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Publications
Publications (34)
Autism spectrum disorder (ASD) has become one of the most well-known disorders encountered since early childhood among people. Nowadays, the main concerns are its high prevalence and the lack of proper therapeutic interventions. In this way, the necessity of using animal models that can mimic some of the spectrum symptoms, besides deepening the mec...
Background and Objectives: Alcoholic hepatitis (AH) poses a medical challenge, causing moderately severe to life-threatening episodes with high short- and long-term mortality. This study aimed to explore real-world corticosteroid utilization in severe AH, response predictors, and patient outcomes. Materials and Methods: We conducted a retrospective...
Citation: Robea, M.A.; Ilie, O.D.; Nicoara, M.N.; Solcan, G.; Romila, L.E.; Ureche, D.; Ciobica, A. Vitamin B 12 Ameliorates Pesticide-Induced Sociability Impairment in Zebrafish (Danio rerio): A Prospective Controlled Intervention Study. Animals 2024, 14, 405. https://doi.org/10.3390/ ani14030405
Abstract
Constant exposure to a variety of environ...
Constant exposure to a variety of environmental factors has become increasingly problematic. A variety of illnesses are initiated or aided by the presence of certain perturbing factors. In the case of autism spectrum disorder, the environmental component begins to play an important part in de-termining the overall picture. Moreover, the lack of the...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. Its incidence is progressively rising and it is possibly becoming a worldwide epidemic. NAFLD encompasses a spectrum of diseases accounting for the chronic accumulation of fat within the hepatocytes due to various causes, excluding excessive alcohol consumption. In...
Background:
Lately, the high incidence of pesticide usage has attracted everyone's interest due to the serious effects produced. Fipronil (FIP) is a phenylpyrazole compound that acts on the insect's GABA neurotransmitter by inhibiting its activity. Moreover, the literature reports highlight its implication in neurodevelopmental abnormalities and o...
Introduction
Autism spectrum disorder (ASD) is a disorder with social, communication and behavioral disturbances that start from early childhood. There are many difficulties in diagnosing people with ASD. The diagnostic criteria are in terms of behavior descriptions, and as methods of intervention the most used is the applied behavior analysis (ABA...
Introduction
Autism spectrum disorder (ASD) is currently defined as persistent deficits in social communication and social interaction additional to repetitive behavioural patterns, and restrictive interests or activities. Several studies suggested that ASD is accompanied by defective perception and altered response to the environmental factors, in...
Introduction
Celiac disease (CD), triggered by gluten ingestion, occurs in people genetically predisposed to develop this chronic autoimmune condition. The triggering environmental factor, gluten, is known as a protein present in wheat, rye and barley. In recent decades, specialists have found more knowledge about the disease mechanisms, how it dev...
Background: Lately, the high incidence of pesticide usage has attracted everyone's interest due to the serious effects produced. Fipronil (FIP) is a phenylpyrazole compound that acts on the insect’s GABA neurotransmitter by inhibiting its activity. Moreover, literature reports highlight its impli-cation in neurodevelopmental abnormalities and oxida...
For the past several decades, the modeling of specific neuropsychiatric disorders using animal models has been the most useful tool in characterizing the etiological causes, symptoms and treatments in their appearance and development. Because of this increased demand, but also due the need for knowledge from an early stage, the spread of animal mod...
Detergents are now defined as emerging pollutants, primarily
because of their ubiquity in the environment, and their
toxic effects even at low concentrations. Sodium lauryl sulfate
(SLS) is an anionic surfactant and is a common ingredient in
household cleaning and personal care products. Due to the
heavy use of all these products, SLS is commonly f...
Sodium lauryl sulfate (SLS) is an anionic surfactant and is a common ingredient in personal care products and household cleaning products. Detergents are today defined as emerging pollutants, mostly because of their ubiquity in the environment, and their toxic effects also at
low concentrations. Due to the daily use of all these detergents, SLS is...
Background:
As every organ within the body, the brain is also extremely susceptible to a plethora of noxious agents that change its chemistry. One component frequently found in current products against harmful species to crops is rotenone whose effect under prolonged exposure has been demonstrated to cause neurodegenerative disorders such as Parki...
Autism spectrum disorder (ASD) is one of the most salient developmental neurological diseases and remarkable similarities have been found between humans and model animals of ASD. A common method of inducing ASD in zebrafish is by administrating valproic acid (VPA), which is an antiepileptic drug that is strongly linked with developmental defects in...
