Lena Schmidt

Newcastle University | NCL

Background: Schizophrenia is a serious chronic mental illness affecting an estimated 21 million people worldwide and there is increasing evidence linking inflammation in the brain to the pathophysiology of schizophrenia. Antipsychotic drugs are the conventional treatment for people with schizophrenia but are not always fully effective. Acetylsalic...

Background: The COVID-19 pandemic has caused morbidity and mortality, as well as, widespread disruption to people’s lives and livelihoods around the world. Given the health and economic threats posed by the pandemic to the global community, there are concerns that rates of suicide and suicidal behaviour may rise during and in its aftermath. Our liv...

Background: Glioblastoma is an aggressive form of brain cancer. Approximately five in 100 people with glioblastoma survive for five years past diagnosis. Glioblastomas that have a particular modification to their DNA (called methylation) in a particular region (the O6-methylguanine-DNA methyltransferase (MGMT) promoter) respond better to treatment...

Background: The reliable and usable (semi)automation of data extraction can support the field of systematic review by reducing the workload required to gather information about the conduct and results of the included studies. This living systematic review examines published approaches for data extraction from reports of clinical studies. Methods: W...

Living reviews are an increasingly popular research paradigm. The purpose of a 'living' approach is to allow rapid collation, appraisal and synthesis of evolving evidence on an important research topic, enabling timely influence on patient care and public health policy. However, living reviews are time- and resource-intensive. The accumulation of n...

The amount of grey literature and ‘softer’ intelligence from social media or websites is vast. Given the long lead‐times of producing high‐quality peer‐reviewed health information, this is causing a demand for new ways to provide prompt input for secondary research. To our knowledge, this is the first review of automated data extraction methods or...

Background: The reliable and usable (semi)automation of data extraction can support the field of systematic review by reducing the workload required to gather information about the conduct and results of the included studies. This living systematic review examines published approaches for data extraction from reports of clinical studies. Methods: W...

The amount of grey literature and "softer" intelligence from social media or websites is vast. Given the long lead-times of producing high-quality peer-reviewed health information this is causing a demand for new ways to provide prompt input for secondary research. To our knowledge this is the first review of automated data extraction methods or to...

Molecular biology-focused knowledge graphs (KGs) are directed graphs that integrate information from heterogeneous sources of biological and biomedical data, such as ontologies and public databases. They provide a holistic view of biology, chemistry, and disease, allowing users to draw non-obvious connections between concepts through shared associa...

The COVID-19 pandemic has harmed many people's mental health globally. Whilst the evidence generated thus far from high-income countries regarding the pandemic's impact on suicide rates is generally reassuring, we know little about its influence on this outcome in lower- and middle-income countries or among marginalised and disadvantaged people. Th...

Background Evidence on the impact of the pandemic on healthcare presentations for self-harm has accumulated rapidly. However, existing reviews do not include studies published beyond 2020. Aims To systematically review evidence on presentations to health services following self-harm during the COVID-19 pandemic. Method A comprehensive search of d...

Background Wikipedia is among the most popular sites on the internet, and around a fifth of all healthcare searches online directs to a Wikipedia page. In recent years steps have been taken to enhance the quality of their healthcare pages, such as the creation of the WikiProject Medicine initiative. In 2014 a partnership was formalised between Wiki...

There is widespread concern over the potential impact of the COVID-19 pandemic on suicide and self-harm globally, particularly in low- and middle-income countries (LMIC) where the burden of these behaviours is greatest. We synthesised the evidence from the published literature on the impact of the pandemic on suicide and self-harm in LMIC. This rev...

Objective: The COVID-19 pandemic has had a complex impact on risks of suicide and non-fatal self-harm worldwide with some evidence of increased risk in specific populations including women, young people, and people from ethnic minority backgrounds. This review aims to systematically address whether SARS-CoV-2 infection and/or COVID-19 disease conf...

Background: Complete deletion of both the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q), known as 1p/19q codeletion, is a mutation that can occur in gliomas. It occurs in a type of glioma known as oligodendroglioma and its higher grade counterpart known as anaplastic oligodendroglioma. Detection of 1p/19q codeletion in gli...

Background Evidence on the impacts of the pandemic on healthcare presentations for self-harm has accumulated rapidly. However, existing reviews do not include studies published beyond 2020. Aims To systematically review evidence on health services utilisation for self-harm during the COVID-19 pandemic. Methods A comprehensive search of multiple d...

Codeletion of chromosomal arms 1p and 19q, in conjunction with a mutation in the isocitrate dehydrogenase 1 or 2 gene, is the molecular diagnostic criterion for oligodendroglioma, IDH-mutant and 1p/19q-codeleted. 1p/19q codeletion is a diagnostic marker and allows prognostication and prediction of the best drug response within IDH-mutant tumours. W...

Background : The COVID-19 pandemic has had an impact on the mental health of healthcare and social care workers, and its potential effect on suicidal thoughts and behaviour is of particular concern. Methods : This systematic review identified and appraised the published literature that has reported on the impact of COVID-19 on suicidal thoughts an...

There is widespread concern over the potential impact of the COVID-19 pandemic on suicide and self-harm globally, particularly in low- and middle-income countries (LMIC) where the burden of these behaviours is greatest. We synthesised the evidence from the published literature on the impact of the pandemic on suicide and self-harm in LMIC. This rev...

