Khalid Benkhadra

Mayo Foundation for Medical Education and Research | MMS

Background This systematic review summarizes the benefits of treating blood pressure (BP) in individuals 65 years and older. Methods We included randomized trials that evaluated BP-lowering medications or BP targets in individuals 65 years and older. Trials were selected and appraised by pairs of independent reviewers. Results We included 19 tria...

Background Osteoporosis and osteopenia are associated with increased fracture incidence in postmenopausal women. We aimed to determine the comparative effectiveness of various available pharmacological therapies. Methods We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ISI Web of Science, and Scopus for randomized contr...

Background: Real time continuous glucose monitoring (RTCGM) may help in the management of individuals with type 1 diabetes mellitus (T1DM); however, the evidence supporting its use is unclear. The available meta-analyses on this topic use aggregate data which weaken inference. Objective: Individual patient data were obtained from randomized tria...

Background The healthcare needs of physician are not well studied. Methods We surveyed physicians attending a large primary care conference about their access and perceived barriers to receiving healthcare services. ResultsResponse rate was 46 % (270/592). The majority were trained in family medicine. The age category of above 60 years was the most...

Introduction: Various glucocorticoid regimens have been used in the treatment of patients with adrenal insufficiency, yet the differences between such regimens on health outcomes are unclear. Objective: We performed a systematic review and meta-analysis to compare the effect of various glucocorticoid regimens on quality of life, bone density, in...

The relative efficacy of continuous subcutaneous insulin infusion and multiple daily injections in individuals with type 1 diabetes is unclear. We sought to synthesize the existing evidence about the effect of continuous subcutaneous insulin infusion on glycosylated hemoglobin, hypoglycemic events, and time spent in hypoglycemia compared to multipl...

Purpose: To systematically appraise and summarize the available evidence about the diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy (USFNA) for thyroid malignancy, and to explore the integration of these estimates with the probability of thyroid malignancy before USFNA. Methods: A comprehensive search of multiple databases...

Objective: We conducted a systematic review and meta-analysis to synthesize the evidence about predictors that may affect biochemical remission and recurrence after transsphenoidal surgery (TSS), radiosurgery (RS), and radiotherapy (RT) in Cushing disease. Methods: We searched multiple databases through December 2014 including original controlle...

Conclusion: Most of the current literature focuses on the immune active phases of chronic HBV infection; decision-making in other commonly encountered and challenging clinical settings depends on indirect evidence. (Hepatology 2015).

Background: Menopausal hormone therapy is widely used to alleviate climacteric symptoms but may increase the risk of venous and arterial vascular events. Objective: The objective was to synthesize the evidence about the risk of vascular events in postmenopausal women who use oral estrogen therapy (ET) and transdermal ET. Methods: We searched b...

Objectives: The objective was to assess the effect of menopausal hormonal therapy (MHT) on all-cause and cause-specific mortality. Methods: We conducted a comprehensive search of several databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews, and Scopus) from inception until August 2013. We...

OBJECTIVES: The objective was to assess the effect of menopausal hormonal therapy (MHT) on all-cause and cause-specific mortality. METHODS: We conducted a comprehensive search of several databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews, and Scopus) from inception until August 2013. We inc...

The aim of this systematic review and meta-analysis is to study the utility of the commonly used bone turnover markers in evaluating disease activity in patients with Paget's disease of bone before and after treatment with bisphosphonates. We found good correlation between the bone turnover marker concentrations and disease activity assessed by bon...

Purpose: The existing guidance on bladder cancer surveillance following radical cystectomy is limited and variable. Additionally, the effect of surveillance on mortality is debatable. Herein, we perform a systematic review to evaluate the characteristics of alternative oncologic surveillance protocols and determine the association of detection of...

Management of intervertebral disc (IVD) degenerative disease is challenging, as it is accompanied by irreversible loss of IVD cells. Stem cell transplantation to the disc has shown promise in decelerating or arresting the degenerative process. Multiple pre-clinical animal trials have been conducted, but with conflicting outcomes. To assess the effe...

Background: Physicians may face unique challenges in accessing health care and managing their own health. Aims: To evaluate physicians' perceptions of their health care needs and desired services. Methods: A written survey, distributed and collected anonymously among attendees at a large primary care continuing medical education conference. R...

This editorial refers to ‘ Percutaneous closure of patent foramen ovale in patients with crypotogenic embolism: a network meta-analysis’ by S. Stortecky et al. , on page doi:10.1093/eurheartj/ehu292 Over the last 20 years, the number of published meta-analyses has exploded and, therefore, clinicians have become more familiar with this study desig...

Identifying patients with increased risk of suicidal behaviors is a constant challenge and concern for clinicians caring for patients with psychiatric conditions. We conducted a systematic review to assess the association between suicidal behaviors and sleep disturbances in psychiatric patients. A systematic literature search of Ovid Medline In-Pro...