Flora Forouzesh

Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran · Genetics

Celiac disease (CD) is a chronic autoimmune disorder with a common genetic pathogenesis with type 1 diabetes (T1D). This study aimed to investigate the immune regulation in patients with both CD and T1D. A total of 29 CD patients, 29 T1D patients, and 16 patients with both CD and T1D, along with 30 healthy controls (HCs) were included. The mRNA exp...

Celiac disease (CD) is characterized by the disruption of the intestinal barrier integrity and alterations in the microbiota composition. This study aimed to evaluate the changes in the fecal microbiota profile and mRNA expressions of intracellular junction-related genes in pediatric patients with CD compared to healthy controls (HCs). Thirty treat...

Tongue cancer is a malignancy affecting the head and neck region that has exhibited an increased incidence in recent decades, primarily attributed to alterations in lifestyle patterns. In recent times, there has been a growing interest in investigating the impact of the secretome of mesenchymal stem cells on cellular function. However, the findings...

Background Celiac disease (CD) is a chronic autoimmune disorder characterized by an abnormal immune response to gluten, a protein found in wheat, barley, and rye. It is well established that the integrity of epithelial tight junctions (TJs) and adherens junctions (AJs) plays a crucial role in the pathogenesis of CD. These junctional complexes contr...

LncPVT1 and CircPVT1 are isoforms for the PVT1 gene and are associated with cancer progression and carcinogenesis. Our study investigated the expression of LncPVT1 and CircPVT1 in colon adenoma polyps. 40 tissues of colorectal polyps and 40 normal-adjacent tissues (NATs) were taken. The expression of LncPVT1 and CircPVT1 was evaluated through qRael...

The average survival of patients with glioblastoma is 12–15 months. Therefore, finding a new treatment method is important, especially in cases that show resistance to treatment. Extremely low-frequency electromagnetic fields (ELF-EMF) have characteristics and capabilities that can be proposed as a new cancer treatment method with low side effects....

Colorectal cancers are derived from intestinal polyps. Normally, alterations in cell adhesion genes expression cause deviation from the normal cell cycle, leading to cancer development, progression, and invasion. The present study aimed to investigate the elusive expression pattern of CDC42, TAGLN, and GSN genes in patients with high and low-risk p...

Recent studies have shown that non-ionizing electromagnetic fields (NIEMFs) in a specific frequency, intensity, and exposure time can have anti-cancer effects on various cancer cells; however, the underlying precise mechanism of action is not transparent. Most cancer deaths are due to metastasis. This important phenomenon plays an inevitable role i...

Background Colorectal cancers are derived from intestinal polyps. Normally, alterations in cell adhesion genes expression cause deviation from the normal cell cycle, leading to cancer development, progression, and invasion. The present study aimed to investigate the elusive expression pattern of CDC42, TAGLN, and GSN genes in patients with high and...

Aims: Without any doubt, vaccination was the best choice for Coronavirus disease 2019 (COVID-19) pandemic control. According to the American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO), people with cancer or a history of cancer have a higher risk of dying from Covid-19 than ordinary people; hence, they shou...

https://civilica.com/doc/1661039/

Background. One of the effective genes in the pathogenesis of the celiac disease is the Ets1 gene, which encodes the transcription factor Ets1 and is highly conserved during evolution. The Ets1 gene inhibits the differentiation of T helper 17 (Th17) cells and the production of interleukin-17A (IL-17A) by these cells and decreased expression of the...

Background & Objective: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global infection and a continuing pandemic. Symptoms have been associated with age, biological sex, and other previous present health situations. The aim of this study was to make a genetic comparison between the SARS-CoV-2, SARS-CoV, and Mid...

Background Celiac disease (CD) is a hereditary immune-mediated disorder, which is along with the enormous production of pro-inflammatory cytokines and the reduced level of tight junction proteins. The aim of this study was to determine the expression of TNF-α, IFN-γ, IL-18, Occludin, miR-122-5p and miR-197-3p genes in duodenal biopsies of treated C...

SARS-CoV-2 was the first severe epidemic of the digital age. Computational approaches have been widely used in the effort to deal promptly and effectively with the resulting global health crisis. Bioinformatics and computational biology are important in understanding and analyzing protein dynamics, primarily in relation to sequence, structure, and...

