Hacer Yapicioglu

Cukurova University | CU · Department of Neonatology

Purpose: Transport of neonates with critical congenital heart disease (CCHD) necessitates professional and experienced staff and, well-equipped facilities for both the procedure and post-operative care. In this study, we aimed to evaluate the effect of transport on operation time and survival in neonates with CCHD and determine the relationship bet...

Purpose We aimed to investigate the role of lung ultrasound (LUS) score in the closure of hemodynamically insignificant patent ductus arteriosus (PDA) and the clinical findings of the patients before and after closure. Methods The study groups (107 preterm neonates under 34 gestational weeks) were classified as hemodynamically significant PDA (gro...

Background Hypoxic ischemic encephalopathy (HIE) is a significant cause of mortality and short- and long-term morbidities. Therapeutic hypothermia (TH) has been shown to be the standard care for HIE of infants ≥36 weeks gestational age (GA), as it has been demonstrated to reduce the rates of mortality, and adverse neurodevelopmental outcomes. This...

Purpose: The aim of this study was to examine the relationship between mechanical ventilation modes and stress levels by measuring salivary cortisol levels in preterm infants. Materials and Methods: The study group comprised 65 preterm infants on respiratory support and 43 control preterm infants. The Neonatal Infant Pain Scale (NIPS) was used to e...

Background Many medical experts prescribe indomethacin because of its anti‐inflammatory, analgesic, tocolytic, and duct closure effects. This article presents an evaluation of the enduring impact of indomethacin on neonatal rats with hypoxic–ischemic (HI) insults, employing behavioral tests as a method of assessment. Methods The experiment was con...

A BSTRACT Background/Aim Oxidative stress is considered to have a significant role in the development of cardiovascular diseases (CVDs) as well as many other diseases. Therefore, the purpose of the study is to evaluate the antioxidant system status at pre- and post-operative period in newborns with congenital heart disease (CHD) requiring operatio...

Neonatal lupus syndrome (NLS) is a rare disease with dermatological, cardiac, hepatic and hematologic involvement due to placental transfer of anti-Ro/ SSA and anti-La/ SSB antibodies in infants of mothers with autoimmune diseases. Multisystemic involvement is common in infants. Here we present a baby with neonatal lupus syndrome whose mother had S...

Objective The factors affecting the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from mother to newborn and the duration of seropositivity rates in these infants have not yet been clearly demonstrated. The objectives of this study were (1) to assess the levels of SARS-CoV-2 spike–specific immunoglobulin G...

Objectives Ischemia-modified albumin (IMA) is a new biochemical marker of ischemia. We aimed to search blood IMA levels in neonates with congenital heart defects. Study Design During the study period, patients diagnosed with congenital heart disease and newborns with a diagnosis of hyperbilirubinemia as a control group were included in the study. I...

Amaç: Seftriakson yan etkileri nedeniyle yenidoğanda sınırlı kullanıma sahiptir. Yenidoğan enfeksiyonlarında kullanımı ile ilgili sınırlı sayıda çalışma vardır. Bu çalışma ile setriakson alan yenidoğanlarda seftriakson sonrası oluşabilecek yan etkilerin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çukurova Üniversitesi Tıp Fakültesi Balcalı Ha...

Alpers-Huttenlocher syndrome (AHS) is an uncommon autosomal recessive mitochondrial DNA depletion disease. The classic clinical triad of progressive developmental regression, liver degeneration, and seizures helps define the disorder, but a wide range of clinical expressions occur. The most common mutations in childhood have been identified in the...

Purpose The International Nosocomial Infection Control Consortium (INICC) found a high mortality rate in ICUs of the Middle East (ME). Our goal was to identify mortality risk factor (RF) in ICUs of the ME. Materials From 08/01/2003 to 02/12/2022, we conducted a prospective cohort study in 236 ICUs of 77 hospitals in 44 cities in 10 countries of ME...

Objective Newborns in NICUs experience many painful procedures. The aim of the study was to evaluate the effect of whole body massage therapy on pain scores during venipuncture and to compare with oral 10% dextrose and Kangaroo care. Study design Newborns with gestational age ≥34 weeks were randomly enrolled to one of three groups: dextrose, massa...

