Filipe Modolo

Federal University of Santa Catarina | UFSC · Departamento de Patologia

After two years of the pandemic, there is still concern about COVID-19, mainly among non-vaccinated and specific groups such as patients at risk, particularly, a group of young people who may or may not be vaccinated and who are hookah users. These are exposed to trachea and lung damage considering that they use the equipment in closed places with...

Glandular odontogenic cyst (GOC) is an unusual entity, locally aggressive and with a high recurrence rate. A 60-year-old male patient was referred with the diagnosis of GOC from an incisional biopsy. Computed tomography revealed a hypodense unilocular lesion with cortical bone resorption involving the mandibular anterior region. After ostectomy, mi...

Objectives To investigate the prevalence of actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC) among lip lesions in an oral pathology service and compare the results with literature data. Study Design A retrospective review of histopathologic and biopsy files of patients with lip lesions from an oral pathology service was conducted. Dat...

Low-Grade Myofibroblastic sarcoma (LGMS) is categorized as an extremely rare malignant neoplasia of myofibroblasts, which has only recently become more widely studied. Our patient was referred for evaluation of a nodule involving the palate. The histopathological analysis showed a mesenchymal tumor formed for stellate-shaped cells. Negativity for L...

Objectives The aim of this study was to perform a systematic review to assess the sensitivity, specificity, and accuracy of magnetic resonance imaging (MRI), computed tomography (CT), and intraoral ultrasound (US) to determine the depth of invasion (DOI) and/or tumor thickness (TT) in oral cavity cancers, with histopathological evaluation as the go...

Objective: To evaluate the impact of the COVID-19 pandemic on the number of diagnoses of oral and maxillofacial lesions in public laboratories after one year of COVID-19 outbreak in Brazil. Material and methods: This is a cross-sectional study. Biopsies submitted to histopathologic examination from March 2019 to February 2020 (pre-pandemic perio...

DNA methylation is one of epigenetic changes most frequently studied nowadays, together with its relationship with oral carcinogenesis. A group of enzymes is responsible for methylation process, known as DNA methyltransferases (DNMT). Although essential during embryogenesis, DNA methylation pattern alterations, including global hypomethylation or g...

Purpose Inferior alveolar nerve block (IANB) is a frequently used anesthetic technique for restorative and surgical procedures in the mandible and its success rate usually ranges from 80 to 85%. Thus, this study aimed to compare the anesthetic efficacy of an alternative technique named superficial nerve block (SNB) - which consists of a modified ap...

Hybrid lesions encompass the occurrence of different entities in 1 lesion. A 67-year-old woman was referred to the oral and maxillofacial surgery service for treatment of mandibular central giant cell lesion (CGCL) previously diagnosed. Intra-oral examination revealed edentulism and a painless swelling extending to the buccal vestibule with hard co...

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplastic proliferation with variable clinical behavior; the male:female ratio is 1.6:1.0. The pathogenesis of LCH is imperfectly understood. A newborn boy, 1 month old, had a small focal lesion with a papillomatous surface, was cured, and the tissue removed was granulomatous, friable,...

Neural crest cells possess characteristics of stem cells including plasticity and ability to differentiate into various cell types. HNK1 and Sox10 are markers of neural crest cell progenitors that have been demonstrated in osteoblasts during osteogenesis of the maxilla and mandible. We investigated the presence of Sox10 and HNK1 during regeneration...

Purpose Main study: undertake a histological study of odontogenic cysts (OC) to determine the prevalence of dystrophic calcification and metaplasia to respiratory epithelium on a Brazilian population. Literature review: to review the literature for studies that investigated the prevalence of respiratory metaplasia and dystrophic calcification on OC...

Hybrid lesions encompass the occurrence of different entities in one lesion. A 67-year-old woman was referred to the Oral and Maxillofacial Surgery Service for treatment of mandibular Central Giant Cell Lesion (CGCL) previously diagnosed. Intraoral examination revealed edentulism and a painless swelling extending from the alveolar ridge to the bucc...

