José Antonio Robles-Zurita

University of Malaga | UMA · Applied Economics (Statistics and Econometrics)

Background: Diagnostic blood tests have the potential to identify lung cancer in people at high risk. We assessed the cost-effectiveness of a lung cancer screening intervention, using the EarlyCDT®-Lung Test (ECLS) with subsequent X-ray and low-dose chest CT scans (LDCT) for patients with a positive test result, compared to both usual care and LDCT...

Background Diagnostic blood tests have the potential to identify lung cancer in people at high risk, which is important as detecting lung cancer at an early stage is associated with survival advantages. We conducted an economic evaluation to assess the cost-effectiveness of a lung cancer screening intervention, using the EarlyCDT-Lung Test with sub...

Even if public health interventions are successful at reducing the spread of COVID-19, there is no guarantee that they will bring net benefits to the society because of the dynamic nature of the pandemic, e.g., the risk of a second outbreak if those interventions are stopped too early, and the costs of a continued lockdown. In this analysis, a disc...

Given the advantages in transparency, reproducibility, adaptability and computational efficiency in R, there is a growing interest in converting existing spreadsheet-based models into an R script for model re-use and upskilling training among health economic modellers. The objective of this exercise was to convert the Scottish Cardiovascular Diseas...

Earlier detection of lung cancer is possible, but difficult and costly to achieve. Screening with Low Dose Computed Tomography (LDCT)scanning has been shown to reduce mortality by 20-25% over the past decade but uptake amongst those most likely to suffer the disease has been slow. Resource constraints and a high false positive rate have also limite...

Objective To assess whether a weight management intervention for pregnant women with obesity was effective in reducing body mass index (BMI) 12 months after giving birth. Methods Pragmatic, cluster randomised controlled trial (RCT) with embedded cost-effectiveness analysis. 598 women with a BMI of ≥30 kg/m² (between 12 and 20 weeks gestation) were...

Introduction The Short Course Oncology Treatment (SCOT) trial demonstrated non-inferiority, less toxicity and cost-effectiveness from a UK perspective of 3 versus 6 months of oxaliplatin-based chemotherapy for patients with colorectal cancer. This study assessed the cost-effectiveness of shorter treatment, and the budget impact of implementing tria...

Background The CULPRIT-SHOCK trial compared two treatment strategies for patients with acute myocardial infarction and multivessel coronary artery disease complicated by cardiogenic shock: (a) culprit vessel only percutaneous coronary intervention (CO-PCI), with additional staged revascularisation if indicated, and (b) immediate multivessel PCI (MV...

The EarlyCDT-Lung test is a high specificity blood-based autoantibody biomarker that could contribute to predicting lung cancer risk. Here we report on the results of a phase IV biomarker evaluation of whether using the EarlyCDT-Lung test and any subsequent CT scanning to identify those at high risk of lung cancer reduces the incidence of patients...

e19341 Background: The Short Course Oncology Treatment (SCOT) trial demonstrated that three months of adjuvant, doublet chemotherapy for patients with colorectal cancer was non-inferior and significantly less toxic than six months. To understand if and how these results were implemented, this study analysed prescribing practice before and after dis...

7076 Background: The international Short Course Oncology Treatment (SCOT) trial demonstrated non-inferiority and significantly less toxicity of 3 versus 6 months of adjuvant chemotherapy for patients with colorectal cancer (CRC). This study assesses the value of shorter treatment and the economic implications of implementing the findings from the p...

Background Oxaliplatin and fluoropyrimidine chemotherapy administered over 6 months is the standard adjuvant regimen for patients with high-risk stage II or III colorectal cancer. However, the regimen is associated with cumulative toxicity, characterised by chronic and often irreversible neuropathy. Objectives To assess the efficacy of 3-month ver...

Background: The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer. Methods: In total, 6088 patients with fully rese...

The alternation bias is the tendency of people to believe that random events alternate more often than statistical laws imply. This paper examines the theoretical effect of this psychological bias on preferences over repeated investments by using a model of the belief in the law of small numbers. An alternation bias agent (ABA) has a different perc...

We use data from the Spanish sample of the Programme for the International Assessment of Adult Competencies to analyze the effect of the LOGSE (Spanish acronym for General Law of the Education System) reform passed in 1990 on numeracy and literacy proficiency of the adult population. The LOGSE effect is identified by exploiting the variability of t...

Introduction: Emergency percutaneous coronary intervention (PCI) of the culprit lesion for patients with acute myocardial infarctions is an accepted practice. A majority of patients present with multivessel disease with additional relevant stenoses apart from the culprit lesion. In haemodynamically stable patients, there is increasing evidence fro...

We present data of a contingent valuation survey, testing the effect of evaluation mode on the monetary valuation of preventing road accidents. Half of the interviewees was asked to state their willingness to pay (WTP) to reduce the risk of having only 1 type of injury (separate evaluation, SE), and the other half of the sample was asked to state t...

Theoretical predictions entails that subjective beliefs of randomness affect the aggregation of medical outcomes of multiple-play medical treatments. Particularly, those who believe in more repetition of random events would tend to believe that multiple-play treatments are riskier medical interventions. As a consequence, the level of repetition bia...

We analyze data of a Spanish nationally-representative survey where subjects reported their willingness to pay (WTP) for road safety improvements, specifically they hypothetically paid for a reduction of the risk of a road fatality and several injuries. Respondents also reported their current income (CI) and permanent income (PI). The latter refers...

Grade retention practices are at the forefront of the educational debate. In this article, we measure the effect of grade retention on Spanish students’ achievement by using data from Programme for International Student Assessment (PISA). We find that grade retention has a negative impact on educational outcomes, but we confirm the importance of en...

Grade retention practices are at the forefront of the educational debate. In this article, we measure the effect of grade retention on Spanish students’ achievement by using data from Programme for International Student Assessment (PISA). We find that grade retention has a negative impact on educational outcomes, but we confirm the importance of en...

Grade retention practices are at the forefront of the educational debate. In this paper, we use PISA 2009 data for Spain to measure the effect of grade retention on students' achievement. One important problem when analyzing this question is that school outcomes and the propensity to repeat a grade are likely to be determined simultaneously. We add...

PISA 2006 results showed huge differences in educational attainment across Spanish regions. The aim of this paper is to analyze the factors explaining these differences. Our results indicate that differences in family characteristics of students from different regions are crucial in explaining them. However, we also find that differences in regiona...

Grade retention practices are to the forefront of the educational debate. In this paper we use PISA 2009 data for Spain to measure the e¤ect of grade retention on student's achievement. One important problem when analyzing this question is that school outcomes and the propensity to repeat a grade are likely to be simultaneously determined. We addre...