Magdalena Joanna Winkiel

Adam Mickiewicz University | UAM · Department of Animal Physiology and Developmental Biology

Glycoalkaloids (GAs) are produced naturally by plants and affect insect survivability and fertility. These compounds can be considered potential bioinsecticides; however, the mechanisms and effects of their action remain undiscovered. As lipids are essential molecules for the proper functioning of an insect organism, this research aimed to determin...

Recently, plant secondary metabolites have been considered for developing new generation nematicides. Carlina acaulis L. (Asteraceae) contains an essential oil (EO) exhibiting significant insecticidal activity with limited impact on beneficial aquatic and terrestrial organisms. Herein, we report the development of a C. acaulis essential oil EO (CEO...

Context Solanaceae glycoalkaloids (SGAs) possess cardiomodulatory activity. Objective This study investigated the potential interaction between verapamil and glycoalkaloids. Material and methods The cardioactivity of verapamil and glycoalkaloids (α-solanine and α-chaconine) was tested in adult beetle (Tenebrio molitor) myocardium in vitro using m...

Cancer is still one of the main causes of death worldwide. For this reason, new compounds that have chemotherapeutic potential have been identified. One such group of substances is Solanaceae glycoalkaloids (GAs). They are natural compounds produced by plants widely used in traditional medicine for healing many disorders. Among others, GAs exhibit...

Lipids play a significant role in insect organisms. These compounds are a magazine of energy, component of cell membranes and take part in cell signaling. They are a highly diverse group of organic substances including e.g. glycerides, fatty acids and sterols. Lipids constitute the main ingredient of fat body tissue from where they are secreted int...

Glycoalkaloids (GAs) are produced by many plant species and have high biological activity. In plants, they act as natural protectants against pathogens and herbivores. The studies of GAs in insects are focused mainly on the lethal and sublethal effects. There are only a few studies concerning the mechanisms of GAs action in these organisms and, thu...

The insulin-like peptide (ILP) and insulin-like growth factor (IGF) signalling pathways play a crucial role in the regulation of metabolism, growth and development, fecundity, stress resistance, and lifespan. ILPs are encoded by multigene families that are expressed in nervous and non-nervous organs, including the midgut, salivary glands, and fat b...

The nightshade plant family (Solanaceae) is widespread in the world and contains many useful plant species, such as eggplant, pepper and petunia. Nightshade plants are a source of numerous biologically active substances, including alkaloids. For example, atropine present in deadly nightshade acts as an antagonist of muscarinic receptors and nicotin...

Greater wax moth (Galleria mellonella) is a common pest of honeybees hives, where it can cause serious economic losses. Recently, many alternative methods of pest management are intensively studied to limit the emission of toxic synthetic pesticides. One of the alternatives is the usage of plant derivatives that are easy to obtain, biodegradable an...

Dibromides of gemini 3-hydroxy- and 3-hydroxymethylpyridinium salts with a 10- and 12-carbon linker (1–4) and monobetaine of 1,10-di(3-hydroxypyridinium)decane monobromide (1Bet) were synthesized and characterized by FTIR, ¹H and ¹³C NMR, and UV–vis spectroscopic methods. Geometrical structures of the studied compounds were optimized by B3LYP metho...