Objective: Respiratory failure is common in preterm infants and mechanical ventilation treatment may be required. Pain and stress in newborns during mechanical ventilation may have negative effects on neurological development of the babies. Salivary cortisol level is one of the important non-invasive tests to detect stress. In this study, we aimed...

Objective: Newborns in NICUs experience many painful procedures. The aim of the study was to evaluate the effect of whole body massage therapy on pain scores during venipuncture and compare with oral 10% dextrose and Kangaroo care. Study Design: Newborns with gestational age ≥34 weeks were randomly enrolled to one of three groups: massage, dextrose...

Purpose: Incidence of diabetes during pregnancy is increasing worldwide, and intrauterine hyperglycemia exposure may have long-term adverse effects on the cardiovascular health of children. We investigated risk of atherosclerosis and carotid intima-media thickness (CIMT) in infants born macrosomic and in infants of diabetic mothers (IDM) at the age...

Hiperinsülinemik hipoglisemi (HH), pankreatik β hücrelerinde kan glukozundan bağımsız olarak düzensiz insülin salınımına bağlı gelişir ve tekrarlayıcı hipoglisemiye neden olur (1). Yenidoğan ve süt çocuklarında ısrarlı hipogliseminin en sık sebebidir. Sporadik ve genetik nedenli HH nadir görülürken (insidansı 1/40000) akraba evliliği sık görülen ye...

Yenidoğan yoğun bakım ünitelerinde özellikle prematüre yenidoğanlarda agresif resüsitasyon ve destekleyici önlemler nedeniyle özofagus perforasyonu adı verilen yeni bir komplikasyon ortaya çıkmıştır. Çok sayıda yenidoğan resüsitasyonuna rağmen, iyatrojenik özofagus perforasyonu hala nadirdir

Intravenous lipid emulsions are commonly used as a part of parenteral nutrition in premature infants. The potential bilirubin-displacing effects of high free fatty acid (FFA) levels during lipid infusions are known. Levels of free bilirubin (FB) predict the risk of bilirubin neurotoxicity more accurately than indirect serum bilirubin levels. In the...

Vitamin B12, folate, and other micronutrients are essential for healthy growth. We hypothesized that there is a high prevalence of vitamin B12 deficiency in mothers and their newborns, and that blood serum vitamin B12 and folate levels may affect anthropometric measurements at birth. A total of 204 newborn babies and their 196 mothers were included...

Objective: Hydroxychloroquine (HCQ) has immunomodulatory, antithrombotic, cardiovascular, antimicrobial, and antineoplastic effects. In this study, we aimed to investigate antiapoptotic and immunomodulator effect of intraperitoneal HCQ in hypoxic-ischemic (HI) injury in newborn rats. Study design: Seven to 10 days old Wistar-Albino rats were ran...

Dandy-Walker malformation is a rare congenital malformation, characterized by agenesis or hypoplasia of the cerebellar vermis, cystic dilatation of the 4th ventricle and enlargement of the posterior fossa. Postnatal hydrocephalus develops in approximately 70-90% of the patients. The relationship of Dandy-Walker malformation with postaxial polydacty...

Konjenital batın ön duvarı defektleri nadir görülen yapısal anomalilerdir. Bu olguların ve eşlik eden anomalilerin erken saptanması, bebeklerin doğumdan sonra yatırılarak izleminin ve bakımlarının erken başlanması prognozu etkilemektedir. Bu çalışma 4 yıllık süre içinde hastanemizde doğmuş ve yenidoğan yoğun bakım ünitemizde takip edilmiş batın ön...

Aim: Premature babies are vulnerable to environmental stress factors mostly in the first weeks of life. During this time, supportive positioning, especially used all-around the baby, makes them feel better as if they are in utero. The aim of the study was to evaluate the effect of supportive positioning on weight gain, vital signs, feeding intolera...

Purpose: Delaying the cord clamping for at least 30 seconds in infants who did not require cardiopulmonary resuscitation after birth has been recommended in the revised guidelines of American Academy of Pediatrics in 2015. We aimed to evaluate the effect of delayed cord clamping on hematological and biochemical parameters, need for hospitalization,...

The non-Langerhans cell histiocytosis (non-LCH) is a group of diseases characterized by cutaneous involvement in the neonatal period. The non-LCH affects less than 1 in 200,000 children born each year. A definitive diagnosis is important for the treatment of the disease. Therefore, skin biopsies should be performed in neonates with cutaneous lesion...

