Jay Parekh

Bridgeport Hospital · Department of Medicine

e12661 Background: The addition of pembrolizumab to neoadjuvant chemotherapy on the Keynote522 (KN522) clinical trial, changed the standard of care for early stage triple negative breast cancer (TNBC). This regimen demonstrated longer event free survival and higher percentage of patients with pathologic complete responses (pCR). However, limited da...

445 Background: Atezolizumab plus bevacizumab (A+B) is approved by the Food and Drug Administration (FDA) for treatment of advanced stage hepatocellular carcinoma (HCC) as first line systemic therapy following results of the IMBRAVE150 trial. Since its approval, limited real-world data is available. The benefit of this treatment in patients with ad...

Background: No standard of care first line therapy has been established for treatment naive patients with mantle cell lymphoma (MCL). Limited options exist in the treatment armamentarium for patients who cannot tolerate induction therapy. Venetoclax (V) based regimens have been studied recently in retrospective studies and in early phase clinical t...

b>Zweck der Übersichtsarbeit: Seit Jahrzehnten ist das nicht kleinzellige Lungenkarzinom (non-small cell lung cancer, NSCLC) im Frühstadium potenziell heilbar, weist aber eine inakzeptabel hohe Rückfallrate auf. Jüngste Ergebnisse: Die Anti-PD-(L)1-Immuncheckpoint-Blockade (ICB) hat die Behandlung des fortgeschrittenen NSCLC revolutioniert. Mit den...

Thrombotic complications from COVID-19 are now well known and contribute to significant morbidity and mortality. Different variants confer varying risks of thrombotic complications. Heparin has anti-inflammatory and antiviral effects. Due to its non-anticoagulant effects, escalated-dose anticoagulation, especially therapeutic-dose heparin, has been...

Background: The addition of immunotherapy in neoadjuvant hepatocellular carcinoma (HCC) has been studied recently in early phase clinical trials due to high rate of recurrence after surgery. We aim to systematically review the evidence of efficacy and safety of neoadjuvant immunotherapy treatment. Methods: We carried out a systematic search on MED...

Purpose of Review For decades, early-stage resectable non-small cell lung cancer (NSCLC), while potentially curable, has been marred by unacceptably high recurrence rates. Recent Findings Anti-PD(L)1 immune checkpoint blockade (ICB) has revolutionized the treatment of advanced NSCLC, and with recent approvals in the peri-operative space, is now po...

Background: The most common mutations in pancreatic cancer are found in the KRAS, TP53, CDKN2A, or SMAD4 genes. Mutations in genes involved in the DNA damage repair (DDR) pathway are also frequently seen. Despite extensive research on the patho-genomic features of pancreatic cancer, the clinical significance of these recurring mutations remains poo...

Background Certain chronic co-morbidities are associated with increased odds of sudden cardiac arrest (SCA). The aim of this study is to evaluate which chronic co-morbidities predispose patients without underlying coronary artery disease (CAD) to have a sudden cardiac arrest. Methods The National Inpatient Sample (NIS) was queried for the years 20...

Pulmonary embolism (PE) can present with a variety of electrocardiographic findings. Bradycardia is a rare finding in acute PE, which typically manifests with sinus tachycardia. Bradycardia in acute PE might arise from the physiologic Bezold–Jarisch reflex, which describes the constellation of bradycardia, peripheral vasodilation, and hypotension....

813 Background: Gastrointestinal (GI) cancers account for highest ED revisits among cancer patients. Weekend ED visits are also associated with higher mortality. We aimed to analyze factors associated with weekend ED visits among GI cancer patients. Methods: Nationwide Emergency Department Sample (NEDS) database was queried from 2009 to 2017 for ED...

Introduction: Potassium disorders are common among hypertensive patients. There is a paucity of data on the prevalence and risk factors of dyskalemia in patients with hypertensive emergency. Hypothesis: We sought to investigate the prevalence and risk factors of potassium disorders in patients presenting with hypertensive emergency. Methods: A retr...

Backgrounds: Takotsubo syndrome (TTS) is known to be associated with malignancy. However, the exact etiology of TTS in cancer patients is still unclear. There have been several reports of TTS development from the exposure to cancer therapies. We aimed to identify risk factors for the early development of TTS among patients receiving inpatient chemo...

Background Alpelisib is an oral α-specific phosphatidylinositol 3-kinase (PI3K) inhibitor use in combination with fulvestrant to treat postmenopausal women with HR+/HER2−, PIK3CA-mutated, advanced or metastatic breast cancer that has acquired resistance to endocrine-based therapy. (1)Alpelisib interferes with the PI3K/Akt signalling pathway resulti...

Background: Severe hypertension is an obstetric emergency. Timely identification and management can reduce risk of serious events. Aims of our study were to 1)assess whether severe hypertension is being recognized and managed within the recommended time frame and 2)evaluate the factors that are associated with timely identification and treatment of...

Surgical correction of abdominal muscle diastasis may decrease intra-abdominal volume and increase intra-abdominal pressure. The induced changes may ultimately lead to respiratory compromise. In abdominoplasty, one of the most frequently performed esthetic procedures, those changes are believed to be transient and clinically insignificant. We descr...

e20594 Background: Malignant pleural mesothelioma (MPM) is a highly aggressive and rare cancer type that carries dismal prognosis with a median survival of only 12 months. Often patients are diagnosed at advanced age and tend to have many co-morbid conditions. More precise prognostication should help physicians to decide on the best treatment appro...

Temporary central venous hemodialysis (HD) catheters are commonly used in end-stage renal disease (ESRD) patients while awaiting peritoneal dialysis catheter, arterio-venous fistula or graft placement and maturation. Catheter-related right atrial thrombus (CRAT) is a common finding in patients with central venous catheters (CVCs) and can cause CVC...

The advent of bone marrow transplant has opened doors to a different approach and offered a new treatment modality for various hematopoietic stem-cell-related disorders. Since the first bone marrow transplant in 1957, there has been significant progress in managing patients who undergo bone marrow transplants. Plasma-cell disorders, lymphoprolifera...

Radiotherapy plays an important role in the treatment of localized primary malignancies involving the chest wall or intrathoracic malignancies. Secondary effects of radiotherapy on the lung result in radiation-induced lung disease. The phases of lung injury from radiation range from acute pneumonitis to chronic pulmonary fibrosis. Radiation pneumon...

Background With increase in the number of non-matched hematopoietic stem cell transplants (HSCT), there has been growth in evidence regarding factors affecting graft outcomes. One of the factors affecting graft outcomes that are currently being evaluated is anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs). Objective We design...

Mycobacterium abscessus is a rapidly growing mycobacterium. It rarely causes disseminated infection or endocarditis. A 55-year-old male with a history of hepatitis C, liver cirrhosis, intravenous drug use (last use was four years ago), and chronic back pain presented with a three-week history of a right calf nodular lesion. He did not have a fever,...

Cavitary lung lesions are quite common findings on chest imaging and often pose a diagnostic challenge to the clinicians. We describe a case of a 75-year-old male who presented to the emergency room with hemoptysis. Computed tomography of the chest demonstrated multiple cavitary pulmonary nodules with peripheral groundglass opacities. Bronchoscopy...