Mitra Rahimi

Shahid Beheshti University of Medical Sciences · Department of Toxicology and Pharmacology

Treatment management for opioid poisoning is critical and, at the same time, requires specialized knowledge and skills. This study was designed to develop and evaluate machine learning algorithms for predicting the maintenance dose and duration of hospital stay in opioid poisoning, in order to facilitate appropriate clinical decision-making. This s...

Background: Early and appropriate antidotal therapy is crucial for patients with organophosphate poisoning. Objectives: Given the lack of a comprehensive consensus on the optimal dose of pralidoxime for patients with organophosphate poisoning, this study aims to develop a machine learning-based prediction model to determine the individualized prali...

Background: The use of hemodialysis is a prevalent extracorporeal technique for managing the poisoning of certain patients. Objectives: In this study, we examined the frequency of extracorporeal methods and the prognosis of using these methods in various poisonings. Methods: This retrospective study was conducted at Loghman Hakim hospital in Tehran...

Methanol poisoning is a global public health concern, especially prevalent in developing nations. This study focuses on predicting the severity of methanol intoxication using machine learning techniques, aiming to improve early identification and prognosis assessment. The study, conducted at Loghman Hakim Hospital in Tehran, Iran. The data pertaini...

Background Hemodialysis is a life-saving treatment used to eliminate toxins and metabolites from the body during poisoning. Despite its effectiveness, there needs to be more research on this method precisely, with most studies focusing on specific poisoning. This study aims to bridge the existing knowledge gap by developing a machine-learning predi...

Background: Nowadays, erythropoietin is employed as a substitute therapy for eye ailments, particularly optic nerve damage induced by methanol toxicity. Despite its benefits, erythropoietin can have negative effects on blood factors. These effects may include thrombosis, stroke, seizures, and changes in hematological function. This study examined t...

Background: Alcohol toxicity is a significant medical emergency with implications for patient management and outcomes. This single-blinded randomized intervention study investigated the effects of oral probiotics on various laboratory parameters in patients with acute alcohol toxicity. Methods: A total of 30 eligible patients were randomly assigned...

Background: Many studies have investigated the rate of suicide attempts and their risk factors during the coronavirus disease 2019 (COVID-19) pandemic; however, the results are still challenging. Objectives: This study investigated and compared the risk factors effective in suicide attempts during the pandemic period and one year before. Methods: T...

Ketamine, primarily utilized as an analgesic agent, has gained attention for its diverse applications, including its use as an antidepressant. However, there has been a concerning rise in ketamine misuse in Asia particularly Southeast Asian countries, as a recreational drug. This study aims to analyze the emergence of ketamine abuse in Tehran, Iran...

Here we report a case of lead poisoning having a serum lead level of 412 mcg dL⁻¹ who presented with decreasing level of consciousness and recurrent seizures. He responded well to treatment with chelation therapy.

Background: Theophylline belongs to the category of bronchodilators and belongs to the family of methylxanthines. The purpose of this study was the epidemiological and clinical investigation of theophylline poisoning in patients admitted to Loghman Hakim Hospital in Tehran. Methods: This retrospective study reviewed the archived files of hospitaliz...

Introduction: Rhabdomyolysis is a clinical syndrome accompanied with biochemical changes that is diagnosed in some patients with acute chemical or drug poisoning. In this regard, the present study aimed to evaluate the effects of Montelukast in the treatment of intoxication-induced rhabdomyolysis. Methods: This single-blind randomized clinical t...

Introduction: Even though naloxone is the main treatment for methadone poisoning treatment there are controversies about the proper method of its tapering. This study aimed to compare two methods in this regard. Method: This study was a prospective, single-blind pilot quasi-experimental study on non-addicted adult patients poisoned with methadon...

Key Clinical Message Aluminum phosphide poisoning may cause rare visual impairment. In a case, a 31‐year‐old female, visual loss was linked to shock‐induced hypoperfusion, causing oxygen lack and cerebral atrophy, emphasizing the need for identifying atypical symptoms. Abstract This case report describes the multidisciplinary evaluation of a 31‐ye...

Poisoning with organophosphate compounds is a significant public health risk, especially in developing countries. Considering the importance of early and accurate prediction of organophosphate poisoning prognosis, the aim of this study was to develop a machine learning-based prediction model to predict the severity of organophosphate poisoning. The...

