Hyun Jin Shin

Konkuk University | KU · Department of Ophthalmology

Purpose: The aim of this study was to investigate binocular visual function and ocular fatigue after the use of smart glasses.Methods: A total of 17 healthy volunteers (age range 13-45 years) were examined for ocular fatigue before and after watching videos for 20 minutes with a binocular smart glasses device. Subjective ocular fatigue was evaluate...

Strabismus can be caused by abnormal tension of the extraocular muscles (EOMs) attached to the eyeball in superior, inferior, lateral, medial, superior oblique, and inferior oblique positions. Evaluating the tension in each EOM is crucial for surgical planning in strabismus, which is conducted by adjusting the tension on the EOM. The purpose of thi...

Due to anatomic proximity to the surgical site, iatrogenic trauma to the frontal branch of the facial nerve (FbFN) with resultant brow paralysis is a recognized major complication of temporal direct browplasty. This study was aimed to elucidate the course of the FbFN in the area superolateral to the brow in order to facilitate safer temporal direct...

Background: The inferior temporal septum (ITS) is a fibrous adhesion between the superficial temporal fascia and the superficial layer of the deep temporal fascia (sDTF). This study identified detailed anatomical relationship between the ITS and the temporal branch of the facial nerve (TBFN) for facial nerve preservation during temple intervention...

Background Patients with strabismus are more likely to have mental health problems, including high rates of depressive symptoms and social phobia. Intermittent exotropia (IXT) typically occurs in early childhood and is more common in Asian populations. We aim to assess the health-related quality of life (HRQOL) concerns in children with intermitten...

Purpose: To determine the distribution of the angular artery (AA) in the medial canthal area with the aim of defining an arterial course to prevent AA injury during facial surgery in this region. Methods: We dissected 36 hemifaces of 18 cadavers. The horizontal distance from the vertical level through the medial canthus to the AAs was measured....

Background: To report the clinical manifestations of non-arteritic anterior ischemic optic neuropathy (NAION) cases after coronavirus disease 2019 (COVID-19) vaccination in Korea. Methods: This multicenter retrospective study included patients diagnosed with NAION within 42 days of COVID-19 vaccination. We collected data on vaccinations, demogra...

This study investigated the determination of detailed microstructure modeling of the trochlea of the superior oblique muscle (SOM) using micro-computed tomography (micro-CT) and modeling of a potential prototype for a trochlea implant using three-dimensional (3D) printing.We dissected 15 intact orbits of 15 embalmed cadavers. The trochleae of the S...

Purpose: To determine the relationship between consecutive esotropia (ET) and passive duction force (PDF) in patients with intermittent exotropia (XT). Methods: The study enrolled 70 patients in whom PDF was measured under general anesthesia prior to XT surgery. The preferred eye for fixation (PE) and the nonpreferred eye for fixation (NPE) were...

Peptides, short protein fragments, can emulate the functions of their full-length native counterparts. Peptides are considered potent recombinant protein alternatives due to their specificity, high stability, low production cost, and ability to be easily tailored and immobilized. Stem cell proliferation and differentiation processes are orchestrate...

The expression of GPR50 in CSLC and several breast cancer cell lines was assessed by RT-PCR and online platform (UALCAN, GEPIA, and R2 gene analysis). The role of GPR50 in driving CSLC, sphere formation, cell proliferation, and migration was performed using shGPR50 gene knockdown, and the role of GPR50-regulated signaling pathways was examined by W...

To determine the effectiveness of conjunctivoplasty using a modified argon laser photocoagulation method on patients with conjunctivochalasis (CCh). This study included 25 cases of symptomatic inferior CCh. After staining the surface of a redundant conjunctiva using a dark-purple marker, low-energy argon laser photocoagulation (500 μm spot size for...

Background To report about the therapy of benign eyelid tumors with a modified argon laser technique as an alternative to surgery. Methods Nineteen benign tumors of the eyelid were included in this study. After staining the surface of the tumor with a violet marker, low-energy argon laser photoablation was performed. A mean number of 312 spots (sp...

