Fabien Le Marec

Univ. Bordeaux, INSERM U1219, Bordeaux

Objectives: We studied the link between T-cell activation, differentiation and senescence phenotypes and non-AIDS-related comorbidities in HIV-suppressed patients. Design: Patients included in the ANRS CO3 Aquitaine Cohort were consecutively enrolled in this cross-sectional study between October 2011 and May 2013 called Chronic Immune Activation...

Background: The objective of the study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) in the French ANRS CO3 Aquitaine prospective cohort, observed both in 2004 and in 2014 in order to improve long-term healthcare management. Methods: The ANRS CO3 Aquitaine cohort prosp...

Background Ritonavir-boosted darunavir (DRV/r) is a protease inhibitor (PI) indicated for the treatment of naïve and pretreated HIV-infected patients since 2007. Our study aims to describe DRV/r-treated patients experiencing virological failure (VF) documented with HIV resistance testing. Methods Data from patients belonging to the ANRS CO3 Aquita...

Objective: Cancers represent one of the leading cause of mortality/morbidity in patients living with HIV (PLHIV) in industrialized countries. The objective of our study was to compare incidence of lung and HPV-related cancers among PLHIV with general population over the 2010-2017 period.Design: Prospective and multicenter cohort study. Methods:...

Background: To evaluate drug use (alcohol, tobacco, cannabis and other drugs) and its association with mean CD4/CD8 T cell count ratio, a marker of chronic inflammation, in virally suppressed people living with HIV-1 (PLWH) in Nouvelle Aquitaine, France. Methods: A multi-centric, cross-sectional analysis was conducted in 2018-19 in the QuAliV st...

Background Severe non-AIDS bacterial infections (SBIs) are one of the leading causes of hospital admissions among persons with HIV (PWH) in regions with high ART coverage. Methods This large prospective cohort study of PWH examined the types of infections, bacterial documentation, and evolution of antibiotic resistance among PWH hospitalized with...

Objective To assess the efficacy of raltegravir, etravirine, and darunavir/ritonavir in treatment-experienced HIV-1 patients by describing the proportion of patients who experienced virological failure (VF) at W24. Secondary objectives were to follow HIV-1 plasma viral load (pVL) after W24, the proportion of patients who underwent dual/monotherapy...

Introduction Les cancers représentaient la première cause de mortalité chez les personnes vivant avec le VIH (PVVIH), soit 34 % en France en 2010. Depuis la mise en place des traitements antirétroviraux (ARV), les cancers classant SIDA ont vu leur incidence diminuer alors que l’incidence des cancers non liés au VIH était stable ou augmentait durant...

Objectives Bacterial infections remain one of the main causes of morbidity and death in people living with HIV (PLHIV) in the most recent years. Several studies have demonstrated a protective effect of statins in the primary prevention of bacterial infections in other immunocompromised populations, but this effect remains controversial. The objecti...

Background The objective of the study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) in the French ANRS CO3 Aquitaine prospective cohort, observed both in 2004 and in 2014 in order to improve long-term healthcare management. Methods The ANRS CO3 Aquitaine cohort prospe...

Background: Antiretroviral therapy has prolonged the lives of those with human immunodeficiency virus (HIV), but the effects of chronic infection on their health-related quality of life (HRQoL) remain a concern. Numerous instruments have been developed to measure HRQoL, yet evidence of their cross-cultural equivalence and continued applicability i...

Background Long-term protection and herd immunity induced by existing pertussis vaccines are imperfect, and a need therefore exists to develop new pertussis vaccines. This study aimed to investigate the safety, colonisation, and immunogenicity of the new, live attenuated pertussis vaccine, BPZE1, when given intranasally. Methods This phase 1b, dou...

Background: The objective of the present study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) included in the French ANRS CO3 Aquitaine prospective cohort, observed both in 2004 and in 2014 in order to improve long-term healthcare management. Methods: The ANRS CO3 Aquit...

Objective The objective of the present study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) included in the French ANRS CO3 Aquitaine prospective cohort, observed both in 2004 and in 2014 in order to improve long-term healthcare management. Patients and Methods The ANRS...

