Hesham Saleh Khalil Almoallim

King Saud University | KKUH · College of Dentistry

Due to the high solubility of Cd in water, it is considered a potential toxin which can cause cancer in humans. In plants, it is associated with the development of oxidative stress due to the generation of reactive oxygen species. To overcome this issue, the roles of different plant hormones are vital. Strigolactones, one of such natural plant horm...

Salinity stress significantly impacts crops, disrupting their water balance and nutrient uptake, reducing growth, yield, and overall plant health. High salinity in soil can adversely affect plants by disrupting their water balance. Excessive salt levels can lead to dehydration, hinder nutrient absorption, and damage plant cells, ultimately impairin...

Chili (Capsicum annuum L.) is one of the most important vegetable cum spice crops grown throughout the world. Evaluation of genotypes based on morphological and yield contributing traits provides the opportunity to assess variability and select superior genotypes. The present investigation was carried out from April 2018 to November 2018 in the sum...

Salinity stress is a significant challenge in agricultural production. When soil contains high salts, it can adversely affect plant growth and productivity due to the high concentration of soluble salts in the soil water. To overcome this issue, foliar applications of methyl jasmonate (MJ) and gibberellic acid (GA3) can be productive amendments. Bo...

Segmenting nuclei in histopathological images presents challenges due to variable sizes and overlapping regions, compounded by inter-class heterogeneity in shape and function. To overcome these, we proposed a robust deep learning architecture integrated with a novel edge detection technique based on local standard deviation. This method efficiently...

Female mortality is frequently caused by ovarian cancer (OC). Because of its late detection, ovarian cancer seems to have a low survival rate, and new techniques are required for its early identification. One of the more prevalent gynecologic cancers is ovarian cancer. The various diagnoses of ovarian cancer depend on the efficient classification o...

Background: Glioma is a recurrent form of primary malignant cancer that occurs in the brain and central nervous system. The adults are the major victims of gliomas, and the men are mostly affected. At present, gliomas are treated with surgical resection followed by radiation and the administration of chemodrugs such as temozolomide. The invasive an...

The advancement of digital microscopic scanning has made the study of image processing as well as categorization an exciting field of diagnostic studies. The literature describes a number of methods for detecting acute lymphocytic leukemia (ALL) using blood smear pictures. The goal of this research is to create an efficient approach for segmenting...

Because of the two sequenced methods stated above, SG and AMP, are being used in different ways, present a deep learning methodology for taxonomic categorization of the metagenomic information which could be utilized for either. To place the suggested pipeline to a trial, 1000 16 S full-length genomes were used to generate either SG or AMP short-re...

This study was designed to appraise the antioxidant and anticancer competence of solvent extracts of Tecoma stans (Linn) and analyze the phytoligands interaction against Bcl2 VEGFR2 through in silico studies. The phytochemical analysis revealed that the ethyl acetate extract contains more number of pharmaceutically valuable phytochemicals than othe...

In the current age of technology, various diseases in the body are also on the rise. Tumours that cause more discomfort in the body are set to increase the discomfort of most patients. Patients experience different effects depending on the tumour size and type. Future developments in the medical field are moving towards the development of tools bas...

The incorporation of textile technology and medical science has emerged into a new field known as medical textiles. Here, we formulated zinc oxide nanoparticles from B. serrata resins (BS-ZnONPs) and coated it on cotton fabrics for antibacterial and wound healing applications against the nosocomial pathogens. The synthesized BS-ZnONPs were characte...

The development of alternate sources for the production of natural pigments has been targeted to overcome the utilization of artificial coloring, which is dangerous to human health and the environment. Dyes extracted from microbial sources are more important for beneficial food industry use, especially Monascus spp. produces several critical second...

Introduction Oral cancer is the sixth most common cancer worldwide with increased mortality cases. Recently, nanomedicines have received greater research attention for cancer treatments. The current exploration focuses to formulate the zinc oxide nanoparticles from C.verum bark (CV-ZnONPs) and assess its in vitro anticancer potentials against oral...

