Matteo BradicichUniversity Hospital Zürich · Division of Respiratory Medicine
Matteo Bradicich
Doctor of Medicine
About
36
Publications
16,058
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151
Citations
Introduction
ECMC Representative for the European Respiratory Society Assembly 4 - Sleep Disordered Breathing. Resident Physician at Zollikerberg Hospital (Switzerland). Since 2018 affiliated to the University Hospital Zurich (Switzerland). In 2021 awarded with the Dr. med. title at the University of Zurich (Switzerland). Main research topics: OSA-related cardiovascular pathophysiology, domotics applied to SDB, OSA diagnostics, asthma, COPD, smoking biomarkers.
Additional affiliations
December 2018 - present
Position
- Medical Doctor
Description
- Clinical research on obstructive sleep apnoeas pathophysiology, their link with cardiovascular outcomes, and with other respiratory conditions. Breath analysis in different subsets of patients via mass spectrometry.
December 2017 - November 2018
Severe Asthma Network Italy (SANI)
Position
- Manager
Description
- Collection of clinical data of severe asthmatic patients, which are stored and analysed in a national registry, whose main aims are the evaluation of treatment efficacy on a large scale and the gathering of a vast quantity of data for clinical research.
November 2017 - November 2018
Position
- Research Associate
Description
- Clinical research and outpatient clinic activities. Management of severe asthmatic patients and evaluation of their eligibility to biological treatment with omalizumab, mepolizumab, and dupilumab.
Education
September 2011 - October 2017
Publications
Publications (36)
Abbiamo caratterizzato un gruppo di pazienti asmatici gravi in presenza o assenza di ostruzione non reversibile, correlandovi specifici marcatori di infiammazione e rimodellamento. Sull’espettorato indotto dei pazienti, in terapia di mantenimento con ICS/LABA ad alta dose, sono state effettuate conta cellulare e quantificazione di periostina, TGF-β...
We analysed blood and sputum eosinophilia and fractional exhaled nitric oxide (FeNO) levels in severe asthmatic patients with frequent exacerbations, correlating different biomarkers levels with different exacerbation rates (≥1 vs ≥3 in the last 12 months).
Submitted to the ERS Annual International Congress 2018, Paris, France.
Quantification of different sputum cytokine concentrations in different asthmatic endotypes, previously labelled on the basis of their sputum differential cell count as affected by eosinophilic, neutrophilic, mixed or paucigranulocytic asthma.
Introduction
Post-mortem studies of patients who have died from asthma show that mucus plugging of the airways is a prominent feature. We have investigated whether this can be identified and quantified on CT scans taken at the time of a severe asthma attack and tested the hypothesis that mucus plugging is specific to attacks associated with a raise...
We analysed the impact of asthma-like features (airways reversibility, high FeNO levels, sputum eosinophils >3%) on lung function and inflammatory parameters of COPD patients.
Submitted to the ERS Annual International Congress 2018, Paris, France.
The topic of sleep-related breathing disorders is always evolving, and during the European Respiratory Society (ERS) International Congress 2023 in Milano (Italy), the latest research and clinical topics in respiratory medicine have been presented. The most interesting issues ranged from new diagnostic tools, including cardiovascular parameters and...
This paper presents some of the highlights of the Sleep and Breathing Conference 2023 https://bit.ly/46MxJml
In this article, we provide a brief description of the @EuroRespSoc 2023 Lung Science Conference and the Sleep and Breathing Conference https://bit.ly/3WsCzj6.
Abstract
During the European Respiratory Society International Congress 2022 in Barcelona (Spain), the latest research and clinical topics in respiratory medicine have been presented. The sleep medicine-focused presentations and symposia provided novel insights into the pathophysiology of sleep-disordered breathing, its diagnostics and new trends...
Reliable detection of sleep positions is essential for the development of technical aids for patients with position-dependent sleep-related breathing disorders. We compare personalized and generalizable sleeping position classifiers using unobtrusive eight-channel pressure-sensing mats. Data of six male patients with confirmed position-dependent sl...
For this article, we invited early career members (ECMs) to interview the past and current Presidents of the European Respiratory Society (ERS), Professor Anita Simonds and Professor Marc Humbert, to share their motivations for becoming ERS President, experiences and goals during their presidency, perspectives on career development, visions for the...
Each year, the European Respiratory Society (ERS) offers many opportunities to support Early Career Members (ECMs) working in the respiratory field in advancing their careers, including fellowships, representation at ERS assemblies, and presentations at the ERS Congress. Through these opportunities, ECMs can meet other respiratory professionals, fi...
This article provides a brief description of some of the most remarkable sessions of the @EuroRespSoc Lung Science Conference and the Sleep and Breathing Conference 2021 and presents the new incoming members of the ECMC (@EarlyCareerERS) https://bit.ly/2RSDP40.
Background: Obstructive sleep apnoea (OSA) results in sympathetic overdrive. Increased nocturnal heart rate variability (HRV) is a surrogate marker of autonomic disturbance. The aim was to study the association of the apnoea-hypopnea index (AHI), nocturnal
hypoxaemia, and sleep fragmentation with nocturnal HRV to address the pathophysiological mec...
Background
There is strong evidence for clinically relevant night-to-night variability of respiratory events in patients with suspected obstructive sleep apnoea (OSA).
Research Question
How many sleep study nights are required to diagnose OSA accurately?
Methods
Patients with suspected OSA underwent up to 14 nights of pulse oximetry (PO) at hom...
Background
It is current practice to use a single diagnostic sleep study in the diagnostic workup of obstructive sleep apnoea (OSA). However, a relevant night-to-night variability (NtNV) of respiratory events has been reported.
Methods
We evaluated the NtNV of respiratory events in adults with suspected or already diagnosed OSA who underwent more...