The greatest battle of the 21st century against the Covid-19 virus has led to the unprecedented use of bioinformatics tools in deciphering the molecular properties of infectious pathogens. Because SARS-COV-2 viral genome data became available only a few weeks after the outbreak, bioinformatics platforms have become a vital tool for gaining time to...

Introduction: The microRNA-326 (miR-326) gene, by targeting ETS Proto-Oncogene 1 (ETS1), regulates the differentiation and interleukin-17A production of T helper 17 (Th17) cells. Celiac disease (CD) is an intestinal autoimmune disorder, in which the cascade of Th17 cells plays an important role in its pathogenicity. The aim of this study was to eva...

Free radicals are highly reactive molecules with short lifetime which are now well accepted to act as regulators for different signaling pathways and hence can affect various cellular processes. Furthermore, they play pivotal role in different physiological/pathophysiological processes including homeostasis, metabolism, immunity, proliferation, dif...

Background As a well-known protein, Bid links the extrinsic and intrinsic apoptotic pathways and plays important roles in cell proliferation. In this study, we evaluated the expression of two isoforms of the Bid gene (BidSi6 and BidEL) in colorectal adenomatous polyps as a biomarker and investigated the relationship between their expression levels...

The Covid-19 Pandemic is a global warning. In the event of future pandemics or COVID-19 waves, it is critical to focus on the ethical problems that have been raised and continue to be raised throughout this COVID-19 tension. There are ethical challenges to COVID-19 in many ways. How governments treat people in relation to drug quotas or mandatory a...

Background and Objectives One of the molecules that associated with cancer progression are Long non coding RNA (LncRNAs). HOX transcript antisense RNA (HOTAIR) is a member of the lncRNA family. Homeobox C13 (HOXC13) gene is one of the several HOX genes that is located near the HOTAIR. This study was to evaluate the expression of HOTAIR and HOXC13 g...

Background Schizophrenia is a multifactorial psychiatric disorder with unknown etiology and prevalence of around 1% worldwide. ANK3 and ZNF804A are two most related genes with Schizophrenia and many psychiatric related phenotypes. Several studies have revealed the association of Schizophrenia with two intronic single nucleotide polymorphisms (SNPs)...

Objective: miR-105-5p either acts as an oncomiR or tumor suppressor that has been shown to have various expression levels in a wide range of diseases and targets RAC-alpha serine/threonine-protein kinase (AKT1) and Growth Factor Receptor-bound protein 2 (GRB2) genes. GRB2 is a signaling protein that takes part in various signaling pathways. Due to...

Spinal muscular atrophies (SMAs) are a heterogeneous group of neuromuscular diseases characterized by loss of motor neurons, muscle weakness, hypotonia and muscle atrophy, with different modes of inheritance; however, the survival motor neuron 1 (SMN1) gene is predominantly involved. The aims of the current study were to clarify the genetic basis o...

Many studies were performed to unravel the effects of different types of Electromagnetic fields (EMFs) on biological systems. Some studies were conducted to exploit EMFs for medical purposes mainly in cancer therapy. Although many studies suggest that the EMFs exposures can be effective in pre-clinical cancer issues, the treatment outcomes of these...

Background: Colorectal cancer (CRC) is the third most common cancer among men and the second most common type of cancer among women worldwide. The resistance of tumor cells to apoptosis is caused by changes in the expression of anti-apoptotic or pro-apoptotic proteins. Histone deacetylase inhibitors (HDACi) are known to cause changes in gene expres...

Background and Aim: Coronaviruses are a large family of viruses that cause disease in humans and animals. Coronavirus Disease 2019 (COVID-19) is an acute respiratory infectious disease caused by a new coronavirus. The World Health Organization has declared this infectious disease as a global pandemic. Objective: This study aims to review the latest...

Colorectal cancer (CRC) is the third most common type of cancer and the fourth leading cause of cancer related deaths worldwide. The Histone Deacetylase 8 (HDAC8) gene is a gene with unique features which can be used as a potential target for drug design. The LHX1 transcription factor is an important transcription factor for this gene. The aim of t...

