Joseph Kamtchum TatueneWolfson Centre for Prevention of Stroke and Dementia - University of Oxford
Joseph Kamtchum Tatuene
MD MAS PhD FEBN
About
104
Publications
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Introduction
I am a self-motivated, hardworking Neurologist and Stroke Researcher with expertise in cerebrovascular ultrasound, biostatistics & epidemiology, clinical and laboratory research. My work focuses on (1) biomarkers of stroke and arterial diseases (2) contribution of genetic or environmental factors (including acute and chronic infections) to the risk of stroke.
Additional affiliations
January 2017 - January 2018
September 2015 - March 2018
September 2011 - September 2015
Publications
Publications (104)
Abstract #2799: ETHNIC DIFFERENCES IN STROKE INCIDENCE, SUBTYPES, MANAGEMENT, AND OUTCOME IN THE UNITED KINGDOM: A SYSTEMATIC REVIEW
Abstract #2778: ETHNIC DIFFERENCES IN PREVALENCE OF ATRIAL FIBRILLATION AND RELATED RISK FACTORS IN THE UNITED KINGDOM: A META-ANALYSIS
Background:
Whether carotid artery disease could improve stroke risk stratification tools in patients with atrial fibrillation (AF) remains uncertain.
Aim:
To investigate the risk of ischemic stroke associated with occlusive and non-occlusive carotid disease in patients with AF in the prospective population-based Cardiovascular Health Study.
Me...
Thrombosis is central to the pathogenesis of acute ischemic stroke, with higher thrombin generation being associated with increased stroke risk. The immune system may contribute to thrombin generation in stroke and thus may offer novel strategies for stroke prevention. This study addresses the research question regarding the relationship of thrombi...
Advances in genomic technology including the development of next-generation sequencing (NGS) have enabled the identification of thousands of variations at a time, allowing the discovery of novel genetic diseases. Given the volume of data generated by these investigations, attention is drawn towards reporting relevant clinical features by clinicians...
Background and Aims
Interleukin-6 (IL-6) has important roles in atherosclerosis pathophysiology. To determine if anti-IL-6 therapy could be an adjuvant stroke prevention strategy in patients with carotid atherosclerosis, we tested whether circulating IL-6 levels predict carotid plaque severity, vulnerability, and progression in the Cardiovascular H...
Background and Objectives: Thrombosis is central to the pathogenesis of acute ischemic stroke, with higher thrombin generation being associated with increased stroke risk. The immune system may contribute to thrombin generation in stroke, and thus may offer novel strategies for stroke prevention. This study addresses the research question regarding...
BACKGROUND:
IL-6 (interleukin-6) has important roles in atherosclerosis pathophysiology. To determine if anti-IL-6 therapy warrants evaluation as an adjuvant stroke prevention strategy in patients with carotid atherosclerosis, we tested whether circulating IL-6 levels predict carotid plaque severity, vulnerability, and progression in the prospectiv...
Check these #AHA #Stroke #InterSECT tips to outpace the reviewers and avoid unnecessary rejections.
We read with interest the findings of the ACST-2 trial. However, some of the observations made us wonder whether it was accurate to conclude that carotid artery stenting (CAS) and carotid endarterectomy (CEA) were comparable.
Background and purpose:
There are reports of decline in the rates of acute emergency presentations during coronavirus disease 2019 (COVID-19) pandemic including stroke. We performed a meta-analysis of the impact of COVID-19 pandemic on rates of stroke presentations and on rates of reperfusion therapy.
Methods:
Following the Meta-analysis Of Obse...
Atrial fibrillation (AF) is a major cause of adverse cardiovascular outcomes, and its prevalence is fast rising in Africa. The advent of direct oral anticoagulants (DOACs) has been a major revolution for the prevention of AF‐related stroke and systemic embolism given the significant advantage over vitamin K antagonists in terms of both efficacy, sa...
Check these #AHA #Stroke #InterSECT #tips to keep up with medical literature & boost your
#career!
