Jason Ward

Oregon State University | OSU · Department of Physics

Liposomes are spherical-shaped vesicles that enclose an aqueous milieu surrounded by bilayer or multilayer membranes formed by self-assembly of lipid molecules. They are intensively exploited as either model membranes for fundamental studies or as vehicles for delivery of active substances in vivo and in vitro. Irrespective of the method adopted fo...

Lysenin is a pore-forming protein extracted from the earthworm Eisenia fetida, which inserts large conductance pores in artificial and natural lipid membranes containing sphingomyelin. Its cytolytic and hemolytic activity is rather indicative of a pore-forming toxin; however, lysenin channels present intricate regulatory features manifested as a re...

Liposomes, enclosed spherical vesicles that mimic the cell membrane, are currently used for a large variety of scientific and medical applications, including drug delivery into tumors. They may be produced by employing a large variety of methods such as sonication, extrusion, organic phase separation, and several others. Dialysis, i.e. separation o...

Cancer is expected to become the leading cause of death in America within the next few years. In the fight against cancer, chemotherapeutics are historically among the most effective methods to treat this deadly disease. Among the chemotherapeutics is a subclass of drugs that exert their anticancer activity via the formation of permanent chemical b...

Cancer is expected to become the leading cause of death in America within the next few years. In the fight against cancer, chemotherapeutics are historically among the most effective methods to treat this deadly disease. Among the chemotherapeutics is a subclass of drugs that exert their anticancer activity via the formation of permanent chemical b...