...

Background Changes in blood lipid level (dyslipidemia) play a central role in the onset and pathogenesis of macrovascular complications of diabetes mellitus. Traditional herbal healers commonly use anti-diabetic polyherbal formulations to provide a multi-therapeutic approach for the treatment of diabetes mellitus and its associated complications. T...

Plantain (Musa paradisiaca) fruit constitutes a staple food widely consumed predominantly in Africa. The peel, a major by-product, of plantain fruit is largely viewed to be of little or no significance and consequently discarded, thereby constituting a threat to the environment. It is on account of the foregoing that this study was designed to inve...

Cadaba farinosa Forssk is a wild shrub whose seeds are eaten as a famine food in North Eastern Nigeria when there is poor harvest of conventional crops. This research was carried out in order to evaluate the protein quality of the seeds and to carry out the growth performance of experimental animals fed on seeds processed by different methods. The...

Metabolic Syndrome (MS) is a term that describe the presence of conditions that increase an individual risk for heart disease and other disorders such as diabetes and stroke, and its occurrence is in the rise in residents of North-Western Nigeria, The aim of this study was to investigate the prevalence and determinants of metabolic syndrome in resp...

Background: Okra fruits have been found to be efficient in managing hyperlipidemia. But, there are different varieties of Okra, and whether antihyperlipidemic efficiency varies with the varieties has not been reported. Aim of the Study: The aim of the study was to validate antihyperlipidemic efficiencies of some Okra fruits varieties on rats fed hi...

Aim: To evaluate hypolipidaemic potentials of column chromatography fractions (F1 to F6) of the chloroform leaf extract of Ficus polita and to detect the bioactive compounds present in the most active fraction using spectroscopic techniques. Study Design: Fourty-five (45) wistar rats were grouped into nine groups of five rats each: normal control,...

Most acute and chronic liver diseases today are due to drugs and other chemical-induced hepatotoxicity. A great number of herbal preparations have become increasingly popular for the treatment of liver disorders due to the absence of reliable hepatoprotective drugs in modern medicine. The aim of this work is to carry out acute toxicity study and in...

Background: The impairment of male fertility has been linked to exercise in a volume-, intensity-, and modality-dependent manner. Infertility is a worldwide problem and male factor infertility is found to be increased. Chronic administration of honey results in elevating sorbitol dehydrogenase activity and decreases lactose dehydrogenase activity,...

Tiger nut (Cyperus esculentus) is an edible perennial grass-like plant that has long been recognized for its health benefits as it is rich in fiber, protein, vitamins, minerals and natural sugars. It can be eaten raw, roasted or made into a refreshing milk which is very nutritive and healthy for consumption. There were several efforts to mass-produ...

Fats and oils are part of food constituents, and may play a vital role in cosmetics and pharmaceuticals industries. There are several underutilized plants which their seeds have not been fully studied in terms of oil extraction and characterization. In this work two underutilized plants seeds Nymphaea lotus and Nymphaea pubescens were studied. Oils...

In a preliminary research, the authors reported that solvents extracts of Alstonia boonei (Egbu) possess strong antimalarial activity against NK-65 Chloroquine sensitive Plasmodium berghei infected mice with aqueous extract having the highest decrease in mean percentage parasitaemia. This research is therefore aimed at evaluating the acute and sub-...

In a preliminary research, the authors reported that solvents extracts of Alstonia boonei (Egbu) possess strong antimalarial activity against NK-65 Chloroquine sensitive Plasmodium berghei infected mice with aqueous extract having the highest decrease in mean percentage parasitaemia. This research is therefore aimed at evaluating the acute and sub-...

Alstonia boonei, a plant locally called 'Egbu' in South Eastern Nigeria is used traditionally in the treatment of malaria in the region. This research was carried out to evaluate in vivo antimalarial activity of different solvents extract (aqueous, methanol and chloroform) of Alstonia boonei against NK-65 Chloroquine sensitive Plasmodium berghei in...

