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Introduction
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Publications
Publications (34)
Introduction: Joint linkage and association (JLA) analysis combines two disease gene mapping strategies: linkage information contained in families and association information contained in populations. Such a JLA analysis can increase mapping power, especially when the evidence for both linkage and association is low to moderate. Similarly, an assoc...
Background: Previous studies indicated preterm birth to be a risk factor for hypertension in adolescence and adulthood. However, studies in children investigating the underlying mechanisms are scarce.
Objective: We hypothesized children born preterm to have higher excretion of cortisol and/or androgen metabolites per day concomitantly with higher b...
PURPOSE
Despite undergoing allogeneic hematopoietic stem cell transplantation (HCT), patients with acute myeloid leukemia (AML) with internal tandem duplication mutation in the FMS-like tyrosine kinase 3 gene ( FLT3-ITD) have a poor prognosis, frequently relapse, and die as a result of AML. It is currently unknown whether a maintenance therapy usin...
The semiaquatic mammalian species Eurasian beaver Castor fiber LINNAEUS, 1758 and Eurasian otter Lutra lutra (LINNAEUS, 1758) simultaneously occur in European freshwater ecosystems. Knowledge about the interaction between the two species can be helpful in the prediction of species distribution and colonization. The present study compares beaver and...
The orchid species Dactylorhiza majalis is endangered by continuing habitat destruction and fragmentation. This requires more detailed information with respect to its sexual reproduction, which is especially relevant for Germany, where from 10 % to 30 % of the world-wide remaining populations grow. In the present study, we determined both the numbe...
Genomic imprinting is a parent-of-origin effect apparent in an appreciable number of human diseases. We have proposed the new imprinting test statistic MOBIT, which is based on MOD score analysis. We were interested in the properties of the MOBIT concerning its distribution under three hypotheses: (1) H0,a : no linkage, no imprinting; (2) H0,b : li...
Introduction: Most patients with FLT3-ITD-positive AML, who relapse after allogenic stem cell transplantation (allo-SCT) die from their disease. Whether prophylactic FLT3-ITD inhibition with sorafenib can prevent AML relapse and improve outcome of patients in complete hematological remission (CHR) after allo-SCT is unknown and was tested in the SOR...
Background
Utilizing psychological resources when dealing with chronic low back pain might aid the prevention of disability. The observational study at hand examined the longitudinal impact of resilience and coping resources on disability in addition to established risk factors. Methods
Four hundred eighty four patients with chronic low back pain (...
This prospective, randomized, placebo-controlled, double-blinded phase I clinical trial investigates safety and efficacy of botulinum toxin (BoNT) to preserve gland function after radiotherapy in patients with head and neck cancer. Twelve patients with advanced head and neck cancer were injected with BoNT into the submandibular glands prior to prim...
Study protocol, additions 2.
(PDF)
Sample case report form.
(PDF)
Study synopsis.
(DOCX)
Consort checklist.
(DOC)
Caption to S3 Table.
(PDF)
Raw scintigraphic data.
(CSV)
Study protocol, additions 1.
(PDF)
Study protocol.
(PDF)
ICMJE Form for Disclosure of Potential Conflicts of Interest.
(PDF)
Background/aims:
Theoretically, the trait-model parameters (disease allele frequency and penetrance function) can be estimated without bias in a MOD score linkage analysis. We aimed to practically evaluate the MOD score approach regarding its ability to provide unbiased trait-model parameters for various pedigree-type and trait-model scenarios. We...
Prospective cohort study with chronic low back pain patients at primary care setting.
The aim of our study was to identify predictors for transition from localized chronic low back pain to chronic widespread pain in general practice. In contrast to the typically investigated risk factors, this study also focuses intensively on protective factors, w...
As the mode of inheritance is often unknown for complex diseases, a MOD-score analysis, in which the parametric LOD score is maximized with respect to the trait-model parameters, can be a powerful approach in genetic linkage analysis. Because the calculation of the disease-locus likelihood is the most time-consuming step in a MOD-score analysis, we...
Chronic pain is a common reason for consultation in general practice. Current research distinguishes between chronic localized pain (CLP) and chronic widespread pain (CWP). The aim of this study was to identify differences between CWP and chronic low back pain (CLBP), a common type of CLP, in primary care settings.
Fifty-eight German general practi...
Due to the heterogeneous nature of chronic low back pain (CLBP), it is necessary to identify patient groups and evaluate treatments within these groups. We aimed to identify groups of patients with CLBP in the primary care setting.
We performed a k-means cluster analysis on a large data set (n = 634) of primary care patients with CLBP. Variables of...
Previously, we reported strong influences of genetic variants on metabolic phenotypes, some of them with clinical relevance. Here we hypothesize that DNA methylation may have an important and potentially independent effect on human metabolism. To test this hypothesis we conducted what is to the best of our knowledge the first epigenome-wide associa...
To compare body composition and abdominal fat partitioning between 5- to 7-year old children born preterm and born at term. We hypothesized children born preterm to have a higher body fat percentage and higher percentage of intra-abdominal adipose tissue (%IAAT) compared with their peers born at term.
A total of 236 children aged 5-7 years, ie, 116...
As has been shown for children born small for gestational age, low birth weight due to prematurity might be a risk factor for developing increased body fat mass and a higher percentage of intraabdominal adipose tissue which has been shown to be associated with cardiovascular disease, insulin resistance and finally metabolic syndrome. Thus, body com...
Premature birth which is associated with impaired pulmonary and renal function implies higher cardiovascular risk by developing elevated blood pressure early in life. In this study, systolic blood pressure (SBP) and diastolic blood pressure (DBP) was determined from 236 children aged 5 to 7 years, i.e., 116 children born preterm (gestational age 29...
Aberrant DNA methylation constitutes a well-established epigenetic marker for breast cancer. Changes in methylation early in cancer development may be clinically relevant for cancer detection and prognosis-based therapeutic decisions. In the present study, a combination of methyl-CpG immunoprecipitation (MCIp) and human CpG island (CGI) arrays was...
Chronic localized pain syndromes, especially chronic low back pain (CLBP), are common reasons for consultation in general practice. In some cases chronic localized pain syndromes can appear in combination with chronic widespread pain (CWP). Numerous studies have shown a strong association between CWP and several physical and psychological factors....
In the genetics of asthma, single genetic polymorphisms confer only a small individual risk factor. Haplotype-based association analyses, including joint analyses of several candidate genes, might therefore yield more convincing results than single-region statistics. We set out to test for joint influences of asthma genes previously identified in o...
The incidence of caesarean section (CS) is steadily rising world-wide. In particular, CS on maternal demand is performed more frequently. In parts, this might be due to insufficient information of pregnant women about neonatal risks of CS. We sought to specify neonatal outcomes following different modes of delivery, i.e. vaginal delivery, primary C...
