Jingru Sun

South China Normal University · Department of Psychology

Purpose: The incidence of cutaneous paradoxical reactions associated with IL-17 inhibitors has gained attention in recent literature. Our report aims to investigate the characteristics of one rare paradoxical reaction, presenting as Behcet’s disease. Methods: We reported one case of Behcet’s-like disease induced by secukinumab in a patient with pso...

Background: The immunophenotype of peripheral blood lymphocytes and T-cell receptor (TCR) gene rearrangement of cutaneous T cell lymphoma (CTCL) patients were retrospectively analyzed to explore their value in the diagnosis of CTCL. Methods: A total of fifty patients' results were enrolled from 2013 to 2021, including 29 malignant skin disorders...

Mycosis fungoides (MF) is the most prevalent type of cutaneous T-cell lymphoma and is generally characterized by multiple patches or plaques with fine scales. One of its variants manifests with multiple purpuric eruptions, mimicking benign pigmented purpuric dermatosis (PPD). To investigate clinicopathological features of PPD-like MF patients. We r...

Background Discriminating between cutaneous anaplastic large cell lymphoma (cALCL) and CD30-positive transformed mycosis fungoides (CD30+ TMF) is challenging, particularly when they arise in the context of pre-existing mycosis fungoides. The development of molecular diagnostic tools was hampered by the rarity of both diseases and the limited unders...

Differential diagnosis of erythroderma is challenging in dermatology, especially in differentiating erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses. This study retrospectively reviewed the peripheral blood flow cytometric results of 73 patients diagnosed with erythroderma at Peking University First Hospital from 2...

Abstract is missing (Quiz)

Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis and bulk whole-exome sequencing on 19 skin lesions from 15 CTCL...

Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature T cells. However, in advanced stages, CTCL may manifest as aggressive clinical behavior and lead to a poor prognosis. The mechanism of disease progression in CTCL remains unknown. Here, with a large clinical cohort, we identified that IKZF2, an essential trans...

Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, undergoes large-cell transformation (LCT) in the late stage, manifesting aggressive behavior, resistance to treatments, and poor prognosis, but the mechanisms involved remain unclear. To identify the molecular driver of LCT, we collected tumor samples from 133 MF patients an...

SATB1 is an important T-cell specific chromatin organizer in cutaneous T cell lymphoma, while its expression and function in Mycosis fungoides (MF) remain ambiguous. Our study aimed to investigate the clinicopathological significance of SATB1 in a cohort of 170 MF patients. SATB1 expression was heterogeneous among MF patients in each clinical stage...

Cutaneous CD30+ lymphoproliferative disorder (CD30+LPDs), including lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large-cell lymphoma (PCALCL), comprises the second most common group of cutaneous T cell lymphoma. Previously, we reported that special AT-rich sequence-binding protein1 (SATB1), a thymocyte specific chromatin organizer,...

Primary cutaneous anaplastic T cell lymphoma (PCALCL), characterized by the CD30+ anaplastic large T cells, comprises the second most common group of cutaneous T-cell lymphoma (CTCL). Little is known about the mechanisms of disease progression. Here we report that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive comp...

Poly(lactide) stereocomplex (PLA SC) and poly(ethylene glycol) (PEG) crystallites were obtained in MPEG-b-PLLA/MPEG-b-PDLA (linear blend, 1/1) and 4PEG-b-PLLA/4PEG-b-PDLA (4-arm blend, 1/1) by solution-casting method. The molecular weights of PLLA and PDLA (Mn, PLA) were similar in all the linear and 4-arm blends. Only PLA SC and PEG crystallites w...

The crystallization behaviors and microstructures of poly(l-2-hydroxyl-3-methylbutanoic acid)/poly(l-lactide) blends [P(L-2H3MB)/PLLA] were investigated by OM, DSC, SAXS, in situ temperature-dependent WAXD, and in situ synchrotron WAXS. The blends exhibited a homogeneous state at 250 °C. In the cooling process, P(L-2H3MB), with higher melting tempe...

The treatment options for advanced cutaneous T-cell lymphoma (CTCL) are limited due to its unclear pathogenesis. HDAC inhibitors (HDACi) are recently developed therapeutics approved for refractory CTCL. However, the response rate is relatively low and unpredictable. Previously, we discovered that BCL11B, a key T-cell development regulator, was aber...

Chronic lymphedema predisposes to develop malignant cutaneous tumors, including angiosarcoma, Kaposi's sarcoma and B cell lymphoma. T cell malignancy has rarely been associated with chronic lymph stasis. Here we report a case of primary cutaneous anaplastic large cell lymphoma (pcALCL) with lymphatic spread associated with chronic lymphedema. The p...