Sodium butyrate, Histone Deacetylase Inhibitors, affect on Mouse L929 fibroblastic cell line

Background: LHX1 is an important transcription factor for the HDAC8 gene. The aim of this study was to investigate the effect of Sodium Butyrate (SB), as a histone deacetylase inhibitor, on the expression of LHX1 gene in colorectal cancer cell lines. Methods: HT-29 and HCT-116 cell lines were treated with 6.25 to 200 mM concentrations of SB at 2...

Spinal Muscular Atrophy (SMA) is the second most common autosomal recessive genetic disorder. Deletion/ duplication changes in SMN1 gene are common features in SMA patients. MLPA (Multiplex Ligation-dependent Probe Amplification) is a robust method for investigation of copy number changes because it not only deals with investigating the SMN1 gene b...

The chemokine receptor CXCR3 and its ligands CXCL10 and CXCL11 have been suggested to give rise to the most relevant chemokine axis able to facilitate the entrance of immune cells into inflamed tissues and be activated in different inflammatory disorders, such as celiac disease (CD). The aim of this study was to investigate the expression level of...

Gastrointestinal cancers including colorectal, liver, gastric and esophageal cancers are an increasing health problem throughout the world. Next Generation Sequencing (NGS) of cancer tissues is progressively being carried out to identify somatic genomic alterations that may guide physicians to make therapeutic results. Treating tumors based on muta...

Background: Based on lack of data on the distribution of the related alleles in the T1D population in Iranian population, we assessed the frequency of HLA DQ2 and DQ8 haplotypes in patients with T1D with/without CD compared to healthy population. Materials and methods: 70 patients with T1D without celiac disease, 60 T1D cases with CD were compar...

Objective: Most cases of colorectal cancer originate from adenoma polyps. The identification of the expression pattern of cancer related genes such as Hypoxia-inducible factor-1 (HIF-1α), can be useful in detection of the malignancy in polyps. The aim of this study is the evaluation of HIF-1alpha mRNA expression and risk of malignancy transitions i...

Objective: Most cases of colorectal cancer originate from adenoma polyps. The identification of the expression pattern of cancer related genes such as Hypoxia-inducible factor-1 (HIF-1α), can be useful in detection of the malignancy in polyps. The aim of this study is the evaluation of HIF-1alpha mRNA expression and risk of malignancy transitions i...

Objective: Most cases of colorectal cancer originate from adenoma polyps. The identification of the expression pattern of cancer related genes such as Hypoxia-inducible factor-1 (HIF-1α), can be useful in detection of the malignancy in polyps. The aim of this study is the evaluation of HIF-1alpha mRNA expression and risk of malignancy transitions i...

In recent years, knowledge of the biology of stem cell has been very effective and the precise and proper regulation of stem cell function are important for their bio-activity. Several main signaling pathways have roles in regulating them including Wnt/β-catenin, and Hedgehog which mediate different stem cell properties including self-renewal, surv...

Introduction: Colorectal cancer mostly be derived from adenomatous polyposis including tubular, villous and tubulovilluos types. Investigation of some genes that play role in angiogenesis can be used as a biomarker in molecular diagnosis for polyp progress to malignancy. The aim of this study is Comparing the expression level of VEGF-A gene in ade...

Background: Most of colorectal cancers arise from intestinal polyps. Evaluating of the expression level of genes that are involved in tumors growth and development, may consider as diagnostic factor of malignancy in the polyps. Failure of apoptosis is one of the causes of cancers. One of the key molecules in this pathway is Bid gene which connects...

Introduction: Efforts are made to identify the new potential components such as anti-cancer drugs. Medicinal plants belonging to Euphorbia genus are widely studied with promising effects. The current study aimed at investigating the effect of ethanolic extract of the root of E. tehranica, grown in Iran, on Caco-2 human colorectal cancer cell-line....

Introduction: Efforts are made to identify the new potential components such as anticancer drugs. Medicinal plants belonging to Euphorbia genus are widely studied with promising effects. The current study aimed at investigating the effect of ethanolic extract of the root of E. tehranica, grown in Iran, on Caco-2 human colorectal cancer cell-line. M...

Introduction T-cells have the potential to extirpate abnormal cells. the genetic modification and characterization of t-cells with chimeric antigen receptors (cars) allow functionally distinct t-cell subsets to recognize specific tumor cells. the aim of this study is to review recent findings of strategies of cars as a therapeutic potential and saf...