Congenital hypothyroidism is a significant issue in neonates. A variety of cardiac abnormalities have been described in cases of severe hypothyroidism. It is commonly associated with sinus bradycardia, low QRS complexes, prolonged QT interval and conduction blocks but may rarely cause arrhythmias. Although supraventricular arrhythmias are ordinary...

Aim: Children requiring intensive care in the neonatal period have more fine motor injuries, learning difficulties, eating disorders and sleeping problems. Sleep disorder rate is about 10-30% in children who had no problem in newborn period. We aimed to investigate the rate of sleep disorder in children who were hospitalized in the neonatal intensi...

Amaç: Nozokomiyal sepsis, hastane kaynaklı kazanılmış infeksiyonlar arasında en sık olanıdır. Uygun antibiyotik tedavisine rağmen sepsisin mortalitesi ve morbiditesi hala yüksektir. Bu nedenle diğer tedavi yöntemleri hala aranmaktadır. Yenidoğan yoğun bakım ünitesinde yatan prematüre bebeklerde pentoksifilinin neonatal nozokomiyal sepsisin prognozu...

Amaç: Plasental implantasyon defektleri, antepartum vajinal kanamanın en önemli nedenleridir. Ek olarak, perinatal komplikasyonların insidansı da, özellikle preterm ve gebelik yaşına göre küçük doğan bebeklere bağlı olarak artmaktadır. Yenidoğanlarda diğer komplikasyonlar intrauterin asfiksi, enfeksiyonlar, solunum sıkıntısıdır. Bu çalışmanın amacı...

Amaç: 34 gestasyonel haftadan once doğan bebeklerin annelerine yapılan antenatal magnesiyum sulfatın, bebeklerdeki intraventriküler kanama, beslenme intoleransı, retinopati ya da bronkopulmoner displazi gibi morbiditeler üzerine etkisi henüz tam açıklığa kavuşturulmamıştır. Biz antenatal uygulanan magnezyum sulfatın prematüre bebeklerde erken ve ge...

Background: Very low birth weight (VLBW) infants often demonstrate postnatal growth failure (PGF). We aimed to analyze incidence and risk factors for PGF in surviving VLBW infants hospitalized more than 28 days. Materials and methods: Fenton growth chart (2013) was used for Z-scores for birth weight (BW) and discharge weight. Infants with a decr...

Aim: To evaluate the effect of umblical cord clamping time on lymphocyte subgroups in term and late preterm infants. Material and methods: Seventy-four infants between 34 and 41 weeks of gestation were included in the study. Of these, 37 were umbilical cord clamped immediately after birth and the remaining 37 were clamped after waiting one minut...

Yapıcıoğlu Yıldızdaş H, Ece Ü, Bilen Yurdakul G, Kolağasıgil E. Spontaneously resolved uterine prolapse in a neonate with spina bifida. Turk J Pediatr 2019; 61: 979-981. Neonatal uterine prolapse is rare and mostly due to spina bifida. It is probably due to abnormal innervation of levator ani and subsequent atrophy of the muscle in patients with sp...

Midaortik sendrom nadir bir hastalık olup abdominal veya distal inen aortanın segmental veya difüz darlığı ile karakterizedir. Olguların çoğu idiyopatik olmakla birlikte bir kısmı da fibromüsküler displazi, dev hücreli aterit, Moyamoya hastalığı veya nörofibramatozis, Williams’ sendromu ve Alagille sendromu gibi genetik hastalıklara ikincildir. Bur...

Background: Olive oil-soybean oil (OO/SO) based lipid emulsions (LE) lack ω-3 PUFAs eicosapentaenoic acid -EPA and docosahexaenoic acid- DHA, which have clinical benefits on inflammatory processes. Fish oil based LEs are good sources of DHA and EPA. Fish oil, MCT, Olive oil and Soya oil (FMOS) lipid is one of the fish oil containing LEs supplement...

Background/aim: Peritoneal dialysis (PD) is generally considered the practical dialysis modality for neonates in the treatment of acute kidney injury (AKI) and metabolic disturbances. The aim of this study was to evaluate the indications, complications, and outcomes of PD between January 2011 and December 2016. Materials and methods: This study...

