Francisco Forriol

Universidad Pontificia Comillas | UPCO · MOBIOS (Mobility

Background: The etiopathogenesis of ACL rupture is not clarified. The aim of this study is to identify genomic regions and genetic variants relevant to anterior cruciate ligament injury susceptibility that could be involved in non-contact anterior cruciate ligament ruptures. Methods: A systematic review of the literature was performed according to...

Introducción: La Hormona Gonadotrofina Coriónica (HGC) es uno de los elementos a detectar en los controles antidopaje en el fútbol, pues está incluida en la Lista de Prohibiciones 2023 de la Agencia Mundial Antidopaje (AMA-WADA), en el grupo S2 Hormonas peptídicas, factores de crecimiento, sustancias afines y miméticos. Las cantidades elevadas de h...

The aim was to evaluate the feasibility of a home-based neurodynamic programme for patients with knee osteoarthritis (KO). Thirty participants (70% women) ≥ 50 years old with KO (Kellgren–Lawrence grades I–II) were included. Active mobilisation of the femoral nerve was performed at home over a period of 6–8 weeks. The feasibility of the programme w...

Fracture healing is a physiological process that aims at a complete functional recovery without deformities. It implies an anatomical process of bone consolidation, rehabilitation of the muscle tone, and articular function. In order to quicken bone consolidation, fractures should be stabilized. Fracture stabilization is the absence of movement betw...

Bones constitute a part of the musculoskeletal system that defines the shape of the body and protects vital organs. Bones are essential in movement, acting as a rigid lever for the action of muscles. In addition, they have a hematopoietic function and act as phosphorus and calcium (P/Ca) homeostasis regulators. Bone mass contributes to the maintena...

A bone fracture is defined as a medical condition in which a partial or complete interruption of the bone integrity occurs due to mechanical trauma. The bone tissue repairs without scarring. The repair starts with the formation of an elastic soft tissue called bone callus, which is then replaced by a new hard bone. The fracture callus aims to preve...

Background: Cell therapy has been proposed as part of the therapeutic arsenal to assist bone formation and remodeling in the early stages of osteonecrosis of the femoral head. The purpose of this study is to determine the effects of intraosseous inoculation of mesenchymal stem cells on bone formation and remodeling in an established experimental mo...

A shallow sulcus characterizes trochlear dysplasia (TD) of the femoral trochlea, which can lead to chronic pain or instability of the patellofemoral joint. Breech presentation at birth has been identified as a risk factor for developing this condition, which an ultrasound can identify early. Early treatment could be considered at this stage, given...

Introduction: The fat of the synovial joints can be used to maintain the joint structure. Our objective is to analyze the evolution of joint degeneration in knees with and without adipose pack. Material and methodology: In 6 sheep, the anterior cruciate ligament was sectioned in both knees, to cause osteoarthritis. In one group the fat pack was...

Resumo Objetivo Analisar as dimensões do ligamento cruzado posterior (LCP), do ligamento cruzado anterior (LCA), a presença de ligamentos meniscofemorais (LMFs) em joelhos humanos e a correlação com as dimensões do esqueleto do joelho. Métodos Estudo anatômico em 29 espécimes de joelhos humanos nos quais medimos o comprimento e a largura dos ligame...

Bone is a heterogeneous, hierarchical biocomposite material made of an organic matrix filled with a mineral component, which plays an important role in bone strength. Although the effect of the mineral/matrix ratio on the mechanical properties of bone during aging has been intensively investigated, the relationship between the mechanical properties...

Major sporting events were suspended during the most acute phase of the COVID-19 pandemic. Competitions are resuming with enhanced hygiene protocols and altered mechanics. While risks for players and staff have been studied, the impact of large-scale tournaments on the communities that host them remains largely unstudied. CONMEBOL Copa América is o...

Purpose: It has been argued that the meniscus-femoral ligaments disappear with age. We therefore analyzed the presence of the meniscus-femoral ligaments, in MRI. Materials and methods: We measured the PCL, ACL and MFL, noting their presence or absence in 120 Knee MRIs, 51 in women and 69 in men. All knees underwent MRI in the coronal, sagittal a...

