James A. Stokes III

Alabama State University · Biological Sciences

Resveratrol (RES) is a naturally occurring polyphenol found in fruits, green leafy vegetables, and peanuts. This versatile compound, which has potent regenerative, anti-oxidative, and cancer-fighting properties, is produced in plants, particularly in response to stress stimuli. By various mechanisms, including regulation of genes and proteins, RES...

In bone tissue engineering, the organo-ceramic composite, electrospun polycaprolactone/hydroxyapatite (PCL/HA) scaffold has the potential to support cell proliferation, migration, differentiation, and homeostasis. Here, we report the effect of PCL/HA scaffold in tissue regeneration using human mesenchymal stem cells (hMSCs). We characterized the sc...

Found in the skins of red fruits, including grapes, resveratrol (RES) is a polyphenolic compound with cancer chemopreventive activity. Because of this activity, it has gained interest for scientific investigations. RES inhibits tumor growth and progression by targeting mitochondria-dependent or -independent pathways. However, further investigations...

Within the last quarter century, technology has been a major catalyst of the advancement in various fields of scientific knowledge, particularly medical research. This new enlightenment has spurred the exploration of alternative treatment methods to some of society's most problematic diseases. One such innovative treatment is the use of Resveratrol...

Epigenetics is an area of research that has recently gained much attention from scientists. Epigenetic processes can induce changes within an organism without altering its genetic makeup. More interestingly, epigenetic mechanisms have the strong ability to modulate gene expression without directly altering the sequences of DNA bases. Dietary compou...

Mounting evidence of epigenetic dysregulation in cancer development has received lots of attention from cancer researchers and physicians. Enhancer of zeste homology 2 (Ezh2), an epigenetic regulator, plays an important role in cellular growth and survival. Ezh2 is a catalytic core protein, which belongs to Poly comb Repressor Complex 2 (PRC2). Ezh...