Pnömomediastinum mediastene hava girişi ile oluşmaktadır. Çocuklarda genellikle astıma bağlıdır, ancak yenidoğanlarda pnömoni veya mekonyum aspirasyon sendromu predispozan faktörlerdir. Pnömomediastinum tanısı genellikle akciğer grafisi ile konur, yenidoğan bebeklerde pnömomediastinal hava ile kalbin üstündeki timik lopların yukarı ve dışa doğru sa...

Background: Organophosphates, pythyreoids, carbamate pesticides and fungicides are heavily used in agriculture. They may have dangerous effects on newborn health especially on immune system and growth via prenatal transmission by placenta or postnatal transmission by breastfeeding. Methods: In 2015, 144 non-persistent pesticides in 64 milk samples...

The human major histocompatibility complex class I chain-related gene A and B (MICA and MICB) is one of the genes in chromosome 6. As MIC expression is inducible by heat, viral infection, inflammation and DNA damage, the molecules have been thought to be stress markers for the cells. We aimed to find the level of mRNA concentrations of MICA and MIC...

Amaç: Bu çalışmanın amacı prematüre bebeklerde beslenme intoleransı ve ağırlık artışı üzerine Bifidobakteryum laktis ve Hindiba inülini’nin etkisinin değerlendirilmesidir. Gereç ve Yöntem: Beslenme intoleransı tanısıyla izlenmekte olan 89 prematüre bebek bu çalışmaya alınmıştır. Çalışma grubundaki olgulara Bifidobakteriyum laktis (5x109 CFU) + Hind...

Jarcho-Levin sendromu vertebra deformitelerin olduğu ve sinir sistemi, kardiyak, üriner ve gastrointestinal sistemi ilgilendiren birçok anomalinin de eşlik edebildiği bir sendromdur. İnsidansı 2.5/100.000 olup meningomiyelosel ve hidrosefali bu olguların dörtte birine eşlik eder. Hastalar genellikle solunum yetmezliği ile kaybedilirler. Bu yazıda m...

Amaç: Bu çalışmada yenidoğan yoğun bakım ünitemize yatırılan sağlıklı preterm bebeklerdeki normal kanbasıncı değerlerini sağlamayı amaçladık.Gereç ve Yöntem: Yaşamının ilk saatlerinde yenidoğan yoğun bakım ünitemize yatırılan 34 gestasyonel haftadan küçük hemodinamik olarak stabil 141 preterm bebek çalışmaya dahil edildi.Bulgular: 141 bebek çalışma...

Amaç: Bu çalışmadaki amacımız yenidoğan döneminde sağlık bakımı ilişkili enfeksiyon (SBİE) geçiren ve geniş spektrumu antibiyotik kullanan çocuklarda astma, allerjjk rinit ve atopic dermatit sıklığını araştırmaktır. Gereç ve Yöntem: Çalışmaya Yenidoğan Yoğun Bakım Ünitesi’nde 6 yıl içinde izlenen 73 SBİE olan çocuk ile bu çocukların yenidoğan dönem...

Umbilical venous catheterization is frequently used for treatment, monitorization, blood sampling and total parenteral nutrition in neonatal intensive care units. During umbilical catheterization, complications such as occlusion, bleeding, breaking, leaking, thrombosis, infection, distal embolization, perforation and cardiac tamponade may be observ...

Akçalı M, Yapıcıoğlu H, Akay E, Özlü F, Kozanoğlu B, Erdoğan K, Gönlüşen G, Satar M. A congenital soft tissue Ewing sarcoma in a newborn patient. Turk J Pediatr 2017; 59: 76-79. < p < Congenital Ewing sarcoma is extremely rare. Here we present a newborn baby born with a mass on the left shoulder. Immunohistochemical staining showed congenital Ewing...

Because of the increase in ceserean section, assited fertilization and multiple births, late preterem births was suspected to be increased. We aimed to investigate the incidence of late preterm births in our hospital and evaluate their postnatal medical problems in this study. Late premature infants born alive between 340/7- 366/7 pregnancy weeks b...

Yapıcıoğlu-Yıldızdaş H, Ece Ü, Sucu M, Yurdakul G, Şimşek H, Özlü F. Twin reversed arterial perfusion syndrome in a monochorionic monoamniotic twin pregnancy. Turk J Pediatr 2017; 59: 724-727. Twin reversed arterial perfusion syndrome is mostly seen in monochorionic diamniotic twin pregnancies with an estimated incidence of 1/9500-11000 pregnancies...

