Mehrdad Khakbiz

Rutgers, The State University of New Jersey | Rutgers

Applying hydrophilic coatings on polymeric nanofibers combined with layered double hydroxide (LDH) not only enhances the efficiency of drug delivery systems but also increases cell adhesion. This work aimed to prepare poly(vinyl alcohol)/sodium alginate (PVA/SA) (2/1)-coated poly(lactic acid) (PLA) nanofibers containing curcumin-loaded layered doub...

Applying hydrophilic coatings on polymeric nanofibers combined with layered double hydroxide (LDH) not only enhances the efficiency of drug delivery systems but also increases cell adhesion. This work aimed to prepare poly(vinyl alcohol)/sodium alginate (PVA/SA) (2/1)-coated poly(lactic acid) (PLA) nanofibers containing curcumin-loaded layered doub...

The development of architectured nanomater-ials has been booming in recent years in part due to their expanded applications in the biomedical field, such as biosensing, bioimaging, drug delivery, and cancer ther-apeutics. Nanomaterials exhibit a wide variety of shapes depending on both the intrinsic properties of the materials and the synthesis pro...

The development of architectured nanomaterials has been booming in recent years in part due to their expanded applications in the biomedical field, such as biosensing, bioimaging, drug delivery, and cancer therapeutics. Nanomaterials exhibit a wide variety of shapes depending on both the intrinsic properties of the materials and the synthesis proce...

In the past, many people lost their lives due to superficial wound infections. Over time, the importance of wound healing as the reconstruction of the body's first defense barrier, the skin, became more important. Today, traditional medicine has given way to reconstructive medicine. Tissue engineering has always been a pioneer in the development an...

In the past, many people lost their lives due to superficial wound infections. Over time, the importance of wound healing as the reconstruction of the body's first defense barrier, the skin, became more important. Today, traditional medicine has given way to reconstructive medicine. Tissue engineering has always been a pioneer in the development an...

The development of architectured nanomaterials has been booming in recent years in part due to their expanded applications in the biomedical field, such as biosensing, bioimaging, drug delivery, and cancer therapeutics. Nanomaterials exhibit a wide variety of shapes depending on both the intrinsic properties of the materials and the synthesis proce...

Background Nitric oxide is a chemical agent produced by endothelial cells in a healthy blood vessel, inhibiting the overgrowth of vascular smooth muscle cells and regulating vessel tone. Liposomes are biocompatible and biodegradable drug carriers with a similar structure to cell bilayer phospholipid membrane that can be used as useful nitric oxide...

Recently, Fe-Mn-based alloys have been increasingly catching the attention of the scientific community, because of their tunable and outstanding mechanical properties, and suitable degradation behavior for biomedical applications. In spite of these assets, their corrosion rate (CR) is, in general, too low to satisfy the requirements that need to be...

Recently, Fe-Mn-based alloys have been increasingly catching the attention of the scientific community, because of their tunable and outstanding mechanical properties, and suitable degradation behavior for biomedical applications. In spite of these assets, their corrosion rate (CR) is, in general, too low to satisfy the requirements that need to be...

In the development of vascular tissue engineering, particularly in the case of small diameter vessels, one of the key obstacles is the blockage of these veins once they enter the in vivo environment. One of the contributing factors to this problem is the aberrant proliferation and migration of vascular smooth muscle cells (VSMCs) from the media lay...

In the development of vascular tissue engineering, particularly in the case of small diameter vessels, one of the key obstacles is the blockage of these veins once they enter the in vivo environment. One of the contributing factors to this problem is the aberrant proliferation and migration of vascular smooth muscle cells (VSMCs) from the media lay...

Background: Enhancing the efficiency of cell-based skin tissue engineering (TE) approaches is possible via designing electrospun scaffolds possessing natural materials like amniotic membrane (AM) with wound healing characteristics. Concentrating on this aim, we fabricated innovative polycaprolactone (PCL)/AM scaffolds through the electrospinning pr...