Alstonia boonei, a plant locally called ‘Egbu’ in South Eastern Nigeria is used traditionally in the treatment of malaria in the region. This research was carried out to evaluate in vitro antimalarial activity of different solvents extract (aqueous, methanol, ethyl acetate, chloroform and hexane) of Alstonia boonei against NK-65 Chloroquine sensiti...

Alstonia boonei, a plant locally called 'Egbu' in South Eastern Nigeria is used traditionally in the treatment of malaria in the region. This research was carried out to evaluate in vitro antimalarial activity of different solvents extract (aqueous, methanol, ethyl acetate, chloroform and hexane) of Alstonia boonei against NK-65 Chloroquine sensiti...

Alstonia boonei, a plant locally called 'Egbu' in South Eastern Nigeria is used traditionally in the treatment of malaria in the region. This research was carried out to evaluate in vivo antimalarial activity of different solvents extract (aqueous, methanol and chloroform) of Alstonia boonei against NK-65 Chloroquine sensitive Plasmodium berghei in...

Any association between body mass index and kidney disease has so far proved inconclusive. Therefore, this study is aimed to provide association between glomerular filtration rate and body mass index among orthopaedic patients. A total of sixty (60) patients irrespective of gender were recruited. Weight and height were measured prior to the sample...

Momordica charantia (bitter melon) has been used extensively in herbal medicine as remedy for many disease conditions. The present study was undertaken to evaluate the effect of Momordica charantia (MC) aqueous leaf extract on serum fasting blood glucose (FBG) and lipid profile (total cholesterol TC, triglyceride TAG, high density lipoprotein HDL,...

Use of potent antioxidants and inhibitors of intestinal glucose uptake are one of the current therapeutic approaches employed clinically to control post porandial hyperglycemia and hyperglycemic induced oxidative stress for achievement of good glycemic control and to prevent the onset of diabetic complications. The present study was aimed at evalua...

The Antioxidant effect of Citrullus Vulgaris (Watermelon) extract was evaluated against lipid oxidation in freshly caught fishes during cooking. GC-MS analysis of Hexane and total phenolic extract of Citrullus Vulgaris flesh reveals that the extracts contain 55 compounds which includes 5- hydroxymethyl furfural, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihy...

Background: AIDS has been one of most li fe threatening and fatal disease conditions. The causal virus, HIV, belongs to retroviral group which gradually attacks and weakens immune system, thus leaving the body susceptible to multitude of infections leading to death. A woman diagnosed with HIV wa s recommended to replace breastmilk by formulation. U...

Proper understanding of the correlation between various forms of stress and lipid profile can help in the management of stress related diseases. This study was carried out to assess serum lipid profile in stress condition on a total of thirty (30) Bayero University, Kano students whose information on general lifestyle, including reading habits as w...

Background: Alternative methods for stress monitoring and evaluation prove very useful in proper dealing with it. Thus, establishing a link between stress exposure and serum antioxidant vitamins’ levels would certainly provide a clue towards stress management. Aim: The study aimed at evaluating the status of serum antioxidant vitamins in stress con...

The seeds of baobab used in the preparation of local condiments were analyzed to establish the proximate compositions and the mineral elements present. Proximate analysis showed that the seed has very high protein content (45.57%) and moderately high content of carbohydrates (34.20%) with good fat content (7.07%), fiber content (4.80%), moisture co...

The present study determined body weight and height (Body Mass Index-BMI) was calculated according to the formula weight (kg)/height2 (m), Blood Pressure (BP), Hemoglobin (Hb), Fasting Blood Glucose (FBS) and Total Cholesterol (TC) in pregnant women (PW) in the three trimesters and in non-pregnant women (NPW). Sixty apparently healthy pregnant wome...

This study was carried out to determine the phytochemical constituents and acute toxicity of the aqueous root bark extract of Securidaca longipedunculata Linn. The result of phytochemical screening revealed the presence of some secondary metabolites of pharmacological significance in the aqueous root bark extract including alkaloids, cardiac glycos...

The hepatocurative effect of aqueous root extract of Calitropis Procera on CCl4 induced hepatotoxicity in rabbits was studied in groups of rabbit and the levels of liver enzymes; aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP). Serum concentrations of total bilirubin and direct bilirubin were found...

