Federica FrezzatoUniversity of Padova | UNIPD · Department of Medicine DIMED
Federica Frezzato
PhD in Oncology and Surgical Oncology
About
110
Publications
11,314
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1,525
Citations
Introduction
Additional affiliations
February 2014 - present
Campus Biomedico Pietro d'Abano - University of Padua
Position
- PostDoc Position
May 2008 - January 2014
January 2005 - April 2008
Position
- PhD Student
Description
- PhD in Oncology and Surgical Oncology
Publications
Publications (110)
2436
Cortactin is an ubiquitous actin-binding protein that is encoded by EMS1 gene, localized in chromosome 11q13 region. Cortactin is expressed in nearly all mammalian tissues and it was observed to migrate in two different bands with an apparent molecular weight of 80–85kDa, where p85 isoform originates from the p80 because of tyrosine phosphoryl...
To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL).
Human FLS isolated from synovial tissue explants were stimulated with MSU crystals (0.01 to 0.5...
B-chronic lymphocytic leukemia (B-CLL) is a malignant disorder characterized by the accumulation of the leukemic cells in the G0-G1 phase of the cell cycle and expressing high levels of the anti-apoptotic protein Bcl-2. Since we observed that the treatment of autoimmune complications with Cyclosporine A (CsA) determined in some CLL patients an impr...
Lyn, a tyrosine kinase belonging to the Src family, plays a key role as a switch molecule that couples the B-cell receptor to downstream signaling. In B-CLL cells, Lyn is overexpressed, anomalously present in the cytosol, and displays a high constitutive activity, compared with normal B lymphocytes. The aim of this work was to gain insights into th...
B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in adults and is characterized by the accumulation of clonal CD5+ B lymphocytes. Several protein kinase pathways have been claimed to be involved in the regulation of apoptosis and cell survival. We previously demonstrated that Src kinase Lyn is overexpressed at the protein lev...
B-cell chronic lymphocytic leukemia (B-CLL) is the most common form of leukemia in adults and is characterized by the accumulation of clonal CD5+ B lymphocytes due to uncontrolled growth and resistance to apoptosis. Several protein kinase pathways have been claimed to be involved in the regulation of cell survival. We previously demonstrated that t...
