Liming Ge

Sichuan University | SCU · College of Chemical Engineering

Transarterial radioembolization (TARE) is a promising technology in hepatocellular carcinoma (HCC) therapy, which utilizes radionuclide-labeled microspheres to achieve arterial embolization and internal irradiation. However, the therapeutic effect of liver cancer can be affected by low radionuclide labeling rate and stability, as well as poor bioco...

Pathogenic bacterial infection is the most frequent wound complication, which has become a major clinical and healthcare challenge in wound management worldwide, leading to impaired healing processes, the risk of amputation, and even death. Here, collagen‐based nanocomposite dressings (APZC) with broad‐spectrum antibacterial activity are developed...

Diabetic chronic wound healing still faces huge clinical challenge. The arrangement and coordination of healing processes are disordered in diabetic wound caused by the persistent inflammatory response, microbial infection, impaired angiogenesis, resulting in the delayed and even non-healing wounds. Here, the dual-drug loaded nanocomposite polysacc...

Antibacterial conductive hydrogels have been extensively utilized in tissue repair and regeneration on account of their unique electrochemical performances and advantages of anti-pathogenic bacterial infection. Here, multi-functional collagen-based hydrogels (CHLY) with adhesivity, conductivity, and antibacterial and antioxidant activities were dev...

Background: Bladder cancer, characterized by a high potential of tumor recurrence, has high lifelong monitoring and treatment costs. To date, tumor cells with intrinsic softness have been identified to function as cancer stem cells in several cancer types. Nonetheless, the existence of soft tumor cells in bladder tumors remains elusive. Thus, our...

The extracellular matrix (ECM) serves as signals that regulate specific cell states in tumor tissues. Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression. In this study, we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status. Experiments were conduc...

The development of intelligent edible films with food preservation and monitoring function is of great significance and applications. Herein, active intelligent edible films with pH-responsiveness, long term antioxidant and antibacterial activities were prepared base on gelatin. In this work, gelatin was chemically and physically combined with rosm...

Microsphere with sphere-in-capsule structure is a multi-drugs delivery system to achieve the purpose of combination therapy. In this paper, we have prepared gelatin/alginate-based microspheres with sphere-in-capsule structure by a relatively fast, simple, and easily large-scale industrialized emulsification method for spatiotemporal manipulative dr...

Nanoparticle drug delivery systems have drawn considerable attention worldwide due to their unique characteristics and advantages in anticancer drug delivery. Herein, the curcumin (Cur) loaded nanomicelles with two-stage drug release behavior were developed. β-Cyclodextrin (β-CD) and cholesterol were conjugated onto both ends of the poly(ethylene g...

Food security is an important global public health issue, which will not only endanger consumers’ life and health, but also cause serious food waste. Herein, antibacterial dialdehyde sodium alginate /ε-polylysine microspheres (DSA-PL MPs) were developed to effectively prolong the shelf life of fruit. DSA was prepared by periodate oxidation of sodiu...

Drug delivery system and intra-articular injection have been clinically applied to prolong drug residence time and reduce side effects in the treatment of osteoarthrosis. Herein, injectable hydrogels with sustained-dexamethasone sodium phosphate (DSP) release behavior in response to matrix metalloproteinase (MMP) were developed for osteoarthritic t...

Background A diminished sensitivity towards chemotherapy remains the major impediment to the clinical treatment of bladder cancer. However, the critical elements in control of chemotherapy resistance remain obscure. Methods We adopted improved collagen gels and performed cytotoxicity analysis of doxorubicin (DOX) and mitomycin C (MMC) of bladder c...

Crosslinking is frequently used to improve the inherent poor physicochemical properties of collagen. However, local flocculation and irregular crosslinking of collagen would be unavoidably occurred once contacting with crosslinking agents due to widespread complex interactions. Herein, dialdehyde starch-based nanoparticles were developed to crossli...

Guided bone regeneration technique is an effective approach to repair bone defects, in which a barrier membrane is essential. However, the collagen barrier membranes commonly used lose stability quickly, leading to connective tissue invasion and failure of osteogenesis. Herein, we presented an oxidized sodium alginate (OSA)-collagen heterogeneous b...

pH-Responsive nanoparticles (NPs) have emerged as an effective antitumor drug delivery system, promoting the drugs accumulation in the tumor and selectively releasing drugs in tumoral acidic microenvironment. Herein, we developed a new amphiphilic modified hydroxyethyl starch (HES) based pH-sensitive nanocarrier of antitumor drug delivery. HES was...

