Jafar Abbasi Shiran

Institute for Advanced Studies in Basic Sciences | IASBS · Department of Chemistry

Trypanosomiasis is caused by parasitic protozoan trypanosomes in vertebrates. T. cruzi and T. brucei are causative agents of Chagas disease (CD) and Human African Trypanosomiasis (HAT), respectively. These life-threatening diseases are a serious threat to public health, with considerable incidence in sub-Saharan African and continental Latin Americ...

Due to the lack of effective vaccine(s) against leishmania and also pharmacokinetics issues of current drugs, it is necessary to discover new antileishmanial agents. Within this particular study, a series of novel 1-aryl/alkyl-3-benzoyl/cyclopropanoyl thiourea derivatives were synthesized (yields 69–84%) and evaluated as antileishmanial compounds (...

Background & objective Anti-tumor activity of some thioureas derivatives is well documented in literatures and received considerable attention. The present study aims to the synthesis and characterization of some novel thioureas and carbonylthioureas as anti-tumor agents for MCF-7 breast cancer cells in vitro and in vivo. Materials & methods Sever...

A novel, simple and efficient synthetic protocol has been developed for the synthesis of a series of thiazolidine-4-one and 3H-thiazole derivatives via a one-pot four-component condensation-cyclization reaction of hydrazine with allyl isothiocyanate and an α-haloketone in the presence of various aldehydes. This new protocol produces novel thiazolid...

The catalyst-free condensation reaction between alkylisothiocyanates, α-haloketones and aryl amines delivers the products in often very high yields.

A new series of 4-cyclopropyl-5-(2-fluorophenyl)arylhydrazono-2,3-dihydrothiazole derivatives was synthesized via the reaction of prepared thiosemicarbazones with 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone in the presence of Et3N as a catalyst through a semi Hantzsch cyclization. The optimized reaction conditions for this one-pot reaction were...

Thiazol-2-imine derivatives were synthesized in an easy and efficient route from the regioselective one-pot three-component reaction of aryl amine, alkylisothiocyanate, and various α-haloketones in [omim][OH] basic ionic liquid. Recyclable reaction media, catalyst free, and short reaction times are the main advantages of this protocol. This method...

A convenient one-pot three-component regioselective synthesis of novel 2,2′-(1,4-phenylene)-bis-(3-aryl-2-substituted imino-4-aryl-3H-thiazole) derivatives from 1,4-phenylene diisothiocyanate, aryl amines and various phenacyl bromide, and also the regioselective synthesis of 3-alkyl-2-(aryl imino)-4-cyclopropyl-5-(2′-fluorophenyl)-thiazole derivati...

Poly(4-vinylpyridine) is reported as a green, efficient and reusable basic catalyst for the synthesis of thiazol-2(3H)-imines under one-pot, three component reaction conditions. This simple method produces the products at room temperature in excellent yields (83-97%). Furthermore, this catalyst can be recovered by simple filtration and recycled up...

Several new derivatives of 2,2'-(4,4'-ethylenebiphenyl)bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole], 2,2'-(4,4'-biphenylsulfone)bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole], 2,2'-(4,4'-methylenebiphenyl)bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole] and 2,2'-(1,4-phenylene)bis[2-imino-3-(substituted)-4-phenyl-3H-thiazole] derivatives w...

The competitive bulk liquid membrane transport of six metal cations from an aqueous source phase (SP) containing Ag+, Pb2+, Cu2+, Zn2+, Co2+ and Ni2+ through an organic membrane phase (MP) facilitated by 1,1'-(1,3-phenylene)bis(3-allylthiourea) as a carrier into an aqueous receiving phase (RP) was studied and compared. Fluxes and selectivities for...

In this research efficient procedure for the amination of aryl halides with aqueous ammonia in the presence of poly(4-vinylpyridine)-supported copper iodide nanoparticles catalyst is reported. A wide range of aryl halides including aryl iodides and aryl bromides are converted into the corresponding aniline derivatives. The experimental procedure wi...

A CuO–CeO2 nanocomposite in the presence of amberlite-supported azide has been used for the click synthesis of 1,4-disubstituted-1,2,3-triazoles in good yields. This catalyst can be reused several times without any significant decrease in the catalytic activity. Graphical Abstract A CuO–CeO2 nanocomposite in the presence of amberlite-supported azid...

A CuO-CeO2 nanocomposite in the presence of Amberlite-supported azide has been used for the click synthesis of 1,2,3-triazole derivatives in good yields. This catalyst can be reused several times without any significant decrease in the catalytic activity.