Background: Enhancing the efficiency of cell-based skin tissue engineering (TE) approaches is possible via designing electrospun scaffolds possessing natural materials like amniotic membrane (AM) with wound healing characteristics. Concentrating on this aim, we fabricated innovative polycaprolactone (PCL)/AM scaffolds through the electrospinning pr...

Background: Enhancing the efficiency of cell-based skin tissue engineering (TE) approaches is possible via designing electrospun scaffolds possessing natural materials like amniotic membrane (AM) with wound healing characteristics. Concentrating on this aim, we fabricated innovative polycaprolactone (PCL)/AM scaffolds through the electrospinning pr...

Background Nitric oxide is a chemical agent produced by endothelial cells in a healthy blood vessel, inhibiting the overgrowth of vascular smooth muscle cells and regulating vessel tone. Liposomes are biocompatible and biodegradable drug carriers with a similar structure to cell bilayer phospholipid membrane that can be used as useful nitric oxide...

The osseointegration property of dental and bone implants is a crucial factor for proper healing, and is entirely influenced by the surface characteristics, including surface chemistry and roughness. However, the molecular mechanisms for osteoconductivity remain unclear. This study aimed to investigate the effective cellular interactions and stimul...

The osseointegration property of dental and bone implants is a crucial factor for proper healing, and is entirely influenced by the surface characteristics, including surface chemistry and roughness. However, the molecular mechanisms for osteoconductivity remain unclear. This study aimed to investigate the effective cellular interactions and stimul...

The osseointegration property of dental and bone implants is a crucial factor for proper healing, and is entirely influenced by the surface characteristics, including surface chemistry and roughness. However, the molecular mechanisms for osteoconductivity remain unclear. This study aimed to investigate the effective cellular interactions and stimul...

The osseointegration property of dental and bone implants is a crucial factor for proper healing, and is entirely influenced by the surface characteristics, including surface chemistry and roughness. However, the molecular mechanisms for osteoconductivity remain unclear. This study aimed to investigate the effective cellular interactions and stimul...

The field of neural tissue engineering has undergone a revolution due to advancements in three-dimensional (3D) printing technology. This technology now enables the creation of intricate neural tissue constructs with precise geometries, topologies, and mechanical properties. Currently, there are various 3D printing techniques available, such as ste...

Multi-walled carbon nanotubes (MWCNTs) are one of the preferred candidates for reinforcing polymeric nanobiocomposites, such as acrylic bone type of cement. In this study, at first, bulk samples of the reinforced polymethylmethacrylate (PMMA) matrix were prepared with 0.1, 0.25, and 0.5 wt per wt% of MWCNTs by the casting method. Tensile and three-...

Multi-walled carbon nanotubes (MWCNTs) are one of the preferred candidates for reinforcing polymeric nanobiocomposites, such as acrylic bone type of cement. In this study, at first, bulk samples of the reinforced polymethylmethacrylate (PMMA) matrix were prepared with 0.1, 0.25, and 0.5 wt per wt% of MWCNTs by the casting method. Tensile and three-...

Using poly(lactic acid) (PLA) as biodegradable and biocompatible material is demanded for vascular scaffolds especially a susceptible substitute of permanent metal stents in treatment of coronary heart disease. In this work, PLA nanofibers containing aspirin (Asp) loaded into zeolitic imidazolate framework nanoparticles (ZIF-8@Asp NPs) were prepare...

Using poly(lactic acid) (PLA) as biodegradable and biocompatible material is demanded for vascular scaffolds especially a susceptible substitute of permanent metal stents in treatment of coronary heart disease. In this work, PLA nanofibers containing aspirin (Asp) loaded into zeolitic imidazolate framework nanoparticles (ZIF-8@Asp NPs) were prepare...

This study investigates the effect of simultaneous incorporation of crosslinked gelatin microspheres (GMs) and hydroxyapatite whiskers (HAWs) on the compositional characteristics, phase evolution, setting time, microstructure and mechanical properties of the calcium phosphate cement (CPC) matrix. In addition, the mechanical properties of composite...

The main purpose of this study is to present a systematically assessment of wear characteristics of hybrid dental composites. Lanthanum Oxide (La2¬O3) nanofillers is an imperative part of fillers in hybrid dental composites to increase their cosmetic features and radiopacity which is added as a second filler along with quartz microfillers. In this...

