Hossein Hashempour

Azerbaijan Shahid Madani University | AUSM · Department of Chemistry

Drought stress is a significant environmental constraint that seriously limits crop productivity. A two-year field study was carried out as a split plot based on a randomized complete block design (RCBD) with three replicates in the experimental station of the agricultural faculty of Azarbaijan Shahid Madani University, Tabriz, Iran. This study eva...

Over the past two decades, microfluidic-based separations have been used for the purification, isolation, and separation of biomolecules to overcome difficulties encountered by conventional chromatography-based methods including high cost, long processing times, sample volumes, and low separation efficiency. Cyclotides, or cyclic peptides used by s...

In order to study the effects of the application of two -plant growth regulators/proline on some physiological characteristics in fennel under water -deficit stress conditions, an experiment was conducted as a split -plot based on a randomized complete block design with three replications at the research farm, agricultural faculty of Azarbaijan...

Cyclotides are a class of cyclic peptides that can be self-assembled. This study aimed to discover the properties of cyclotide nanotubes. We performed differential scanning calorimetric (DSC) to characterize their properties. Then, we incorporated the coumarin as a probe and identified the morphology of nanostructures. The stability of cyclotide na...

Cyclotides as a cyclic peptide produced by different groups of plants have been a very attractive field of research due to their exceptional properties in biological activities and drug design applications. The importance of cyclotides as new biological activities from nature caused to attract researchers to develop new separation systems. Recent g...

Cyclotides are categorized as cyclic peptides consisting of 28–37 amino acids. The cyclic nature, as well as the presence of three intramolecular disulfide bonds, resulted in the extraordinary stability of the cyclotides. In addition, they have the ability to self-associate. In this study, we investigated the ability of the cyclotides to be self-as...

Siklotidler (CT), farklı bitki gruplarından izole edilen, disülfid açısından zengin, baştan sona siklik peptit omurgaları ve üçkorunmuş disülfür bağlarının birbirine kenetlenen düzenlemeleri ile karakterize edilen ve normal olarak konakçı savunmaajanları olarak işlev gören biyoaktif küçük peptitlerdir. CT dizileri tipik olarak 28 ila 37 amino asit...

Self-assembling peptides have attracted researchers' attention recently. They are classified as biomedical materials with unique properties formed in response to environmental conditions. Cyclotides are macrocyclic plant-derived peptides containing 28-37 amino acids that have the ability to self-assemble. Herein, we investigated the effect of pH, t...

Background Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that causes chronic inflammation. Cyclotides are small plant proteins with a wide range of biological activity, making them a target for researchers to investigate. This study was conducted to investigate the possible effects of cyclotide-rich fractions from...

Four sesquiterpene lactones, astrodaucanolide A-D (1-4) with unique structures, toghether with two known phenylpropanoid esters (5 and 6) were isolated from a flower extract of Astrodaucus orientalis. The structures were established by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry (HRESIMS), and the absolute configuration of 1-4...

Cyclotides (CTs) are cyclic bioactive peptides obtained from different groups of plants and function normally as host defense agents. CTs have become an attractive field from a medical point of view and drug development due to their exceptional stability, structural plasticity, gram-negative selective antimicrobial effect, and anti-cancer propertie...

Cyclotides (CTs) as a cyclic peptide obtained from different groups of plants have been very attractable field of research for scientists because of their specific properties like their natural function as host defense agents. CTs are bioactive peptides from plants that characterized by their head-to-tail cyclic backbone and knotted arrangement of...

Oliveria decumbens Vent, an annual herb, belonging to the Apiaceae family, traditionally used to cure diseases such as gastrointestinal, infections, diarrhea and fever. In this study, we aimed to investigate the effect of ultrasonic pre-treatment prior to hydrodistillation (US-HD) on extraction of O. decumbens essential oil (EO). Optimization of th...

This study designed to conduction an investigation into the effect of low-voltage electric field (EF) on the phenolic acids extraction from plant materials. In this regards, Nepeta racemosa was selected to study as a source of phenolic acids. The EF extracted phenolic acids amounts were compared with ultrasound-assisted and maceration extractions....

Drought stress is one of the most important environmental stresses limiting the growth and effectiveness of plants, however, exogenous application of salicylic acid (SA) as a signaling molecule may counteract the adverse effects of stress on plant productivity. The present study was designed to determine the effects of different concentrations of S...

In this study, fatty acid (FA) composition of aerial parts of selected Salvia species from Iran was analyzed by gas chromatography. The amount of FAs was quantified for leaf and shoot of species as mg per kg (mg kg-1) of dry weight. The results showed that FA contents of aerial parts for the studied plants vary significantly between 73.05 and 739.5...

Water stress is the most important environmental factor that limits plant growth and yield. However, plant growth-promoting rhizobacteria (PGPR) can stimulate resistance of the plant host in unsuitable environmental conditions such as water stress. In order to evaluate whether PGPR improve morphological, physiological, and phytochemical traits of t...

Cyclotides describe a unique cyclic peptide family that displays a broad range of biological activities including uterotonic, anti-bacteria, anti-cancer and anti-HIV. The vigno cyclotides consist of vigno 1-10 were reported recently from viola ignobilis. In the present study, we examined the effects of vigno 5, a natural cyclopeptide from Viola ign...

Keywords: " Fatty acids " , " Salvia " , " Lamiaceae " N-6 PUFAs and n-3 PUFAs play multiple roles in cell membrane structure, lipid metabolism, blood clotting, blood pressure, controlling inflammation, which appear to contribute to their healthy benefits. It is well known that various fatty acids have anti-inflammatory activities [1]. Salvia is th...

Curcumin is the main bioactive constituent of turmeric rhizome. A wide range of pharmacological activities of curcumin have been reported. There has been growing interest in development of preparative purification of curcumin. Objective of this study is isolation of curcumin from other components by using recycling preparative HPLC method from curc...

Cyclotides are a very abundant class of plant peptides that display significant sequence variability around a conserved cystine-knot motif and a head-to-tail cyclized backbone conferring them with remarkable stability. Their intrinsic bioactivities combined with tools of peptide engineering make cyclotides an interesting template for the design of...

Abstract: Cyclotides are macrocyclic knotted peptides originating from plants. They are extremely stable and have a range of bioactiv- ities including anti-HIV and insecticidal activity. Given the stability of the cyclotide framework, there is interest in using these peptides as scaffolds in drug design. In the current study, we have shown that na...

Summary. In this study, different columns, including C18, C8, and CN, were investi- gated for the analysis of cyclotides in Viola ignobilis. Because of the complexity of the cyclotide matrix in V. ignobilis and the presence of their different isomers, suitable sepa- rations could not be obtained by high-performance liquid chromatography (HPLC). Als...