Objective
The rate of infarct core progression in patients with acute ischemic stroke is variable and affects outcome of reperfusion therapy. We evaluated hypoperfusion index (HI) to estimate the initial rate of core progression in patients with medium-vessel-occlusion (MeVO) compared to large-vessel-occlusion (LVO) stroke and within a larger time...
Embolic stroke of unknown source (ESUS) represents one in five ischemic strokes. Ipsilateral non-stenotic carotid plaques are identified in 40% of all ESUS. In this narrative review, we summarize the evidence supporting the potential causal relationship between ESUS and non-stenotic carotid plaques; discuss the remaining challenges in establishing...
Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier (BBB) into the brain following ischemic stroke. Preventing HT is important as it worsens stroke outcome and increases mortality. Factors associated with increased risk o...
Introduction:
Mechanisms driving neurodegeneration in Parkinson's disease (PD) are unclear and neurovascular dysfunction may be a contributing factor. White matter hyperintensities (WMH) are commonly found on brain MRI in patients with PD. It is controversial if they are more prevalent or more severe in PD compared with controls. This systematic r...
Objective
To summarize data on atrial fibrillation (AF) detection rates and predictors across different rhythm monitoring strategies in patients with cryptogenic stroke (CS) or embolic stroke of undetermined source (ESUS).
Methods
MEDLINE, Embase, and Web of Science were searched to identify all published studies providing relevant data through Ju...
Introduction:
although the main manifestations of COVID-19 are respiratory, several neurological symptoms and complications have also been reported. The pandemic seems to have some epidemiological specificities in sub-Saharan Africa, and this may be reflected in the type and frequency of neurological symptoms. This study aimed to report neurologic...
Objective:
This review aimed to summarize the evidence on the risk of thromboembolism associated with carotid and aortic atherosclerosis in patients with AF, and the potential impact of their inclusion in current stroke risk stratification scores.**
Methods:
MEDLINE, Web of Science and EMBASE were systematically searched to identify all published...
Introduction
Bien que les principales manifestations de la COVID-19 soient respiratoires, de plus en plus de données de la littérature rapportent de multiples symptômes et complications neurologiques liées au SARS-CoV-2.
Objectifs
Le but de ce travail était de décrire le spectre des manifestations neurologiques de la COVID-19 dans un contexte sub-...
Background and Purpose: With advancing age, alterations occur to the immune system, including an increase in inflammation (inflammaging) and a reduced ability to respond to new immune challenges. The role of an aging immune system in patients with ischemic stroke remains unclear, although age is an important determinant of stroke risk and outcome....
Background and Purpose: Thrombus formation is central to pathophysiology of stroke in patients with atrial fibrillation. Whether factors in plasma contribute to thrombus generation in patients with atrial fibrillation remains unclear. In this study we sought to determine whether plasma contributes to thrombin generation in patients with atrial fibr...
Background and purpose: Detection of atrial fibrillation (AF) after acute ischemic stroke is pivotal for the timely initiation of anticoagulation to prevent recurrence. Besides heart rhythm monitoring, various blood biomarkers have been suggested as complimentary diagnostic tools for AF. We aimed to summarize data on the performance of cardiac natr...
Background: Advancing age is associated with changes to the immune system, which affect stroke outcome. We previously demonstrated an age-associated alteration in leukocyte gene expression in patients with ischemic stroke. The aim of this study is to validate these findings in an independent stroke cohort and assess the relationship to stroke outco...
To the Editor Cook and colleagues¹ should be congratulated for compiling studies on the accuracy of medical students’ or physicians’ electrocardiogram (ECG) interpretations. However, in reading their report, we identified several methodological issues that undermine the validity of their analyses and the suggested implications.
Background and purpose:
Detection of atrial fibrillation (AF) after acute ischaemic stroke is pivotal for the timely initiation of anticoagulation to prevent recurrence. Besides heart rhythm monitoring, various blood biomarkers have been suggested as complimentary diagnostic tools for AF. We aimed to summarise data on the performance of cardiac na...
Dear Editor,
We read with great interest the study published by Million and colleagues in the Journal.
