Mikhail Kesler

Tel Aviv Sourasky Medical Center | TASMC · Nuclear medicine

Although prostate-specific membrane antigen (PSMA) PET/CT has been shown valuable for staging biopsy-proven [B(+)] high-risk prostate cancer, elderly patients are occasionally referred for PSMA PET/CT without a preimaging confirming biopsy [B(-)]. The current study evaluated the rate, clinical characteristics, and PET-based stage of elderly B(-) pa...

Prostatic neuroendocrine malignancies represent a spectrum of diseases. Treatment-induced neuroendocrine differentiation (tiNED) in hormonally treated adenocarcinoma has been the subject of a large amount of recent research. However, the identification of neuroendocrine features in treatment-naïve prostatic tumor raises a differential diagnosis bet...

Purpose The recent introduction of integrated PET-MRI systems into practice seems promising in oncologic imaging, and efforts are made to specify their added values. The current study evaluates the added values of PET-MRI over PET-CT in detecting active malignant hepatic lesions. Methods As part of an ongoing prospective study in our institution t...

Purpose: While PSMA PET-CT has been shown valuable for staging biopsy-proven [B(+)] high-risk prostate cancer (PCa), elderly patients are occasionally referred to PSMA PET-CT without pre-imaging confirming biopsy [B(-)]. The current study evaluates the rate, clinical characteristics, and PET-based stage of B(-) elderly patients, and explores if bio...

Purpose: The recent introduction of integrated PET-MRI systems into practice seems promising in oncologic imaging. Efforts are made to specify the added-values of this modality. The current study evaluates the added-values of PET-MRI over PET-CT in detecting active malignant hepatic lesions. Methods: As part of an ongoing prospective study in our i...

Purpose to assess the value of staging ⁶⁸Ga-PSMA-11 PET/CT in elderly patients with biopsy-proven or high clinical suspicion of prostate cancer (PCa). Methods 100 consecutive patients 80 years of age and older referred for ⁶⁸Ga-PSMA-11 PET/CT with biopsy proven high-risk PCa (n = 66 pts) or high clinical suspicion of clinically relevant PCa withou...

Background Neuroendocrine malignancies of the prostate represent a spectrum of diseases. Treatment-induced neuroendocrine differentiation (tiNED) in hormonally treated adenocarcinoma has been the subject of a large amount of recent research. However, the identification of neuroendocrine features in treatment-naïve prostatic tumor raises a different...

PurposeThe aim of the study was to elaborate the incidence and type of skeletal involvement in a large cohort of patients with newly diagnosed prostate cancer (PCa) referred for Ga-68 PSMA-11 PET/CT staging in a single center.Methods Study cohort included 963 consecutive patients with newly diagnosed PCa referred for Ga-68 PSMA-11 PET/CT study for...

Simple Summary MALT lymphoma represents a relatively rare lymphoma subtype that arises in different extranodal anatomic locations. In the current paper we summarize our experience in assessing disease extent and metabolic characteristics of MALT lymphomas with [¹⁸F]FDG PET-CT at staging, and aim to highlight the strengths and challenges this imagin...

Purpose: The aim of the study was to elaborate the incidence and type of skeletal involvement in a large cohort of patients with newly diagnosed prostate cancer (PCa) referred for Ga-68 PSMA-11 PET/CT staging in a single center. Methods: Study cohort included 963 consecutive patients with newly diagnosed PCa referred Ga-68 PSMA-11 PET/CT study for...

Introduction: Accurate evaluation of the extent of disease in patients with prostate cancer is of great importance in guiding suitable treatment at all disease stages. Conventional imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), which rely on morphological criteria, are limited in assessing the real exten...

Bone metastases from prostate cancer (PCa) often show an increase in density on computed tomography (CT) after successful androgen deprivation therapy (ADT). Density may be reduced, however, as the disease progresses or, contrarily, when disease is no longer active. The current study investigated the role of 68Ga-PSMA-11 positron emission tomograph...

Background:68Ga-Prostate Specific Membrane Antigen (68Ga-PSMA), a positron emission tomography (PET) tracer that was recently introduce for imaging of prostate cancer, may accumulate in other solid tumors including Hepatocellular Carcinoma (HCC). The aim of the study was to assess the potential role of 68Ga-PSMA PET-Computed Tomography (CT) for ima...

Follicular lymphoma (FL) is the 2nd most common type of lymphoma diagnosed in the Western World. Bone marrow (BM) involvement is an adverse prognostic factor in FL, routinely assessed by an arbitrary biopsy of the iliac crest. This study was aimed to investigate the role of positron emission tomography/computed tomography (PET/CT) in identifying BM...

Background: Cadmium zinc telluride (CZT) solid-state detectors have been recently introduced in the field of nuclear medicine in cardiology and breast imaging. The aim of the current study was to evaluate the performance of the novel detectors (CZT) compared to that of the routine NaI(Tl) in bone scintigraphy. A dual-headed CZT-based camera dedica...