Meenakshi Bharkatiya

BN Institute of Pharmaceutical Sciences, Udaipur · Pharmaceutics

In order to cure a range of ailments, scientists have investigated a number of bioactive antioxidant compounds produced from natural sources. Mangiferin, a C-glycosyl xanthone-structured yellow polyphenol, is abundant in mangoes and other dietary sources. In-depth examinations found that it is effective in the treatment of a variety of disorders du...

Pidotimod is a synthetic biological and immunological modulator with dipeptide structure. It has been used for a long time to treat and prevent recurring respiratory infections. .Pidotimod stress testing and degradation profiling were carried out under ICH-recommended stress degradation protocols. To resolve Pidotimod and its impurities, the degrad...

Objective: The goal of the current research is to identify the dominant phytochemical from the plantNyctanthesarbor-tristis Linn. and to investigate their binding affinities against the proteins BRaf Kinase mutant (3OG7) and Hsp90 Chaperone (2VCJ) that causesmelanoma. Methods: In this work, Schrodinger software was utilized to investigate the anti-...

Objective: The present investigation was aimed to develop Flurbiprofen Sodium suppositories by using different suppository bases with a view to avoid loss of drug by first pass effect and to minimize toxic effects, thereby producing safe and effective dosage form which will improve the solubility and absorbability of poorly soluble drug. Methods: F...

β-Cyclodextrin/ibuprofen inclusion complex was synthesized by freeze-drying method and characterized for phase solubility profiles, infrared spectra, thermal analysis, and X-ray powder diffractograms. The inclusion complex with HP-β-CD, as confirmed by molecular dynamics simulations, enhanced the aqueous solubility of ibuprofen by almost 30-fold co...

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A synthetic dipeptide, pidotimod (3-L-pyroglutamyl-L-thiaziolidine-4-carboxylic acid, PTD) is an immunomodulator and it possesses anti-infective activity against variety of infections. The objective of this study was to explore into and identify pidotimod’s major degradation product. Pidotimod was degraded in ICH prescribed stress conditions. pidot...

In situ gelling drug delivery systems have gained enormous attention over the last decade. They are in a sol-state before administration, and they are capable of forming gels in response to different endogenous stimuli, such as temperature increase, pH change and the presence of ions. Such systems can be administered through different routes, to ac...

Objective: This study aimed to develop and in vitro characterize an organogel (OG) loaded Ibuprofen. ABSTRACT Methods: Organogel (OG) composed of water, isooctane, sorbitan esters, sorbitan monopalmitate (Span-40), and poly(oxyethylene) sorbitan monostearate (Polysorbate-60) was loaded with Ibuprofen. The partial phase behavior of ibuprofen OG was...

Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastro retentive drug delivery system is novel drug delivery systems which h...

Many ocular diseases or disorders require frequent administration of the drug. But poor ocular bioavailability of drugs (< 1%) from conventional ophthalmic formulations is a serious concern. The epithelial layers protect the eye and consequently limit the penetration of ocular drugs. In order to overcome the shortcomings of the standard form of oph...

Validation is integral part of cGMP, and assured production of quality based pharmaceutical products special reference to extended release tablets. The quality of pharmaceutical dosage form can be achieved by performing finished product testing and in-process monitoring. Hence, the present study was planned to developed process validation protocol...

The demand of herbal medicine is rapidly growing in today's time. Now days, herbal medicines have existed with extensive recorded olden times as they were used in the ancient period for a variety of therapies. In Ayurveda, the use of single or multiple herbs (polyherbal) for the treatment of several diseases. The present study deals with developmen...

A large portion of the medications having low solubility brings about low bioavailability of the specific medication. This can be expanded by various strategies like salt development, strong scattering, and complex arrangement. Self-emulsifying drug delivery system (SEDDS) is a fundamental device in tackling low bioavailability issues of ineffectiv...

Objectives: The present study was aimed to develop Eudragit S100 coated colon-targeted sustained-release formulations of alginate-pectin and alginate-hydroxypropyl methylcellulose microbeads containing norfloxacin (NF) and tinidazole (TZ) for the treatment of amebiasis which was simultaneous estimated. Methods: Taguchi L9 orthogonal array design ha...

Pharmaceutical solid dosage forms include tablets, pellets, pills, beads etc. Tablet is most commonly used pharmaceutical dosage form which has ease of administration. Tablets are coated for many reason such as masking odour, taste, colour of the drug, providing physical and chemical protection to drug, protecting drug from the gastric environment....

Tablets may be defined as solid pharmaceutical dosage forms containing drug substances with or without suitable diluents and prepared either by compression or molding methods. They have been in widespread use since the latter part of the 19 th century and their popularity continues. In the present study inlay tablets of an anti-inflammatory drug wa...

The aim of the present investigation was to formulate and evaluate herbal shampoo containing natural ingredients with an emphasis on safety and efficacy, which will avoid the risk posed by chemical ingredients. The main objective of this study was to eliminate harmful synthetic ingredient from shampoo formulation and substitute them with safe natur...

Abstract Nanotechnology means that what we are working with is very small. It generally means that we are working on the molecular level or, at least, in sizes of a few nanometers in the semiconductor industry Smaller…smaller….smaller mantra translates to Faster….. Faster…faster. . What is new is that we are learning to manipulate nanoparticles and...

Background: Withania somnifera (family solanaceae) is a well-investigated medicinal plant which is also called Indian ginseng due to its wide spectrum of medicinal properties. The contents and activity of the plant may vary depending on the habitat and part of the plant and the solvent used for extraction. The present study deals with the comparat...

Qualification as a part of validation is the task performed to identify or check that utilities, equipment and ancillary systems are capable of operating within limits for their intended use. Equipment qualification is a key element in the pharmaceutical quality system. In recent times regulatory agencies are more focusing on qualification of equip...

Validation is one of the important steps in achieving and maintaining the quality of the final product. If each step of production process is validated, we can assure that the final product is of the best quality. Validation is the art of designing and practicing the designed steps alongside with the documentation. Validation and quality assurance...

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non toxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS inc...

Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human body. Matrix type transdermal patches containing Metoprolol tartrate were prepared by solvent casting method employing a mercury substrate by using the combinations of EC-PVP and Eudragit RL...

Hair is filamentous growth of dennal dead cells in mammals, which are of 2 types- Lanugo and Tenninal. Hair is distinguished into 2 parts- Root (lies underneath epidermis) and Shaft (lies outside epidermis). Characteristics like elasticity, static electricity, moisture content, diameter, porosity, texture, pH etc. are properties that govern physica...

Transdermal drug delivery systems allow delivery of a drug into the systemic circulation via permeation through skin layers at a controlled rate. In addition to the currently marketed formulations, new drugs are being formulated using the transdermal system because of the inherent advantage of administration by this route. It offers a noninvasive r...