Based on data from 1061 COVID-19 patients (94.7% symptomatic, 85.7% outpatients), the
authors concluded that early treatment of COVID-19 (before complications occur) with the
combination of hydroxychloroquine and azithromycin (HCQ+AZ) “is safe an...
WMP46: Frequency of High-Risk Features and Stroke Risk in Asymptomatic Carotid Atherosclerosis: Systematic Review and Meta-Analysis. -- FULL ARTICLE: https://jamanetwork.com/journals/jamaneurology/fullarticle/2769015 -- PMID: 32744595
Importance:
There is an ongoing debate regarding the management of asymptomatic carotid stenosis. Previous studies have reported imaging features of high-risk plaques that could help to optimize the risk-benefit ratio of revascularization. However, such studies have not provided an accurate estimate of the prevalence of high-risk plaques and the a...
OBJECTIVE:
To determine if pooled estimates of the prevalence of unexpected findings in patients with headache and normal neurologic examination support current expert opinion-based neuroimaging guidelines.
**METHODS:
We searched PubMed and EMBASE for studies reporting neuroimaging findings in patients with headache and normal neurologic examinati...
BACKGROUND AND OBJECTIVE:
In sub-Saharan Africa, data on prevalence, risk factors and pathobiology of carotid atherosclerosis are scarce. We aimed to investigate the relationship between biomarkers of endothelial dysfunction and carotid atherosclerosis.
**METHODS:
Carotid ultrasound was performed in 66 patients. Plasma concentration of ICAM-1, PAI...
WP177: Frequency of Carotid Plaque With High-Risk Features in Cryptogenic Stroke: Systematic Review and Meta-Analysis.
Related article: PMID 31752616
Background
In sub-Saharan Africa, there is a dearth of epidemiologic data on the burden of cerebral atherosclerosis. This is explained by the limited availability and the high cost of standard vascular imaging techniques. Neurovascular ultrasound is portable, cheaper and non-invasive and could, therefore, represent a reasonable alternative to fill...
Introduction: Immune system dysregulation occurs with age. This includes an increase in inflammation, and immunosenescence, the inability to efficiently respond to new immune challenges. These changes are evident in various diseases but have yet to be evaluated in a population with ischemic stroke. Age is an important factor in stroke, contributing...
Background: Atrial fibrillation (AF) is an important cause of stroke, for which anticoagulation provides substantial benefit. However, not all patients with AF will have a stroke. There remains uncertainty regarding factors that promote thromboembolism and stroke in patients with AF. In this study we examined differences in blood cell gene expressi...
Background:
The Queen Elizabeth Central Hospital (QECH) is preparing to set up the first stroke unit in Blantyre, Malawi. We conducted this audit to assess current stroke management practices and outcomes at QECH and identify priority areas for intervention.
Methods:
From April to June 2018, we prospectively enrolled patients with acute stroke a...
Biomarkers are objective indicators used to assess normal or pathological processes, evaluate responses to treatment and predict outcomes. Many blood biomarkers already guide decision-making in clinical practice. In stroke, the number of candidate biomarkers is constantly increasing. These biomarkers include proteins, ribonucleic acids, lipids or m...
Purpose of review:
Diagnosis of stroke and understanding the mechanism of stroke is critical to implement optimal treatment. RNA expressed in peripheral blood cells is emerging as a precision biomarker to aid in stroke diagnosis and prediction of stroke cause. In this review, we summarize available data regarding the role of RNA to predict stroke,...
Background and Purpose—
An ipsilateral mild carotid stenosis, defined as plaque with <50% luminal narrowing, is identified in nearly 40% of patients with embolic stroke of undetermined source and could represent an unrecognized source of atheroembolism. We aimed to summarize data about the frequency of mild carotid stenosis with high-risk features...
Introduction
In Sub-Saharan Africa, the rising rates of cerebrovascular and cardiovascular diseases (CBD/CVD) are intersecting with an ageing HIV-infected population. The widespread use of antiretroviral therapy (ART) may confer an additive risk and may not completely suppress the risk associated with HIV infection. High-quality prospective studies...
