Martin Eduardo Santocildes Romero

AFYX Therapeutics, Copenhagen, Denmark

Protein-based biologics constitute a rapidly expanding category of therapeutic agents with high target specificity. Their clinical use has dramatically increased in recent years, but administration is largely via injection. Drug delivery across the oral mucosa is a promising alternative to injections, in order to avoid the gastrointestinal tract an...

Chronic ulcerative oral mucosal inflammatory diseases, including oral lichen planus and recurrent aphthous stomatitis, are painful and highly prevalent, yet lack effective clinical management. In recent years, systemic biologic therapies, including monoclonal antibodies that block the activity of cytokines, have been increasingly used to treat a ra...

Bone injuries that arise from trauma, cancer treatment, or infection are a major and growing global challenge. An increasingly ageing population plays a key role in this, since a growing number of fractures are due to diseases such as osteoporosis, which place a burden on healthcare systems. Current reparative strategies do not sufficiently conside...

The delivery of biopharmaceuticals to the oral mucosa offers a range of potential applications including antimicrobial peptides to treat resistant infections, growth factors for tissue regeneration, or as an alternative to injections for systemic delivery. Existing formulations targeting this site are typically non-specific and provide little contr...

Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are chronic inflammatory conditions often characterised by erosive and/or painful oral lesions that have a considerable impact on quality of life. Current treatment often necessitates the use of steroids in the form of mouthwashes, creams or ointments, but these are often ineffective...

Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composit...

Additive manufacturing technologies enable the creation of very precise and well-defined structures that can mimic hierarchical features of natural tissues. In this article, we describe the development of a manufacturing technology platform to produce innovative biodegradable membranes that are enhanced with controlled microenvironments produced vi...

Oral mucosal lesions are related to several etiologies including trauma, infection, and immunologic and neoplastic diseases. Their prevalence varies greatly depending on ethnicity, gender and exposure to risk factors. Currently, most oral mucosal lesions are treated with creams, mouthwashes or gels containing suitable drugs. However, topical medica...

Barrier membranes used for the treatment of bone tissue defects caused by periodontitis lack the ability to promote new bone tissue regeneration. However, the addition of an osteogenic component to membranes may enhance their regenerative potential. Here the manufacturing of composite membranes made of poly(caprolactone) and strontium-substituted b...

A major problem in the treatment of oral mucosal diseases such as oral lichen planus is the delivery of an appropriate amount of drug to the affected region. Frequently, drugs are applied in the form of mouthwashes or ointments that may result in variable dosage and potential undesired side effects. Additionally, mouth movements and the production...

Bioactive glasses are known to stimulate bone healing, and the incorporation of strontium has the potential to increase their potency. In this study, calcium oxide in the 45S5 bioactive glass composition was partially (50%, Sr50) or fully (100%, Sr100) substituted with strontium oxide on a molar basis. The effects of the substitution on bioactive g...

Objective: Recent papers have suggested that strontium-substituted bioactive glasses (BGs) may possess superior bioactivity compared to their unmodified parent glasses. If true, these BG compositions could form the basis for a new generation of bone graft substitutes, an area of considerable clinical need. Therefore, the aim of this research was to...

Objectives: Electrospinning is a widely studied method of producing scaffolds for bone tissue engineering due to its simplicity and versatility. Particulate strontium-substituted bioactive glass (Sr-BG) may be incorporated within the fibres, where it will potentially release strontium ions post-implantation into the defect site. It has been reporte...

Introduction: Electrospinning is a method that may be used for the fabrication of polymeric scaffolds for tissue engineering. Particulate strontium-substituted bioactive glass may be incorporated within the fibres, potentially releasing strontium ions. Strontium has been reported to stimulate bone formation via action on osteoblasts. The aim of thi...

Introduction: Regeneration of critical-sized bone defects is still a challenge in maxillofacial and orthopaedic surgery. Over the last decade attempts have been made to combine materials (scaffolds), cells and growth factors. The most common support scaffolds are based on calcium phosphate (CaP) and the amount and type of porosity of a scaffold is...