Majed Shtaiwi

Hashemite University | HU · Department of Chemistry

In the present study, the aimed enamines 3 a–j were synthesized with yield ranging between 65 and 81 % by the reaction of 5‐((dimethylamino)methylene)‐1,3‐dimethylpyrimidine‐2,4,6(1H,3H,5H) ‐trione (2) with different amines at room temperature (25 °C). The structures of all synthesized compounds were characterized using different spectroscopic tech...

This review highlights the multifaceted usefulness of o-halobenzyl halides as pivotal substrates for the construction of five- to nine-membered cyclic structures with the aid of transition metals as catalysts. These privileged entities engage dual active sites, enabling the combination of both intermolecular benzylation and intramolecular arylation...

The copper‐catalyzed regioselective domino synthesis of 4H‐benzo[4,5]thiazolo[3,2‐a]pyrimidin‐4‐ones 3 through N,S‐arylation strategies has been accomplished. This transformation was operated by the reaction of 1‐bromo‐2‐iodobenzenes 1 with 2‐thioxo‐2,3‐dihydropyrimidin‐4(1H)‐ones 2 in the presence of trans‐4‐hydroxy‐L‐proline as a ligand in DMSO a...

Three Schiff base ligands, NQ, CQ and HQ, were prepared from the reaction of quinoline-3-carbohydrazide with 2-nitrobenzaldehyde, 2-chlorobenzaldehyde and 2,4-dihydroxybenzaldehyde, respectively, and were investigated for their coordination to Cu (II), Ni(II), Co(II), Cd(II), Cr(III) and Fe(III) chlorides. The NQ preparation and the X-ray structure...

A new type of anthracene dimer was synthesized through an efficient approach involving the Strecker reaction and self-condensation of α-aminonitrile. This anthracene dimer contains a flexible Ncyanomethylmethanimine (CMMI) bridge, the...

The p-toluene sulfonic acid (p-TSA) catalyzed cascade ring closing transformation has been executed for the preparation of novel spiroquinazolinone compounds 4 and 5 by the reaction between anthranilamide and cyclohexanone followed by subsequent acylation. These molecules were then examined against the inhibitory activity of Acetylcholinesterase (A...

Schiff bases have played significant roles in the development of inorganic or coordination chemistry. Three Schiff base (NB, CB and HB) ligands, prepared for the reaction of 2-amino-6-methoxy-benzothiazole with 2-Nitrobenzaldehyde, 2-chlorobenzaldehyde and 2,4-Dihydroxybenzaldehyed, respectively, were investigated for their transition metal complex...

Background The desirable levels of lipids, especially in patients with coronary artery disease, might not be achievable with a single lipid-lowering drug; thus, combination therapy using atorvastatin and gemfibrozil seems to be a promising approach. However, the potential for drug-drug interaction needs to be taken into consideration, and the combi...

In the present work, two protocols were compared for magnetic solid phase extraction (MSPE) of Cd(II) and Pb(II) from aqueous medium. The first novel protocol involved adding Schiff base into the extraction medium using either magnetite (Mag) or magnetic carbon nanotubes (MCNT). It was found that adding vanillin Schiff base (VSB) with Mag to the ex...

ABSTRACT Keywords: Magnetic solid phase extraction Magnetite Adsorption Magnetic schiff base Cadmium Lead In this work, three Schiff bases were prepared and characterized: E-2-methoxy-4-(((3-(triethoxysilyl)propyl) imino)-methyl)phenol (VSB), E-4-(((3-(triethoxysilyl)propyl)imino)-methyl)phenol (4-HSB) and E-2-(((3-(triethoxysilyl)propyl)imino)meth...

In this study, a new and simple magnetic solid phase extraction (MSPE) method was developed for the preconcentration of Cd+2 and Pb+2 metal ions from water and to overcome interferences using AAS. It is based on the complexation ability of the chelating reagent with the studied metal ions. The chelating reagent was added to the water medium using M...

Background: The efficient analytical method for the analysis of nonsteroidal antiinflammatory drugs (NSAIDs) in a biological fluid is important for determining the toxicological aspects of such long-term used therapies. Methods: In the present work, multi-walled carbon nanotubes reinforced into a hollow fiber by chitosan sol-gel assisted-solid/...

A series of biologically active 3-quinoline carboxylic acid hydrazide-hydrazones has been synthesized from 3-quinoline carboxylic acid hydrazide and a variety of aldehydes, with moderate to good yields. The chemical structures of the new products were confirmed by elemental analysis, IR, and 1H NMR, 13C NMR spectral data. The structural and frontie...