Two newborn babies with generalized arterial calcification of infancy, two new mutations. Idiopathic generalized arterial calcification of infancy-1 (GACI-1) is a rare and potentially lethal disease characterized by diffuse calcification of large and medium-sized arteries such as aorta, renal, pulmonary, cerebral and mesenteric arteries. Here we re...

Purpose: The aim of this study is to determine risk factors associated with delayed regression of retinopathy of prematurity and prolonged vascular completion in patients not requiring treatment. Material and Methods: Patients with acute retinopathy of prematurity not requiring treatment were grouped as control and delayed vascularization groups, o...

The usage of drugs during pregnancy affect the fetus and the newborn. In this report, we present findings from a newborn baby, whose mother was epileptic, and was under the treatment of valproic acid and carbamazepine during pregnancy. We have found symptoms of withdrawal syndrome, hyponatremia and feeding problem, which was most probably related t...

Objective: This study aims to determine mortality risk by calculating SNAP-PE-II score, CRIB score and predetermine the effects of antenatal corticosteroid and surfactant treatment on mortality. Study design: The multicenter study was conducted simultaneously in five different centers in four different provinces in Southern Turkey between July 2...

Prune Belly syndrome (PBS), comprises a triad of anomalies that include abdominal wall flaccidity, urologic anomalies and bilateral cryptorchidism in males. The abdominal musculature hypoplasia predisposes to respiratory problems, respiratory infections secondary to impaired cough mechanism, and cause chronic constipation secondary to ineffective v...

In newborns, hyperammonemia leads to encephalopathy which is usually characterized by vomiting, hypotonia, lethargy, seizures and coma. Continuous venovenous hemodiafiltration (CVVHDF) is a modality choice to treat acute decompensation in hyperammonemia. Here we report three newborn patients with hypotonia, convulsion and hyperammonaemia. In the fi...

Purpose: Spinal anesthesia for caesarean delivery is often associated with hypotension. This study was conducted to evaluate the effects of rapid crystalloid (Lactated Ringer’s solution; LRS) or colloid (hydroxyethyl starch; HES) cohydration with a second intravenous access line on the incidence of hypotension and ephedrine requirement during spina...

The aim of this study was to assess the ex-utero intrapartum therapy (EXIT) applied to 3 of the 7 cases with oropharyngeal or neck masses and review the indicators of the need for an EXIT procedure. Prenatal presentation, size and localization of the masses, existence of fetal hydrops and associated findings such as polyhydramnios, intraoperative m...

In this study, newborns with congenital heart disease in the Cukurova University Neonatal Intensive Care Unit during 2007-2011 have been retrospectively evaluated. The incidence of congenital heart disease in newborn babies admitted to the NICU in the 5 years studied was 6.6% (217/3287 patients). 133 (61.3%) of the patients were cyanotic; 76 (35.1%...

Necrotising enterocolitis (NEC), an important disease of the gastrointestinal system in neonatal period, is characterised by total or partial ischemia of the intestines. Although most of the affected neonates are premature, 10% of the patients are term neonates. Here we present three term neonates who were operated due to Grade 3 NEC during their f...

Abstract Objective: Neonatal systemic infection is a leading cause of morbidity and mortality both in industrialized and developing countries. The aim of this prospective study was to evaluate if vital signs had a predictive power in neonatal sepsis as an early marker Methods: The study was designed as a matched case control study. Vital signs were...

Aim To evaluate the influence of bifidobakterium lactis 2011 and hindiba inulin on feeding intolerance and necrotising enterocolitis in premature babies Material and method 89 premature babies with the diagnosis of feeding intolerance were enrolled in the study. Premature babies were divided into two groups; Study group (group 1) had Bifidobakteriu...

Objective: Identifying antibiotic use in pediatric and neonatal intensive care units with a point prevalence study in Adana, TÜRkey's sixth largest city. Material and Methods: In this point prevalence study, demographic information and antibiotic treatment data were taken on the same day from patients in pediatric and neonatal intensive care units...

Retinopathy of prematurity is a retinal vascular disorder seen frequently in very premature infants, and is associated with poor clinical outcomes. The aim of the present study was to assess the association between the incidence of retinopathy of prematurity and mechanical ventilation, oxygen therapy, gestational age, and antenatal steroids in extr...

