Jing Liang

Stevens Institute of Technology · Department of Chemical Engineering & Materials Science

Self-defensive biomaterial surfaces are being developed in order to mitigate infection associated with tissue-contacting biomedical devices. Such infection occurs when microbes colonize the surface of a device and proliferate into a recalcitrant biofilm. A key intervention point centers on preventing the initial colonization. Incorporating antimicr...

Freezing and sublimation effects on cryo-SEM imaging and microanalysis - Volume 25 Supplement - Jing Liang, Xixi Xiao, Tseng-Ming Chou, Matthew Libera

The complexation of polyvalent macro-ions with oppositely charged polyelectrolyte microgels can lead to core-shell structures. The shell is believed to be highly deswollen with a high concentration of counter macro-ions. The core is believed to be relatively free of macro-ions but under a uniform compressive stress due to the deswollen shell. We us...

Despite extensive engineering of tissue-contacting biomedical devices to control healing, these devices remain susceptible to bacterial colonization, biofilm formation, and chronic infection. The threat of selecting for resistance genes largely precludes sustained antimicrobial elution as a wide-spread clinical solution. In response, self-defensive...

Cryo-SEM: Direct Evidence of Water and Counterion Release upon Complexation - Volume 24 Supplement - Jing Liang, Xixi Xiao, Matthew Libera, Tseng-Ming Chou

Microgel Swelling Studied by Cryo-SEM - Volume 23 Issue S1 - Jing Liang, Feiyue Teng, Tseng-Ming Chou, Matthew Libera

The swell ratio is a key parameter characterizing the structure and properties of a hydrogel. In macroscopic gels, the swell ratio can be determined by straightforward measurements of the gel weight in the dry and hydrated states. However, measuring the swell ratio characteristic of microgels (gel particles with dimensions of 0.1–100 μm) is substan...

div class="title">Cryo-SEM Imaging and Analysis of Frozen-Hydrated PEG-AA Microgels - Volume 22 Issue S3 - Jing Liang, Feiyue Teng, Matthew Libera, Tsengming Chou

Electrostatic interactions within a semi-interpenetrating network (semi-IPN) gel can control the postsynthesis loading, long-term retention, and subsequent release of small-molecule cationic antibiotics. Here, electrostatic charge is introduced into an otherwise neutral gel [poly(ethylene glycol) (PEG)] by physically entrapping high-molecular-weigh...

We report on negatively charged layer-by-layer (LbL) hydrogel films, which turn hydrophobic and bactericidal in response to bacteria-induced acidification of the medium. Single-component hydrogel thin films, abbreviated as PaAALbLs, consisting of chemically crosslinked poly(2-alkylacrylic acids) (PaAAs) with varying hydrophobicity [polymethacrylic...

Biofilms are three-dimensional communities of bacteria distributed in a highly hydrated extracellular matrix (ECM). They can be visualized by scanning electron microscopy (SEM), but the requisite SEM sample preparation can modify the biofilm morphology. Here, four different approaches to prepare biofilms of hydrated Staphylococcus aureus for SEM im...

Microgels are hydrogel particles with micron and sub-micron diameters. They have beendeveloped, studied, and exploited for a broad range of applications because of their uniquecombination of size, soft mechanical properties, and controllable network properties. We havebeen using microgels to modulate the properties of surfaces to differentially con...