Ghenadie Curocichin

State University of Medicine and Pharmaceutics „Nicolae Testemiţanu" · Department of Family Medicine

Background Moldova strives for universal health coverage (UHC) and considers health technology assessment (HTA) an important policy instrument to inform the choice of services that should be covered to progressively realize UHC. It plays a key role in determining which technologies are coved, considering various dimensions often including cost-effe...

Background The COVID-19 pandemic has had an enormous impact on health systems in Europe and has generated unprecedented challenges for tertiary care. Less is known about the effects on the activities of local family doctors (FDs), who have shifted tasks and adapted their practice to accommodate the new services brought by the pandemic. The PRICOV-1...

The technical revolution has generated large numbers of data in healthcare and biomedical research. Thus, research and innovation became a growing priority to support a change from the one-size-fits-all paradigm of healthcare to Personalized medicine, also called precision medicine. This important pillar in realizing innovation priority in healthca...

The potential of Personalised Medicine makes it attractive to health systems, and personalised approaches are being applied in practice in highly developed countries. However, the implementation of personalised medicine in low- and middle-income countries (LMICs) faces a number of barriers. In this group of countries, where resources allocated for...

Genetic polymorphisms of drug-metabolizing enzymes, such as cytochrome P450 oxidases, can alter the pharmacokinetic properties of administered drugs, leading to variability in drug responses. Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial. In the current study, the frequency of the CYP2C19*2, CYP2C...

Implementing Personalized Medicine in the operational and functional context of a healthcare system is a complex challenge for most countries. Pharmacogenetics represents the application domain of individual genetic profile testing for drug prescription purposes. Health insurance systems are the mechanism by which drug treatment expenses can be cov...

Clopidogrel is one of the most commonly antiplatelet agents used for the secondary prevention of atherothrombotic events in patients with cardiovascular disease (CVD). Clopidogrel is a prodrug that requires biotransformation by cytochrome P450 (CYP450). This study evaluated the effect of genetic polymorphism in CYP2C19*2 on clinical response in Mol...

Background/Objectives The electrocardiographic PR interval reflects atrial and atrioventricular nodal conduction time. Prolongation of the PR interval increase risk of atrial fibrillation (AF) and heart block. Genome-wide association studies (GWAS) have identified association of a nonsynonymous single nucleotide polymorphism (SNP), rs6795970, in th...

Background: Guanine deletion 35delG in GJB2 exon 2 is the pathogenic mutation responsible for up to 70% of cases of congenital non-syndromic sensorineural hearing loss (NSHL) among Europeans. The early molecular diagnostic of hearing loss nature has become important while considering the cochlear implants. The purpose of this study was to establish...

Noncommunicable diseases (NCDs) are a growing challenge in the Republic of Moldova. A previously reported pilot cluster randomized controlled trial aimed to determine the feasibility of implementing and evaluating essential interventions for NCDs (e.g. cardiovascular risk scoring, hypertension management, statin treatment, etc.) in primary health c...

Background: The aim of this study is to determine the feasibility of implementing and evaluating the World Health Organization Package of Essential Non-communicable Disease Interventions (WHO PEN) approach in primary healthcare in the Republic of Moldova. Methods: According to our published a priori methods, 20 primary care clinics were randomiz...

In 2014, the Republic of Moldova started a systematic process of reforming its mental health system, implementing priority actions set out in the National Mental Health Programme. The reform entailed a service delivery re-design, instituting mechanisms for collaboration across health and social sectors, and revision of the policy framework. Outcome...

Introduction Nearly 90% of all deaths in the Republic of Moldova are caused by non-communicable diseases, the majority of which (55%) are caused by cardiovascular diseases (CVD). In addition to reducing premature mortality from CVD, it is estimated that strengthening primary healthcare could cut the number of hypertension-related hospital admission...

Congenital sensorineural hearing loss (SNHL) is recognized as a major public health burden. Mutations in the GJB2 gene are among the most frequent encountered etiological factors (approximately 50% of cases of autosomal recessive sensorineural non-syndromic hearing loss in the Caucasian population). Single nucleotide polymorphisms (SNPs) are import...

Cardiovascular diseases are responsible for more than half of total mortality in the Republic of Moldova. Dyslipidaemia and obesity are recognized as modifiable cardiovascular risk factors, and lipid levels have a tendency to track from childhood to adulthood. Early identification and delimitation of the risk group is important for potential indivi...

IS ASPIRINE USE A PROTECTOR FACTORS OF NONALCOHOLIC FATTY LIVER DISEASE? Peltec A, IvanovaV, Curocichin G, Munteanu A, Dumbrava V, Popovici M. Background: Nonalcoholic fatty liver disease is now conceptualized as a 'multiple hit' process, consisting of insulin resistance, which causes a reversible fat accumulation in hepatocytes as the first hit,...

C-reactive protein (CRP) is a component of nonspecific immune defense and is a reliable marker of low-grade inflammation involved in obesity, type 2 diabetes and cardiovascular disease. Genome-wide association studies in middle-aged and elderly populations, predominantly of European descent, demonstrated associations of CRP levels with single-nucle...

Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism. We conducted a genome-wide association study to investigate the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CL...

As in other former Soviet republics, Moldova's health system has been dependent upon multispecialty and hospital care. The government has undertaken a planning process to develop a primary care-based system utilizing family physicians. Carelift International and Moldova State Medical and Pharmaceutical University joined together to design an educat...