Serotonin syndrome is a potentially life‐threatening adverse drug reaction typically caused by a single or combination of two or more medications with serotonergic properties due to increased serotonin release. Our case is a 60‐year‐old drug‐addict man who was admitted to the poisoning department of Loghman hospital with methadone poisoning. On the...

This case report displays some of the possible complications of sumatriptan poisoning, including nephritic syndrome. This study aims to demonstrate some of the adverse effects related to sumatriptan toxicity; a drug is used to treat migraine. Other studies are required to reveal these side effects, especially for patients with underlying diseases s...

The purpose of this study is to show the effectiveness of hemodialysis and hemoperfusion in colchicine toxicity when the patient does not respond to other treatments or other methods cannot be applied due to the symptoms caused by poisoning.

Background: Drug-induced liver injury is a major cause of hepatitis worldwide. In patients diagnosed with acute poisoning, drug-induced liver injury is a critical challenge. This study aims to evaluate the pattern of hepatotoxicity in poisoned patients admitted to Loghman Hakim Hospital. Methods: In this cross-sectional study that was conducted at...

Background: Tracheal intubation is a life-saving measure in patients poisoned acutely with opioid, and when naloxone treatment is inadequate. This study determined the risk factors for early unplanned extubation in these patients and evaluated the effects on the clinical outcomes. Methods: At a poisoning center in Tehran, Iran, 165 opioid overdose...

Background: Suicide is one of the most important psychological emergencies and it is necessary to deal with it. The goal of this study was to evaluate the frequency of suicide attempts, suicide re-attempt, and guesstimated risk factors in suicidal patients in the poisoning ward of Loghman Hakim Hospital. Methods: This study was performed on suicida...

Background: Organophosphates are among the most common causes of poisoning worldwide—responsible for 3 million poisoning and 200000 deaths every year. Nearly 15% of people who are poisoned die. This cross-sectional toxicological/clinical study aimed to investigate the prevalence and influential factors in the incidence of delayed peripheral neuropa...

Introduction: Opioids have been the leading cause of death from poisoning in Iran for several years. This study aimed to evaluate the clinical and para-clinical presentations of naltrexone intoxication, its toxic dose, and its epidemiological properties. Methods: This retrospective cross-sectional study was conducted on medical records of patien...

We present a case of serotonin syndrome due to administration of linezolid in a patient with Methadone addiction. This challenging entity is potentially life threatening but proper education and awareness about serotonin syndrome will improve the accuracy of diagnosis and prevent significant morbidity and mortality.

We present a case of serotonin syndrome due to administration of linezolid in a patient with methadone addiction. This challenging entity is potentially life threatening but proper education and awareness about serotonin syndrome will improve the accuracy of diagnosis and prevent significant morbidity and mortality.

: In this study, we investigated the naphthalene poisoning cases using the archived medical records of patients who were referred to Loghman-Hakim Hospital in Tehran, Iran, from 2008 to 2018. In the 52 studied cases, the highest prevalence was observed in the age groups of below five years and 20 - 25 years. Eighteen (34%) patients had no symptoms,...

Objectives: Organ transplant from poisoned donors is an issue that has received much attention, especially over the past decade. Unfortunately, there are still opponents to this issue who emphasize that toxins and drugs affect the body's organs and do not consider organs from poisoned donors appropriate for transplantation. Materials and methods:...

Background: There is limited data on refined opium extract (Shireh) abuse, especially the magnitude of its complications and its mortality rates. To bridge such a gap, in this study, we aimed to investigate the frequency of pure refined opium extract poisoning and its consequences in a sample of our patients. Methods: This retrospective study was c...

Background: There is limited data on refined opium extract (Shireh) abuse, especially the magnitude of its complications and its mortality rates. To bridge such a gap, in this study, we aimed to investigate the frequency of pure refined opium extract poisoning and its consequences in a sample of our patients. Methods: This retrospective study was c...

Introduction: Metformin is one of the most used oral antidiabetic agents. Intentional and unintentional overdose of metformin can be associated with life threatening condition. In this study we evaluate prognostic factors for metformin intoxication. Methods and Results: This case-control study was performed on patients referred to Loghman Hakim tox...