Onchocerciasis and lymphatic filariasis (LF) are human filarial diseases belonging to the group of neglected tropical diseases, leading to permanent and long-term disability in infected individuals in the endemic countries such as Africa and India. Microfilaricidal drugs such as ivermectin and albendazole have been used as the standard therapy in f...
Malawi is a country in Southern Africa
(figures 1 and 2) and gained its independence from the British Colony in 1964.
Currently 17.5 million people live in
Malawi, and about 85% reside in rural
areas and depend on farming for survival.1
Although one of the poorest countries in
the world (with a gross domestic product
of $338.48 per capita), it is b...
Objective
To study the relationship between endothelial dysfunction, HIV infection, and stroke in Malawians.
Methods
Using a cross-sectional design, we measured plasma levels of intercellular adhesion molecule-1 (ICAM-1), plasminogen activator inhibitor-1 (PAI-1), vascular endothelial growth factor (VEGF), and soluble thrombomodulin (sTM) in strok...
This poster is released following this publication http://nn.neurology.org/content/6/2/e531
This poster is released following this publication:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208040
Background
Studies in high-income settings have shown association between Cytomegalovirus (CMV) infection and adverse cardiovascular outcome, especially in HIV infection. We aimed to study the association between serum concentration of anti-CMV IgG and ischaemic stroke in HIV-infected Malawians.
Methods
Our sample was derived from a case-control s...
Introduction
Cryptococcal meningitis is a neglected disease and an AIDS-defining illness, responsible for 15% of all AIDS-related deaths globally. In 2014, the estimated number of incident cryptococcal meningitis cases was 223 100, with 73% of them occurring in Africa. Currently available data on the prevalence, incidence, aetiologies and mortality...
Introduction
Stroke is the second most common cause of death after ischaemic heart diseases and the third leading cause of disability worldwide. The contribution of cardiac complications to the mortality of patients with stroke is variable across studies, ranging from 12.5% to 22.7%. Many of these cardiac complications are preventable, and early re...
Introduction
Headache disorders (HD) are among the most frequent neurological disorders seen in neurology practice. Because secondary HD are rare, patients’ examination is most often unremarkable. However, the will to relieve patients’ anxiety and the fear of prosecutions lead to overuse of neuroimaging thus resulting in the discovery of incidental...
Cardiovascular disease (CVD) has become a major concern in low- and middle- income countries, which bear about 80% of the cardiovascular mortality worldwide. Curbing the burden of CVD implies the management and control of many cardiovascular risk factors that act synergistically to increase cardiovascular mortality. Such actions may require expensi...
Objective: To summarize prevalence data on the neurologic complications of sickle cell disease (SCD) in Africa.
Methods: We searched EMBASE, PubMed, and African Index Medicus to identify all relevant articles published from inception to May 31, 2016. Each study was reviewed for methodologic quality. A random-effects model was used to estimate the...
A 42-year-old woman presented with a 6-month history of diffuse headache of moderate intensity and gradual onset of generalized weakness, imbalance, apathy, memory decline, hypophonia, dysphagia, constipation and urinary incontinence. Clinical examination revealed several elements of a frontal lobe dysfunction including apathy with motor impersiste...
A 19-year-old man presented with a one-year history of headache, generalized body weakness, progressive memory loss and disorientation.
One month prior to admission, there was aggravation of the weakness of the right upper limb with new onset difficulty to masticate
food, speech impairment, apathy, and urinary incontinence. On clinical examination,...
To the Editor Raifman et al¹ use robust statistical tools to demonstrate an association between the legalization of same-sex marriage (SSM) in the United States and a decrease in adolescent suicide rates, the absolute reduction being 0.6 percentage points for all students and 4 percentage points in sexual minorities. Nevertheless, we are concerned...
Background:
Stroke knowledge and awareness in the general public is important to improve stroke prevention and ensure prompt response to disease onset. Addressing the dearth of data in Africa, this study aimed to determine the level of knowledge on stroke definition, symptoms, risk factors and complications in the general population living in Yaou...
Most studies on sensory extinction have focused on selected patients with subacute and chronic right hemisphere lesions. In studies conducted on acute stroke patients, risk factors and time course were not evaluated. Our aim was to determine the prevalence, risk factors, and time course of sensory extinction in the acute stroke setting. Consecutive...
