Jagdeesh Singh Uppal

University of Alberta | UAlberta · Department of Laboratory Medicine and Pathology

Objective: Hypnotherapy has been proposed as an emerging tool that can be implemented in management of different aspects of postoperative cardiac surgical care. This technique involves hypnotic induction to redirect focus and attention away from post-surgical pain. Emerging literature has shown that hypnosis significantly improves emotional distre...

More than 100 different arsenic species of diverse characteristics are present in the environment and biological systems. The identification and quantification of individual arsenic species are critical to understanding the distribution, environmental fate and behaviour, metabolism, and toxicity of arsenic. This review summarizes sample preparation...

Binding of nucleic acid aptamers to specific targets and detection with fluorescence anisotropy (FA) or fluorescence polarization (FP) take advantage of the complementary features of aptamers and the fluorescence techniques. We review recent advances in affinity binding assays using aptamers and fluorescence anisotropy/polarization, with an emphasi...

MicroRNAs (miRNAs) are a class of endogenous, non-coding RNAs with a typical length of 19-23 nucleotides. miRNAs regulate the expression of specific genes by binding to complementary regions of messenger RNA (mRNA), which represses mRNA translation or induces mRNA degradation. To date, more than 2500 human miRNAs have been reported and registered i...

Arsenic affects hundreds of millions of people around the world, with majority of the arsenic-affected populations living in Southeast Asia. Recent reports estimated that population exposed to water arsenic at concentrations higher than the World Health Organization guideline level of 10 μg/L or higher than 50 μg/L included 70–80 million people liv...

Affinity probes, such as nucleic acid aptamers, have been combined with fluorescence anisotropy (FA)/fluorescence polarization (FP) technology for the development of a diverse range of assays. Formation of a complex between a small fluorescent molecule and its binding partner usually increases the overall size of the fluorescent molecule and decrea...

Environmental and health studies of arsenic require the determination of arsenic species of diverse properties and toxicities. This review summarizes recent analytical advances in speciation of phenylarsenicals. Arsenic speciation techniques have taken advantage of high performance liquid chromatography (HPLC) separation with inductively coupled pl...