This study aimed to evaluate the use of human dental pulp stem cells (hDPSCs) in non-critical-sized mandibular bone defects in rats. hDPSCs from permanent teeth were isolated and engrafted in mandibular bone defects in rats for 7, 14, and 28 days; bone defects without cells formed the control group. Samples were evaluated by scanning electron micro...

A 47-year-old man was referred for treatment of a painful lesion of 5 months' duration located on the left side of the maxilla. A small perforation in the buccal cortex was observed during the intraoral examination. Cone beam computed tomography (CBCT) showed an extensive, well-delimited radiolucent lesion extending from the alveolar ridge to the n...

Background: The aim of this study was to systematically review the literature for studies that investigated the effects of sclerosing agents on head and neck hemangiomas. Material and methods: Clinical trials, cohort studies, and descriptive studies were considered eligible and selected in a two-phase process. Six main electronic databases, in a...

Background To investigate the prevalence of malignant and potentially malignant lesions of the lip in an oral pathology service and to compare these data with a literature review. Material and Methods A total of 3173 biopsy reports and histopathological records were analyzed. Cases with a histological diagnosis of actinic cheilitis (AC) with or wi...

HDAC1 is a Class I histone deacetylase (HDACs) encoded by this gene. HDACs remove acetyl group from amino-terminal tail of histone lysine recovering the positive charge of histone tail, permitting interactions between negatively charged DNA and histone protein, resulting in chromatin structure condensation which is associated with gene repression....

Objective This study was conducted to correlate and compare the immunoexpression of sex‐determining region Y‐box 2 (SOX‐2) in oral leukoplakia (OL) lesions with that in normal buccal mucosa (control) Materials and Methods In this observational study, OL with low‐risk (n = 34) and high‐ risk (n = 33) dysplasia and controls samples (n = 25) were sub...

Cancer stem cells ( CSC ) proteins have been observed in several lesions and are associated with tumor beginning, evolution, and resistance to treatment. Objectives to investigate the presence of NANOG, NESTIN, and β‐tubulin in lip squamous cell carcinoma (LSCC), actinic cheilitis (AC), and normal epithelium (NE). Materials and Methods thirty cas...

Organic silicon (OS), glucosamine sulfate (GS), and methylsulfonylmethane (MSM) have been related to bone and connective tissue health and have been considered as basic therapy for osteoarthrosis disorders. Therefore, the aim was to analyze the effect of the association of these three components in mandibular bone defects in rats. Nine rats were us...

Among the epigenetic changes, histone acetylation has been recognized as a fundamental process that strongly affects gene expression regulation. Disrupt of this phenomenon has been linked to carcinogenesis. In this review, we analysed studies reporting the process of histone modification, the enzymes associated and affected genes concerning human m...

Background: Acetylation/deacetylation are the most studied covalent histone modifications resulting in transcriptional regulation with histone deacetylases (HDAC) and histone acetyltransferases (HAT) as the main associated enzymes. These enzymes overexpression induces abnormal transcription of key genes that regulate important cellular functions,...

The selection of an appropriate demineralizing solution in pathology laboratories depends on several factors such as the preservation of cellularity, urgency of diagnostic and financial costs. The aim of this study was to test different decalcification bone procedures in order to establish the best value of these in formalin-fixed and paraffin-embe...

Objective: This study aimed to determine the histopathological findings in actinic cheilitis (AC) and lip squamous cell carcinomas (LSCC) diagnosed at Federal University of Santa Catarina in order to attempt to predict the evolution from AC to LSCC based on the comparison of two dysplasia classification systems. Methods: Histopathological featur...

Background: Epigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis. Although there are studies concerning to its expression in several cancer types, DNMTs expression pattern is not known in photoinduced lip carcinogenesis. The aim of this s...