The addition of noble elements such as Ag was shown as a successful method to accelerate the corrosion rate of absorbable Fe-based alloys. One major concern of Ag addition is its effect on hemocompatibility and biocompatibility. In this study, in vitro degradation and surface analysis of Fe-30Mn-xAg (x= 0, 1 and 3 wt.%) alloys as well as their effe...

In this study, electrospun poly (lactic acid) (PLA) nanofibrous nanocomposites containing zeolitic imidazolate frameworks-8 nanoparticles (ZIF-8 NPs) with three different concentrations of 1, 3, and 5 wt.% were prepared to investigate their morphological and mechanical properties. In this regard, the FE-SEM images showed that the mean diameters of...

Graphical abstract: Highlights: Preclinical animal studies on decellularized small diameter vascular grafts Non-modified acellular small caliber vascular grafts with/without pre-seeding Preclinical studies on surface modified acellular small-caliber vascular grafts Surface modification of acellular grafts by anti-thrombotic molecules Surface modifi...

Layered double hydroxide (LDH) nanoparticles (NPs) have potential applications for the loading and controlled release of drugs. This study investigated the synthesis of Zn/Al-LDH using the co-precipitation and ion-exchange methods, coating with SiO2 NPs and precise control of the release of vitamin C (VC). The results showed that more VC could be l...

In the present study, two three-layer feed-forward artificial neural networks (ANNs) and multiple linear regression (MLR) models were developed for modeling the effects of material and process parameters on the powder particle size characteristics generated during high-energy ball milling of Al and B 4 C powders. The investigated process parameters...

In the present comparative study, gelatin microspheres (GMs) were prepared by Emulsification-solvent-extraction method using well-known crosslinker: Glutaraldehyde (GA) and biocompatible silane-coupling agent: Glycidoxypropyltrimethoxysilane (GPTMS). Crosslinking with GA was done by a definite and common procedure, while GPTMS crosslinking potency...

In this paper, the narrow size and spherical shape of boron carbide nanoparticles are synthesized by milling, purification and then the classification of nanoparticles by sedimentation method. In addition, the fractal behavior of particles is studied during synthesizing systematically and a fractal equation is proposed for prediction of nanopowders...

Wear properties of Al6061-CNT nanocomposites have been studied using dry sliding method. Nanostructured Al6061 powder has been prepared using 30 h mechanical milling of atomized powder, and mixed with different percent of CNT. The yielded mixture was subjected to mechanical milling for 0.5 and 4 h. Mixtures were cold compacted, homogenized and extr...

In this study, nanostructured biodegradable pure Zn, Zn-4 wt. % Mn and Zn-24 wt. % Mn alloys were produced by 20 h mechanical alloying and consequent cold pressing and sintering. Structural evolutions were investigated using the X-ray diffraction technique. Also, the microstructure was characterized by scanning electron microscopy. The effects of a...

Various compositions and synthesis methods of biodegradable iron-based alloys have been studied aiming for the use of temporary medical implants. However, none is focused on nano-structured alloy and on adding antibacterial property to the alloy. In this study, new Fe-30Mn-(1-3)Ag alloys were synthesized by means of mechanical alloying and assessed...

The rheological behaviour of powder injection moulding feedstock comprising of 316L stainless steel and 3 wt-%TiC powders was studied using a capillary rheometer. The flowability and the sensitivity of viscosity to shear rate and temperature of the feedstock were investigated and compared with those of the binder system and the 316L SS PIM feedstoc...

There is variety of stem cell sources but problems in ethical issues, contamination and normal karyotype cause many limitations in obtaining and using these cells. The cells in Wharton's jelly region of umbilical cord are abundant and available stem cells with low immunological incompatibility, which could be considered for cell replacement therapy...

Small molecules as useful chemical tools can affect cell differentiation and even change cell fate. It is demonstrated that LY294002, a small molecule inhibitor of phos-phatidylinositol 3-kinase (PI3K)/Akt signal pathway, can inhibit proliferation and promote neuronal differentiation of mes-enchymal stem cells (MSCs). The purpose of this study was...

