Jingwei Xiao

CRMH-CAS

BACKGROUND Cardiomyocyte differentiation involves a stepwise clearance of repressors and fate-restricting regulators through the modulation of BMP (bone morphogenic protein)/Wnt-signaling pathways. However, the mechanisms and how regulatory roadblocks are removed with specific developmental signaling pathways remain unclear. METHODS We conducted a...

Focal adhesion (FA) organization and signaling are essential for cell growth and differentiation. However, the molecular mechanism that coordinates the FA signaling with cardiomyocyte differentiation has not been fully understood. Here, we provide empirical evidence that BNIP-2, a BCH-domain-containing protein, is the organizer of FA nanostructure...

Cell collectives undergo fracture and transit from a solid-to-fluid-like behaviour that flows during development and disease. How collective cell invasion of a tissue barrier emerges from a combination of these processes has not been addressed. An outstanding challenge is to achieve a comprehensive understanding of the invasion cascade by integrati...

Cancer cells in secondary tumors are found to form metastases more efficiently as compared to their primary tumor counterparts. This is partially due to the unfavorable microenvironments encountered by metastasizing cancer cells that result in the survival of a more metastatic phenotype from the original population. However, the role of deleterious...

BNIP‐2 Activation of Cellular Contractility In article number 2202834 by Darren Chen Pei Wong, Pakorn Kanchanawong, Boon Chuan Low, and co‐workers, the multifaceted roles of the scaffold protein, BNIP‐2, are demonstrated to induce the expression of two cardiac markers, cTnT and Myl2, in H9c2 and hESC cells. During this process, BNIP‐2 activation of...

Cancer cells derived from secondary tumors can form new distant metastases more efficiently as compared to their primary tumor counterparts. This is partially due to the unfavorable microenvironments encountered by metastasizing cancer cells that result in the survival of a more metastatic phenotype from the original population. However, it is uncl...

Actomyosin-mediated cellular contractility is highly conserved for mechanotransduction and signalling. While this phenomenon has been observed in adherent cell models, whether/how contractile forces regulate the function of suspension cells like natural killer (NK) cells during cancer surveillance, is unknown. Here, we demonstrated in coculture set...

The goal of this study was to measure the mechanical properties of porcine brain tissue and determine if they were dependent on anatomical region or direction. Multistep stress relaxation indentations with a cylindrical probe were performed at 10, 20, and 30% nominal strain on multiple regions in the sagittal, horizontal, and coronal planes. Linear...

Microtubules display dynamic turnover during cell migration, leading to cell contractility and focal adhesion maturation regulated by Rho guanosine triphosphatase activity. This interplay between microtubules and actomyosin is mediated by guanine nucleotide exchange factor (GEF)–H1 released after microtubule depolymerization or microtubule disconne...