Objetivo: Analizar los resultados clínicos de las metatarsalgias tratadas con osteotomías metafisarias metatarsales distales (DMMO) por vía percutánea. Material y métodos: Estudio prospectivo y continuo de 29 pacientes afectados de metatarsalgia mecánica aislada unilateral, intervenidas con una DMMO, con un seguimiento medio de 38 meses. La edad m...

The indications of wrist arthroscopy are expanding with the advancement of technical and instrumental development. Most of the diseases in the joint can be managed by this minimally invasive technique with proper portal selection and establishment. This chapter describes in detail the various portals of radiocarpal and midcarpal joint and indicatio...

Objective: To analyze the clinical results of metatarsalgia treated with percutaneous distal metatarsal metaphyseal osteotomies (DMMO). Material and methods: Prospective and continuous study of 29 patients with isolated unilateral mechanical metatarsalgia, operated on with DMMO, with a mean follow-up of 38 months. The mean age of the patients wa...

Osteoarthritis (OA) of the glenohumeral (GH) joint is a common cause of shoulder pain, resulting in considerable invalidity. Unfortunately, the study of its pathogenesis is challenging. Models of OA are necessary to identify specific targets for therapy and to be able to interfere with the development and evolution of OA. This study aims to assess...

Resumo Objetivo O objetivo do nosso estudo é analisar os resultados clínicos e funcionais do tratamento de lesões nas articulações do joelho com condrócitos autólogos embebidos em arcabouço de fibrina. Métodos O estudo foi realizado com 56 pacientes (36 homens e 20 mulheres) com idade média de 36 anos; 6 indivíduos eram atletas profissionais. Os pa...

PurposeIn the athletic population, the prevalence of isolated syndesmotic lesions is high. To detect potential instability of the ankle is crucial to define those lesions in need of surgical management.The aim was to define how the extent of tibio-fibular syndesmotic ligament injury influences the overall stability of the ankle joint in a cadaver m...

Background We analyzed the clinical and radiographic evolution of patients with knee unicompartmental osteoarthritis and axis alteration and osteochondral lesions in the femoral condyle, treated with tibial plateau and meniscus allograft and cultured autologous chondrocyte implantation in the femur in two steps.PurposeTo analyze the clinical result...

Objective: Increasing evidence has shown the involvement of the innate immune system and inflammatory response in osteoarthritis (OA) pathogenesis; however, anterior cruciate ligament (ACL) tears are recognized risk factors for development of post-traumatic OA. We investigated (1) whether inflammatory mediators involved in OA pathogenesis are also...

Objetivo: Analizar el nivel de citoquinas proinflamatorias en la grasa articular del paquete adiposo en pacientes con gonartrosis, en relación con la grasa subcutánea del muslo. Material y métodos: Efectuamos un estudio de grasa del paquete adiposo articular de la rodilla afectada de artrosis y de la grasa subcutánea del muslo del mismo lado, a la...

The reinforcement of PMMA bone cements using carbon based nanomaterials has demonstrated to be a potential solution to their poor mechanical properties. The achievement of an optimal dispersion of the nanoparticles within the polymeric matrix is a crucial but not easy stage in the production of high-quality reinforced materials. In this work, a use...

Objective: To analyze the level of pro-inflammatory cytokines in osteoarthritis knee joint fat pad in relation to the subcutaneous fat of the thigh. Material and methods: We performed a study of fat of the knee joint adipose affected of osteoarthritis and subcutaneous fat of the thigh of the same side to the greater distance of the joint in six...

The infrapatellar fat pad (IPFP) is a periarticular adipose knee tissue. This tissue contains a large number of mesenchymal stem cells (MSCs). In the present work, we wanted to study the IPFP MSCs and their relationship and differences in two groups, anterior cruciate ligament (ACL) ruptures knees and ostheoarthrosis (OA). The IPFP of 42 patients w...

In the last few decades, several techniques have been used to optimize tendon, ligament, and musculoskeletal healing. The evidence in favor of these techniques is still not proven, and level I studies are lacking. We performed an analysis of the therapeutic strategies and tissue engineering projects recently published in this field. Here, we try to...