Background: Scorpion sting is an important public health problem in Iran. This study aimed to describe the demographics, clinical and laboratory findings of the scorpion stings victims in Tehran Province. Methods: This cross-sectional retrospective study evaluated demographic characteristics, clinical presentations, laboratory findings, treatments,...

Objective: Delirium is one of the most common complications in patients admitted to intensive care units (ICUs). Delirium is a definite cause for more extended hospital stays, higher mortality rates, and possibly persistent cognitive decline in the future. Antipsychotics have been frequently evaluated as first drugs of choice, but the most appropri...

Introduction: Colchicine is a medication with narrow therapeutic index, leading to both accidental and suicidal poisonings incidents. This study aimed to investigate the clinical and laboratory manifestations, as well as outcomes of colchicine poisoning patients referred to emergency department. Methods: In this retrospective cross sectional study...

Introduction: Colchicine is a medication with narrow therapeutic index, leading to both accidental and suicidal poisonings incidents. This study aimed to investigate the clinical and laboratory manifestations, as well as outcomes of colchicine poisoning patients referred to emergency department. Methods: In this retrospective cross sectional stu...

Background: The present study is conducted with the aim to assess the lead contamination in opium tincture, methadone oral solution, and opium. Methods: 10 samples from each of the matters of opium tinctures, methadone oral solutions, and opium (provided by the Law Enforcement Force of the Islamic Republic of Iran) were collected. Then, an atomi...

NSAIDs are nonsteroidal anti-inflammatory drugs, thus, they will provide analgesic, antipyretic, anti-inflammatory, antiplatelet effects. Severe poisoning and death because of acute intoxication can occur by ingestions of more than 400 mg/kg. This cross-sectional retrospective study was carried out in on all patients referred to Loghman Hakim Hospi...

Background: Carbon monoxide (CO) poisoning results in hundreds of deaths and thousands of emergency department visits all over Iran annually. In this study, we aim to provide an epidemiologic analysis of this poisoning in different consciousness levels. Methods: This single-center retrospective study was conducted at a referral poison center fro...

Lidocaine belongs to class 1-B antiarrhythmic agents and is primarily used in the treatment of ventricular arrhythmias. This agent is also used in pharmaceutical cocktails as a pain reliever for conditions such as aphthous stomatitis and dyspepsia. Regardless of its efficacy, it is necessary to consider the safety of lidocaine in pharmaceutical coc...

Background: Because in todaychr('39')s societies, not only the nutritional role of plants and fungi is very high, but also the main basis of many drugs are plants and plant products, therefore one of the problems of clinical toxicologists is the toxicity of these products. Objective: This study aimed to define the prevalence, symptoms, complication...

Background: Benzodiazepine is one of the most important causes of substance abuse and intoxication throughout the world and Iran. Objective: The aim of our study was to determine the role of stimulants in reversing CNS level in acute Benzodiazepine poisoning patients who were hospitalized a referral poison center. Method: This was a randomized dou...

Introduction Amphetamine type stimulants (ATS) such as amphetamine and methamphetamine (MA) are one of the most important causes of poisoning in the world. In this study we aimed to define the predictive factors of mortality in acute ATS poisoning patients. Methods This is a retrospective cross-sectional study on all cases with acute ATS poisoning...

Introduction: Parenteral form of lidocaine is the best-known source of lidocaine poisoning. This study aimed to evaluate the characteristics of acute lidocaine toxicity . Methods: In this retrospective cross-sectional study, demographics, clinical presentation, laboratory findings, and outcome of patients intoxicated with lidocaine (based on ICD...

Background: Methadone toxicity is one of the major causes of death in opioid dependent individuals. Objective: We aimed to compare two different protocols for naloxone in terms of reversal of overdose and frequency of complications in opioid-dependent methadone-intoxicated patients. Methods: One-hundred opioid-dependent patients with signs/sym...

In a retrospective case series from 2007 to 2014, we searched for any accidental/intentional, and recreational cases of pure camphor poisoning through hospital records. Epidemiological data, as well as factors correlated with seizure, were evaluated. Thirty cases including 29 males were recruited with a median age of 18 years (range; 0.2-87). Patie...

OBJECTIVE: Colchicine is a naturall-alkaloid that has been used for centuries as a medicine for prevention and treatment of diseases such as gout, familial Mediterranean fever. It has a narrow therapeutic index so there is narrow index between the amounts of non-toxic and toxic or fatal Methods: who were admitted in loghman Hakim poison center betw...