Tweety family member 3 (TTYH3) is a calcium-activated chloride channel with a non-pore-forming structure that controls cell volume and signal transduction. We investigated the role of TTYH3 as a cancer-promoting factor in bladder cancer. The mRNA expression of TTYH3 in bladder cancer patients was investigated using various bioinformatics databases....

Purpose: To determine the detailed microstructure modeling of the trochlea of the superior oblique muscle (SOM) using micro-computed tomography (micro-CT) and to model a potential prototype for a trochlea implant using three-dimensional (3D) printing Methods: We dissected 15 intact orbits of 15 embalmed cadavers. The trochleae of the SOM were deta...

The facial artery is the main artery supplying blood to the face and is known to have facial branches of the inferior labial, superior labial, lateral nasal and angular arteries. These known major branches of facial artery run medially, however, there are sometimes branches of the facial artery heading laterally. The purpose of the present study wa...

The purpose of this study is to identify the location of the orbital part of the lacrimal gland using external landmarks to facilitate effective botulinum toxin A (BTX‐A) injections for epiphora treatment. Dissections were performed on 45 hemifaces from 27 cadavers. The length, anterior protrusion, and thickness of the orbital part of the lacrimal...

Most LGPA showed typical findings such as well-defined,heterogenous lacrimal fossa mass with bony remodeling on CT, and hypointense to isointense on T1-weighted image, isointense to hyperintense on T2-weighted image, and moderate to marked enhancement on contrast-enhanced CT and MRI. CT provide more detail information about adjacent bone change and...

New technique for involutional entropion repair

Extracellular vesicles (EVs) are paracrine factors that mediate stem cell therapeutics. We aimed at evaluating the possible therapeutic and esthetic applications of EVs prepared from the waste human facial tissue-derived orbicularis oculi muscle stem cells (OOM-SCs). OOM-SCs were isolated from the ocular tissues (from elders and youngsters) after u...

Background: Glaucoma, is the most common cause of irreversible visual deficits, presents as an injury to the optic nerve and it is mainly associated with elevated intraocular pressure. The main symptom of glaucoma is a reduction of the visual field, which is usually a source of complaint at the advanced stage of disease. Because of visual deficit,...

Background This study aimed to determine the morphological changes in Asian lower eyelid epiblepharon patients after surgery. Methods The medical records of 59 patients who underwent lower eyelid epiblepharon repair were reviewed retrospectively. Eighty-nine patients who underwent strabismus surgery were set as the control group. The photographs f...

PurposeTo evaluate the passive duction force (PDF) in extraocular muscles (EOMs) in patients with intermittent exotropia (IXT) using a quantitative tension-measuring device.Methods This prospective, case–control study enrolled 25 patients with IXT and 26 age- and sex-matched controls. PDF was measured under general anesthesia as the eyeball was rot...

Background: Retrobulbar filler injection has recently been considered an ideal method for orbital volume enhancement due to its nontoxic, easily reversible, and noninvasive characteristics. This study determined the arterial distribution in the orbit with the aim of defining a safety zone for retrobulbar filler injections used to enhance the orbit...

Background/Aim: This study aimed to investigate the usefulness of in vivo bioluminescence imaging (BLI) to examine the role of matrix metalloproteinases (MMP)-2 and MMP-9 activation in the development and healing of ethanol-induced damage in the cornea of mice. Materials and Methods: Mouse corneal injury was induced by topical treatment with 20% et...

Background: Atopic dermatitis (AD) has been clarified that imbalance of bacterial and fungal communities in the skin and gut play key roles in immunologic dysfunction. Atopic keratoconjunctivitis (AKC), one of severe ophthalmic manifestation of AD, could be related with dysbiosis as same as AD. Objective: In this case-control study, the roles of...

The purpose of this study was to determine and compare the effects between injecting botulinum toxin A (BTX-A) transconjunctivally into the palpebral lobe and transcutaneously into the orbital lobe of the lacrimal gland in patients with epiphora due to lacrimal outflow obstruction. This randomized controlled study included 53 eyes of 31 patients wi...

Purpose: The objective of this study was to investigate the change in near visual function after the administration of oral silodosin to patients with lower urinary tract symptom (LUTS). Methods: This prospective study included treatment naïve patients who were scheduled to start treatment with silodosin for LUTS. A comprehensive ophthalmologica...

