Ibrahim A Abdel-Hamid

Mansoura University · Faculty of Medicine

Background: Normal anatomy of penis could be directly harmed by hyperlipidemia, which can lead to corpora cavernosum fibrosis, which can compromise erectile function and endothelial dysfunction. Substantial number of men and their spouses suffer with erectile dysfunction, which is very common health issue. Aim: Aim of this research had been to eval...

Introduction The place of phosphodiesterase type 5 inhibitors (PDE5-Is) in treating premature ejaculation (PE) remains a therapeutic challenge. Objectives (1) To summarize the evidence of the efficacy and safety of PDE5-Is from published systematic reviews/meta-analyses (SRs/MAs). (2) To evaluate the reporting, methodological quality, and evidence...

Background: HPV and AAV infection are suggested to be a risk factor for infertility in men. Objective: To detect the prevalence of human papilloma virus (HPV) and adenoassociated virus (AAV) in semen of men suffering from infertility. Methodology: One-hundred and thirty-eight Egyptian men were included in the study, 69 infertile patients and 69 fer...

Genetic association studies (GAS) may have the capability to probe the genetic susceptibility alleles in many disorders. This systemic review aimed to assess whether an association exists between gene(s)/allelic variant(s), and varicocele-related male infertility (VRMI). This review included 19 GAS that investigated 26 genes in 1,826 men with varic...

Diabetes mellitus (DM) is a metabolic disorder that is characterized by elevated blood glucose levels due to absolute or relative insulin deficiency, in the background of β-cell dysfunction, insulin resistance, or both. Such chronic hyperglycemia is linked to long-term damage to blood vessels, nerves, and various organs. Currently, the worldwide bu...

Introduction: The process of ejaculation has important meanings not only for its association with orgasm but also for the timing to ejaculate in the context of sexual activity. Spontaneous (involuntary) ejaculation (SE) without any sexual stimulation is a distressing symptom. Our understanding of SE is limited. Unfortunately, many physicians are no...

Introduction A growing number of genetic association studies have been performed to investigate the association between the genetic susceptibility alleles and the risk of premature ejaculation (PE); however, the results remain inconclusive. Objectives This systematic review aimed: (i) to determine whether an association exists between gene(s) or a...

Key Points • Defects in the genes regulating gonadal determination generally result in defective organ formation and a subset of disease states grouped under the title “disorders of Sex Determination” or DSD. • Reaching a genetic diagnosis, taking into account the clinical and biochemical phenotypes, has an impact on the provision of medical care a...

The aim of this study was to evaluate the levels of adiponectin in diabetic patients with and without erectile dysfunction (ED). In addition, the correlations of adiponectin with the scores of international index of erectile function (IIEF) and total testosterone levels were explored in diabetic and nondiabetic patients with ED. The study included...

Delayed ejaculation (DE) is a poorly defined and uncommon form of male sexual dysfunction, characterized by a marked delay in ejaculation or an inability to achieve ejaculation. It is often quite concerning to patients and their partners, and sometimes frustrates couples’ attempts to conceive. This article aims to review the pathophysiology of DE a...

Purpose: Delayed puberty (DP) is a common condition caused by the deficient production or action of gonadotropin-releasing hormone, gonadotropins, or androgens. It is often quite concerning to patients and can affect psychosocial well-being of patients. This review addresses developments in the diagnosis and treatment of male DP, highlighting some...

Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically. We also highlighted specific settings where drugs could be introduced to medical practice. Electronic databases were searched from 1966...

Introduction: Tramadol exhibits an effect profile similar to that of opioid agonists, and tramadol abuse seems to be a problem for a number of countries. The relationship between tramadol and sexual function appears to be controversial. Men with premature ejaculation (PE) may benefit from taking tramadol off label; however, these patients live "on...

This study aimed to identify seminal Corynebacterium strains in infertile men with and without leucocytospermia. Semen samples from 60 infertile men were allocated into two equal groups: semen samples with leucocytospermia and semen samples without leucocytospermia. Semen culture for Corynebacterium species was carried out on Columbia agar medium c...