The iminopropadienones, RN==C==C==C==O, constitute a recently discovered class of compounds 1. While the simple alkyl derivatives (methyl 1 , isopropyl 2 and tert-butyl 2) are unstable compounds, which can, however, be isolated and characterized in low temperature matrices, the aryl derivatives are more stable and undergo chemical reactions, often...

New oxytetracycline Mannich bases were prepared and analytically and spectroscopically characterized. The antimicrobial screening tests by Well diffusion method revealed that some derivatives are biologically more active than the parent oxytetracycline and they are more active against E. coli and K. pneumonia bacteria than A. niger Fungus.

Homotrimetallic Cu(II), Co(II), Ni(II) and Fe(III) Complexes of N'1,N'2,N'3-triphenylpropane-1,2,3-tricarbohydrazide were prepared and analytically and spectroscopically characterized. The ligand was found to be acted as neutral or tribasic hexadentate N3O3 ligand bonded covalency or coordinationally via the carbonyl oxygen of carboxylate moieties...

Homotrimetallic Cu(II), Co(II), Ni(II) and Fe(III) Complexes of N'1,N'2,N'3-triphenylpropane-1,2,3- tricarbohydrazide were prepared and analytically and spectroscopically characterized. The ligand was found to be acted as neutral or tribasic hexadentate N3O3 ligand bonded covalency or coordinationally via the carbonyl oxygen of carboxylate moieti...

New oxytetracycline Mannich bases were prepared and analytically and spectroscopically characterized. The antimicrobial screening tests by Well diffusion method revealed that some derivatives are biologically more active than the parent oxytetracycline and they are more active against E. coli and K. pneumonia bacteria than A. niger Fungus.

Chalcones (CHAL)were synthesized from substituted benzaldehyde and acetophenone, benzaldehyde and substituted acetophenone and substituted benzaldehyde and substituted acetophenone subjected to the cooxidation in presence of oxalic acid in aqueous acetic acid medium by chromic acid (Cr (VI)). The reactions were carried out under pseudo–first ord...

Chalcones (CHAL)were synthesized from substituted benzaldehyde and acetophenone, benzaldehyde and substituted acetophenone and substituted benzaldehyde and substituted acetophenone subjected to the cooxidation in presence of oxalic acid in aqueous acetic acid medium by chromic acid (Cr (VI)). The reactions were carried out under pseudo-first order...

Chalcones can be easily oxidized in presence of oxalic acid, by Cr(VI) in acetic acid medium, the rate of cooxidation was found to be a fractional order with respect to the chalcones and its substituents. The order with respect to the chromic acid is unity whereas order with respect to oxalic acid is also a fractional order. The effect of various p...

This is the first comprehensive review of the biological activity of hydrazone-transition metal complexes. Hydrazone complexes gained much attention because of their antifugial, antibacterial anticonvulsant, and analgesic, antiinflammatory, antimalarial, antimicrobial, antituberculosis, anticancer, and antiviral activities. Additionally, some of th...

Chalcones can be easily oxidized in presence of oxalic acid, by Cr(VI) in acetic acid medium, the rate of cooxidation was found to be a fractional order with respect to the chalcones and its substituents. The order with respect to the chromic acid is unity whereas order with respect to oxalic acid is also a fractional order. The effect of variou...

This investigation was carried out to study the effect of addition of different concentrations of alum salt used in the treatment of sewer water of the pond and also to study the physico-chemical parameters such as pH ,electrical conductivity ,salinity and total sediments besides that the bacteriological analysis such as total viable count (TVC)...

The present study aimed to assess the antihyperglycemic effect of Cleome droserifolia (samwa) ethanol extract in alloxan-induced diabetic rats and to shed more light on the phytochemical screening of this plant and the chemical analysis of its ethanol extract. Alloxan-induced diabetic male albino rats were treated with ethanol extract at intraga...

The addition of methanol to the mesityliminopropadienone compound A were studied by using 1H NMR spectra which shows a complicated kinetics involving a fast reaction to about 35 % consumption followed by slow one. Consideration of the kinetics behaviours under different experimental conditions at 10 °C and the product assignment provide valuable me...

This book describes the thermal fragmentation of heterocycles to give extended cumulenes called iminopropadienones, observed by infrared spectroscopy at 8 K and trapped by preparative flash vacuum pyrolysis (FVP). Chapter 1 describes the generation of iminopropadienones from Meldrum's acid derivatives. Chapter 2 describes the generation of 2,6- dif...

A fast and reliable method for the determination of repaglinide is highly desirable to support formulation screening and quality control. A first-derivative UV spectroscopic method was developed for the determination of repaglinide in tablet dosage form and for dissolution testing. First-derivative UV absorbance was measured at 253 nm. The develope...