Purpose To compare the variations in ocular torsion measurements made using different fundus photographic methods. Methods We enrolled subjects with three conditions: (1) patients with intermittent exotropia (IXT) ( n = 44), (2) patients with unilateral superior oblique palsy (SOP) ( n = 10), and (3) normal subjects as controls ( n = 85). Ocular t...

PurposeEvaluating the passive duction force of the extraocular muscles is important for the diagnosis of and surgical planning for strabismus. This is especially relevant in patients with an observable limitation of duction movement. The purpose of this study was to validate passive duction forces in healthy subjects using a novel instrument.Method...

Accurate knowledge of extraocular muscle (EOM) tension is important for the diagnosis of and surgical planning for strabismus, such as choosing which eye to operate or determining the amount of muscle displacement. Previous evaluations of passive EOM tension have relied extensively on the experience and skill of ophthalmic surgeons, who generally p...

Purpose Knowledge of the distribution of intramuscular nerves of the extraocular muscles is crucial for understanding their function. The purpose of this study was to elucidate the intramuscular distribution of the oculomotor nerve within the inferior rectus muscle (IRM) using Sihler’s staining. Method Ninety-three IRM from 50 formalin-embalmed ca...

The aim of this study was to define the location of the accessory infraorbital foramen (AIOF) with reference to accessible external landmarks in order to facilitate orbital and oculoplastic surgical procedures in the maxillofacial region. Forty-four hemifaces from 25 cadavers were dissected. The lateral canthus, subnasal point, and lacrimal caruncl...

Purpose An infraorbital nerve (ION) block is widely used to accomplish regional anesthesia during surgical procedures involving the midface region. This study aimed to elucidate the exact location of the infraorbital foramen (IOF) in relation to clinically useful soft‐tissue landmarks for achieving an effective ION block. Methods Forty‐three hemif...

Introduction: Periorbital metastasis of colorectal cancer is rare. Therefore, herein, we report a patient with rectal cancer who presented with periorbital metastasis without any systemic metastasis. Patient concerns: The patient was a 57-year-old man who had a painless nodule on his left eyelid. Diagnosis: The patient presented with loose and...

Purpose: To evaluate the effectiveness of conjunctival cyst removal using a modified method of argon laser photoablation. Methods: Seventeen cases of symptomatic conjunctival cysts were included. After staining the surface of a conjunctival cyst with a dark purple marker, the cyst was incised using a 26-gauge needle. Low-energy argon laser photo...

Purpose: The intramuscular nerve distribution in the extraocular muscles is important for understanding their function. This study aimed to determine the intramuscular nerve distribution of the oculomotor nerve within the inferior oblique muscle (IO) using Sihler’s staining. Method: Seventy-two IOs from 50 formalin-embalmed cadavers were investigat...

The aim of this study was to identify the three-dimensional topography of the sphenoid door jamb (SDJ) in the lateral orbital wall and to propose navigational guidelines for safe deep lateral decompression using surgical landmarks. The 120 orbits and SDJs of 60 subjects were three-dimensionally reconstructed using Mimics software. The mean volumes...

The aim of the study was to report the surgical outcome of mini-incisional correction method to treat involutional entropion. This is a retrospective interventional case series of 46 eyelids in 31 patients with involutional entropion and significant ocular irritation. In this technique, after turning the lower eyelid inside out, threads are introdu...

Successful oculofacial procedures require the availability of a reliable surgical and anatomic landmark. This study aimed to determine the usefulness of the lateral canthus as a surface landmark. Seventy‐seven from 42 Korean cadavers were dissected. The horizontal distance from the lateral canthus to the lateral orbital margin and the vertical dist...

Purpose: The intramuscular nerve distribution in the extraocular muscles may be crucial for understanding their physiological and pathological responses. This study aimed to determine the oculomotor nerve distribution in the medial rectus muscle (MR) using Sihler’s staining. Method: Thirty-seven MRs from 23 cadavers were investigated. The MR includ...

