Mei-Shin Wu

Max Planck Institute for the Science of Human History · Department of Linguistic and Cultural Evolution

Compounding and derivation are frequent in many language families. As a consequence, words in different languages are often only partially cognate, sharing some but not all morphemes. While partial cognates do not constitute a problem for the phonological reconstruction of individual morphemes, they are problematic for phylogenetic reconstruction b...

Kho-Bwa, Hrusish, Mishmic, Tani, and Tshangla are language clusters that have been recurrently proposed as subgroups of the Trans-Himalayan (also known as Tibeto-Burman and Sino-Tibetan) language family. Nonetheless, their internal classification, as well as the relation with each other and with other linguistic groups in the family, is hitherto un...

Historical language comparison opens windows onto a human past, long before the availability of written records. Since traditional language comparison within the framework of the comparative method is largely based on manual data comparison, requiring the meticulous sifting through dictionaries, word lists, and grammars, the framework is difficult...

Advances in computer-assisted linguistic research have been greatly influential in reshaping linguistic research. With the increasing availability of interconnected datasets created and curated by researchers, more and more interwoven questions can now be investigated. Such advances, however, are bringing high requirements in terms of rigorousness...

Background— Intravenous immunoglobulin (IVIG) is the treatment of choice in Kawasaki disease (KD). IVIG is used to prevent cardiovascular complications related to KD. However, a proportion of KD patients have persistent fever after IVIG treatment and are defined as IVIG resistant. Methods and Results— To develop a risk scoring system based on gene...

A major challenge in personalized cancer medicine is to establish a systematic approach to translate huge oncogenomic datasets to clinical situations and facilitate drug discovery for cancers such as endometrial carcinoma. We performed a genome-wide somatic mutation-expression association study in a total of 219 endometrial cancer patients from TCG...

Colorectal cancer is one of the most common cancers worldwide. Surgery is usually the primary treatment for colon cancers that have not spread to distant sites. However, chemotherapy may be considered after surgery to eliminate remaining cancer cells or in case the cancer has a high risk of recurrence. Oxaliplatin is often used in combination regim...

Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calcium homeostasis. However, whether...

Kawasaki disease (KD) is characterized by pediatric systemic vasculitis of an unknown cause. The low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) gene was reported to be involved in the susceptibility of KD. DNA methylation is one of the epigenetic mechanisms that control gene expression; thus, we hypothesized that methylation sta...

Kawasaki disease (KD) is known as systemic vasculitis with unknown etiology; thus, the multifactorial interaction of genes and environmental factors may be one possible cause worth examining. Recently, the targeted genetic association and Genome-Wide Association Studies (GWAS) have helped to provide a better understanding of KD from infection to im...

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (Her2/neu). TNBC has worse clinical outcomes than other breast cancer subtypes. However, the key molecules and mechanisms of TNBC migration remain unclear. I...

Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 ge...

Background: Osteoporosis and periodontitis are both considered global health issues that threaten postmenopausal women and the older population. However, the correlation between osteoporosis and periodontitis is still unclear. Methods: Using a nationwide Taiwanese population-based database, data from patients with osteoporosis (2003 to 2005; n =...

Unlabelled: Genome-wide association studies have linked single nucleotide polymorphisms (SNPs) near the interleukin-28B gene to the hepatitis C virus genotype 1 (HCV-1) response to peginterferon/ribavirin treatment. We aimed to explore the impact on the treatment outcomes of Asian HCV-2 patients. We determined rs8105790, rs8099917, rs4803219, and...