Purpose: to investigate if there were a correlation between blood gas measurements and if we could predict arterial (A) values from capillary (C) or venous (V) measurements in premature infants. Material and Methods:Premature infants with umbilical artery and venous catheters in Newborn Intensive Care Unit were enrolled in to the study. Umbilical a...

Purpose: To present our experience with a leukocyte depletion procedure performed on a one-day-old baby weighing 2900 grams. Case Report: A one-day-old male baby with hyperleukocytosis (WBC count: 232.000/mm3) was referred to our hospital. Physicians from neonatal medicine requested urgent leukocyte depletion to decrease the WBC count rapidly and t...

The coincidence of necrotizing enterocolitis and rotavirus infections and potentional associations with cytokines. Can J Infect Dis Med Microbiol 2012;23(4):e10303-e105. BACKgrounD: Necrotizing enterocolitis (NEC) is the most com-mon gastrointestinal disease in neonatal intensive care units. Although the pathogenesis of NEC remains unclear, evidenc...

Yenidoğan döneminde mediyastinal enterik kist nadiren görülür. Çoğunlukla bulgu vermez. En sık solunum güçlüğü ile kendini belli eder. Mediyastinal kist omuz anomalilerinin eşlik ettiği bir durumdur ve enterik özellik gösterir. Tanısı esas olarak histolojik bulgularla konulur. Bu yazıda doğum öncesi ultrasonografik incelemede akciğerde kistik adeno...

Exposure to parenteral nutrition (PN) is one major factor in the development of cholestasis. The aim of this retrospective study was to compare the effect of these two different PN regimens on PN associated cholestasis. The files of the patients who have received different PN regimens for > 14 days in 2005 and 2009 were retrospectively reviewed. 13...

Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease in neonatal intensive care units. Although the pathogenesis of NEC remains unclear, evidence suggests that infections, especially bacterial infections, may play an important role. Viral infections may also result in NEC. Several outbreaks of NEC associated with rotaviruses...

Severe congenital heart defects might be symptom free in first days of life. Therefore only half of the congenital heart defects were diagnosed in neonatal period. In six years period, 86 neonates with the diagnosis of cyanotic congenital heart defects out of 3672 neonates hospitalized in our unit were evaluated. Neonates with the diagnosis of Down...

Neonatal withdrawal syndrome is characterized by non-specific signs and symptoms that occur in infants following in-utero drug exposure. The incidence of neonatal withdrawal syndrome is 16-90% in infants of mothers abusing heroin. Clinical signs of withdrawal syndrome usually occur within the first 48-72 hours after birth. Central nervous system an...

Aim: To determine whether paediatrician attendance to deliveries with elective caesarean section (CS) is really needed for term and also for preterm babies with 35-37 weeks gestational age. Methods: Singleton newborns ≥35 gestational weeks without any identified risk factor were evaluated for resuscitation steps prospectively after CS under regiona...

Background: Transient tachypnea of neonate (TTN) and respiratory distress syndrome (RDS) of the newborn are the most common cause of early respiratory distress in the immediate neonatal period. There is increasing evidence to support the role for the activation of the renin angiotensin system during acute lung injury. Objectives: The purpose of thi...

Double trisomy may occur as autosomal with sex chromosome trisomy or double autosomal trisomy. This coincidence is very rare. Trisomy 18, that is first recognized as a specific entity in 1960 by discovery of the extra 18 chromosome, is characterized by intrauterine growth retardation, prominent occiput, micrognathia, rocker-bottom feet. Klinefelter...

To evaluate the role of electronic faucets in a newborn intensive care unit during a Pseudomonas aeruginosa outbreak. After three patients had P. aeruginosa bacteremia, environmental cultures including those from patient rooms, incubator, ventilators, total parenteral nutrition solutions, disinfection solutions, electronic and hand-operated faucet...

Transient Tacypnea of Neonate (TTN) and Respiratory Distress Syndrome (RDS) are the most common causes of respiratory distress in early neonatal period. The pathogenesis of TTN is still not well understood and is thought to be due to inadequate clearance of fetal lung fluid. In last decades, the evidence of the role of renin-aldostrene-angiotensin...

In this study, we have prospectively recorded healthcare-associated infections (HAIs) in NICU and found incidence density as 18 infections per 1000 patient days. Of the infections, 51.3% was bacteriemia (BSI), and 45.1% was ventilator-associated pneumonia (VAP). Gram-negative microorganisms were predominant in VAP and Staphylococcus epidermidis was...