Background and Objectives
Low adherence impairs the effectiveness of continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnoea (OSA), but knowledge on CPAP usage micro-patterns is mostly lacking. Thus, the aim of this study was to analyse usage micro-patterns among patients with suboptimal CPAP adherence.
Methods...
The 2019 European Respiratory Society (ERS) International Congress took place in Madrid, Spain, and served as a platform to find out the latest advances in respiratory diseases research. The research aims are to understand the physiology and consequences of those diseases, as well as the improvement in their diagnoses, treatments and patient care....
Introduction
Tobacco smoke worsens COPD and asthma. For healthy individuals, quantifying active and second-hand smoke (SHS) exposure clarifies the epidemiology of tobacco consumption and the efficacy of nonsmoking measures. Identifying tobacco exposure biomarkers and cut-offs might allow the creation of sensitive and specific tests.
Aim
We describ...
Objective
To evaluate the clinical implementation of pharmacotherapy recommendations for chronic obstructive pulmonary disease (COPD) based on the Global Initiative for chronic obstructive lung disease (GOLD) guidelines, in a longitudinal setting.
Methods
This is a sub-analysis of a prospective, non-interventional cohort study including patients w...
Objectives:
To evaluate the short-term repeatability of Epworth Sleepiness Scale (ESS) in patients with suspected obstructive sleep apnoea (OSA), and whether transitory sleepiness of the patient influenced ESS-results.
Methods:
Adult subjects with suspected OSA taking part in a study on the diagnostic accuracy of repeated sleep studies were elig...
Background:
Both inflammatory and remodelling processes are associated with irreversible airway obstruction observed in severe asthma. Our aim was to characterize a group of severe asthmatic patients with or without persistent airway obstruction in relation to specific sputum inflammatory and remodelling biomarkers.
Methods:
Forty-five patients...
In a group of 113 patients with non-CF bronchiectasis, we evaluated if type and severity of airway colonisation are able to influence several indices of disease (FEV1, DLCO and sputum neutrophilia amongst the others). The patients were subdivided in 4 groups: without colonisation by microorganisms with potential pathogenicity (MPP), with one MPP, w...
Understanding how nasal polyposis correlates with particular asthmatic (blood and sputum eosinophilia, FeNO level, ACT score, FEV1) and atopic (total serum IgE count, aspirin intolerance, skin prick test positivity) features.
Submitted to the ERS Annual International Congress 2018, Paris, France.
Questions
Questions (13)
Hello everyone,
As described above, I would like to compare two correlation coefficients from two linear regression models that refer to the same dependent variable (i.e. different x-variables, same y-variable). Is there a command in Stata to test whether the two correlation coefficients (or anything else that could be derived from a linear regression model, such as slope or angle) are significantly different (null hypothesis: the two coefficients are not different)?
Thank you in advance, best regards.
Hi everyone, I would like to calculate an overall median with quartile range starting from a group of three medians of three subpopulations, each one with its own quartile range. Could you suggest me an algorithm/online calculator/software able to do so?
Thank you in advance for your kind suggestions!
Hi everyone. I would like to graphically represent a multiple linear regression model with 3-4 variables. I normally use GraphPad and Stata, what would you suggest to use and why? I am rather flexible and I can also use other softwares when needed.
Thank you in advance for your answers.
Hi everyone, I checked for regression between two variables and it is statistically signifcant. Now I would like to assess if such correlation might have been influenced by other variables (for instance gender or age). Which would be the best statistical test to run?
Thank you in advance.
Hi everyone, as stated above, I would like to know whether it is possible to export data of SpO2 and Nasal Flow in .csv or .xls(x) format from ApneaLink for further analysis.
Thank you in advance, best regards.
Hi everyone, I would like to run a Cox regression progressively including potential confounding factors in the models (Model 0: no confounding factors; Model 1: 1 confounding factor; Model 2: 2 confounding factors; ...)
Since I never did it on my own, I am wondering if you could suggest a practical statistics software for this purpose.
PS I usually use Stata or GraphPad Prism.
Thank you for your collaboration and time.
Hi everyone. I would like to run a Spearman's correlation test between two non-normal variables positively checked for monotone regression. I would like to be sure that some confounding factors are not influencing the result. Is that a way to check the presence of confounding factors and weigh their impact on the result?
Thank you in advance for your collaboration.
Hi everyone. Let's suppose that we have an index which summarizes an event of a real-life situation. Let's suppose then that we want to compare the same index of two patients and one index is way bigger than the other one (crude ratio around 200). If we do the ratio between the inverse log10 of the index (1/Log10(index)) of the two patients we obtain a 10-fold ratio, which might be easy to "handle" and to understand in a publication. Would it be better to run statistical analysis with the crude ratio, the ratio of inversed log10, or both? Which other transformation would you suggest for presenting and working with such data? Thank you in advance for your time and suggestions.
Hi everybody. I would like to understand from a pathophysiological point of view how long does it take to a nasal flow reduction-associated desaturation to be visible on the pulse oximeter SpO2% signal. In Literature I found that such time depends mainly on functional residual capacity (FRC) and oxygen consumption (VO2), and that the delay for the average person is 60 seconds. Considering that OSA patients show often a higher BMI, would it be correct to expect a reduced delay time, since weight affects, among other factors, FRC? If patients had CV comorbidities, would it be correct to expect a reduced delay time as well?
Thank you in advance for your time and advice.
Hello everyone.
From a pathophysiologic point of view, how long is it reasonable to look back in the nasal flow signal of OSA patients to see whether a desaturation episode is related to a previous nasal flow reduction? The delay amount might depend on specific patient's characteristics. In that case, are there phenotypes of patients with obstructive sleep apnoeas that take such delay variability into account?
Thank you in advance.