Wear mechanisms maps of CNT reinforced Al6061 nanocomposites treated by cryomilling and mechanical milling, Tribiology International, http://dx. Abstract In this study, wear mechanisms of Al6061-CNT nanocomposites produced by cryomilling and mechanical milling, cold compacting and extrusion have been studied.The wear maps showed that the maximum am...

In this study, bioactive glass of the type SiO 2-CaO-SrO-P 2 O 5 was obtained by the sol-gel processing method and the effects of SrO/CaO substitution on the in vitro biological properties of the synthesized glasses were evaluated. The obtained bioactive glasses were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy...

Dexamethasone, an anti-inflammatory drug, was intercalated in both Zn/Al-NO3 and Zn/Al-CO3 layered double hydroxides with three different LDH/DEXA molar ratios through ion-exchange technique. Then the maximum added drug nanohybrid (NL-1D) deposited into nanotubes of anodized titanium (ATS-NL-1D). The X-ray diffraction (XRD) demonstrated that dexame...

Layered double hydroxide (LDH) nanoparticles (NPs) have potential applications for the loading and controlled release of drugs. This study investigated the synthesis of Zn/Al-LDH using the co-precipitation and ion-exchange methods, coating with SiO2 NPs and precise control of the release of vitamin C (VC). The results showed that more VC could be l...

Additive manufacturing has attracted a lot of attention in fabrication of bio medical devices and structures in recent years. 4D printing, a new class of 3D printing where time is considered as a 4th dimension, allows us to build biological structures such as scaffolds, implants, and stents with dynamic performance mimicking the body's natural tiss...

In the present study, nanostructured Fe-30 wt.% Mn alloys produced by mechanical alloying of Fe and Mn powders mixture. The phase composition and morphology of nanostructured powder were analyzed by X-ray diffraction and scanning electron microscopy. It was found that by milling time up to 10h, crystallite size was decreased to 6 nm, on the contrar...

In this study, electrospun poly (lactic acid) (PLA) nanofibrous nanocomposites containing zeolitic imidazolate frameworks-8 nanoparticles (ZIF-8 NPs) with three different concentrations of 1, 3, and 5 wt.% were prepared to investigate their morphological and mechanical properties. In this regard, the FE-SEM images showed that the mean diameters of...

Dexamethasone, an anti-inflammatory drug, was intercalated in both Zn/Al-NO3 and Zn/Al-CO3 layered double hydroxides with three different LDH/DEXA molar ratios through ion-exchange technique. Then the maximum added drug nanohybrid (NL-1D) deposited into nanotubes of anodized titanium (ATS-NL-1D). The X-ray diffraction (XRD) demonstrated that dexame...

Additive manufacturing has attracted a lot of attention in fabrication of bio medical devices and structures in recent years. 4D printing, a new class of 3D printing where time is considered as a 4th dimension, allows us to build biological structures such as scaffolds, implants, and stents with dynamic performance mimicking the body's natural tiss...

Recently, surface modification of biodegradable metals by plasma immersion ion implantation (PIII) attracted the attention of the scientific community. Nitrogen implantation can increase the resistance to localized corrosion and improve the biological response of the tissue surrounding the implant [1]. However, surface modification can affect the c...

Additive manufacturing (AM) has attracted growing interest for different industries. This article provides a review of fabrication of biosensors and diagnostic tools via additive manufacturing. This mini-review will provide an applicable classification of diagnostic tools fabricated by different AM methods such as fused deposition modeling, stereol...

Additive manufacturing (AM) has attracted growing interest for different industries. This article provides a review of fabrication of biosensors and diagnostic tools via additive manufacturing. This mini-review will provide an applicable classification of diagnostic tools fabricated by different AM methods such as fused deposition modeling, stereol...

Additive manufacturing (AM) has attracted growing interest for different industries. This article provides a review of fabrication of biosensors and diagnostic tools via additive manufacturing. This mini-review will provide an applicable classification of diagnostic tools fabricated by different AM methods such as fused deposition modeling, stereol...