Background: Human papilloma virus (HPV) infection forms a major etiological factor for oropharyngeal cancer (OPC), which has exhibited increased global incidence. Aim: To compare the knowledge regarding HPV, its association with OPC, and HPV vaccine among students from different countries, years of the undergraduate program, and gender. Methods...

The aim of this research was to identify a biopolymer producing potential actinobacteria candidate from polluted soil. The Streptomyces toxytricini D2 was enumerated as potential biopolymer producer, which was isolated and characterized using 16S rRNA sequencing. The S. toxytricini D2 produced polymeric granules were categorized through FTIR, 1H NM...

Objective Diabetic nephropathy (DN) is a foremost complications among diabetic patients worldwide with growing prevalence and mortality rates annually. Nearly, 25-40 % of diabetic patients suffer from DN. Objective The current research work was done to ascertain the therapeutic properties of ononin against the streptozotocin (STZ)-challenged DN in...

Background: Coronavirus is an emerging respiratory pathogen that causes coronavirus disease‑2019 (COVID‑19), as per the Chinese Center for Disease Control and Prevention. Objective: This study aimed to assess the state of awareness and extent of knowledge about COVID‑19 among dental students from India, Pakistan, and Saudi Arabia. Materials and M...

Contexte: Le coronavirus est un agent pathogène respiratoire émergent qui provoque la maladie à coronavirus-2019 (COVID-19), selon le Centre chinois chinois de contrôle et de prévention des maladies. Objectif: Cette étude visait à évaluer le degré de sensibilisation et l’étendue des connaissances sur le COVID-19 parmi les étudiants en médecine dent...

In the current research, AA6082 aluminum alloy matrix composites (AAMCs) incorporated with various weight fractions of titanium diboride (0, 3, 6 and 9wt. %) were prepared via an in-situ casting technique. The exothermic reaction between inorganic powders like dipotassium hexafluorotitanate (K2TiF6) & potassium tetrafluoroborate (KBF4) in molten Al...

Zerovalent Iron Nanoparticles (MC-ZVI NPs) were synthesized from Musa coocinea peel extract as reducing and stabilizing agent using a novel synthesis technique. The synthesis of MC-ZVI NPs was confirmed using UV–Vis spectroscopy showing a absorption maximum at 341 nm. Further the chemical and structural characterization of MC-ZVI NPs was performed...

The purpose of this study was to determine the antibacterial competence of various solvent leaf extracts of Pedalium murex against bacteria that cause skin infections such as Staphylococcus aureus, (folliculitis), Streptococcus pyogenes (impetigo), and Corynebacterium sp. (pitted keratolysis). The presence of phytochemicals, antioxidant activity, a...

This research was designed to evaluate the AgNPs synthesizing potential of methanol leaf extract of Justicia adhatoda and assessed their potential against multi-drug resistant microbes and in anticancer activity. The results obtained from this study showed that the methanol leaf extract of J. adhatoda has the potential to synthesized AgNPs, and it...

Background: While the prevalence of rheumatic heart disease (RHD) in Egypt is relatively high, data on the awareness of Egyptians about the cause of RHD are lacking. Methods: Using a pre-tested questionnaire, we performed a multicenter survey of outpatients attending 15 university hospitals across Egypt. Results: A total of 6958 participants w...

Citation: Sayed, A.K.; Se'eda, H.; Eltewacy, N.K.; El Sherif, L.; Ghalioub, H.S.; Sayed, A.; Afifi, A.M.; Almoallim, H.S.; Alharbi, S.A.; Abushouk, A.I. Awareness of Rheumatic Heart Disease in Egypt: A National Multicenter Study. J. Cardiovasc. Dev. Dis. 2021, 8, 108.

Microbial infections are a general public health problem worldwide, and their resistance to antibiotics has increased rapidly. The prevention of microbial growth on the surface of cotton fabric is essential to control skin-related infections. In this work, we evaluated A.calamus- zinc oxide nanoparticle (AC-ZnONPs) coated cotton fabrics for antibac...