Linear and three-armed poly(L-lactide)/poly(D-lactide) (PLLA/PDLA, 3PLLA/3PDLA and 3PLLA/PDLA) specimens were prepared through a solution mixing method, and the morphology and the spherulite growth of poly(lactide) stereocomplex crystallites (PLA sc) from the melt with various structures and molecular weights were investigated. Polarized optical mi...

The crystallization and melting behaviors of weakly segregated diblock copolymer (MPEG-b-PLLA) have been investigated by differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD), and small-angle X-ray scattering (SAXS). The microphase separation of MPEG-b-PLLA significantly influenced the crystallization behavior of PEG and the...

The block copolymers of poly(d-lactide)-b-poly(butylene succinate)-b-poly(d-lactide) (PDLA-b-PBS-b-PDLA) were added into PLLA matrix to enhance the toughness of PLLA by solution casting method. The properties of the films were investigated by wide angle X-ray diffractometry (WAXD), differential scanning calorimetry (DSC) and tensile testing. The WA...

Two types of polylactide-poly(butylene adipate-co-terephthalate)-polylactide (PLA-PBAT-PLA) tri-block copolymers with different molecular weights (CP1 and CP2) were synthesized as compatibilizers for PLA/PBAT blends. Synergistic effects of CP1 and CP2 on the mechanical and rheological properties of the blends have been studied in detail. The additi...

PEG/PLLA block copolymers bearing various number of arms were synthesized. The molecular weights of PLLA in the block polymers were determined by 1H NMR and GPC. For 1-arm, 2-arm, 4-arm PEG/PLLA block copolymers, DSC and WAXD results indicated that the different architectures and compositions of the block copolymers didn't alter the structures of P...

The linear PLLA/PDLA blends were prepared by solution mixing method, and the melting behavior and structure evolution of neat PLLA and PLLA/PDLA specimens were investigated in this study. Results indicated that PLA stereocomplex crystallites (sc) preferentially formed in all blends, and the crystal structure of PLA sc and homochiral crystallites (h...

Linear and four-armed poly(l-lactide)-block-poly(d-lactide) (PLLA-b-PDLA) block copolymers are synthesized by ring-opening polymerization of d-lactide on the end hydroxyl of linear and four-armed PLLA prepolymers. DSC results indicate that the melting temperature and melting enthalpies of poly (lactide) stereocomplex in the copolymers are obviously...

Interaction of Herpes Simplex Virus (HSV) glycoprotein D (gD) with the host cell surface during Chlamydia trachomatis/HSV co-infection stimulates chlamydiae to become persistent. During viral entry, gD interacts with one of 4 host co-receptors: HVEM (herpes virus entry mediator), nectin-1, nectin-2 and 3-O-sulfated heparan sulfate. HVEM and nectin-...

PLLA grafted poly(castor oil) copolymers (PCO-g-PLLA) were successfully synthesized and used to enhance the tensile toughness of PLLA. The tensile toughness and elongation at break of the blends are 10 times greater and 30 times more than those of neat PLLA, respectively, with minimal reduction in the tensile strength of PLLA. Strong interfacial in...

In this article, two types of poly (D-lactide)-b-poly (ethylene glycol)-b-poly (D-lactide) (PDLA-b-PEG-b-PDLA) were added into PLLA matrix by solution casting method. The obtained films were characterized by wide angle X-ray diffractomery (WAXD), differential scanning calorimetry (DSC), tensile testing and thermal gravimetric analyzer (TGA). Result...

The crystallization and melting behaviors of polylactide (PLA) homochiral polymer under the confinement of stereocomplex crystallites were studied in the linear and three-armed poly(d-lactide)/poly(l-lactide) (PDLA/PLLA and 3PDLA/3PLLA) solution casting blends. WAXD results showed that novel modified crystallites formed when PLA homopolymer crystal...

The poly(D-lactide)/poly(L-lactide) (PDLA/PLLA) blends with low molecular weights were casted from solution. After heated above the melting temperature, and then cooled at various rates, DSC, WAXD and FTIR studies revealed that a mesomorphic phase developed in the PDLA/PLLA 90/10 and 80/20 (or 10/90 and 20/80) specimens when the temperature window...

In this article a facile way of producing starch-based nanoparticles (SNPs) with high yields and predictable size is presented by an alkali-freezing treatment. The new mix solvent, sodium hydroxide/urea aqueous solution has been developed to disperse corn starch. After refreezing, thawing, stirring at room temperature and dialysis, the resultant su...

