Gina Solomon

UCSF University of California, San Francisco | UCSF · Division of Occupational and Environmental Medicine

OPEN ACCESS at https://awwa.onlinelibrary.wiley.com/doi/10.1002/aws2.1337 This case study compared microcystins in tap water from 18 public water systems (PWSs) and 46 households with private intakes or nearshore wells (called self-supplied water systems [SSWS]) from Clear Lake, California during a major cyanobacterial bloom in 2021. Microcystin c...

Background Hazard identification, risk assessment, regulatory, and policy activity are usually conducted on a chemical-by-chemical basis. Grouping chemicals into categories or classes is an underutilized approach that could make risk assessment and management of chemicals more efficient for regulators. Objective and methods While there are some av...

The manufacture and production of industrial chemicals continues to increase, with hundreds of thousands of chemicals and chemical mixtures used worldwide, leading to widespread population exposures and resultant health impacts. Low-wealth communities and communities of color often bear disproportionate burdens of exposure and impact; all compounde...

Objectives Healthcare personnel have faced unprecedented mental health challenges during the COVID-19 pandemic. The study objective is to assess differences in depression, anxiety, and burnout among healthcare personnel with various occupational roles and whether financial and job strain were associated with these mental health outcomes. Methods W...

Previous studies have reported associations between air pollution and COVID-19 morbidity and mortality, but most have limited their exposure assessment to a large area, have not used individual-level variables, nor studied infections. We examined 3.1 million SARS-CoV-2 infections and 49,691 COVID-19 deaths that occurred in California from February...

Background: To date, health-effects research on environmental stressors has rarely focused on behavioral and mental health outcomes. That lack of research is beginning to change. Science and policy experts in the environmental and behavioral health sciences are coming together to explore converging evidence on the relationship-harmful or beneficia...

After the devastating wildfire that destroyed most of the town of Paradise, California in 2018, volatile organic compounds were found in water distribution pipes. Approximately 11 months after the fire, we collected tap water samples from 136 homes that were still standing and tested for over 100 chemicals. Each participant received a customized re...

We investigated patterns of volatile organic compound (VOC) contamination in drinking water systems affected by the California 2018 Camp Fire. We performed spatial analysis of over 5000 water samples collected over a 17 month period by a local water utility, sampled tap water for VOCs in approximately 10% (N = 136) of standing homes, and conducted...

Background: Numerous types of rapid toxicity or exposure assays and platforms are providing information relevant to human hazard and exposure identification. They offer the promise of aiding decision-making in a variety of contexts including the regulatory management of chemicals, evaluation of products and environmental media, and emergency respo...

Background: Identification of female reproductive toxicants is currently based largely on integrated epidemiological and in vivo toxicology data and, to a lesser degree, on mechanistic data. A uniform approach to systematically search, organize, integrate, and evaluate mechanistic evidence of female reproductive toxicity from various data types is...

In 2008, California enacted laws to restructure chemical policy and promote green chemistry. Ten years after the passage of California’s green chemistry laws, we assessed their performance through structured interviews with a sample of experts from government, academia, business, and the nonprofit sector. We combined the interviews with a scoping l...

We developed an integrated, modular approach to predicting chemical toxicity relying on in vitro assay data, linkage of molecular targets to disease categories, and software for ranking chemical activity and examining structural features (chemotypes). We evaluate our approach in a proof-of-concept exercise to identify and prioritize chemicals of po...

Research on disease causation often attempts to isolate the effects of individual factors, including individual genes or environmental factors. This reductionist approach has generated many discoveries, but misses important interactive and cumulative effects that may help explain the broad range of variability in disease occurrence observed across...

Climate change is projected to cause widespread and serious harm to public health and the environment upon which life depends, unraveling many of the health and social gains of the last century. The burden of harm will fall disproportionately on the poorest communities, both in the U.S. and globally, raising urgent issues of “climate justice”. In c...

Regulatory agencies face daunting challenges identifying emerging chemical hazards because of the large number of chemicals in commerce and limited data on exposure and toxicology. Evaluating one chemical at a time is inefficient and can lead to replacement with uncharacterized chemicals or chemicals with structural features already linked to toxic...

We are living in a world of over seven billion people, with annual greenhouse gas emissions of approximately 50 billion tons a year and rising steadily. If continued unabated, the world is on target to warm by about 2 °C in less than 40 years, pushing the climate to a regime unlike any that has been witnessed in the last million years. Nonetheless,...

Communities located near multiple sources of pollution, including current and former industrial sites, major roadways, and agricultural operations, are often predominantly low-income, with a large percentage of minorities and non-English speakers. These communities face additional challenges that can affect the health of their residents, including...

Many communities are located near multiple sources of pollution, including current and former industrial sites, major roadways, and agricultural operations. Populations in such locations are predominantly low-income, with a large percentage of minorities and non-English speakers. These communities face challenges that can affect the health of their...