Using poly(lactic acid) (PLA) as biodegradable and biocompatible material is demanded for vascular scaffolds especially a susceptible substitute of permanent metal stents in treatment of coronary heart disease. In this work, PLA nanofibers containing aspirin (Asp) loaded into zeolitic imidazolate framework nanoparticles (ZIF-8@Asp NPs) were prepare...

Being biocompatible, bioactive, having low solubility in wet environment and showing similarities to mineral part of hard tissue in human's body, hydroxyapatite has so many applications in dentistry and related hard tissue concerns. Fluoride ion being found in bone and enamel can be joined to hydroxyapatite and reduce solubility and also hold bioco...

The development of decellularized small diameter vascular grafts is a potential solution for patients requiring vascular reconstructive procedures. However, there is a limitation for acellular scaffolds due to incomplete recellularization and exposure of extracellular matrix (ECM) components to whole blood resulting in platelet adhesion. To address...

High (cation/Ca+cation=16 mol.%) and low (cation/ca+cation=4.76 mol.%) concentrations of Mg 2+ , Zn 2+ and Sr 2+ , as divalent cations with interesting biological properties were tried to incorporate into the structure of well-known bioceramic: hydroxyapatite (HA). An established hydrothermal synthesis method was employed for preparation of HA in w...

Schwann cells, in addition to forming myelin sheaths, have pivotal roles in regenera-tion of injured axons in the peripheral nervous system such as producing a natural permissive conduit between distal and proximal stumps and secreting nerve growth factors. Due to the atrophy and senescence of Schwann cells in long nerve gap, and the need to ensure...

Schwann cells, in addition to forming myelin sheaths, have pivotal roles in regenera-tion of injured axons in the peripheral nervous system such as producing a natural permissive conduit between distal and proximal stumps and secreting nerve growth factors. Due to the atrophy and senescence of Schwann cells in long nerve gap, and the need to ensure...

In this study, nanostructured biodegradable Fe-35wt.%Mn alloy prepared by 10 h high energy ball milling followed by conventional cold press and sintering. Structural and microstructural properties were studied by X-ray diffraction, optical microscopy, scanning electron microscopy and transmission electron microscopy. Corrosion rate, mechanical prop...

Researchers in absorbable metals have been putting efforts to accelerate the corrosion of iron-based absorbable metals. These include by alloying iron with manganese and noble elements such as silver, but its corrosion rate still needs further improvement. In this study, we prepared a bimodal nano/microstructured Fe-30Mn-1Ag alloy by mechanical all...

In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated with poly(ε-caprolactone)/gelatin composite mats in order to develop a potential wound dressing. The composite mats were prepared by electrospinning of poly(ε-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.50 %, 3 % and 6 %...

In the present study, nanostructured Fe-30 wt.% Mn alloys produced by mechanical alloying of Fe and Mn powders mixture. The phase composition and morphology of nanostructured powder were analyzed by X-ray diffraction and scanning electron microscopy. It was found that by milling time up to 10h, crystallite size was decreased to 6 nm, on the contrar...

In the present work, the synergetic effect of Ti-based catalysts (TiH 2 and TiO 2 particles) on hydrogen desorption kinetics of nanostructured magnesium hydride was investigated. Nanostructured 84 mol% MgH 2 e10%mol TiH 2 e6%mol TiO 2 nanocomposite powder was prepared by high-energy ball milling and subjected to thermal analyses. Evaluation of the...

The possibility of in situ fabrication of Cu-MnO nanocomposite using mechanochemical route was studied in the present paper. Cu ∼50 wt.%MnO nanocomposite powder was prepared by combustion reaction between CuO and Mn induced by high energy ball milling. The product was characterized by X-ray diffraction and scanning electron microscopy. Structural a...

An experimental rheological study has been performed to evaluate the influence of TiC addition on the rheological behavior and stability of 316L stainless steel powder injection molding (PIM) feedstock. The effects of TiC concentration, solid loading, shear rate and temperature were investigated via capillary rheometer method. The stability of feed...