Purpose: Although oral phosphodiesterase 5 inhibitors (PDE5-Is) are efficacious for many men with erectile dysfunction, a relatively large subset of erectile dysfunction patients who do not respond to PDE5-Is has been identified. This review explored the possible alternative therapeutic strategies. Methods: The review was based on a previously pub...

Although oral phosphodiesterase 5 inhibitors (PDE5-Is) are highly efficacious for many men with erectile dysfunction (ED), a relatively large subset of ED patients who do not respond to PDE5-Is has been identified. This review assessed the possible factors related to nonresponse to PDE5-Is in patients with ED. The review was based on previously pub...

The varying patterns of premature ejaculation (PE), along with their types and severity, suggest that they might have differing pathogenesis. The possibility exists that the neurological disorders are involved in the pathogenesis of PE either through direct enhancement of the normal neurophysiologic mechanisms or by producing endocrine, metabolic o...

Purpose: We report on our experience with 10 hyperprolactinemic infertile men with macroprolactinemia to avoid unnecessary studies or treatment. Methods: Ten infertile men were recruited from a cohort of 62 infertile men with hyperprolactinemia for the determination of macroprolactin because of the absence of the usual symptoms associated with hyp...

Persistent Müllerian duct syndrome is a rare form of internal male pseudohermaphroditism. The condition is characterized by cryptorchidism and retention of Müllerian derivatives (uterus, fallopian tubes, and upper vagina). We report the case of a 29-year-old man with this syndrome, who presented for workup of infertility. The condition is associate...

Premature ejaculation (PE) is the most common male sexual complaint, and may exert a profound negative impact on the man's life and partnership. Using currently available treatment alternatives (e.g., selective serotonin uptake inhibitor, agents acting locally on the penis), PE can be treated in most, but not all patients. However, since long term...

This study aims to provide further insight into the phenotypic heterogeneity of Klinefelter syndrome (KS) by presenting clinical, hormonal, and genetic data from a large series of Egyptian infertile patients with KS. A retrospective case series of KS patients was studied over a period from January 2003 to April 2010. All patients underwent a comple...

In this study, we describe nine patients with 47,XYY presenting with male infertility. All patients were subjected to history taking, clinical examination, duplex ultrasonographic examination of the scrotum, endocrinological investigations and cytogenetic analysis of peripheral lymphocytes. Two patients tried intracytoplasmic sperm injection (ICSI)...

Introduction: Peyronie's disease (PD) is an acquired benign connective tissue disorder of the penis, characterized by the development of fibrotic plaques, that can cause different degrees of bending, narrowing or shortening. Medical treatment for PD remains a major challenge. Impressive progress in our understanding of the molecular mechanisms of...

Introduction: The ratio between research and successful targets in a disease class gives a good indication about the extent of the exploration of additional targets for diseases in that class. This ratio is still very low for the field of sexual medicine. 'Failures' in drug development can be highly instructive, but are not often addressed. Areas...

In contrast to premature ejaculation and secondary delayed ejaculation (DE), primary lifelong DE has not been studied extensively. In addition, there is no approved drug treatment. To explore the clinical and laboratory characteristics of a series of men complaining of lifelong DE and to report the response to bupropion. Nineteen consecutive men wi...

Although treatment of different types of sexual dysfunction has improved in the past decade with the introduction of phosphodiesterase type 5 inhibitors and selective serotonin reuptake inhibitors, response rates to these targeted therapies are variable. There are a number of studies in the published literature that provide proof-of-concept that ge...

Premature ejaculation (PE) is poorly defined but the most common male sexual complaint. It can be treated with strategies including oral pharmacotherapy, topical anaesthetics, behavioural therapy and surgery. Although PE is treatable in most, but not all, patients by currently available modalities, long term success rates have been disappointing. A...

Targeting smooth muscle cells (SMC) for sexual dysfunctions represents a major approach in the armamentarium of sexual dysfunction treatment. Erection is simply a manifestation of corporal SMC relaxation. Emmision and ejaculation depend on contractions of SMC of accessory sex organs. Recently, priapism is proposed to be a manifestion of phosphodies...