US EPA’s Toxicity Forecaster (ToxCastTM) is a tool with potential use in evaluating safer consumer products, conducting chemical alternatives analyses, prioritizing chemicals for exposure monitoring, and ultimately performing screening level risk assessments. As a case study exploring a potential use of ToxCast, we evaluated ToxCast results for ort...

Current approaches to chemical screening, prioritization and assessment are being re-envisioned, driven by innovations in chemical safety testing, new chemical regulations, and demand for information on human and environmental impacts of chemicals. To conceptualize these changes through the lens of a prevalent disease, the Breast Cancer and Chemica...

INTRODUCTIONThe U.S. Environmental Protection Agency's (EPA's) Toxicity Forecaster (ToxCast) is a potential tool for chemical prioritization, hazard identification, and risk assessment. We conducted a case study to compare ToxCast data with endpoints from other in vitro and in vivo studies for two data-rich pesticides: endosulfan and methidathion.M...

USEPA’s Toxicity Forecaster (ToxCastTM) program is of interest to the California Environmental Protection Agency (Cal/EPA) as a tool for chemical prioritization, understanding hazard traits, weighing product safety concerns, and risk assessment. In order to improve our understanding of the applicability, strengths, and limitations of the ToxCast hi...

The BP oil spill of 2010 resulted in contamination of one of the most productive fisheries in the United States by polycyclic aromatic hydrocarbons (PAHs). PAHs, which can accumulate in seafood, are known carcinogens and developmental toxicants. In response to the oil spill, the U.S. Food and Drug Administration (FDA) developed risk criteria and es...

Thousands of chemicals are used in food processing and food packaging and approved by the FDA as indirect food additives. This includes hormone disrupting chemicals, such as BPA and a group of chemicals called phthalates, both of which are present in the bodies of over 90 percent of the U.S. population and have been linked to reproductive and devel...

Over 5.2 billion pounds of pesticides are used in agriculture annually worldwide, including on food crops where they leave residues. Recent studies have identified residues on food as a major route of exposure for organophosphate pesticides which are neurotoxins particularly hazardous to children. The U.S. Environmental Protection Agency (EPA) sets...

In 2010, the BP Oil Spill contaminated the Gulf of Mexico, which supplies approximately 30% of the seafood consumed in the US, with polycyclic aromatic hydrocarbons (PAHs). The U.S. Food and Drug Administration developed risk criteria to determine the allowable levels of PAH contaminants in Gulf Coast seafood. We evaluate the FDA risk assessment me...

The future health costs associated with predicted climate change-related events such as hurricanes, heat waves, and floods are projected to be enormous. This article estimates the health costs associated with six climate change-related events that struck the United States between 2000 and 2009. The six case studies came from categories of climate c...

The oil spill in the Gulf of Mexico poses direct threats to human health from inhalation or dermal contact with the oil and dispersant chemicals, and indirect threats to seafood safety and mental health. Physicians should be familiar with health effects from oil spills to appropriately advise, diagnose, and treat patients who live and work along th...

With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a Strategy, the U.S. National Academy of Sciences, in 2007, precipitated a major change in the way toxicity testing is conducted. It envisions increased efficiency in toxicity testing and decreased animal usage by transitioning from current expensive and leng...

The flooding of New Orleans in late August and September 2005 caused widespread sediment deposition in the flooded areas of the city. Post-flood sampling by US EPA revealed that 37% of sediment samples exceeded Louisiana corrective screening guidelines for arsenic of 12mg/kg, but there was debate over whether this contamination was pre-existing, as...

The physician’s duty extends beyond treating individual patients to reporting public health threats when they are identified. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.

Climate models project that heat waves will increase in frequency and severity. Despite many studies of mortality from heat waves, few studies have examined morbidity. In this study we investigated whether any age or race/ethnicity groups experienced increased hospitalizations and emergency department (ED) visits overall or for selected illnesses d...

Assessing adverse effects from environmental chemical exposure is integral to public health policies. Toxicology assays identifying early biological changes from chemical exposure are increasing our ability to evaluate links between early biological disturbances and subsequent overt downstream effects. A workshop was held to consider how the result...

There are increasing concerns over the presence and implications of pharmaceutical agents in water. In 2002, California banned pharmaceutical use of lindane because of concerns about water quality, as lindane treatment for head lice and scabies was found to be a significant factor adversely affecting wastewater quality. In this article we describe...

New Orleans has long had a documented problem with lead contaminated soil. Small-scale remediation efforts in that city have historically been shown to reduce both soil lead and children's blood lead levels in highly-affected locations. The flooding after Hurricanes Katrina and Rita distributed a coating of sediment throughout many areas of the cit...

Children encounter pesticide products and their residues where they live and play and in the food supply. Pesticide exposure affects pediatric health both acutely and chronically; effects range from mild and subtle to severe. Pediatricians play an important role in identifying and reducing significant pesticide exposure in their patients by taking...

