Kübra Tombultürk

Istinye Universitesi

Diabetes is an important public health problem, and it is well known that healing processes are impaired in diabetic wounds, one of its complications. Keratins are structural proteins found in skin cells and play a vital role in wound healing and skin integrity. While there is increasing interest in the anti-inflammatory properties of metformin, a...

The wound healing process, which is a pathophysiological process that includes various phases, is interrupted in diabetes due to hyperglycemia, and since deterioration occurs in these phases, a normal healing process is not observed. The aim of the current study is to investigate the proliferative and antiapoptotic effects of metformin on wound hea...

Background Diabetic chronic wound, which is one of the diabetic complications caused by hyperglycemia, characterized by prolonged inflammation has become one of the most serious challenges in the clinic. Hyperglycemia during diabetes not only causes prolonged inflammation and delayed wound healing but also modulates the activation of nuclear factor...

Introduction: In many types of itch, the interaction between immune system cells, keratinocytes, and sensory nerves involved in the transmission of itch is quite complex. Especially for patients with chronic itching, current treatments are insufficient, and their quality of life deteriorates significantly. Objective: In this study, we aimed to i...

Chronic wounds caused by underlying physiological causes such as diabetic wounds, pressure ulcers, venous leg ulcers and infected wounds affect a significant portion of the population. In order to treat chronic wounds, a strong debridement, removal of necrotic tissue, elimination of infection and stimulation of granulation tissue are required. Magg...

Aims Lucilia sericata larvae have been successfully used on healing of wounds in the diabetics. However, the involvement of the extraction/secretion (ES) products of larvae in the treatment of diabetic wounds is still unknown. Activator protein-1 (AP-1) transcription, composed of c-jun and c-Fos proteins, has been shown to be the principal regulato...

Background: A notable proportion of idiopathic male infertility cases is accompanied by oligozoospermia; and yet, the molecular mechanisms of fertilization problem underlying this defect are still unclear. Epithelial cadherin has been involved in several calcium-dependent cell-to-cell adhesion events; however, its participation in gamete interactio...

The use of Lucilia sericata larvae on the healing of wounds in diabetics has been reported. However, the role of the excretion/secretion (ES) products of the larvae in treatment of diabetic wounds remains unknown. This study investigated whether application of the ES products of L. sericata on the wound surface could improve the impaired wound heal...

Background: A notable proportion of idiopathic male infertility cases is accompanied by oligozoospermia; and yet, the molecular mechanisms of fertilization problem underlying this defect are still unclear. Epithelial cadherin has been involved in several calcium-dependent cell-to-cell adhesion events; however, its participation in gamete interacti...

Lucilia sericata larvae have been successfully used as medical maggots in the healing process of wounds nowadays and shown to efficiently debride wounds is reported.But the molecular mechanisms underlying excretion/secretion(ES) products are not yet completely unknown.These analysis was investigated to observe the proteome content of L.sericata sec...

INTRODUCTION&OBJECTIVES: Late or inadequate wound healing is are serious clinical problem for patients with diabetes nowadays. The NFkB gene is activated during the healing process. Which in turn may play a detrimental role on wound tissue remodelling and regeneration. NF-kB is also known to stimulate the production of collagen. During the wound he...

The impaired wound healing in diabetes mellitus is a major clinical problem. The use of Lucilia sericata larvae on the healing of wounds in diabetics is reported. However, the role of the excretion/secretion(ES) products of the larvae in treatment of diabetic wounds remains unknown. This study investigated whether application on the wound surface o...

Morbid obesity(MO) is associated with an increase in circulating levels of systemic acute phase proteins such as C-reactive protein (CRP).Toll-like reseptor is possible candidate for inflamatory responses which is mainly mediated by NFKB. The aim of this study was to investigate the relationship between NFKB1 and TLR-2 polymorphisms and the risk of...

MiRNAs and NFKB1 are well-known immune response and inflammation regulators. MiRNA gene polymorphisms may affect miRNA biogenesis and function and, may thus, lead to changes in the expression of hundreds of genes such as NFKB1. The aim of this study was to investigate the association of Behcet's disease (BD) with NFKB1 rs28362491, pre-miRNA-146a rs...