Surfactant-free Pickering emulsion has been considered as a promising carrier to load oil-soluble active agents for preparation of active edible films to keep food quality and safety. Herein, dialdehyde cellulose nanocrystals (DCNC) were obtained by the periodate oxidation. Then, the DCNC-stabilized Pickering emulsion loaded with dihydromyricetin w...

Solid edible fat obtained by hydrogenation of vegetable oils is widely used in food market. However, the produced partially hydrogenated oils usually contain trans-fatty acids, which are harmful to health. It is meaningful to develop effective ways to directly structure edible liquid oil into gel-like state with good stability. Herein, we presented...

The present work focuses on in situ studying the transformation process of collagen molecules and fibrils in pigskin along with hydrothermal shrinkage. The results indicate that the triple helix of collagen molecules is firstly destabilized by hydrothermal treatment and more water molecules enter the space of three polypeptide chains of collagen mo...

Self-healing hydrogel and conductive hydrogel have attracted extensive attention in tissue engineering. Self-healing hydrogel can restore its original structure and functionality after damage. Conductive hydrogel is beneficial to differentiation and proliferation of electrical stimuli responsive cells. It is significant to integrate self-healing ab...

Many strategies have been employed to artificially reconstruct adipose tissue in tissue engineering. The functionalization and survival of reconstructed adipose tissue depend on sufficient angiogenesis. Notably, agglomeration growth of adipose-derived stem cells (ASCs) is beneficial to promoting angiogenesis. Herein, we present a porous collagen-ba...

It is of great significance to use safe raw materials, and spontaneously form covalent crosslinking during the fabrication process to obtain active edible films with excellent performance. Herein, l-cysteine as the source of thiol group was firstly conjugated onto gelatin backbone via 1-ethyl-3-(30-dimethylaminopropyl) carbodiimide (EDC) and N-hydr...

The guided bone regeneration (GBR) has been regarded as the valuable way to effectively induce bone remodeling. The key factor of GBR is to place a barrier membrane between the soft tissue and bone defect, preventing the untimely intrusion of fibroblasts and permitting the prior settlement of internal osteoblasts. Notably, the heterogeneous double-...

The bioactive peptides drugs are mostly delivered by parenteral administration, which brings great pain and risks to patients. Oral administration is an acceptable alternative form. However, the peptides drugs are extremely sensitive to strong acid environment in stomach after oral administration. They would be degraded by pepsin and trypsin in gas...

Silver nanoparticles (AgNPs) are effective antimicrobial reagent, especially for the treatment of multidrug-resistant microorganisms. However, it is difficult to remove the residual harmful reducing agents in AgNPs synthesized by the traditional chemical reduction method. In addition, AgNPs exhibit cytotoxicity when exposed directly to cells for bi...

The self-healing hydrogels are extremely attractive in biological and biomedical fields. Imine bond obtained by Schiff’s base reaction is a commonly used dynamic covalent bond to fabricate self-healing hydrogel. Gelatin is a commonly used natural macromolecule in biomedical field with excellent biocompatibility, biodegradability and non-immunogenic...

The porous microstructure of scaffolds is an essential consideration for tissue engineering, which plays an important role for cell adhesion, migration and proliferation. It is crucial to choose optimum pore sizes of scaffolds for the treatment of various damaged tissues. Therefore, the proper porosity is the significant factor that should be consi...

Collagen is the favorable candidate in the field of biomaterials as wound dressings. However, it cannot be ignored that the application of collagen is limited to its poor physicochemical and perishable properties. It is significant to endow collagen with antibacterial activity and simultaneously improve the physicochemical properties. Here, we pres...

It is significant to develop new approaches to incorporate naturally active agents into gelatin-based edible films for effective antioxidant and long-term antibacterial activities. Here the naturally active compound rosmarinic acid (RosA) was firstly conjugated onto gelatin backbone via EDC/NHS chemistry. Then the conjugates were plasticized by gly...

The utilization of petroleum-derived synthetic materials causes severe ecological problems, such as environmental pollution and soil degradation. Hence, using naturally derived and renewable materials to fabricate novel biodegradable films for safe and effective food packaging has been a subject of interest over the years. Here, the novel antimicro...

The oxidized κ-carrageenans with different oxidation levels were prepared through the hydrogen peroxide and copper sulfate redox system. The oxidation level of oxidized κ-carrageenan was successfully controlled by adjusting the dosage of hydrogen peroxide. The results showed that the microtopography of oxidized κ-carrageenan changed from rough gran...

Genipin is an ideal crosslinking agent in biomedical applications, which can undergo ring-opening polymerization in alkaline condition. The polygenipin can create short-range and long-range intermolecular crosslinking between protein chains. In this paper, the polygenipin with different degree of polymerization was successfully prepared and used to...