The COVID-19 pandemic has caused largescale morbidity and mortality and a tremendous burden on the healthcare system. Healthcare workers (HCWs) require adequate protection to avoid onward transmission and minimize burden on the healthcare system. Moreover, HCWs can also influence the general public into accepting the COVID-19 vaccine. Therefore, de...

Green material/solvents have been extensively investigated for biomedical applications, including drug delivery applications.In this work, the material design of deep eutectic solvents (DESs) grafted chitosan (CS) with biotin nanocarrier was synthesized from green solvents or deep eutectic solvents and evaluated for sustained anticancer drug releas...

In this study, the botanical pesticide Suaeda maritima (L) leaf extract was evaluated against the yellow stem borer (YSB), Scirpophaga incertulas Walker (Lepidoptera: Pyralidae), and bacterial leaf blight disease Xanthomonas oryzae pv. oryzae (Xoo), of rice. S. maritima leaves were powdered and subjected to various organic solvents, like petroleum...

The family Calliphoridae is a group of heterogenous calyptrate flies with a worldwide distribution including species of ecological, veterinary, medical, and forensic importance. Notorious for their parasitic habits, the larvae of many blowflies are characterised – like some other dipteran larvae – by their ability to develop in animal flesh. When p...

In recent years, silver nanoparticles have been used as modern chemotherapeutic drugs to treat several cancers such as pancreatic, breast, prostate, and blood cancers. No previous reports demonstrated the in vitro anti‐human pancreatic cancer effects of the novel chemotherapeutic drug formulated by silver nanoparticles containing Berberis thunbergi...

Coronavirus disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Up to date, there has been no specific cure to treat the disease. Indonesia is one of the countries that is still fighting to control virus transmission. Yet, at the same time, Indonesia has a rich biodiversity of natural medi...

We herein report the facile synthesis of ternary hybrid g-C3N4@Ag-ZnO nanocomposites (NCs) via a simple physical mixing method. The synthesized g-C3N4@Ag-ZnO NCs were successfully characterized using different spectroscopic techniques such as X-Ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), energy...

Objective The present study assessed physico-chemical, techno-functional, thermal and textural characteristics of propolis samples (n=30) collected from four Northern zones of India. Methods The propolis samples were analyzed according to the Association of Official Analytical Chemists (AOAC) official protocols for their ash, moisture, and protein...

The family Calliphoridae is a group of heterogenous calyptrate flies with a worldwide distribution including species of ecological, veterinary, medical, and forensic importance. Notorious for their parasitic habits, the larvae of many blowflies are characterised-like some other dipteran larvae-by their ability to develop in animal flesh. When paras...

Leukemia is amongst the cancers accountable for substantial mortality around the world. Tomentosin is a bioactive compound with a pharmacological significance, and its anticancer property against human leukemia MOLT‐4 cell line has never been reported. Hence, the objective of this study was to explore the anticancer activity of tomentosin in MOLT‐4...

Over the past few years, the photogenic fabrication of metal oxide nanoparticles has attracted considerable attention, owing to the simple, eco-friendly, and non-toxic procedure. Herein, we fabricated NiO nanoparticles and altered their optical properties by doping with a rare earth element (lanthanum) using Sesbania grandiflora broth for antibacte...

This study deals with the green synthesis of chromium oxide (Cr2O3) nanoparticles using a leaf extract of Abutilon indicum (L.) Sweet as a reducing and capping agent. Different characterization techniques were used to characterize the synthesized nanoparticles such as X-ray diffraction (XRD), Scanning electron microscope (SEM), Transmission electro...

The color of food is a critical factor influencing its general acceptance. Owing to the effects of chemical colorants on health, current research is directly aimed at producing natural and healthy food colorants from microbial sources. A pigment-producing fungal isolate, obtained from soil samples and selected based on its rapidity and efficiency i...