Matrix metalloproteinases (MMPs), myofibroblasts (MFs) and epithelial proliferation have key roles in neoplastic progression. In this study immunoexpression of MMP-1, MMP-2 and MMP-9, presence of MFs and the epithelial proliferation index were investigated in actinic cheilitis (AC), lip squamous cell carcinoma (LSCC) and mucocele (MUC). Thirty case...

Histologically, these lesions can range from hyperkeratosis and acanthosis to epithelial dysplasia and even OSCC. The aim of this study was to investigate the proliferative activity, using AgNORs quantification proteins, in low- and high-risk oral epithelial dysplasia, OSCC, and nondysplastic epithelium (inflammatory fibrous hyperplasia). The sampl...

Mucoepidermoid carcinoma ex pleomorphic adenoma (MCxPA) is a rare salivary gland tumor predominantly found in major salivary glands. A case of MCxPA involving the soft tissue and bone of the retromolar region of a 26-year-old man is presented. The histopathological features revealed a neoplasm with predominance of pleomorphic adenoma (PA) elements,...

INTRODUÇÃO: O Folículo Pericoronário envolve a coroa do germe dental durante seu desenvolvimento. Quando o dente permanece incluso, alterações do folículo podem originar doenças, como cistos e tumores odontogênicos. OBJETIVO: Analisar as alterações histológicas no tecido mole circundante a terceiros molares inclusos e semi-inclusos, independenteme...

Introdução: A formação do Cisto Radicular (CR) está associada à proliferação dos restos epiteliais de Malassez por estímulos inflamatórios, provenientes da proliferação bacteriana do canal radicular de um dente não vital. Quando o dente é removido, esse cisto passa a ser denominado Cisto Residual (CRe). O tratamento de escolha para o CR é endodônti...

Adenoid cystic carcinoma (ACC) is a malignant neoplasm of the salivary glands consisting of epithelial and myoepithelial cells in variable morphologic configurations, including tubular, cribiform, and solid patterns. It occurs most frequently in the parotid, submandibular, and minor salivary glands and evidences aggressive behavior, usually with fa...

There are few cases of “kissing molars” related in English language literature. The term “kissing molar” was given by Van Hoof [1] in 1973, describing four impacted molars in a 31-year-old patient. The imaginological appearance consisted of a single follicular space associated with two molars with their occlusal surfaces in close apposition and the...

Primary teeth are interesting models that can be used to study physiological and pathological processes involving cells and extracellular matrices in hard and soft tissues. This study investigated the expression and distribution of biglycan and decorin-the non-collagenous components of the extracellular matrix-in primary teeth tissue, during physio...

The objective of this study was to evaluate the immunolocalization of bone morphogenetic protein 2 (BMP-2) after autogenous block grafting covered or not with an e-PTFE membrane. Forty-eight rats were divided into 2 groups, autogenous block graft (B) and autogenous block graft + e-PTFE membrane (MB), and were evaluated by immunohistochemistry at ba...

INTRODUÇÃO: A busca por novos métodos que auxiliem e simplifiquem de maneira eficaz o diagnóstico de lesões maxilares, cistos e tumores, objetiva beneficiar os pacientes e facilitar a atuação dos profissionais da área de diagnóstico bucal. Além dos dados clínicos, radiográficos e histopatológicos classicamente utilizados nos protocolos de investiga...

INTRODUCTION: The search for new methods that aid and optimize the diagnosis of cystic and tumoral maxillary lesions aims to benefit both patients and professionals from oral diagnosis. In addition to clinical, radiographic and histological findings traditionally used in research protocol for maxillary lesions, the adaptation of widely used medical...

J Oral Pathol Med (2012) 41: 400–407 Rho GTPases are proteins that regulate cell cycle, shape, polarization, invasion, migration, and apoptosis, which are important characteristics of normal and neoplastic cells. Rho GTPases expression has been reported in normal tooth germ and several pathologies; however, it has not been evaluated in ameloblastom...