Resumen Objetivo: evaluar diferentes modelos animales para el entrenamiento de habilidades artroscópicas en nuestro medio. Material y métodos: Utilizamos seis rodillas de conejo, dos de perro, seis de cordero, dos de vaca y seis de cerdo en los cuales realizamos una artroscopia diagnóstica. Los modelos fueron puntuados por el cirujano responsable,...

Purpose: Sometimes, total knee replacement (TKR) is performed after a tibial osteotomy. It is not known if the osteotomy influences the clinical process of a TKR. The aim of this study was to look at the clinical outcome of a TKR after high tibial osteotomy (HTO) compared to a TKR with no HTO. Methods: Between 1995 and 2005, 41 post-HTO TKRs (gr...

Aim In the osteoarthritis (OA) disease, all structures of the joint are involved. The infrapatellar Hoffa fat pad is rich in macrophages and granulocytes, which also represents a source of adipose mesenchymal progenitor cells (ASC) cells. In our study, we analyze how OA affects the ability of ASC-derived from Hoffa’s fat pad to differentiate into c...

El menisco es una unidad funcional que absorbe y distribuye las solicitaciones de la articulación de la rodilla. El trasplante de menisco pretende la restitución anatómica, la recuperación de la mecánica articular y evitar la degeneración del cartílago articular, en pacientes jóvenes cuando se extirpa el menisco. Material y Métodos: Se han estudiad...

Lower limb pain is fairly common, particularly among runners [1–5]. It equates to about 20% of their injuries and is naturally a big source of frustration. The most common site of shin splints is in the anterior face of the lower third of the tibia, but may extend proximally. Also they may appear in the fibula or femur or foot bones, this is more c...

Los meniscos de la articulación de la rodilla son estructuras fundamentales en la mecánica articular pues actúan en la distribución de las solicitaciones; la absorción de cargas; la regulación de la lubricación y en la propiocepción y estabilidad articular. Los meniscos son estructuras intermedias entre el tejido fibroso y el cartílago con fibras d...

Background The purpose of this study was to evaluate the functional status prior to and at different times after anterior cruciate ligament reconstruction (ACLR), and to analyze the changes in the kinetic patterns of the involved and uninvolved lower limb during gait, sprint and three hop tests. Materials and methodsSeventy-four male patients with...

Graphene (G) and graphene oxide (GO) nano-sized powders with loadings ranging from 0.1 to 1.0 wt% were investigated as reinforced agents for polymethyl methacrylate (PMMA) bone cements. The mechanical properties (i.e. bend strength, bend modulus, compression strength, fracture toughness and fatigue performance) and the thermal properties (i.e. maxi...

Background: Derotational osteotomy of the proximal femur has proved to be effective in the treatment of residual acetabular dysplasia. However, the reason why this osteotomy is effective remains debatable. The purpose of this study is to investigate if an alteration of femoral head orientation affects acetabular growth. Methods: A proximal femor...

La artrosis es una patología que afecta a toda la articulación con unos signos claros pero con un inicio asintomático difícil de diagnosticar. La radiografía simple ha sido el método de diagnóstico más utilizado, aunque durante mucho tiempo es silente y luego se valora por signos indirectos como es la disminución del espacio articular. La resonanci...

In this chapter, we take a look at the long history of developments in the treatments of bone tumors. Early in the twentieth century, only certain small, localized cancers that could be removed by surgery were curable. Then came radiation, which was used after surgery to control the growth of small tumors that could not be widely removed. The intro...

Analizar las lesiones en 4 campeonatos oficiales de la CONMEBOL, masculinos y femeninos, para conocer las diferencias en la localización, el diagnóstico y la gravedad de las lesiones producidas entre futbolistas de ambos sexos.

La biopsia es una etapa importante en el diagnóstico de los tumores óseos y de partes blandas. No es un procedimiento sencillo. El objetivo de este artículo es ofrecer algunas sugerencias a los médicos que se encargan del cuidado de estos pacientes y evitar los riesgos inherentes de la biopsia. Las decisiones relacionadas con la indicación de una b...

Objective: the menisci are easily injured and difficult to repair. The aim of this study was to analyze the current state of meniscal surgery aimed at preserving morphology and conserving the biomechanics of the knee to prevent joint degeneration. Methodology: a search of the electronic medical literature database Medline was conducted, from htt...