Objectives: Alcohols oxidation is one of the important organic transformation in fine chemical industries. Prevailing processes are hazardous due to involvement of stoichiometric oxidants and homogeneous catalysts. In the present work, oxidation of cinnamyl alcohol was carried out using unconventional, affordable , and feasible heterogeneous cataly...

Candida infections and related mortality have become a challenge to global health. Nontoxic and natural bioactive compounds from plants are regarded as promising candidates to inhibit these multidrug resistant strains. In the present study, in vitro assays and in silico molecular docking approach was combined to evaluate the inhibitory effect of cr...

Betulinic acid is one such natural pentacyclic triterpenoid compound, holding various pharmacological properties but its poor bioavailability is the only limitation. One of the biological macromolecules such as Lignin is a plant-derived aromatic, eco-friendly and low-cost polymer that certainly self-assembles into nano-sized colloids. Therefore, on...

Chitosan is a linear polysaccharide and non-toxic bioactive polymer with a wide variety of applications due to its functional properties such as ease of modification, and biodegradability. In this investigation, magnetic cores (Fe3O4) were synthesized using a fabrication method involving coprecipitation of Fe²⁺ and Fe³⁺. Then the magnetic nanoparti...

Objectives The present work aims at the synthesis of metal-doped and undoped titania photocatalysts for the degradation of methylene blue and neutral red dyes. Methods: Un-doped and metal-doped titania photocatalysts were synthesized by hydrothermal treatment, calcined at 673K, and were evaluated by SEM, XRD, and XPS techniques for their phase comp...

Introduction: The adhesion of bacteria to implanted devices in the human body is a major risk factor that can affect the long-term success of these devices. Staphylococcus epidermidis (S. epidermidis) have few virulence factors which have been identified and reported including autolysin (AtlE), Polysaccharide Intercellular Adhesin (PIA), Fibrinogen...

Background: The Cone Beam Computed Tomography (CBCT) is currently being used as the most common diagnostic method to evaluate the bone density of the maxilla and the mandible for planning dental implant. Aim: The aim of the study is to check the quantitative alveolar bone density in complete or partial edentulous and dentulous male and female pati...

antimicrobial resistance pattern of Gram negative nosocomial pathogens

Systematic review and Meta analysis was conducted to determine Efficacy of Cefixime for Treating Gonococcal Infections

This systematic review is focused on the evidence available for the treatment of infections in adult patients presenting with septic arthritis, acute and chronic osteomyelitis and Prosthetic Joint Infections (PJIs). Clinical outcomes, effectiveness and adverse events of intravenous (IV) glycopeptides and aminoglycosides and local aminoglycosides we...

Dental diseases have detrimental effects on the functionality and quality of life of individuals. In addition, a strong relationship has been established between various oral and systemic diseases. In fact, the prevention and treatment of dental caries and periodontal disease have been shown to reduce the risk of diabetes and heart disease signific...

Dental implants have been used in a variety of different forms for many years. Since the mid-20th century, there has been an increase in interest in the implant process for the replacement of missing teeth. Branemark was one of the initial pioneers who applied scientifi cally based research techniques to develop an endosseous implant that forms an...

Dental diseases have detrimental effects on the functionality and quality of life of individuals. In addition, a strong relationship has been established between various oral and systemic diseases. In fact, the prevention and treatment of dental caries and periodontal disease have been shown to reduce the risk of diabetes and heart disease signific...

Introduction: Chemomechanical caries removal (CMCR) is an effective method of caries removal especially for primary teeth as they cause less discomfort when compared with conventional caries removal. The most significant thing about caries removal is the elimination of cariogenic bacteria. This study compares the antibacterial activity of two CMCR...

Summary Background: The prevalence of oral diseases including dental caries and periodontal conditions is remarkably higher in people with disabilities. The provision of accessible oral health services for people with learning disabilities may be challenging. Objectives: The objectives of the review were to identify barriers in accessing oral he...