The development of the oral squamous cell carcinoma (OSCC) is a multistep process that requires the accumulation of multiple genetic alterations usually preceded by detectable mucosal changes, most often leukoplakias and erythroplakias. The clinical appearance of oral precancerous lesions and their degree of epithelium dysplasia suggests the malign...

Paracoccidioidomycosis is an infection caused by the p. brasiliensis fungus. This is a deep, systemic fungal infection considered endemic in Brazil and some Latin American countries. The fungus is acquired by inhalation, resulting in a pulmonary disease which may also affect the skin, oral, nasal and gastrointestinal mucosa, as well as the spleen a...

Over-expression of DNA methyltransferases DNMT1, DNMT3a and DNMT3b has been reported in various cancers and precancerous lesions. To investigate DNMT1, DNMT3a and DNMT3b enzymes in oral squamous cell carcinoma (SCC) and leukoplakia, and their relationship with histopathologic/clinical parameters. Immunohistochemistry was carried out to evaluate the...

Altered expression of extracellular matrix (ECM) components has been reported in several pathologies; however, few ECM proteins have been evaluated in adenomatoid odontogenic tumor (AOT). The aim of this study was to analyze the expression and distribution of the ECM proteoglycans: biglycan and decorin; and glycoproteins: osteonectin, osteopontin,...

La paracoccidioidomicosis es una infección causada por un hongo P. brasiliensis. Se trata de una micosis profunda y sistémica, es considerada una enfermedad endémica en Brasil y en otros países de América Latina. El hongo es adquirido por inhalación, dando lugar a un cuadro clínico pulmonar que puede posteriormente afectar a la piel, mucosa oral, n...

In this study, Bmp-4, Wnt-5a and Shh gene expressions were compared during early craniofacial development in mice by comparative non-isotopic in situ hybridization. Wild-type C57BL/6J mice were studied at various stages of embryonic development (from 8.5- to 13.5-day-old embryos--E8.5-13.5). During early odontogenesis, transcripts for Bmp-4, Shh an...

Objectives: The aim of this study was to evaluate immunolocalization of intracellular BMP-2 growth factor after autogenous block graft covered or not with an e-PTFE membrane on the early phases of bone repair. Methods: Forty-eight wistar male rats had their mandibles augmented by either an autogenous bone block graft (B) or an autogenous bone block...

A 12-year-old girl was referred to the Oral and Maxillofacial Surgery Department by her orthodontist for evaluation of right facial asymmetry. Intraoral examination showed a mandibular dental midline deviated to the right with total disarticulation of the occlusion in the closed mouth position (Fig. 1). The patient reported difficulties during mast...

The purpose of this report is to present the clinical and histological features of a basaloid squamous cell carcinoma (BSCC) occurring in the retromolar trigone of a 59-year-old man and to relate its immunohistochemical characteristics. BSCC is an aggressive distinct variant of squamous cell carcinoma (SCC) requiring recognition as a separate entit...

A case of acinic cell adenocarcinoma of the left facial area of 10-years' duration in a 29-year-old man is presented. The patient reported surgical resection of a nodular lesion in the left buccal mucosa 8 years earlier in another hospital. Since then, the lesion recurred 3 times within 2 years. The first lesion and 2 recurrent ones were surgically...

To determine the possible etiologic factors associated with the development of idiopathic hyperplasia of the sublingual gland (IHSG). Fifty partially or totally edentulous patients were divided into 2 groups, each with 25 subjects, matched by sex. Group 1 was made up of patients with IHSG, whereas group 2 consisted of patients without IHSG. Patient...

To analyze integrin expression and distribution in different histological types of ameloblastoma, compared with dental germ, dental lamina and adult lining epithelium. Three-micrometer sections from paraffin-embedded specimens were evaluated employing a streptavidin-biotin immunohistochemical method and anti-integrin alpha2, alpha3, alpha5, alphav,...