John Leach

Salford Royal NHS Foundation Trust · Neurosurgery

AIMS The aims of this study are to share our experience of a large series of multifocal/multicentric glioblastomas (mGBM) and analyse the clinical, histological/molecular and neuroimaging characteristics as well as the outcomes of the patients in order to inform and contribute to future patient care. METHOD We conducted a retrospective single cent...

Purpose: The purpose of this study was to validate the cauda scale (TCS) in an external population. TCS was proposed as a tool to be used to predict the likelihood of cauda equina compression. Methods: We analysed the presenting condition of consecutive patients attending the emergency department undergoing a magnetic resonance scan with a clinical...

Minimally invasive resection of brain metastases aims to maximize resection while minimizing brain trauma. Patients with one or more metastases resection following neuro-oncology multidisciplinary meeting discussion from Sep 2014 to Oct 2018 with pre- and post-operative MRI were included. All patients including posterior fossa metastases or multipl...

Objective: To determine if preoperative leg pain and low back pain severity affected postoperative outcome. Method: Prospectively collected Spine-Tango data was analysed for 995 consecutive patients who underwent a primary, single level, lumbar micro-decompression/microdiscectomy at a single tertiary spinal centre. Result: At 3 months, 72% of pat...

Background: Minimally invasive resection of brain metastases aims to maximize resection while minimizing brain trauma. Methods: Patients with 1 or more metastases that underwent resection following neuro-oncology multidisciplinary meeting discussion from September 2014 to October 2018, with pre- and postoperative magnetic resonance imaging, were...

Objectives The clinical features of CES are often vague, even the guidelines developed to help clinicians suggest back pain with or without a broad scope of clinical features (BASS, 2015). We aim to see if we can clarify the subjective and objective signs that are most predictive of CES. Design A retrospective analysis was performed on the document...

Background Here we present the first reported case of Hirayama’s disease in the UK. An included literature review on Hirayama’s disease in the Western literature shows that this case is unique in being the first such case in the UK, and constituting one of only a few cases in Europe with supporting MR imaging and reported treatment outcome. Case r...

Intracerebral haemorrhage (ICH) is a common and devastating condition. We describe a 43-year-old man with the rare Churg-Strauss syndrome, which was diagnosed after he presented with an ICH. He was managed initially neurosurgically with clot evacuation and craniectomy. Post-investigation and diagnosis of Churg-Strauss, treatment was with high dose...

Bone morphogenetic proteins (BMPs) are increasingly used in spinal fusion surgery. Previous reports of BMP use in anterior cervical fusion have suggested high rates of complications related to soft tissue swelling. We evaluate the safety of using BMP-7 osteogenic protein (OP-1®; Stryker, Kalamazoo, MI, USA) in a relatively contained form and contro...

A 51-year-old woman presented with a 2-month history of double vision and numbness around her left ear. She subsequently became unsteady on her feet and developed further cranial nerve abnormalities, before complaining of headache, nausea and vomiting. Imaging revealed features suggestive of two intracranial lesions; one non-contrast-enhancing high...

Meningiomas are slow-growing benign brain tumors. They can be sensitive to sex hormones, increasing in size with pregnancy and leading to clinical presentation either before or immediately after delivery. Initial symptoms and signs can present in the antenatal as well as the postnatal period. A patient presented with confusion associated with compl...