Presentation of mediastinal enteric cysts are rare during neonatal period. They are mostly asymptomatic. The commonest mode of presentation in neonatal period is repiratory distress. Basically, diagnosis of enteric cyst is histologically, for all that vertebral anomalies associated with posterior mediastinal cyst is property of enteric cyst. 0-24h...

To report the incidence of healthcare-associated infections (HAIs), site of infection and bacterial epidemiology in the Neonatal Intensive Care Unit in a university hospital in Adana, Turkey, between 2001 and 2006. During these years, HAIs were collected by an active surveillance system. Five hundred one of 2832 infants hospitalised more than 72 h...

Increased serum level of malondialdehyde (sMDA) in neonates with hypoxic-ischaemic encephalopathy (HIE) was evaluated as a possible criterion for determining HIE severity. Mean body weight and gestational age in a healthy control group of neonates (n = 63) and in neonates with HIE (n = 69) were statistically similar. Apgar scores at 1 and 5 min for...

Turkish Neonatal Society Nosocomial Infections Study Group. Nosocomial infections in neonatal units in Turkey: epidemiology, problems, unit policies and opinions of healthcare workers. Turk J Pediatr 2010; 52: 50-57. The epidemiology of nosocomial infections in Turkish neonatal intensive care units (NICUs) shows that nosocomial sepsis is an importa...

A cross-sectional study was performed to determine the rubella seroprevalence in 331 children aged between 0 and 59 months in Turkey who were not vaccinated for rubella and lived in the area covered by Dogankent Health Center, a rural area with a large proportion of residents of low socioeconomic status. Rubella seropositivity was found to be low,...

Coagulation factor VII (FVII) is a vitamin K dependent glycoprotein of the extrinsic pathway and initiates coagulation by binding to tissue factor. Activated prothrombin-complex concentrate ([APCC] FEIBA), an activated prothrombin complex concentrate that is plasma-derived, has also been demonstrated to bypass the need for FVIII or factor IX, resul...

Activation of phospholipase A(2), degradation of membrane phospholipids resulting in tissue accumulation of arachidonic acid, and the activation of cyclooxygenase that leads to the formation of prostaglandin and free radicals may occur after hypoxic-ischemic damage. The aim of this study was to investigate the effects of indomethacin, a nonselectiv...

Pyruvate kinase (PK) plays a key role in erythrocytes, which obtain most of their energy from glycolysis. This study investigated erythrocyte energy metabolism in hypoxic newborns, measuring pyruvate kinase activity, kinetic, and ATP levels in hypoxia. Forty-nine babies who had cord pH value lower than 7.2 and Apgar scores lower than 7 in the first...

Bruck syndrome is characterised by osteogenesis imperfecta and arthrogryposis multiplex. In some patients, mutations in the lysyl hydroxylase 2 gene (PLOD2, 3q23-q24) have been demonstrated. A male newborn with Bruck syndrome is reported.

To evaluate the effectiveness of HFOV in pediatric patients with acute respiratory distress syndrome. In this retrospective study, we reviewed all 20 pediatric patients, who were consecutively ventilated with HFOV in the pediatric intensive care unit of a tertiary medical center, from January 2006 to February 2007. A total of 20 patients were enrol...

Classical neonatal diabetes mellitus is defined as hyperglycemia that occurs within the first month of life in term infants. It can be either permanent or transient. Cerebellar agenesis and permanent neonatal diabetes has been previously reported as a new autosomal recessive disorder. Pancreas Transcription Factor 1 Alpha (PTF1A) mutations have bee...

Homozygous protein C deficiency affects approximately 1/400,000 to 1/1,000,000 live births. Homozygous protein C deficiency is associated with catastrophic and fatal purpura fulminans-like or thrombotic complications and disseminated intravascular coagulation. In the present patient, genetic study revealed Arg178Trp, a mutation found widely in Euro...

The purpose of this study was to determine cord blood cytokine levels and their relationship with morbidity and mortality in neonates with prolonged, premature rupture of membranes (PPROM). Forty two premature neonates of 29-35 weeks gestational age with PPROM exceeding 24 hours were considered as the PPROM group and simultaneously, 41 premature ne...