Introduction Introduction: Colorectal cancer is the third common cancer in women and men and mostly be derived from adenoma polyps that include tubular, villous and tubulo-villous types. MMP-7 gene plays a critical role in angiogenesis, growth and malignancy conversion in colorectal adenoma polyps. Investigation of some genes which play role in gr...

Abstract – Background: Colorectal cancer (CRC) is mostly derived from adenoma polyps. Investigation of some genes which play a critical role in angiogenesis and malignancy conversion can evaluated the risk of progression of adenoma polyps to CRC. This study aims to investigate VEGF-A and MMP-7 genes expression in different types of colorectal ade...

Cancer Stem Cells (CSCs) are a small subpopulation of tumor cells found in many cancers, including breast cancer. Breast cancer is the most common type of cancer, as well as the leading cause of cancer deaths among women worldwide. Breast Cancer Stem Cells (BCSCs) are the main cause of tumor growth, drug resistance, recurrence of disease and metast...

Important aspects of precision medicine in cancer.

Introduction: Nowadays, the advancement of researchers' knowledge in the field of stem cell biology and its key role in the creation of complex multicellular organisms, the importance of stem cells in the development of tumors has become more significant. It has been suggested that cells with stem cell characteristics called cancer stem cells (CSCs...

Drug resistance to current cancer therapies resulting in the imminent accumulation of breast cancer stem cells (BCSCs), the relapse of the disease in treated tumors, and widespread metastasis make new research for effective ways to overcome these burdens a priority. Nanomedicine significantly extends the range of existing anticancer drugs and treat...

Drug resistance to current cancer therapies resulting in the imminent accumulation of breast cancer stem cells (BCSCs), the relapse of the disease in treated tumors, and widespread metastasis make new research for effective ways to overcome these burdens a priority. Nanomedicine significantly extends the range of existing anticancer drugs and treat...

As a chronic immune complication, celiac disease has a broad spectrum of clinical manifestations and gluten ingestion as an external trigger will induce the onset of this disease in genetically predisposed individuals. Because of the complex nature of celiac disease and various cascades of immunological pathways, therapies which are tend to target...

Introduction: Cancer stem cells (CSCs) are subpopulation of tumor cells that cause relapse and metastasis by giving rise to new tumors. Thus it is important to know the mechanisms that regulate self-renewal and differentiation of CSCs. Also it has been demonstrated that CSCs are the cause of chemotherapy resistance. So the study of the properties o...

Expression of receptor tyrosine kinase Ror1 in a wide variety of cancers has emerged as a new era focusing on targeting this receptor in cancer therapy. Our preliminary re-sults indicate the presence of a truncated transcript of Ror1 in tumor cells. The trun-cated Ror1 encompasses extracellular and transmembrane domains, lacking catalytic kinase do...

Expression of receptor tyrosine kinase Ror1 in a wide variety of cancers has emerged as a new era focusing on targeting this receptor in cancer therapy. Our preliminary results indicate the presence of a truncated transcript of Ror1 in tumor cells. The truncated Ror1 encompasses extracellular and transmembrane domains, lacking catalytic kinase doma...

The ectopic expression of receptor tyrosine kinase Ror1 has been reported in patients with hematological malignancies such as chronic lymphocytic leukemia and acute lymphoblastic leukemia. Here we report, for the first time, expression of ROR1 gene in both tumor tissues and peripheral blood mononuclear cells (PBMC) from patients with renal cancer (...

Conjugation of monoclonal antibodies to super paramagnetic nanoparticles is an effective method for cancer diagnosis and treatment. In this study the humanized anti her2/neu monoclonal antibody- Herceptin- was conjugated to super paramagnetic iron oxide (SPIO) nanoparticles using EDC method. The concentration of the conjugated antibodies was measur...

Glutathione S-transferases (GSTs) are a major family of detoxification enzymes which possess a wide range of substrate specificities. Interest in insect GSTs has primarily focused on their role in insecticide resistance. In this study, following World Health Organization (WHO) routine susceptibility test, DNA was extracted from specimens of Anophel...

Anopheles culicifacies is a main malaria vector in southeastern part of Iran, bordring Afghanistan and Pakistan. So far, resistance to DDT, dieldrin, malathion and partial tolerance to pyrethroids has been reported in An. stephensi, but nothing confirmed on resistance status of An. culicifacies in Iran. In current study, along with WHO routine susc...