Introduction
Autism spectrum disorder (ASD) is a multi-factorial disease characterized by impairments in social interaction, communication and repetitive behaviors. The necessity of developing an adequate treatment for ASD is essential. There is an increase in clinical studies assessing the positive effects of vitamins in ASD children. Vitamin C (v...
Background. Affecting 60% of the people diagnosed with dementia, Alzheimer's disease is a neurodegenerative pathology that negatively impacts the cognitive function. It is characterised by symptoms as memory loss, locomotor difficulties, behavioural changes, and even rationalization issues. This disease has been studied on both rodents and fishes....
Chronic exposure to synthetic insecticides in the early life of a child can lead to a series of disorders. Several causes as parental age, maternal smoking, birth complications, and exposure to toxins such as insecticides on childhood can lead to Autism spectrum disorder (ASD) occurrence. The aim of this study was to evaluate the potential protecti...
The complex yet not fully understood pathophysiology of Parkinson's disease includes an important molecular component consisting of oxidative status changes, thus leading to oxidative stress occurrence. While no particular evidence has been reported that describes the relationship between oxidative stress and the molecular mechanisms behind Parkins...
Recently, connections have been made between feeding and eating problems and autism spectrum disorder (ASD) and between autism pathophysiology and diet issues. These could explain some of the mechanisms which have not yet been discovered or are not sufficiently characterized. Moreover, there is an increased awareness for micronutrients in ASD due t...
Deltamethrin is responsible for health and reproduction problems both in mammals and aquatic organisms. In this study, zebrafish adults were exposed for 15 days to 0.25, 0.5, 1, and 2 μg L −1 non-lethal concentrations of deltamethrin, knowing that is used worldwide on agricultural crops. We investigated the chronic effects of deltamethrin on gonads...
Considering the awareness regarding the oxidative stress status implication in most of the actual neuropsychiatric disorders and also the ever increasing importance of zebrafish studies in this context, in the present paper we were interested in the general biological relevance of the oxidative stress status in replicating some neuropsychiatric man...
In this study zebrafish specimens were exposed for 15 days to 0.25, 0.5, 1 and 2 μg L−1 non-lethal concentrations of deltamethrin (DM) knowing that is the active compound in insecticides used on agricultural crops. They were investigated important issues resulted during the chronic exposure with DM: effects on aggressive behavior and swimming perfo...
Considering the awareness regarding the oxidative stress status implication in most of the actual neuropsychiatric disorders and also the ever increasing importance of zebrafish studies in this context, in the present paper we were interested in the general biological relevance of the oxidative stress status in replicating some neuropsychiatric man...
Gold is a noble metal having a long history of human usage and a variety of applications. The present paper was designed in order to see the changes on social and swimming behavior of zebrafish caused by acute gold exposure to high concentrations dissolved in aquatic medium from a standard solution with the highest purity. Some main oxidative stres...
Because insects had developed resistance to several insecticides, today, neonicotinoids and fiproles are used to combat pests. The difference between this two classes of insecticides is that fipronil acts by inhibiting the receptors of nervous cells, while neonicotinoids perturbs the neuronal transmission. The suitable properties of fipronil make t...
Fishes are the first group of vertebrates that respond when the environment is contaminated with pollutants resulted from anthropogenic activities. The development of the toxicity tests is bringing new evidence about the toxicological effects of the pollutants upon the life forms. Behavioural abnormalities in the swimming performance and cognitive...
The predisposition of people to contact or manifest certain diseases is growing. Chemical resistance mixed with other harmful sources could represent one of the causes for the disease appearance. Environmental toxins like rotenone are frequentlyused in agriculture or in fish extermination to control the soil or water fauna population. Despite the b...
Introduction and study objectives Mercury is an aggressive and potent neurotoxin that significantly increased within environment, leading to concern for human and wildlife health in many regions of the world. The most well-known case recorded in the history of mercury mass poisoning in human population is the Minamata disaster from the Japanese isl...
The aim of this overview was to evaluate the toxicological effects of the neonicotinoid insecticide imidacloprid upon vertebrates, based on the data available from scientific publications. Eurostat database was used to extract the quantities of insecticides sold starting with the year 2009 until 2015-the last reported year, with the last update on...
The aim of this study was to identify the impact of pyrethroid-type insecticides upon organisms but also the negative influence upon the quality of people lives. Pyrethroids are synthetic chemical mixtures similar to pyrethrin-a compound from a Chrysantemum flowers extract. The degree of aggressiveness of pyrethroid insecticides depends on a number...