Background . Ventilator-associated pneumonia (VAP) is the most common health care-associated infection. To prevent this complication, aspiration of subglottic secretions using Hi-Lo Evac endotracheal tube (Evac ETT) is a recommended intervention. However, there are some reports on Evac ETT dysfunction. We aimed to compare the incidence of VAP (per...

In pulse CO-oximetry of aluminium phosphide (ALP)-poisoned patients, we discovered that carboxyhemoglobin (CO-Hb) level was elevated. We aimed to determine whether a higher CO level was detected in patients with severe ALP poisoning and if this could be used as a prognostic factor in these patients. In a prospective case-control study, 96 suspected...

The use of pesticides such as aluminium phosphide (AlP) has increased in the recent years and improved the quantity and quality of agricultural products in a number of developing countries. The downside is that AlP causes severe chronic and acute health effects that have reached major proportions in countries such as India, Iran, Bangladesh, and Jo...

The aim of the current study is to compare three different methods of treatment of snake bite to determine the most efficient one. To unify the protocol of snake bite treatment in our center, we retrospectively reviewed files of the snake-bitten patients who had been referred to us between 2010 and 2014. They were contacted for follow-up using phon...

We aimed to determine the clinical manifestations of tramadol intoxication in children and to find its potential poor prognostic factors. In a retrospective study, from 1363 cases of admitted pediatric poisoning, all tramadol-exposed hospitalized patients younger than 12 years were included in the study. They were hospitalized between March 2010 an...

Tramadol is a synthetic and centrally active analgesic. Hypoglycemia as another possible major side effect among abusers has not been known well. Our objective is evaluation of the Blood Glucose Level (BGL) among tramadol-overdosed patients. This prospective cross-sectional study was performed from Feb to June 2013; BGL was measured at the time of...

Aluminium phosphide (ALP) is one of the most commonly used pesticides worldwide with high mortality rates. Cellular damage and cardio-respiratory failure are the most common causes of mortality and morbidity after poisoning. It is supposed that giving enough time to the patient to survive, the most critical hours post-exposure may help the cardiova...

The method of choice for reversal of opioid-toxicity is administration of naloxone. This treatment can be accompanied by complications including acute lung-injury, myocardial infarction, or withdrawal-syndrome (in dependent-patients). We aimed to evaluate the efficacy of buprenorphine in reversal of opioid-overdose syndrome in dependent-rats. A pro...

Buprenorphine can recover signs/symptoms of methadone overdose in dependent rats. Risk of development of withdrawal is less with buprenorphine compared to naloxone. 6 mg/kg dose was the best dose that kept rats symptom-free and did not cause withdrawal. Possible therapeutic effects of buprenorphine in humans should be evaluated. A B S T R A C T The...

Aim To evaluate the clinical features of zinc phosphide poisoning and to investigate whether outcome could be prognosticated based on abdominal radiography on presentation. Materials and methods All zinc phosphide-poisoned patients who were referred to Loghman-Hakim Hospital between March 2011 and September 2013 were retrospectively reviewed. Data...

Abstract Background: The aim of this study was to determine the frequency of each poisoning and its related death in our center as a sample of Tehran in six consecutive years (2006 to 2011). Methods: All poisoned children and adults referring to Loghman-Hakim hospital poison center and hospitalized in the study period were enrolled and evaluated. R...

We aimed to evaluate the efficacy of QT dispersion (QTD) in determining the outcome of the patients poisoned by cardiotoxic medications and toxins. Patients who referred to our emergency department (ED) due to acute toxicity with any cardiotoxic medication or toxin and were admitted to medical toxicology intensive care unit (MTICU) were enrolled in...

Context: Due to an increase in the number of methadone maintenance clinics in the past decade in Iran, acute methadone overdose has become one of the common poisonings in our society. Objective: To compare the characteristics of methadone poisoning between syrup and tablet formulation as well as to discuss the relative advantages and disadvantag...

Acute methadone toxicity is a major public health concern in Iran. Methadone-intoxicated patients are in a great risk of recurrent or delayed respiratory arrest despite the prescription of initial doses of naloxone. This study aimed to evaluate the effectiveness of oral naltrexone in the management of acute methadone overdose in opioid-naive patien...