Rapid (premature) ejaculation (RE) is defined as persistent or recurrent ejaculation with minimal sexual stimulation before, upon, or shortly after penetration and before it is wished by the man or his partner. RE is the most frequently encountered sexual complaint of men and couples. Estimates suggest that as many as one third of all sexually acti...

One hundred and twelve renal transplant recipients and 40 patients with chronic renal failure undergoing maintenance haemodialysis were included in this study. Skin infections were the most common complication in renal transplant recipients (67.8%), with fungal infections being the most frequent (58%). Kaposi's sarcoma was found in three of our tra...

Rapid ejaculation is probably the most common form of male sexual dysfunction. Current research into the treatment of the condition has focused on centrally acting or topical desensitizing agents; however, no treatment has yet been approved. An alternative approach could be to develop drugs that act directly upon the target organ itself and our inc...

To investigate the outcome of intracytoplasmic sperm injection with fresh and cryopreserved-thawed testicular spermatozoa in the first cycle in patients with obstructive azoospermia (OA) and non-obstructive azoospermia (NOA), a total of 90 cases, 48 OA and 42 NOA were studied. All patients underwent sperm retrieval by testicular sperm extraction (T...

Rapid (premature) ejaculation (RE) is a very common sexual disorder. This condition may be primary or secondary to underlying disease. Control of RE has been primarily focused on behavioural therapy, topical anaesthetics, tricyclic antidepressants and selective serotonin reuptake inhibitors; however, an approved treatment does not exist. Recently,...

Studies on pityriasis amiantacea (PA) in the literature are limited and mostly retrospective. We prospectively analyzed the clinical and etiopathologic factors in a large series of PA diagnosed at our department within a defined period (2000-01). All PA patients who attended our department were evaluated clinically and underwent bacteriologic, myco...

The epidemiology of leprosy in rural Egypt is unknown. This prospective household survey was conducted in a high-prevalence Egyptian village in order to explore the epidemiologic characteristics of the disease and to determine the possible socioeconomic and HLA genotype risk factors. The subjects of the study were the residents of Kafr-Tambul villa...

The objectives of this study were to define the role and haemodynamic features of penile vascular insufficiency in impotent renal transplant recipients (RTR) as well as to establish the possible vascular risk factors for impotence in these patients. A total of 54 RTR (35 impotent and 19 potent) and 21 potent healthy subjects were included in this s...

The objective was to compare the efficacy and safety of the as needed use of clomipramine, sertraline, paroxetine, sildenafil and the pause-squeeze technique in treatment of primary premature ejaculation. A prospective double blind randomized crossover study involving 31 patients was performed. Treatment phases comprised five 4-week consecutive tre...

Some studies have addressed the epidemiology of scabies among rural populations in developing countries; however, the epidemiology of scabies among the rural population in Egypt is unknown. We sought to determine the magnitude of scabies infestation in an Egyptian village and to evaluate the control measures after 1 year. This study was carried out...

Khite (also known as fatlah in Egypt) is a manual technique of temporary vellus hair removal that is widely performed in the Middle East. The technique of khite is reviewed as illustrated. Khite is an effective method of removing unwanted vellus hairs. Dermatologists in all parts of the world should be familiar with khite, because the ease of inter...

A total of 34 kidney transplant recipients (18 infertile and 16 fertile) and 31 nontransplant persons (15 infertile and 16 fertile) were included in this study. All subjects were assessed clinically and by measurement of basal concentrations of total testosterone, FSH, cyclosporine whole blood trough levels, serum creatinine, haemoglobin and semen...

The frequency of human leucocytic antigens (HLA) were studied in 27 patients with cutaneous leishmaniasis to evaluate the role of HLA antigens as genetic markers in the pathogenesis of this protozoal skin infection. A significant statistical association was observed between HLA-A11, -B5 and -B7 antigens and diffuse cutaneous leishmaniasis. In concl...