Jingtian Zhang

Nankai University | NKU · College of Life Sciences

The second near‐infrared (NIR‐II) theranostics offer new opportunities for precise disease phototheranostic due to the enhanced tissue penetration and higher maximum permissible exposure of NIR‐II light. However, traditional regimens lacking effective NIR‐II absorption and uncontrollable excited‐state energy decay pathways often result in insuffici...

The second near‐infrared (NIR‐II) theranostics offer new opportunities for precise disease phototheranostic due to the enhanced tissue penetration and higher maximum permissible exposure of NIR‐II light. However, traditional regimens lacking effective NIR‐II absorption and uncontrollable excited‐state energy decay pathways often result in insuffici...

Although the curative effect of hematological malignancies has been improved in recent years, relapse or drug resistance of hematological malignancies will eventually recur. Furthermore, the microenvironment disorder is an important mechanism in the pathogenesis of hematological malignancies. Immunogenic cell death (ICD) is a unique mechanism of re...

Multifunctional phototheranostics that integrate several diagnostic and therapeutic strategies into one platform hold great promise for precision medicine. However, it is really difficult for one molecule to possess multimodality optical imaging and therapy properties that all functions are in the optimized mode because the absorbed photoenergy is...

Induction of immunogenic cell death (ICD) in tumor combined with immune checkpoint blockade (ICB) therapy is widely developed to improve the efficacy of cancer immunotherapy. However, the current ICD induced based on apoptosis, i.e., immunogenic apoptosis, is often restricted in immunogenicity owing to the inflammatory quenching that occurs early i...

The main obstacle of multiple myeloma (MM) therapy is the compromised immune microenvironment, which leads to MM relapses and extramedullary disease progression. In this study, we report a novel strategy of enhanced immunogenic cell death (ICD) immunotherapy with aggregation‐induced emission (AIE) photosensitizer‐loaded BSA nanoparticles (referred...

Precision diagnosis and treatment have received increasing attention for modern medicine, and the optical imaging and therapeutic techniques (e.g., fluorescence imaging, photoacoustic imaging, time-resolved imaging, photodynamic therapy, and photothermal therapy) have greatly advanced this field. It is now becoming very clear that the photophysical...

Accurate and rapid detection of SARS-CoV-2 is significant for early tracing, isolating and treating infected patients, which will efficiently prevent large-scale transmission of COVID-19. Herein, two kinds of test strips for RBD and N antigens of SARS-CoV-2 are established with high sensitivity and specificity, in which AIE luminogens are utilized...

Lysosome‐relevant cell death induced by lysosomal membrane permeabilization (LMP) has recently attracted increasing attention. However, nearly no studies show that currently available LMP inducers can evoke immunogenic cell death (ICD) or convert immunologically cold tumors to hot. Herein, we report a LMP inducer named TPE‐Py‐pYK(TPP)pY, which can...

Lysosome‐relevant cell death induced by lysosomal membrane permeabilization (LMP) has recently attracted increasing attention. However, nearly no studies show that currently available LMP inducers can evoke immunogenic cell death (ICD) or convert immunologically cold tumors to hot. Herein, we report a LMP inducer named TPE‐Py‐pYK(TPP)pY, which can...

Photoacoustic (PA) imaging emerges as a promising technique for biomedical applications. The development of new strategies to boost PA conversion without depressing other properties (e.g., fluorescence) is highly desirable for multifunctional imaging but difficult to realize. Here, we report a new phenomenon that active intramolecular motions could...

A compound with intense intramolecular motions exhibits an amplified photoacoustic signal by specifically elevating the thermal-to-acoustic conversion efficiency, and the fluorescence brightness also increases due to the aggregation-induced emission signature. Precise in vivo image-guided cancer surgery in different stages is conducted, greatly boo...

In article number 2005449, Qiyun Tang, Yang Shi, Dan Ding, and co‐workers report a simple short alkyl modified strategy to regulate the molecular aggregation state and remarkably improve the luminescent efficiency and phosphorescence lifetime of pure organic room temperature phosphorescence (RTP) materials. The crystalline nanoparticles of RTP mole...

Far red/near infrared (FR/NIR) materials have attracted wide attention due to their great potential in various applications, particularly in bio-imaging. However, it is still a challenge to manufacture organic FR/NIR materials with quite high efficiency and long emission wavelength, owing to the dominance of non-radiative deactivation in the dissip...

Pure organic persistent room temperature phosphorescence (RTP) materials have attracted wide attention owing to their great potential in various applications, particularly in bioimaging. However, it is still a challenge to manufacture organic RTP materials possessing quite high efficiency and long lifetime, owing to the high requirements for triple...

A luminogenic bioprobe TPE-DMAB for simple and specific detection of peroxynitrite (ONOO⁻) has been developed. TPE-DMAB exhibits aggregation-induced emission (AIE) characteristic and shows fluorescence enhancement (up to 100-fold) upon cleavage of phenylboronic moieties by ONOO⁻. TPE-DMAB can be facilely synthesized and displays excellent specifici...

As a common method for postoperative adjuvant treatments of bladder tumor, chemotherapy encounters low tumor targeting, short tumor retention time and bad bioavailability in clinical applications, which result in unsatisfactory high chemotherapeutical doses, frequent administration and subsequent severe side effects. Herein, we innovatively introdu...

Reducing cancer cell chemo-resistance or make cancer cells sensitive to chemo-drugs plays a key role in boosting the efficacy of cancer chemotherapeutics in the clinic. Aiming for this, we develop a fluorescence and photoactivity dual-activatable prodrug (HCA-SS-HCPT) consisting of an aggregation-induced emission luminogen (AIEgen) named HCA (4-dim...