Acute toxicity study was carried out on three most common types of “Gadagi” tea preparations, “sak’’,”sada” and “magani”.. LD50 values of each type of the tea were determined. Results of phase I and phase II of the study showed no mortality was recorded in any of the experimental groups of rats in 24hours and up to four weeks after oral administrat...

ABSTRACT Background: world is facing explosive increase in diabetes mellitus. It poses a serious challenge to primary health care in developing countries, with negative consequences on the economy. This research is aim at evaluating the effect of Persea americana aqueous seed extract on alloxan induced diabetes rats. Methodology: Effects of the aqu...

The socioeconomic status and dietary eating habits of 640 apparently healthy adolescents aged between 12 and 19 years (320 males and 320 females) randomly selected from different community schools in Kano metropolis were determined using a structured interview schedule (24-hour dietary recall). Observation from the results indicated a clear trend o...

The influence of marital status and occupation on serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL – CH) concentrations was studied in sixty one (61) adult male and female Hausa subjects aged 20 – 50 years. Irrespective of marital status and occupation, female subjects had higher mean serum TC and HDL – CH levels than male...

Serum levels of total cholesterol (TC), high density lipoprotein cholesterol (HDL-CH) and low density lipoprotein cholesterol (LDL-CH) concentrations were determined in two hundred and fifty (250) apparently healthy females of child bearing age ( non pregnant, 127 and pregnant 123) who attended the antenatal and other clinics at Kura Comprehensive...

Effect of oral administration of “Gadagi” tea on liver function and serum glucose concentration was assessed on thirty (30) healthy non – pregnant female albino rats. The animals were grouped and administered different doses (mg/kg) i.e. (low dose; 0.75mg/kg for “Sak,” 1.40mg/kg for “Sada” and 2.10mg/kg for “magani.” Standard dose; 1.50mg/kg for “S...

The hypoglycaemic effect of aqueous leaf extract of Murraya koenigii was studied in normal and alloxan-induced diabetic rats. The extract was administered orally at 100 mg/Kg, 150 mg/Kg and 200 mg/Kg bodyweight each to respective groups of animals (Groups I, II and III) for seven days. Group IV received normal saline and served as control for the n...

Aim. The aim of this study was to assess the effects of interval training on the lipid profiles of adolescent Nigerian boys (N-30. and girls (N.=30).Methods. The lipid profiles assessed included the Very Low Density Lipoprotein-Cholesterol (VLDL-C); Low Density Lipoprotein-Cholesterol (LDL-C); and the High Density Lipoprotein-Cholesterol (HDL-C). P...

Hepatotoxic properties of the aqueous leaves of highland tea (Camellia sinensis) and aqueous stem bark extract of Khaya senegalensis were studied in rats. This was done by assaying the serum activities of aspartate aminotransferase(AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), glucose and bilirubin in rats administered with 6.5m...

Bodyweight and height measurements were carried out on 2, 100 healthy teenagers (1050 males and 1050 females) randomly selected in Kano metropolis. These measurements were used to calculate Body Mass Index (BMI) according to the formula weight (kg)/height 2 (m). Mean BMI values increased with age in the subjects irrespective of sex. However, female...

The objective of this study is to investigate the effect of ingestion of crude ethanol extract of Garcinia kola seed on erythrocytes. Fifty male Wistar rats with average weight of 200g were divided into 5 treatment groups of 10 rats per group. Group A, served as the control and was fed with standard animal feed only while groups B, C, D and E which...

Water extracts of the leaves of three medicinal shrubs, viz: Guiera senegalensis, Euphorbia lateriflora and Mitracapus scaber, were tested for their antimicrobial activity against seven standard microbial strains (Staphylococcus aureus, Escherichia coli, Candida albicans, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumoniae and Streptoco...

Serum iron concentrations were studied in two groups of Hausa women, one of pregnant subjects attending the antenatal clinics at a health centre and one of lactating subjects attending the centre's postnatal clinics. It was thought possible that the normal diet of the pregnant women had sufficient iron content to meet the women's increased demands...