Background: The COVID-19 pandemic has caused considerable morbidity, mortality and disruption to people’s lives around the world. There are concerns that rates of suicide and suicidal behaviour may rise during and in its aftermath. Our living systematic review synthesises findings from emerging literature on incidence and prevalence of suicidal beh...

BACKGROUND The DNA repair protein O6 methylguanine-DNA methyltransferase (MGMT) causes resistance of tumour cells to alkylating agents. It is a predictive biomarker in high grade gliomas treated with temozolomide, however there is no consensus on which test method, methylation sites, and cut-off values to use. METHODS We performed a Cochrane Revie...

Background: Given the worldwide spread of the 2019 Novel Coronavirus (COVID-19), there is an urgent need to identify risk and protective factors and expose areas of insufficient understanding. Emerging tools, such as the Rapid Evidence Map (rEM), are being developed to systematically characterize large collections of scientific literature. We sough...

Background: The COVID-19 pandemic has caused widespread morbidity and mortality as well as disruption to people’s lives and livelihoods around the world; this has occurred as a result of both infection with the virus itself and the health protection measures taken to curb its spread. There are concerns that rates of suicide, suicidal behaviours and...

Background: Researchers in evidence-based medicine cannot keep up with the amounts of both old and newly published primary research articles. Support for the early stages of the systematic review process – searching and screening studies for eligibility – is necessary because it is currently impossible to search for relevant research with precision...

BACKGROUND: Researchers in evidence-based medicine cannot keep up with the amounts of both old and newly published primary research articles. Support for the early stages of the systematic review process – searching and screening studies for eligibility – is necessary because it is currently impossible to search for relevant research with precision...

Background: Researchers in evidence-based medicine cannot keep up with the amounts of both old and newly published primary research articles. Conducting and updating of systematic reviews is time-consuming. In practice, data extraction is one of the most complex tasks in this process. Exponential improvements in computational processing speed and d...

Objectives To investigate the effects of adding high-grade quantitative evidence of outcomes of treatments into relevant Wikipedia pages on further information-seeking behaviour by the use of routinely collected data. Setting Wikipedia, Cochrane summary pages and the Cochrane Library. Design Randomised trial. Participants Wikipedia pages which w...

This research on data extraction methods applies recent advances in natural language processing to evidence synthesis based on medical texts. Texts of interest include abstracts of clinical trials in English and in multilingual contexts. The main focus is on information characterized via the Population, Intervention, Comparator, and Outcome (PICO)...

This research on data extraction methods applies recent advances in natural language processing to evidence synthesis based on medical texts. Texts of interest include abstracts of clinical trials in English and in multilingual contexts. The main focus is on information characterized via the Population, Intervention, Comparator, and Outcome (PICO)...

Much effort is made to ensure Cochrane reviews are based on reliably extracted data. There is a commitment to wide access to these data—for novel processing and/or reuse—but delivering this access is problematic. To describe a proof-of-concept programme to extract, curate and structure data from Cochrane reviews. One student of Applied Sciences (16...

Objective To assess the effects of using health social media on different days of the working week on web activity. Design Individually randomised controlled parallel group superiority trial. Setting Twitter and Weibo. Participants 194 Cochrane Schizophrenia Group full reviews with an abstract and plain language summary web page. There were no h...

It is an app to populate "Outcomes" section of "Characteristics of included studies" table in any ReviewManager file. After the reviewer entered all their data in the 'Results' section, they can use this app to automatically populate each study's characteristics table with its used outcomes. This can be used to either save time and avoid copy/pase...

Background: Until June 2018, the Cochrane Schizophrenia Group (CSzG) produced and maintained 226 systematic reviews (SR). Their SR contain qualitative and quantitative data of more than 2800 clinical trials. These data are usable only in the context of a SR and with access to the Cochrane Library. In the public health sector, open access and sharin...

Objectives Qualitative and quantitative data relevant to randomised controlled trials (RCT), manually extracted and analysed within Cochrane reviews, are available to those who have access to the Cochrane Library. If, however, one wished to re-use these data, all information has to be extracted from that review before that process can start. There...

Wikipedia, the free-content online encyclopaedia, contains many heavily accessed pages relating to healthcare. Cochrane systematic reviews contain much high-grade evidence but dissemination into Wikipedia has been slow. New skills are needed to both translate and relocate data from Cochrane reviews to implant into Wikipedia pages. This letter intro...

Introduction Micro-blogs such as Twitter, Weibo and Wechat are increasingly used to disseminate health care evidence. Having investigated the absolute effects of disseminating information on Cochrane reviews in this way it remains unclear if one day has advantage over another. Methods In a prospective, parallel, open randomised controlled trial,...

In Deutschland leben Schätzungen zufolge rund 1,6 Millionen Menschen mit Demenz (MmD). Noch immer ohne medikamentösen Durchbruch in der Therapie werden jährlich rund 40.000 neue Fälle prognostiziert. Überlegung und Ziel dieses Projektes war es, im Rahmen der Biografie- und Erinnerungsarbeit den „Tiptoi“-Stift von Ravensburger einzusetzen um interak...