Marina KirklandDartmouth College · Department of Microbiology and Immunology
Marina Kirkland
MS
About
6
Publications
516
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Citations
Introduction
Marina Kirkland currently works at the Department of Microbiology and Immunology at Dartmouth College as a doctoral student. Marina does research in Pathology and Immunology under the guidance of Dr. Joshua Obar.
Additional affiliations
August 2013 - July 2015
September 2011 - May 2013
Publications
Publications (6)
In this study, sixteen unique staphylococcal enterotoxin B (SEB)-reactive nanobodies (nbs), including ten monovalent and six bivalent nbs, were developed. All characterized nbs were highly specific for SEB and did not cross-react with other staphylococcal enterotoxins (SE). Several formats of highly sensitive enzyme-linked immunosorbent assays (ELI...
Independent studies demonstrate the significance of gut microbiota on the pathogenesis of chronic lung diseases; yet little is known regarding the role of the gut microbiota in lung fibrosis progression. Here we show, using the bleomycin murine model to quantify lung fibrosis in C57BL/6 J mice housed in germ-free, animal biosafety level 1 (ABSL-1),...
Purpose of review:
This review aims to describe how the clinical manifestations of sarcoidosis may be shaped by the effects of sex hormones and by age dependent changes in immune functions and physiology This review is intended to highlight the need to consider the effects of sex and sex in future studies of sarcoidosis.
Recent findings:
The cli...
Aspergillus fumigatus is an important human fungal pathogen particularly in immunocompromised individuals. Initiation of growth by A. fumigatus in the lung is important for its pathogenicity in murine models.
Aspergillus fumigatus isolates display significant heterogeneity in growth, virulence, pathology, and inflammatory potential in multiple murine models of invasive aspergillosis. Previous studies have linked the initial germination of a fungal isolate in the airways to the inflammatory and pathological potential; but the mechanism(s) regulating A. f...
In all retroviruses, reverse transcription of viral genes is primed by a host‐cell tRNA whose 3′‐end 18 nucleotides are complementary to the viral primer binding site. For lentiviruses, including HIV, the natural primer is tRNA Lys3 which harbors several modified bases in its anticodon stem‐loop (ASL). Interaction of the fully modified ASL with the...
Questions
Question (1)
I collected BALF from mice using PBS and froze at -80. I have not thawed, downstream analysis includes LDH (Cytotox96 Promega) and Albumin assay. I am mostly worried about the LDH assay, will the enzyme still be active? It doesn't seem to have a metal iono in it's active site so perhaps one freeze thaw cycle without EDTA decrease the enzyme's deficiency?