Aim: to provide an overview of the traumatic injuries sustained by players in the 2015 America Cup. Material and methods: we collected the medical reports on all the matches held during the 2015 America Cup, in Chile, in 2015. Twelve American teams took part in the championship, consisted of 26 matches with a total of 276 players. The physician...

Objective: We performed an epidemiological study of the traumatic injuries during the XVI South American U-17 Football Championship, 2015. Material and methods: Observational surveys submitted by the 10 teams medical services of 220 players. Thirty-five games were held and 116 goals (3.31 per game) were recorded. Results: 103 lesions, ie, 2.94...

información del artículo Historia del artículo: Recibido el 31 de marzo de 2016 Aceptado el 28 de abril de 2016 On-line el 5 de junio de 2016 Palabras clave: Tumor óseo Biopsia Sarcoma Osteosarcoma Sarcoma de Ewing r e s u m e n La biopsia es una etapa importante en el diagnóstico de los tumores óseos y de partes blandas. No es un procedimiento sen...

The basic formulation of an acrylic bone cement has been modified by the addition of a block copolymer, Nanostrength(®) (NS), in order to augment the mechanical properties and particularly the fracture toughness of the bone cement. Two grades of NS at different levels of loading, between 1 and 10 wt.%, have been used. Mechanical tests were conducte...

Resumen Objetivo Estudio epidemiológico de las lesiones traumáticas producidas durante el XVI Campeonato Sudamericano de Fútbol Sub-17 en 2015. Material y metodología Estudio observacional de las encuestas enviadas por los servicios médicos de 220 jugadores, de los 10 equipos participantes en el campeonato. Se celebraron 35 partidos y se anotaron...

Background: The purposes of this study were to (1) validate and assess the reliability of a modified magnetic resonance semi-quantitative score (sheep Magnetic Resonance osteoarthritis Knee Score (sMOAKS)) to evaluate joint degeneration in the ovine knee and to (2) investigate whether the transection of the anterior cruciate ligament (ACL), isolat...

Mechanical stimulation plays a crucial role in bone mineral maintenance. This stimulation prevents osteocyte apoptosis by a mechanism that involves β-catenin accumulation and nuclear translocation of extracellular-signal-regulated kinases (ERKs). The vascular endothelial growth factor (VEGF) and parathyroid hormone-related protein (PTHrP) modulate...

The efficacy and safety of BST-CarGel®, a chitosan scaffold for cartilage repair was compared with microfracture alone at 1 year during a multicenter randomized controlled trial in the knee. This report was undertaken to investigate 5-year structural and clinical outcomes. The international randomized controlled trial enrolled 80 patients, aged 18...

The best treatment option for some acromioclavicular (AC) joint dislocations is controversial. For this reason, the aim of this study was to evaluate the vertical biomechanical behavior of two techniques for the anatomic repair of coracoclavicular (CC) ligaments after an AC injury. Eighteen human cadaveric shoulders in which repair using a coracocl...

Use of antibiotic-loaded bone cements is one of the most effective methods for the prevention and treatment of prosthetic joint infection. However, there is still controversy about the optimal combination and doses of antibiotics that provide the maximum antimicrobial effect without compromising cement properties. In this study, vancomycin and cefa...

Objective: To account the injuries that occurred in the XXVII South American soccer championship U-20. Material and method: Observational surveys submitted by the medical services of all participating teams in the championship. They were young players, all of them under the age of 20. Surveys with parts of incidents were collected and analyzed by t...

Introduction: The most common method to obtain human mesenchymal stem cells (MSCs) is bone marrow aspiration from the iliac crest, but MSCs have also been isolated from different bones. The main purpose of this study was to compare bone marrow MSCs aspirated from the metaphysis of the distal femur and the proximal tibia with those obtained from th...

This study analysed the influence of bone morphogenetic protein-7 (BMP-7) on cells and meniscal structure. The effect of treatment with BMP-7 was assessed in vitro and in vivo in lesions in the avascular area of the meniscus. Cells were extracted from the outer and inner part of eight menisci of four 2-year-old merino sheep. The menisci were digest...

Objective: To evaluate the effects of VEGF, BMP-7, Matrigel(TM), hyaluronic acid, in vitro cultured chondrocytes and trephination to promote and enhance the healing process of avascular meniscal tears in an animal model. Methods: A longitudinal tear was produced in the inner avascular part of the meniscus of 24 sheeps. Each tear was treated with...