Persistent organic pollutants (POPs) are anthropogenic chemicals that are poorly biodegradable and have the potential for adverse human health effects. Although national regulations and an international treaty have resulted in the gradual decline of many POPs in human blood and breast milk, the levels of other POPs continue to rise. Children and de...

The hurricanes and flooding in New Orleans, Louisiana, in October and November 2005 resulted in damp conditions favorable to the dispersion of bioaerosols such as mold spores and endotoxin. Our objective in this study was to assess potential human exposure to bioaerosols in New Orleans after the flooding of the city. A team of investigators perform...

In the United States, companies that use their own funds to test consumer products on their employees are subject to few regulations. Using previously undisclosed tobacco industry documents, we reviewed the history of that industry’s efforts to create internal guidelines on the conditions to be met before employee taste testers could evaluate cigar...

Background The hurricanes and flooding in New Orleans, Louisiana, in October and November 2005 resulted in damp conditions favorable to the dispersion of bioaerosols such as mold spores and endotoxin. Objective Our objective in this study was to assess potential human exposure to bioaerosols in New Orleans after the flooding of the city. Method...

Tobacco is a heavily pesticide-dependent crop. Because pesticides involve human safety and health issues, they are regulated nationally and internationally; however, little is known about how tobacco companies respond to regulatory pressures regarding pesticides. In this study we analyzed internal tobacco industry documents to describe industry act...

Seaports are major hubs of economic activity and of environmental pollution in coastal urban areas. Due to increasing global trade, transport of goods through ports has been steadily increasing and will likely continue to increase in the future. Evaluating air pollution impacts of ports requires consideration of numerous sources, including marine v...

Although they are accustomed to discussing risks in the medical arena through the process of informed consent, primary care clinicians may have difficulty communicating with their patients and communities about environmental health risks. Clinicians are generally trusted and can play important roles as educators, alert practitioners, or even advoca...

Millions of workers are exposed occupationally to diesel exhaust at a wide range of levels. Outside the workplace, ambient air contains diesel exhaust components, including fine particulate, elemental carbon, nitrogen oxides, and volatile organics emitted from diesel engines. Both occupational and environmental exposures to diesel exhaust have been...

Bans and regulation in many countries have reduced the environmental levels of many persistent organic pollutants (POPs). Despite these declines, there is still evidence of exposures in a range associated with adverse health effects. This seeming paradox is a result of the realisation that levels once presumed safe can cause subtle but important he...

Research on environmentally related chemical contaminants in breast milk spans several decades and dozens of countries. The ability to use this research as an environmental indicator is limited because of a lack of consistent protocols. Data on xenobiotics in breast milk are influenced by choices in sample selection, sample pooling, analysis, and r...

Several components of air pollution have been linked to asthma. In addition to the well-studied critera air pollutants, such as nitrogen dioxide, sulfur dioxide, and ozone, diesel exhaust and diesel exhaust particles (DEPs) also appear to play a role in respiratory and allergic diseases. Diesel exhaust is composed of vapors, gases, and fine particl...

There is evidence that diesel exhaust causes cancer and premature death, and also exacerbates asthma and other respiratory illness. Noting that the vast majority of the nation's school buses run on diesel fuel, this report details a study examining the level of diesel exhaust to which children are typically exposed as they travel to and from school...

Occupational asthma may account for a significant proportion of adult-onset asthma, but incidence estimates from surveillance of physician reports and workers' compensation data (0.9 to 15/100,000) are lower than expected from community-based cross-sectional studies of asthma patients. We conducted a prospective cohort study of 79,204 health mainte...

Methylcyclopentadienyl manganese tricarbonyl (MMT) is an organic manganese compound recently approved for use in the United States as a gasoline additive. MMT use is expected to increase. This Commentary analyzes the impact of MMT use on population exposure to manganese, the health effects associated with manganese exposure, and the possibility tha...

Sodium azide is the principal gas-generating agent used to inflate automobile supplemental restraint systems, more commonly called airbags. Although sodium azide is known to affect the cardiovascular system by causing peripheral vasodilation, there is no published literature describing occupational exposures to sodium azide in the rapidly growing a...

Sodium azide is the principal gas-generating agent used to inflate automobile supplemental restraint systems, more commonly called airbags. Although sodium azide is known to affect the cardiovascular system by causing peripheral vasodilation, there is no published literature describing occupational exposures to sodium azide in the rapidly growing a...

N-methyl-2-pyrrolidone is a solvent that is increasingly used in a variety of industries, including petroleum refining, microelectronics, pesticide formulation, and veterinary medicine. animal studies have demonstrated fetotoxic effects after maternal exposure to doses that have minimal to no adverse effect on the mothers. The fetotoxicity comprise...

Thesis (M.D.) - Yale University, 1991. Includes bibliographical references (leaves 41-48).