Objectives: Limited data on Mycoplasma genitalium infection has been reported among PrEP users. The aim of this study was to estimate the prevalence and macrolide resistance of M. genitalium infection among enrollees in a French PrEP program. Patients and methods: M. genitalium infection screening was systematically and prospectively proposed to...

Decisions about when to start or switch a therapy often depend on the frequency with which individuals are monitored or tested. For example, the optimal time to switch antiretroviral therapy depends on the frequency with which HIV‐positive individuals have HIV RNA measured. This paper describes an approach to use observational data for the comparis...

Objective: To evaluate the predictive value of Soluble Suppression of Tumorigenicity 2 (sST2), a decoy receptor of IL-33 involved in several inflammatory and immune diseases, for death in HIV infection. Design: Patients enrolled in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients, who had a plasma sam...

Introduction Mycoplasma genitalium (Mg) est un agent reconnu et émergent d’infections sexuellement transmissibles (IST). Dans le cadre de la Prophylaxie Pré-Exposition (PrEP), essentiellement proposée à des hommes ayant des relations sexuelles avec les hommes (HSH), de nombreuses IST sont diagnostiquées, mais aucune donnée de routine n’est disponib...

Severe non-AIDS bacterial infections (SBI) are the leading cause of hospital admissions among people living with HIV (PLHIV) in industrialized countries. We aimed to estimate the incidence of SBI and their risk factors in a large prospective cohort of PLHIV patients over a 13-year period in France. Patients followed up in the ANRS CO3 Aquitaine coh...

We aimed at assessing in persons living with HIV with a smoking history an association between lung cancer risk and protease inhibitors exposure, especially ritonavir. A nested case-control study was conducted within the ANRS CO4 FHDH, CO3 Aquitaine and Tenon's Hospital Cohorts. Cases and controls were eligible if they were ex-smokers or current sm...

Introduction Avec l’augmentation de la durée de vie, les comorbidités sont devenues une préoccupation majeure chez les patients vivants avec le VIH (PVVIH) traités par des antirétroviraux. Ces comorbidités sont plus fréquentes à un âge donné que dans la population générale sans explications claires, excepté pour les complications reliées à la co-in...

The association between combination antiretroviral therapy (cART) and cancer risk, especially regimens containing protease inhibitors (PIs) or nonnucleoside reverse transcriptase inhibitors (NNRTIs), is unclear. Participants were followed from the latest of D:A:D study entry or January 1, 2004, until the earliest of a first cancer diagnosis, Februa...

Background. The purpose of this study was to assess the efficacy and tolerability of combined antiretroviral therapy (cART) in human immunodeficiency virus (HIV)-1 virologically suppressed patients who switched to rilpivirine (RPV)/tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) as a single-tablet regimen (STR). Methods. A retrospective mul...

Background. The purpose of this study was to assess the efficacy and tolerability of combined antiretroviral therapy (cART) in human immunodeficiency virus (HIV)-1 virologically suppressed patients who switched to rilpivirine (RPV)/tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) as a single-tablet regimen (STR). Methods. A retrospective mul...

Objective: To examine the incidence and risk factors for incident thoracic spine pain (TSP) in workers representative of a French region's working population. Methods: In this prospective study, 3,710 workers were assessed in 2002-2005, and 2,332 (62.9%) of them were reassessed in 2007-2010. TSP was assessed by a self-administered Nordic questio...

Objectives In recent years, emphasis was placed on the determinants of chronic low back pain (LBP) in a tertiary prevention perspective. However, prevention of acute and subacute LBP should remain a goal of primary prevention in the workplace. The objective of this study was to investigate the risk factors for common acute and subacute LBP related...

The current investigations were carried out in the context of a nutritional case study aiming at assessing the postnatal impact of maternal dietary protein restriction during pregnancy and lactation on rat offspring plasma metabolome and hypothalamic proteome. Although data generated by different “Omics” technologies are usually considered and anal...