Jessay Gopuran Devassy

In 2010, Health Canada approved a heath claim acknowledging the link between increased oats (Avena sativa)-soluble fibre consumption and a reduction in total serum cholesterol levels. The approval also recognized the relationship between decreased total blood cholesterol concentration and a reduced risk of coronary heart disease. The functional foo...

Cystic kidney diseases are characterized by multiple renal cysts and are the leading cause of inherited renal disease. Oxylipins are bioactive lipids derived from fatty acids formed via cyclooxygenase, lipoxygenase and cytochrome P450 activity, and are important regulators of renal health and disease. Oxylipins are altered in nephronophthisis, a ty...

Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFA) that are important regulators of kidney function and health. Targeted lipidomic analyses of renal oxylipins from four studies of rodent models of renal disease were performed to investigate the differential effects of dietary flax compared to fish oil, soy protein compar...

Questions remain regarding the potential negative effects of dietary high protein (HP) on kidney health, particularly in the context of obesity in which the risk for renal disease is already increased. To examine whether some of the variability in HP effects on kidney health may be due to source of protein, obese fa/fa Zucker rats were given HP (35...

Alzheimer disease (AD) is becoming one of the most prevalent neurodegenerative conditions worldwide. Although the disease progression is becoming better understood, current medical interventions can only ameliorate some of the symptoms but cannot slow disease progression. Neuroinflammation plays an important role in the advancement of this disorder...

Rationale for dietary advice in polycystic kidney disease (PKD) is based in part on animal studies that have examined non-orthologous models with progressive development of cystic disease. Since no model completely mimics human PKD, the purpose of the current studies was to examine the effects of dietary soy protein (compared to casein) or oils enr...

Dietary oil and protein effects on kidney size in diseased PCK rats. Significant diet effects are shown on figure. Data from Table 4. (PDF)

Dietary oil and sex effects on kidney size in Pkd2WS25/- (diseased) mice. There was a diet x sex interaction and differing lower case superscript letters indicate significant simple effect differences between values. Data from Table 2. (PDF)

Dietary oil and protein effects on renal cyst area in diseased PCK rats. There were no significant diet or sex effects. Data from Table 4. (PDF)

Dietary oil and sex effects on renal cyst area in Pkd2WS25/- (diseased) mice. There were no significant diet or sex effects. Data from Table 2. (PDF)

Details of experimental diets based on the AIN-93G diet for laboratory rodents [17]. (PDF)

Oxylipins are bioactive lipids that are oxygenated metabolites of polyunsaturated fatty acids, and are the main mediators of their effects in the body. These bioactive molecules are involved in numerous essential physiologic processes. For example, oxylipins derived from docosahexaenoic acid (DHA), such as hydroxy DHA (HDoHE) and protectins, have a...

Hereditary polycystic kidney disease (PKD) is characterized by countless renal cysts and often also displays significant liver cysts. Due to lack of a cure and the inefficacy of current treatments in delaying renal replacement therapy, there is much interest in the potential for dietary approaches to slow PKD progression. Rationale for current diet...

Background Oxylipins (e.g. prostaglandins, leukotrienes) are bioactive lipids formed via oxidative metabolism of polyunsaturated fatty acids. The oxylipin profile is altered in the Han:SPRD‐ Cy rat and the pcy mouse, both models of nephronophthisis, a rare type of renal cyst disease. In these models, oxylipins formed via the cyclooxygenase (COX) pa...

Oxylipins are bioactive lipids that are oxygenated metabolites of polyunsaturated fatty acids, and are the main mediators of their effects in the body. These bioactive molecules are involved in numerous essential physiologic processes. For example, oxylipins derived from docosahexaenoic acid (DHA), such as hydroxy DHA (HDoHE) and protectins, have a...

Hereditary polycystic kidney disease (PKD) is characterized by countless renal cysts and often also displays significant liver cysts. Due to lack of a cure and the inefficacy of current treatments in delaying renal replacement therapy, there is much interest in the potential for dietary approaches to slow PKD progression. Rationale for current diet...

Objective: High-protein diets are being promoted to reduce insulin resistance and hepatic steatosis in metabolic syndrome. Therefore, the effect of protein source in high-protein diets on reducing insulin resistance and hepatic steatosis was examined. Methods: Fa/fa Zucker rats were provided normal-protein (15% of energy) casein, high-protein (3...

Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome P450 pathways, resulting in the formation of prostaglandins, thromboxanes, mono-, di-, and tri-hydroxy fatty acids (FAs), epoxy FAs, lipoxins, eoxins, hepoxilins, resolvins, p...

Benefits of omega-3 polyunsaturated fatty acids (PUFA) in health and disease have been extensively studied. Recent attention has been on the metabolites of these PUFA, the oxylipins, which are formed by oxygenation of PUFA by three classes of enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP). Previous studies in non-orthol...

Curcumin is a highly pleiotropic molecule found in the rhizomes of Curcuma longa (turmeric). It is responsible for the yellow color of turmeric and has been shown to inhibit the proliferation of cancer cells and to be of use in preventing or treating a number of diseases. Curcumin has been shown to modulate multiple cell-signaling pathways simultan...

In 2010, Health Canada approved a heath claim acknowledging the link between increased oats (Avena sativa)-soluble fibre consumption and a reduction in total serum cholesterol levels. The approval also recognized the relationship between decreased total blood cholesterol concentration and a reduced risk of coronary heart disease. The functional foo...

Obesity is increasing worldwide, and high-protein (HP) diets are widely used for weight loss. However, the overall safety of HP diets is not well established in obese individuals, who make up a significant proportion of the population. To evaluate the health effects of an HP diet in obesity, obesity-prone (OP) Sprague-Dawley rats were given high-fa...

Renal cyclooxygenase (COX) derived eicosanoids are elevated and lipoxygenase (LOX) products are reduced in the Han:SPRD-Cy rat model of polycystic kidney disease (PKD). Selective COX2 inhibition reduces kidney disease progression, but COX1 levels also are elevated in this model. Since the effect of reducing the products of both COX isoforms and the...

Dietary fish oil (FO) and soy protein (SP) are two interventions that slow disease progression in the Han:SPRD-Cy rat model of polycystic kidney disease (PKD). Inhibition of cyclooxygenase (COX)-derived eicosanoids also reduces disease progression, but the role of lipoxygenase (LOX) products in this disease is not known. Since dietary FO and SP hav...

HP diets may aid in weight control and glucose handling, but also can cause minor damage to healthy kidneys. Since obesity itself increases renal damage, the additive effects of obesity and an HP diet were investigated in diet-induced obese rats. Obesity-prone and -resistant rats were given a high fat diet for 12 wk to induce obesity, followed by e...

HP diets may aid in weight control and glucose handling, but also can cause minor damage to healthy kidneys. Since obesity itself increases renal damage, the additive effects of obesity and an HP diet were investigated in diet‐induced obese rats. Obesity‐prone and ‐resistant rats were given a high fat diet for 12 wk to induce obesity, followed by e...

Oxylipins are fatty acid metabolites (e.g. eicosanoids from arachidonic acid, AA) generated by cyclooxygenase (COX), lipoxygenase (LO) and cytochrome P450 (cP450) pathways. Since oxylipins have differing biologic effects, a targeted lipidomic analysis of oxylipins was performed using kidneys from normal and PCK rats with renal disease, in which dis...