Introduction: Minimally Invasive Dentistry (MID) emphasizes conservative caries management strategies resulting in less destruction of tooth structure, a deviation of the traditional GV Black's restorative principles. However, there seems to be either deficiency in knowledge or little intention by general dental practitioners to adopt these princi...

Automated Implantable Cardioverter Defibrillators (AICD), simply known as an Implantable Cardioverter Defibrillator (ICD), has been used in patients for more than 30 years. An Implantable Cardioverter Defibrillator (ICD) is a small battery-powered electrical impulse generator that is implanted in patients who are at a risk of sudden cardiac death d...

Dental implants have been used in a variety of different forms for many years. Since the mid-20(th) century, there has been an increase in interest in the implant process for the replacement of missing teeth. Branemark was one of the initial pioneers who applied scientifically based research techniques to develop an endosseous implant that forms an...

The purpose of this study is to determine the type and frequency of pathological conditions around third molar teeth among randomly selected patient's records in Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, Riyadh. Totally, 281 patient panoramic radiographs were selected with detectable pathology among 570 files of pa...

Hepatitis B virus (HBV) is considered the most important cross-infection hazard in developing countries. Patients infected with hepatitis virus could encounter difficulties in obtaining dental care. The aim of this study was to investigate the willingness of Saudi dental professionals to treat hepatitis B virus infected patients. This cross-section...

Knowledge of Medical and Dental Practitioners towards dental management of patients on anticoagulant and/or anti-platelet therapyAbstract:Objective The purpose of this study was to evaluate the knowledge of medical and dental practitioners towards the dental management of patients who are on anti-coagulant and/or anti platelet agents. Methods This...

Aim: Excessive gingival display is a problem that can be managed by variety of procedures. These procedures include non-surgical and surgical methods. The underlying cause of gummy smile can affect the type of procedure to be selected. Most patients prefer minimally invasive procedures with outstanding results. The authors describe a minimally inv...

Background Warfarin is one of the most common oral anticoagulants used to prevent thromboembolic episodes. The benefits of discontinuation of this drug before simple surgical procedures are not clear and this approach could be associated with complications. The aim of this study was to evaluate the risk of bleeding in a series of 35 patients (in ca...

The inferior alveolar nerve block is the most common injection technique used in dentistry and many modifications of the conventional nerve block have been recently described in the literature. Selecting the best technique by the dentist or surgeon depends on many factors including the success rate and complications related to the selected techniqu...

Objective Aim is to compare the glycemic level among patients before, and after local anaesthesia containing adrenaline 1: 80, 000 among patients who needs dental extraction. Material and method 60 randomly selected patients including 30 healthy and 30 with diabetes history for this study in Riyadh city. First measure the blood glucose level befor...

Background: Although lidocaine inferior alveolar nerve block is a common dental injection in case of managing mandibular teeth, it may not be the first choice in specific situations. Patients on warfarin therapy are at high risk of bleeding during dental procedures. In this study we aimed to investigate and compare the efficacy of articaine buccal...

ABSTRACT Aim: Gingival deflection techniques can be classified as mechanical, mechanochemical, surgical, or any combination. Comparative evaluations of gingival retraction systems are done rarely mainly because there is no consensus on the evaluation criteria. Therefore, this study aimed to evaluate the efficacy of three different gingival retracti...

Introduction: Over the counter antibiotics have become a routine practice for self-management. No rules or regulations restrict or control the use of such antibiotics in Saudi Arabia. Most antibiotics are available in private pharmacies without prescription. Materials & methods: A single page survey was conducted for Saudi patients attending the or...

Methicillin-Resistant Staphylococcus aureus (MRSA) can be transmitted during pediatric emergency treatment and, occasionally, could result in contamination and infection of both patients and staff. Nasal swabs were taken from a sample of 14 physicians and 22 registered nurses working in a pediatric emergency unit at a tertiary care hospital in Riya...

