Joe Dicostanzo

Hawaii Permanente Medical Group · Occupational Medicine

Progesterone/DHT eye drops might inhibit pregnancy accelerated KC progression through regulation of relaxin and estrogen activity. Pregnancy is linked to very aggressive progression of keratoconus and in patients who have undergone refractive surgery occurrence of keratectasia. This seems to affect even stable patients that have undergone previous...

Sintesi La vitrectomia potrebbe fornire un apporto di ossigeno "collaterale" alla retina ed essere utile nelle condizioni acute e croniche che potrebbero verificarsi dopo la vitrectomia. • Potrebbe mitigare gli effetti di un ripetuto distacco di retina. • o altri processi acuti di natura ischemica/trombotica preservando il tessuto retinico altam...

Develop a thick lubricating ophthalmic gel with a pH that is calibrated to an acidic value/lower pH of ~ 6-6.5 to be used overnight in KC patients and CXL candidates. Rationale: Developing a lubricating ophthalmic gel with a pH that is calibrated to an acidic value/lower pH, yet within a comfortable and safe normal physiologic range could 1. impr...

a “mature” vitrectomy could be protective as it allows oxygen to reach the retinal tissue from anterior eye and from other area of the posterior eye “collateral” oxygen circulation if you will. Mature being silicone oil and such has been drained out (which doesn’t allow oxygen transfer).

the use of pharmacogenomics and SSRIs in adolescents. SSRIs are great for appropriate patients who need them. But course there is a subset of patients who develop suicidal ideation or violent thoughts when they are started on SSRIs. There is even an FDA black box on the labels. Extremely controversial but it is suggested some kids (and adults) who...

It would be desirable to create a mRNA injection that would generate soluble ACE2 we want them released from the cells not projected on the surface like the mRNA vaccines are doing currently. There are 2 types of ACE2 a long and a short one that tethers to the cells and facilitates viral entry(long) and a short one that floats around freely. They b...

Human recombinant soluble ACE2 in severe COVID-19 https://www.sciencedirect.com/science/article/pii/S2213260020304185?via%3Dihub The previous studies of APN01 inhaled and IV were quite successful. Poss clinical trial using APN01 for LONG COVID/PASC There seem to be inhibitory antibodies to ACE2 that occur after COVID19 infection as well as activa...

Hypothesis: A combined regimen of LISW treatment with transdermal L-Arginine could potentially provide benefit in patients suffering from Raynauds. The LISW is thought to break up calcifications in blood vessels increasing blood flow immediately whilst also stimulating new blood vessels (angiogenesis). TD L-arginine causes vasodilation of arteries...

From what I understand about oxygen supply to the cornea as it does not have a proper blood supply it is dependent on direct exposure to the atmosphere when the eye is open and when the eyelid is closed it depends on aqueous humor and tears. I was thinking goggles could be adapted that cover the eyes and have humidified and oxygenated air supplied...

Poss TELMISARTAN, an angiotensin receptor blocker primarily used for treatment in hypertension as an adjunctive treatment in GB. it could offer a lot of benefits to GB patients esp. those getting radiation treatments and TMZ. Positive results would hopefully include decreased tumor growth, decreased seizures, decreased dosing of seizures meds, bett...

Normal saline is of course the default solution used to dissolve medications that are nebulized and inhaled – but it might be worth revisiting this. Using mildly hypotonic solutions might increase the effectiveness of inhaled medications and possibly reduce the total amount needed as well as reducing side effects Hypotonic solutions when compared...

Vaccine hesitancy and the occurrence of elusive variants necessitate further treatment options for coronavirus disease 2019 (COVID-19). Accumulated evidence indicates that clinically used hypertensive drugs, angiotensin receptor blockers (ARBs), may benefit patients by mitigating disease severity and/or viral propagation. However, current clinical...