Poly(l-lactic acid) (PLLA) and Poly(d-lactic acid) (PDLA) with different optical purity were blended in an internal mixer and their crystallization behavior were investigated. Nearly complete stereocomplex crystallites could be obtained at specific condition between PLLA and PDLA. The melting temperature of stereocomplex was related with the optica...

A particular crystallization behavior of PLA stereocomplex was observed when the poly(L-lactide) (PLLA)/poly(D-lactide) (PDLA) (50/50) was subjected to specific melting conditions. The effect of the holding temperature in the melt state of PLLA/PDLA samples on the nonisothermal melt crystallization process and on the structure have been investigate...

Stereocomplex poly(lactide)s (sc-PLAs) were obtained from solution blending of 3-armed poly(L-lactide) (3PLLA) and linear poly(D-lactide) (PDLA) and between enantiomeric 3PLAs. Differential scanning calorimetry and wide-angle X-ray diffraction results indicated that racemic crystallites were preferentially produced in all the binary blends. The mel...

The dependence of phase structure of PLLA/PPC blends on the blend ratio, the heat-treatment temperature and time was investigated by optical microscopy. It is found that, at lower PPC content, e.g., less than 30%, the PLLA crystalline spherulites fill the whole space with the PPC dispersed in the amorphous region of PLLA. No evident phase separatio...

Crystallization behavior, structural development and morphology evolution of a series of poly (ethylene glycol)-poly(ε-caprolactone) diblock copolymers (PEG-b-PCL) were investigated via differential scanning calorimetry (DSC), X-ray diffraction (XRD) and atomic force microscopy (AFM). In these copolymers, both blocks were crystallizable and biocomp...

The effects of the addition of poly(D-lactide) (PDLA) on the crystallization behavior of poly(L-lactide)(PLLA) were investigated by means of differential scanning calorimetry (DSC) and temperature-dependent X-ray diffraction(XRD). When the blends were cooled from different temperatures (250, 240, and 190 °C) at the rate of cooling of 5 °C/min, ster...

Synthetic routes to aluminium ethyl complexes supported by chiral tetradentate phenoxyamine (salan-type) ligands [Al(OC(6)H(2)(R-6-R-4)CH(2))(2){CH(3)N(C(6)H(10))NCH(3)}-C(2)H(5)] (4, 7: R=H; 5, 8: R=Cl; 6, 9: R=CH(3)) are reported. Enantiomerically pure salan ligands 1-3 with (R,R) configurations at their cyclohexane rings afforded the complexes 4...

Novel intelligent hydrogels composed of biodegradable and pH-sensitive poly(l-glutamic acid) (PGA) and temperature sensitive poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate) (PNH) were synthesized and characterized for controlled release of hydrophilic drug. The influence of pH on the equilibrium swelling ratios of the hydrogels was inves...

A series of chromium/Schiff base complexes N,N′-bis(salicylidene)-1,2-phenylenediamino chromiumIII X were prepared and employed for the alternating copolymerization of carbon dioxide with racemic propylene oxide in the presence of (4-dimethylamino)pyridine. The effect of the complex structure and reaction conditions on the catalytic activity, the p...

Nectin-1 is an adhesion protein implicated in the organization of adherens junctions and tight junctions in epithelial cells. Previous studies in our laboratory demonstrated that nectin-1 accumulation was significantly decreased in Chlamydia trachomatis-infected HeLa cells. In the present study, Western blot analyses indicated that nectin-1 down-re...

Nectin-1, a member of the immunoglobulin superfamily, is a Ca(2+)-independent cell adhesion protein implicated in the organization of E-cadherin-based adherens junctions (AJs) and claudin-based tight junctions (TJs) in epithelial cells. Nectin-1 also regulates cell-cell adhesion and cell polarization in a Cdc42- and Rac-dependent manner. Western bl...

Several inducers of chlamydial persistence have been described, including interferon-gamma (IFN-gamma), IFN-alpha, IFN-beta, and tumour necrosis factor-alpha (TNF-alpha) exposure, and iron, amino acid or glucose deprivation. A tissue-culture model of Chlamydia trachomatis/herpes simplex virus type-2 (HSV-2) co-infection indicates that viral co-infe...

Self-assembling of novel biodegradable ABC-type triblock copolymer poly(ethylene glycol)-poly(L-lactide)-poly(L-glutamic acid) (PEG-PLLA-PLGA) is studied. In aqueous media, it self-assembles into a spherical micelle with the hydrophobic PLLA segment in the core and the two hydrophilic segments PEG and PLGA in the shell. With the lengths of PEG and...