Purpose: To determine the effect of granuloma formation in the ostium and intralesional steroid injections (ISIs) on the surgical outcome after endoscopic dacryocystorhinostomy (DCR) in patients with primary acquired nasolacrimal duct obstruction (PANDO). Methods: One hundred and eighty-three cases involving 142 patients were enrolled. The ostiu...

Purpose: To determine whether an infratrochlear nerve block (ITB) can reduce the oculocardiac reflex (OCR) during strabismus surgery on the medial rectus muscle (MR). Methods: This prospective, randomized single-masked study included 60 patients with intermittent exotropia scheduled for unilateral MR resection/lateral rectus recession under gene...

Aims To investigate the clinical and imaging features of primary and recurrent lacrimal gland pleomorphic adenoma (LGPA), as well as lacrimal gland malignant epithelial tumours (LGMET). Methods Retrospective comparative case series from September 2000 to September 2016 in a single tertiary institution. Medical records of cases with histopathologic...

Aims: To elucidate the intramuscular distribution and branching patterns of the abducens nerve in the lateral rectus (LR) muscle so as to provide anatomical confirmation of the presence of compartmentalization, including for use in clinical applications such as botulinum toxin injections. Methods: Thirty whole-mount human cadaver specimens were dis...

Background: The supratrochlear nerve (STN) is relatively superficial and therefore vulnerable to iatrogenic injury. Objective: To elucidate the course of STN with reference to the lacrimal caruncle, with the aim of preventing nerve injury during surgery in the forehead region. Materials and methods: Thirty-four hemifaces from 18 Korean cadaver...

Purpose To elucidate the course of the supraorbital nerve (SON) with reference to the lacrimal caruncle in order to facilitate safer direct browplasty by preventing nerve injury. Methods Thirty-four hemifaces from 18 embalmed Korean cadavers were dissected. A vertical line through the upmost point of the lacrimal caruncle and a horizontal line thr...

Objective: To determine the factors associated with rhinostomy shape after endoscopic dacryocystorhinostomy (DCR) in patients with primary acquired nasolacrimal duct obstruction. Design: Retrospective comparative study. Setting: University hospital. Participants: 102 cases in 70 patients were included in the study. Main outcome measure: Al...

Purpose: The aim of the study was to elucidate the positional relationship of the ethmoidal foramens (EFs) with reference to the nasion to facilitate prediction of the exact location of EFs, the optic canal (OC), and the frontoethmoidal suture (FS), and thereby avoid complications during complex surgery involving the medial wall of the orbit. Mat...

Purpose: The aim of the present study was to assess normal eyeball protrusion from the orbital rim using two- and three-dimensional images and demonstrate the better suitability of CT images for assessment of exophthalmos. Methods: The facial computed tomographic (CT) images of Korean adults were acquired in sagittal and transverse views. The CT...

Background: Blocking the supraorbital nerve (SON) and supratrochlear nerve (STN) by injecting anesthetic distal to the surgical site has the advantage in upper eyelid surgery that avoids obscuring the surgical landmarks and compromising the levator function. Objective: To identify the emerging points of the SON and STN in the supraorbital margin...

Purpose: Clinical study findings regarding the association between repeated injections of intravitreal anti-vascular endothelial growth factor (VEGF) and the risk of retinal nerve fiber layer (RNFL) thinning in patients with age-related macular degeneration (AMD) have been inconsistent. We investigated this association by using a meta-analysis. M...

The present invention relates to a large-sized vinyl chloride seed with an average particle size of 0.65 to 1.5 μm, a vinyl chloride resin with improved low-viscosity properties, and preparation methods thereof. The preparation of the large-sized vinyl chloride seed includes adding a vinyl chloride monomer, an emulsifier, and a polymerization initi...

To identify the location of the inferior oblique muscle (IOM) origin with reference to the lacrimal caruncle in order to facilitate safer oculofacial surgery by preventing morbidity associated with IOM injury. Thirty-seven intact orbits of 20 embalmed Asian cadavers were dissected. The location of the medial border of the IOM origin was determined...

There is provided an apparatus for output buffering having a half-swing rail-to-rail structure. The apparatus provides output buffering by using a switch structure in order to attain a high slew rate and low power characteristics, thereby reducing current consumption. The provided apparatus for output buffering having a half-swing rail-to-rail stru...

