Laura Andrade Junqueira

Federal University of Juiz de Fora · Núcleo de Pesquisa e Inovação em Ciências da Saúde

Three-dimensional (3D) printing is quickly being adopted in pharmaceutics due to the many advantages it offers, including treatment, adaptability, the reduction in waste and the accelerated development of new formulations. In this study, micro-extrusion printing was implemented for the production of modified-release hydrocortisone (HCT) mini-tablet...

Three-dimensional printing technologies can be implemented for the fabrication of personalized vaginal rings (VRs) as an alternative approach to traditional manufacturing. Although several studies have demonstrated the potential of additive manufacturing, there is a lack of knowledge concerning the opinions of patients and clinicians. This study ai...

Objective develop a hydrogel containing tea tree oil (TTO) encapsulated in solid lipid nanoparticles (SLNs) to treat oropharyngeal candidiasis. Methods initially, the TTO chemical composition was evaluated. Next, SLNs containing TTO (TTO-SLNs) were produced and characterized. The TTO-SLNs were incorporated into a hydrogel, and the antifungal activ...

3D printing technologies have gained significant attention for the development of personalized pharmaceutical dosage forms. Here we present the coupling of Fused Deposition Modelling (FDM) and jet dispensing for the printing of polyvinyl alcohol (PVA) tablets followed by dispensing of rosuvastatin calcium (RSV) – polymer inks for customization of t...

RESUMO A manufatura aditiva, mais popularmente conhecida como impressão tridimensional, baseia-se no desenvolvimento de um objeto com a ajuda de um software de desenho assistido por computador seguido de sua impressão por meio da deposição de uma matéria-prima, camada por camada, para a construção do produto desejado. Existem vários tipos de técnic...

In the current study, we have coupled Fused Deposition Modelling (FDM) for the fabrication of plain polyvinyl alcohol (PVA) tablets followed by dispensing of minoxidil ethanolic solutions using inkjet printing. The use of a drop-on-solid printing approach facilitates an accurate and reproducible process while it controls the deposition of the drug...

Objective Develop and assess a transdermal emulsion loaded with nanostructured lipid carriers for vitamin D3 supplementation. Methods Vitamin D3 loaded nanostructured lipid carriers, produced via high shear homogenization and ultrasonication, were assessed for their particle size, distribution, morphology, zeta potential, entrapment efficiency, an...

Background: Psoriatic arthritis is the most frequent and impactful comorbidity among psoriatic patients and appears in most cases after skin disease. Dermatologists play a key role in its early diagnosis and treatment. Objective: To determine the prevalence of psoriatic arthritis and associated variables among patients with plaque psoriasis seen...

Citral ((2E)-3,7-dimethylocta-2,6-dienal), a bioactive component of lemongrass, inhibits oxidant activity, nuclear factor kappa B (NF-κB) activation, and cyclooxygenase-2 (COX-2) expression, even as it activates peroxisome proliferator-activated receptor (PPAR)-α and γ. Additionally, citral produces long-lasting inhibition of transient receptor pot...

Nocturia is a condition that affects the lower urinary tract and has a multifactorial etiology. It impacts negatively the patient quality of sleep and life. Therapy with desmopressin is effective in this condition. However, the routes of administration commonly practiced, oral and intranasal, have low bioavailability. Thus, the transdermal route is...

The application of the three dimensional printing (3DP) in the pharmaceutical industry can lead to a paradigm shift in this area, enabling the development of personalized medicines, as well as an increase in the medicines complexity. In pharmaceutics, the fused deposition modeling (FDM) is the most commonly used 3DP technology, in which the drug ca...

Background: Transdermal delivery is an alternative route for the administration of drugs. However, it requires the development of vehicles that allow the drugs to cross the layers of the skin and reach the systemic circulation. Objective: In this study, a new transdermal vehicle was evaluated using progesterone, estradiol, estradiol + estriol (B...

The objective of this study was to evaluate the stability of 10 commonly used active pharmaceutical ingredients compounded in oral suspensions using an internationally used suspending vehicle (SyrSpend SF PH4): alprazolam 1.0 mg/mL, atropine sulfate 0.1 mg/mL, glutamine 250.0 mg/mL, levofloxacin 50.0 mg/mL, metoprolol tartrate 10.0 mg/mL, nitrofura...