Cysticercosis is the most common helminthic disease of the nervous system in humans. The clinical presentation of neurocysticercosis (NCC)
is nonspecific and can mimic a wide array of primary central nervous system (CNS) disorders, making its diagnosis a challenge especially in
endemic areas. The pathophysiology of episodic CNS manifestations of NC...
The Cardio-PadTM is a touchscreen tablet which enables to perform electrocardiograms (ECG) in remote underserved areas and transfer the test results via mobile phone connection to specialist physicians for interpretation and assistance in case management. As a telemedicine device, it is a potential solution to overcome the shortage of qualified hea...
Purpose of review
Wolbachia is a genus of Gram-negative intracellular bacteria that is naturally found in more than half of all arthropod species. These bacteria cannot only reduce the fitness and the reproductive capacities of arthropod vectors, but also increase their resistance to arthropod-borne viruses (arboviruses). This article reviews the e...
Introduction Sickle cell disease (SCD) is highly prevalent in Africa. Considered as a public health problem, it is associated with high morbidity and mortality. Neurological complications of SCD can cause significant disability with important socioeconomic and psychological impact on the patients and their families, and can even lead to death if no...
We read with great interest the recent article by Tsivgoulis et al1 demonstrating that endovascular thrombectomy (ET) improves the functional outcome of patients with emergent large-vessel occlusion (ELVO) independent of pretreatment with intravenous thrombolysis (IVT). As a consequence, ET could now be viewed as a treatment option on its own and s...
Aim:
The study aims to describe the epidemiology and the neural correlates of peripersonal visuospatial neglect (PVN) in patients admitted to the Geneva Stroke Unit for an acute stroke or a transient ischemic attack (TIA).
Methods:
Eligible subjects were tested for PVN using both the Ota's discriminative cancellation task and a line bisection ta...
Aim: The study aims to describe the epidemiology and the neural correlates of peripersonal visuospatial neglect (PVN) in patients admitted to the Geneva Stroke Unit for an acute stroke or a transient ischemic attack (TIA). Methods: Eligible subjects were tested for PVN using both the Ota's discriminative cancellation task and a line bisection task....
Background: Soil-transmitted helminthiases (STHs) are among the most prevalent afflictions of the developing world, with approximately 2 billion people infected worldwide. Heavily infected individuals suffer from severe morbidity that can result in death. These parasitic diseases also impair physical and mental growth in childhood, thwart education...
Background
Transient or permanent neurological symptoms occur in 17–40% of patients with aortic dissection. They can distract from or even mask the underlying life-threatening condition.
Case presentation
We present the case of a young Caucasian man who consulted for recurrent episodes of stereotyped right-sided sudden-onset severe headache. Upon...
Introduction
Des symptômes neurologiques transitoires ou permanents sont présents chez 17 – ; 40 % des patients ayant une dissection aortique, ce qui peut entraîner des errances diagnostiques.
Observation
Nous présentons le cas d’un caucasien de 44 ans ayant consulté pour des hémicrânies droites récurrentes et stéréotypées. L’examen clinique et l’...
Diving-related decompression illness is classified into 2 main categories: arterial gas embolism and decompression sickness. The latter is further divided into types 1 and 2, depending on the clinical presentation. MR imaging is currently the most accurate neuroimaging technique available for the detection of brain and spinal cord lesions in neurol...
OBJECTIVE
To provide complementary parasitological data on Loa loa and Mansonella perstans filariasis in the Centre Region of Cameroon.
METHODS
For each enrolled subject, a 50 μl calibrated thick blood film was performed using capillary blood obtained between 11 a.m. and 3 p.m. Giemsa stained slides where examined under optical microscope in order...
Questions
Question (1)
I have been unable to get useful results from the REGA HIV-1 subtyping tool for the past 48 hours (link below). Although my sequences are uploaded in the FASTA format (less than 10 sequences at a time), the software constantly returns an empty *.csv file. Has anyone had the same problem? If not, could somebody help me to find what is going wrong? Thank you beforehand!
