Lauryn Winter

University of Texas Health Science Center at San Antonio | UT HSC · Department of Pediatrics

Parenteral Nutrition (PN) Associated Liver Disease (PNALD) affects up to 60% of neonates; however, techniques for diagnosing and monitoring disease progression remain limited. The neonatal baboon model may provide a unique opportunity to identify serologic markers associated with this disease. The purpose of this study was to investigate if Hyaluro...

Bronchopulmonary dysplasia (BPD) is a devastating lung condition that develops in premature newborns exposed to prolonged mechanical ventilation and supplemental oxygen. Significant morbidity and mortality are associated with this costly disease and effective therapies are limited. Mesenchymal stem/stromal cells (MSCs) are multipotent cells that ca...

Background Parenteral amino acid (AA) nutrition administration after premature birth is necessary to ensure adequate growth and neurodevelopment. However, optimizing safety and efficacy remains a major challenge. This study investigated the effects of intravenous AA administration on plasma AA profiles in premature baboons and infants. Methods Pre...

Premature baboons exhibit peripheral insulin resistance and impaired insulin signaling. 5’ AMP-activated protein kinase (AMPK) activation improves insulin sensitivity by enhancing glucose uptake (via increased glucose transporter type 4 [GLUT4] translocation and activation of the extracellular signal-regulated kinase [ERK]/ atypical protein kinase...

Western blot membranes used for analysis. Raw images of western blot membranes used in analysis are shown. Bands used for figures are also indicated. (PDF)

Effects of 90 Minutes of AICAR stimulation in premature baboons. Western blot membranes demonstrating the effects of 90 minutes of AICAR infusion on skeletal muscle protein content of phosphorylated ACC, AMPK, and AKT are shown. B: baseline insulin levels (or clamp time +0 minutes), I: insulin-stimulated (or clamp time +120 minutes). A representati...

Background: Premature infants develop transient hyperglycemia and insulin resistance. Hyperglycemia is not treated by intensivists to avoid caloric restriction and promote growth. Objective: To determine the effects of transient hyperglycemia on endocrine pancreas, skeletal muscle and liver at early stages of development in preterm baboons. Methods...

Introduction Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating neurologic condition with high mortality rates and long-term complications for surviving infants. Mesenchymal stem/stromal cells (MSCs) have emerged as novel therapeutic agents with promising results in experimental studies of HIE. The purpose of this study is to (a) metho...

SYRCLE 2014 protocol format. (DOCX)

SYRCLE risk of bias assessment for included studies. (DOCX)

Bubble plot of sensorimotor outcome variables with fitted meta-regression line of standardized mean difference among. (a) animal, (b) strain, (c) gender, (d) age at HIE induction, (e) MSC source, (f) MSC origin, (g) MSC dose, (h) HIE model, (i) route of administration, (j) timing of administration, (k) anesthetic agents, (l) MSC expansion media. (T...

Literature search terms (i.e. those used in PubMed). (DOCX)

Detailed summary of information extracted from included studies. (DOCX)

Neurobehavioral assessments used in included studies. (DOCX)

MSC criteria reported by included studies. (DOCX)

List of included studies. (DOCX)

Bubble plot of cognitive outcome variables with fitted meta-regression line of standardized mean difference among. (a) animal, (b) strain, (c) age at HIE induction, (d) MSC source, (e) MSC origin, (f) MSC dose, (g) HIE model, (h) route of administration, (i) timing of administration, (j) anesthetic agents, (k) MSC expansion media. (PNG)

Background: Premature birth occurs when nephrogenesis is incomplete and has been linked to increased renal pathologies in the adult. Metabolic factors complicating preterm birth may have additional consequences for kidney development. Here, we evaluated the effects of prematurity and hyperglycemia on nephrogenesis in premature baboons when compare...

OBJECTIVES/SPECIFIC AIMS: To compare functional differences in WJ-MSCs-derived from term Versus preterm infants. METHODS/STUDY POPULATION: WJ-MSCs were enzymatically digested from umbilical cord tissue from Term (gestational age ≥37 wk, n=4) and Preterm (gestational age ≤32 wk, n=5) neonates. Cells were characterized by (1) surface antigen markers...

Table S1. Statistical models and results for the tests of the effect of Spiroplasma MSRO infection on four fly or wasp survival/mortality measures.

Data S1. Commands and rationale for statistical analyses performed in this study.

Insect microbe associations are diverse, widespread, and influential. Among the fitness effects of microbes on their hosts, defense against natural enemies is increasingly recognized as ubiquitous, particularly among those associations involving heritable, yet facultative, bacteria. Protective mutualisms generate complex ecological and coevolutiona...

Maternally transmitted endosymbionts of insects are ubiquitous in nature and play diverse roles in the ecology and evolution of their hosts. To persist in host lineages, many symbionts manipulate host reproduction to their advantage (e.g. cytoplasmic incompatibility and male-killing), or confer fitness benefits to their hosts (e.g. metabolic provis...

Maternally-transmitted associations between endosymbiotic bacteria and insects are pervasive in nature, and vary from commensalism to mutualism to parasitism. The association between the fruit fly Drosophila melanogaster and the maternally-inherited bacterium Spiroplasma involves reproductive parasitism and an apparent defensive mutualism. When att...