The Structural Biology Knowledgebase - search Online for Protein Sequences, Structures, Functions, Methods and More

Abstract

The Structural Biology Knowledgebase (SBKB, URL: http://sbkb.org) is a free online resource designed to combine all protocols and results of the structural genomics and structural biology efforts with information from the biological community in order to have a better understanding living systems and disease. We will present examples of how to navigate the SBKB and how to use it to enable biological research. For example, a protein sequence or PDB ID search will provide a list of protein structures from the Protein Data Bank, associated biological descriptions (annotations), homology models, structural genomics protein target information, experimental protocols, and the ability to order available DNA clones. A text search will find technology reports and publications that were created by the Protein Structure Initiative's high-throughput research efforts. Web tools that aid in bench top research, such as the Sequence Comparison and Analysis tool for protein construct design, will also be demonstrated. Created in collaboration with the Nature Publishing Group, the Structural Biology Knowledgebase Gateway provides a research library, editorials about new research advances, news, and an events calendar also present a broader view of structural genomics and structural biology.The SBKB is funded by the Protein Structure Initiative/NIGMS.