The purpose of this study was to identify the location of the trochlea in order to prevent injury during orbitofacial surgery and to determine the reliability of the lacrimal caruncle as a visible external landmark for the trochlea at the superomedial orbital rim. Fifty-one orbits from 27 embalmed cadavers were dissected. The lacrimal caruncle and...

Aims: To compare the visual performances and patient satisfactions of conventional monovision, which corrects the dominant eye for distance vision, and crossed monovision, which corrects the non-dominant eye for distance vision in patients with pseudophakia. Methods: This prospective randomised study was conducted in 59 patients who underwent im...

Aim: To investigate the aqueous erythropoietin (EPO) levels and associated factors in patients with acute retinal vein occlusion (RVO). Methods: The aqueous EPO level was measured in patients with macular edema (ME) secondary to acute branched retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). Aqueous fluid from cataract pat...

Provided are a vinyl chloride-based resin formed by polymerization of vinyl chloride-based small seed particles having an average particle diameter range of 0.15 μm to 0.5 μm prepared by emulsion polymerization and vinyl chloride-based large seed particles having an average particle diameter range of 0.51 μm to 0.8 μm prepared by micro-suspension p...

Purpose: To investigate the effect of multiple intravitreal injection of anti-VEGF on the retinal nerve fiber layer (RNFL) in AMD, diabetes mellitus retinopathy (DMR), and retinal vein occlusion (RVO). Methods: In this retrospective controlled case series, we reviewed the AMD, DMR, and RVO patients who received more than three anti-VEGF injectio...

Purpose: To investigate the correlation of foveal microstructural changes with vision after intravitreal ranibizumab injection in eye with choroidal neovascularization (CNV) secondary to age-related macular degeneration. Methods: We retrospectively studied 40 eyes of 40 patients with neovascular age-related macular degeneration who had no previo...

To investigate the correlation between fundus autofluorescence (FAF) and the results of spectral-domain optical coherence tomography (SD-OCT) as well as visual acuity (VA) in patients with diabetic macular edema (DME) and to determine the visual prognostic factors. Retrospective, interventional case series. Sixty-one patients with DME who underwent...

To evaluate the association between chronic kidney disease (CKD) and early age-related macular degeneration (AMD) and peripheral retinal drusen in Korean adults 50 years and older. This study included 3008 participants aged 50-87 years. Early AMD was assessed from retinal photographs based on modified Wisconsin AMD grading system and peripheral ret...

To investigate the correlation between foveal photoreceptor integrity and final visual acuity (VA) after treatment of eyes with diabetic macular edema (DME), and to determine the visual prognostic factors. We retrospectively studied 61 eyes of 52 patients with DME who were treated successfully with intravitreal triamcinolone injection (IVTA). Using...

To compare the peripapillary retinal nerve fiber layer (RNFL) thickness of normal patients and those with various glaucoma diseases by time domain (Stratus) and spectral domain (Spectralis) optical coherence tomography (OCT). The RNFL thickness as measured by the Stratus and Spectral OCT was compared (paired t-test). The relationship and agreement...

To investigate the correlation between foveal photoreceptor integrity and final visual acuity after treatment of eyes with neovascular age-related macular degeneration, and to determine the visual prognostic factors. We retrospectively studied 40 eyes of 40 patients with neovascular age-related macular degeneration who were treated successfully wit...

To investigate the correlation between integrity of foveal photoreceptor layer and initial as well as final visual acuity (VA) after successful resolution of macular oedema (ME) associated with retinal vein occlusion (RVO). We retrospectively studied 31 eyes of 31 patients with resolved ME secondary to RVO. The integrity of foveal photoreceptor lay...

To examine the association of diabetes mellitus and early age-related macular degeneration (AMD) in Korean adults 50 years and older. This study included 3008 participants aged 50 to 87 years. Early AMD was assessed from retinal photographs based on a modified Wisconsin AMD grading system. Diabetes mellitus was defined as a fasting glucose level of...

To report the results of pars plana vitrectomy for the treatment of symptomatic lamellar macular holes.