Epidemiological studies have demonstrated that co-infections of herpes simplex virus type 2 (HSV-2) and Chlamydia trachomatis occur in vivo. Data from a tissue culture model of C. trachomatis/HSV-2 co-infection indicate that viral co-infection stimulates the formation of persistent chlamydiae. Transmission electron microscopic (TEM) analyses demons...

The crystallization behavior and morphology of the crystalline-crystalline poly(ethylene oxide)-poly(epsilon-caprolactone) diblock copolymer (PEO-b-PCL) was studied by differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD), Fourier transform infrared spectroscopy (FTIR), small-angle X-ray scattering (SAXS), and hot-stage polar...

The quasiliving characteristics of the ring-opening polymerization of ϵ-caprolactone (CL) catalyzed by an organic amino calcium were demonstrated. Taking advantage of this feature, we synthesized a series of poly(ϵ-caprolactone) (PCL)–poly(L-lactide) (PLA) diblock copolymers with the sequential addition of the monomers CL and L-lactide. The block s...

The structure of active species in the stereoselective ring-opening polymerization (ROP) of rac-lactide with Al Salen complexes derived from an achiral Salen ligand, was investigated. All hydrogen atoms were added to theoretical models, with isotropic thermal parameters related to those of the supporting carbon atoms. LAIOCH(CH3) COOCH3 derived for...

The poly(l-lactide) (PLLA)/starch blends were prepared by the PLLA grafting starch (PLLA-g-St) copolymers as a compatibilizer, and their thermal, mechanical and morphological characterizations were performed to show the better performance of these blends compared to the virgin PLLA/starch blend without the compatibilizer, including PLLA crystallini...

The electron diffraction (ED), morphology and structure of single crystals of poly(ethylene glycol) (PEG)-poly(ε-caprolactone) (PCL) diblock copolymers were examined. The ED patterns of both PEG and PCL were observed by choosing proper operating parameters of electron diffraction. The single crystals of PEG, PCL, and PEG-b-PCL were grown from their...

The crystallization behaviors of the poly(ethylene glycol)-poly(epsilon-caprolactone) diblock copolymer with the PEG weight fraction of 0.50 (PEG(50)-PCL(50)) was studied by DSC, WAXD, SAXS, and FTIR. A superposed melting point at 58.5 degrees C and a superposed crystallization temperature at 35.4 degrees C were obtained from the DSC profiles runni...

A new surface modification method of hydroxyapatite nanoparticles (n-HA) by surface grafting reaction of L-lactic acid oligomer with carboxyl terminal (LAc oligomer) in the absence of any catalyst was developed. The LAc oligomer with a certain molecular weight was directly synthesized by condensation of L-lactic acid. Surface-modified HA nanopartic...

A novel amphiphilic biodegradable cationic hyperbranched poly(ethylene glycol)-polyethylenimine-poly(gamma-benzyl L-glutamate) (PEG-PEI-PBLG) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with PEG-PEI as a macroinitiator. PEG-PEI was firstly prepared by...

An aluminum/Schiff base complex {[2,2-dimethyl-1,3-propylenebis(3,5-di-tert-butylsalicylideneiminato)](isopropanolato)aluminum(III) (2)} based on a bulky ligand and aluminum isopropoxide was prepared and employed for the stereoselective ring-opening polymerization (ROP) of rac-lactide (rac-LA). The initiator was characterized with nuclear magnetic...

A novel method of grafting ring-opening polymerization of l-lactide (LLA) onto the surface of hydroxyapatite nano-particles (n-HAP) was developed. PLLA was directly connected onto the HAP surface through a chemical linkage. The PLLA-g-HAP particles could be stably dispersed in organic solvent such as chloroform for several weeks. The n-HAP particle...

Poly(ethylene glycol)-poly(epsilon-caprolactone) diblock copolymers PEG-PCL were synthesized by ring-opening polymerization of epsilon-caprolactone using monomethoxy poly(ethylene glycol) as the macroinitiator and calcium ammoniate as the catalyst. Obvious mutual influence between PEG and PCL crystallization was studied by altering the relative blo...

Crystallization behavior, structural development and morphology evolution in a series of diblock copolymers of poly(l-lactide)-block-poly(ethylene glycol) (PLLA-b-PEG) were investigated via differential scanning calorimetry, wide-angle X-ray diffraction, polarized optical microscopy and atomic force microscopy. In these copolymers, both blocks are...

A novel structural triblock copolymer of poly(γ-benzyl-l-glutamic acid)-b-poly(ethylene oxide)-b-poly(ε-caprolactone) (PBLG-PEO-PCL) was synthesized by a new approach in the following three steps: (1) sequential anionic ring opening polymerization (ROP) of ethylene oxide and ε-caprolactone with an acetonitrile/potassium naphthalene initiator system...