Manoj Kumar Goshisht

Government Naveen College Tokapal, Bastar, Chhattisgarh · Chemistry

Machine learning (ML), particularly deep learning (DL), has made rapid and substantial progress in synthetic biology in recent years. Biotechnological applications of biosystems, including pathways, enzymes, and whole cells, are being probed frequently with time. The intricacy and interconnectedness of biosystems make it challenging to design them...

Biological species, including reactive oxygen species (ROS), reactive sulfur species (RSS), reactive nitrogen species (RNS), F-, Pd2+, Cu2+, Hg2+, and others, are crucial for the healthy functioning of cells in living organisms. However, their aberrant concentration can result in various serious diseases. Therefore, it is essential to monitor biolo...

As chemistry progressed over the years, modern society witnessed the significant contribution of women chemists. However, the persisting gender imbalance in the scientific community, attributed to improper societal norms and several other reasons, is a matter of concern. The manuscript highlights some great women chemists, such as Nobel Prize award...

Metal ions exist globally. Therefore, the study of the design strategies, mechanistic insights, and applications of fluorescent Schiff base sensors for metal ion detection constitutes an active topic of research. Further, theoretical studies on these systems using various spectroscopic techniques add new flavor in terms of providing a better unders...

The COVID-19 pandemic caused by SARS-CoV-2 is responsible for the global health emergency. Here, we explore the diverse mechanisms of SARS-CoV-induced inflammation. We presume that SARS-CoV-2 likely contributes analogous inflammatory responses. Possible therapeutic mechanisms for reducing SARS-CoV-2-mediated inflammatory responses comprise FcR inac...

Negatively charged ions are an integral part of our ecosystem, where at certain concentrations (fixed by the Environmental Protection Agency (EPA) and World Health Organization (WHO)), they are non-toxic. However, with an increase or decrease in their concentration due to pollution, industrialization, etc., anions show harmful effects. Therefore, t...

Artificial intelligence (AI) renders cutting-edge applications in diverse sectors of society. Due to substantial progress in high-performance computing, the development of superior algorithms, and the accumulation of huge biological and chemical data, computer-assisted drug design technology is playing a key role in drug discovery with its advantag...

By using in situ synthesis of gold nanoparticles (Au NPs) in the presence of binary mixtures of cytochrome c (Cyc,c) and bovine serum albumen (BSA) model proteins, we demonstrated a new method of studying protein – protein interactions on the surfaces of nanomaterials. Such interactions were simultaneously evaluated and supported by the molecular d...

Fundamental aspects of protein complex coated gold nanoparticles (Au NPs) were presented for their possible use in systemic circulation in terms of pharmaceutical formulations. For this purpose, protein complexes of bovine serum albumin (BSA), lysozyme (Lys), and zein with an industrial important bioactive polymer diethylaminoethyl dextran (DEAE) w...

Interactions between the components of lysozyme/cytochrome c (lysozyme/Cyt,c) and lysozyme/zein protein mixtures were determined by following the in vitro synthesis of gold (Au) nanoparticles (NPs). Both UV-visible and fluorescence studies were employed to monitor the interactions and simultaneous synthesis of protein coated NPs. Protein coated NPs...

Industrially important zein protein has been employed to understand its interactions with two model proteins bovine serum albumin (BSA) and cytochrome c (Cyc,c) following the in vitro synthesis of Au NPs so as to expand its applicability for biological applications. Interactions were studied under the effect of temperature variation by UV-visible a...