The purpose of this study was to investigate the reasons for and patterns of extraction of permanent teeth in a subset of the Saudi population. During a 3-month period, dentists were asked to record, using a specially designed survey form, the reasons for every extraction of a permanent tooth. The reasons for tooth extraction were assigned to diffe...

After having been approved over the last few years, a variety of topical hemostatic agents are now commonly used in surgery. Hemostatic agents are used in oral and maxillofacial surgery in order to control bleeding; they can influence a surgical wound as a result of both their physical or chemical properties. The choice of any one of these agents d...

Introduction Local anesthetics are the most commonly used drugs in dentistry. Although they are considered effective and safe in controlling pain during dental procedures, complications related to their use appear inevitable. Many dentists use these drugs routinely but are unaware of the dose calculations required and the maximum safe and effective...

Nematodes, rotifers and tardigrades are extremotolerant invertebrates which can survive long periods of stasis brought about by extreme drying and cold. They can also resist the effects of UV radiation, and as result could act as vehicles for the panspermic transfer of microorganisms. Here we show that NRT contain a variety of bacteria and fungi wi...

The use of implantable foreign devices in medicine has recently increased dramatically. Intravascular cannulae and catheters are used to administer fluids, medications, parenteral nutrition, and blood products in order to monitor hemodynamic status and also to provide hemodialysis. The early and late failure of inserted or implanted devices is larg...

Glutathione S-transferases (GSTs) are an important group of isoenzymes that play an essential role in the detoxification of carcinogens. Polymorphism at exon 5 of the GST π family decreases the catalytic activity and affects the detoxification ability of the enzyme, GSTP1. GSTP1 promoter hypermethylation and loss of expression are frequently observ...

Objective: To investigate the interaction of Staphylococcus epidermidis with commonly used surgical sutures and the role of some of this bacterium virulence factors in this interaction. Summary Background Data: Coagulase negative staphylococci are ranked as the second most common cause of postoperative surgical site infections. Sutures have been su...

Microdeletions in azoospermia factor (AZF) region on distal Yq are associated with male infertility and spermatogenic failure due to intra-chromosomal homologous recombination between large nearly identical repeat amplicons and are found in ∼10% of azoospermic and severe oligozoospermic cases. Although AZFc is deleted in azoospermia or oligozoosper...

This study investigated the relationship of the maxillary sinus floor to the roots of posterior teeth imaged by panoramic radiography in Saudi patients living in Riyadh, Saudi Arabia. Panoramic radiographs of 60 subjects were analyzed. A total of 266 teeth in the left side and 277 teeth in right side were examined in this study. The closest root to...

Sex determining factor (SRY) located on the short arm of the Y chromosome, plays an important role in initiating male sex determination, resulting in development of testicular tissue. Presence of the SRY gene in females results in XY sex reversal and increased risk of gonadal germ cell tumours if the karyotype also includes the so-called GonadoBlas...

Alveolar bone grafting is a standard method for treating alveolar cleft. To ensure the best outcome, improving the arch form as well as soft tissue quality in the area around the cleft is recommended. In this study, 11 patients who presented with alveolar cleft and collapsed maxillary arch were treated in the following sequence: transpalatal distra...

Bone implants infected with Staphylococcus epidermidis often require surgical intervention because of the failure of antibiotic treatment. The reasons why such infections are resistant to therapy are poorly understood. We have previously reported that another bacterium, Staphylococcus aureus, can invade bone cells and thereby evade antimicrobial th...

Squamous cell carcinomas of the head and neck are characterized by their high tendency for invasion and metastasis. Several studies have identified the roles of matrix metalloproteinases (MMPs), vascular endothelial growth factors (VEGF) and urokinase plasminogen activators (uPA) in this process. Photodynamic Therapy (PDT) is an emerging treatment...

Background: Early detection of premalignant/malignant lesions in the oral cavity can certainly improve the patient's prognosis. This study presents fluorescence imaging with the topical application of 5-aminolevulinic as a way to improve detection of various oral tissue pathologies. This procedure depends mainly on comparing the intensity of red a...