Background: Fibronectin, a large dimeric plasma glycoprotein found only in vertebrates, is a core component of several extracellular matrices. Integrin receptors regulate different cell activities. Fibronectin expression patterns in intervertebral disc have not been extensively studied. The aim of this study was to evaluate the distribution of fib...

Purpose: The aim of the present study was to compare the potential for cartilage repair of fresh amniotic membrane (AM), cryopreserved AM and cryopreserved AM previously cultured with bone marrow mesenchymal stem cells (BM-MSCs) in an in vivo sheep animal model. Methods: A full-thickness cartilage defect was surgically produced in 12 adult sheep...

Oxidative stress is a key factor in aging and diabetes. Mechanical loading is critical to maintain bone mass. The response of bone to mechanical stimuli appears to be reduced with aging and probably in bone disease caused by diabetes. Understanding the mechanisms by which oxidative stress affects function of bone cells, and specifically to osteocyt...

Objective To establish a simple, reproducible and safe experimental model, for the development of ischemic vascular necrosis of the hip in the lamb. Material and methods We used 15 lambs (10 males and 5 females) aged four weeks, divided into a control group (7 animals) and an experimental group (8 animals) producing ischemia in the proximal femur....

The purpose of the study is to identify the safe zone in which the surgeon can place the screws for fixation of the coracoid graft during the Latarjet procedure to avoid injuries of the suprascapular nerve with the shoulder in internal and external rotation. The dissection on twelve fresh-frozen shoulders was performed according to a standard poste...

To establish a simple, reproducible and safe experimental model, for the development of ischemic vascular necrosis of the hip in the lamb. We used 15lambs (10males and 5females) aged four weeks, divided into a control group (7animals) and an experimental group (8animals) producing ischemia in the proximal femur. Standard radiography and MRI were pe...

In presenza di lesioni condrali, un’opzione terapeutica è offerta dall’ingegneria tissutale, e principalmente dall’impianto di condrociti. L’uso di “scaffold” porosi e riassorbibili consente la migrazione, l’adesione e la proliferazione dei condrociti e la conseguente rigenerazione del tessuto cartilagíneo. Le tecniche disponibili per il trattament...

The use of bone cement is widespread in orthopaedic surgery. Most of the mechanical tests are performed in dry medium, making it difficult to extrapolate the results. The objective of this study is to assess if the mechanical properties of polymethylmethacrylate (PMMA), obtained in previous reports, are still present in a liquid medium. An experime...

The opinions of 21 experts in knee surgery were evaluated in this study, using a DELPHI questionnaire method in two successive rounds, on 64 controversial scenarios that covered both the diagnosis and possible treatment of painful knee replacements. The level of consensus was significantly unanimous in 42 items and of the design in 5, with no agree...

Microfracture, the standard of care, is recognized to be an incomplete solution for cartilage damage. BST-CarGel, a chitosan-based medical device, is mixed with autologous whole blood and is applied to a microfractured cartilage lesion in which it physically stabilizes the clot and guides and enhances marrow-derived repair. An international, multic...

A trabecular metal screw has been suggested to treat avascular osteonecrosis of the femoral head. Non-surgical management with partial weight bearing can only be selected for early stages and very small lesions. Even in such cases, it has been proven to be ineffective in 80-90 % of patients. Conversely, the results with trabecular metal implants ar...

Objective: To evaluate joint degeneration on four surgically induced models of Osteoarthritis in the Ovine's stifle in order to establish a model of early joint degeneration using different magnetic resonance imaging semi quantitative scales.

Objective: To study the effect of the addition of different nanofillers on the mechanical properties and in the curing process of the bone cement.

Objective: To analyze the alterations produced by the different proximal femoral osteotomies upon acetabular morphology.

The purpose of the study is to evaluate the effect of a selective epiphysiodesis of the ilioischial limb of the triradiate cartilage (TC) in an experimental dysplastic hip. A hip dysplasia was obtained in 23 New Zealand rabbits 3 weeks old by immobilizing the knee in extension with a K-wire, in 4 groups: (1) control group; (2) K-wire maintained unt...