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Publications (24)
Background: Several markers have been proposed for the detection and progression of subclinical atherosclerosis. We aimed to analyse the impact of classical risk factors on the presence and short-term progression of subclinical carotid atherosclerosis in a non-diabetic, primary prevention cohort. Methods: This analysis included participants with co...
Microalbuminuria is closely associated with the risk of cardiovascular disease and all-cause mortality in the general population. Less is known about its relationship with subclinical atherosclerosis. We aimed to assess the prevalence of microalbuminuria and its relationship with subclinical atherosclerosis in middle-aged, nondiabetic, apparently h...
The article researches the COVID-19 pandemic impact on the air traffic and aviation sector. The airlines alike the individual countries are introducing the measures intending to stop the COVID-19 pandemic spread. These measures might have a significant impact on the public health of the inhabitants. In the article, the authors assess the viral dise...
Various cardiac arrhythmias frequently occur in patients with sleep apnea, but complex analysis of the relationship between their severity and the probable arrhythmogenic risk factors is conflicting. The question is what cardiovascular risk factors and how strongly they are associated with the severity of cardiac arrhythmias in sleep apnea. Adult m...
Coronary Artery disease is one of the leading causes of death in industrialized countries and is responsible for one out of every six deaths in the United States. Remarkably, coronary artery disease is also largely preventable. The biggest challenge in the next years is to reduce the incidence of coronary artery disease worldwide. A complete knowle...
The prevalence of type 2 diabetes mellitus is growing and it has become the non-infectious pandemia of the 21th century arround the world. In the past the diabetics were dying predominantly due to the acute complications. Nowadays the late vascular complications are the main cause of morbidity and mortality of the diabetics. Diabetics are compared...
Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Several large population-based cohort studies identified an association between reduced lung function and increased intima-media thickness (IMT). Nevertheless, a vast majority of subjects in these studies did not suffer from COPD and th...
Nocturnal cardiac arrhythmias (NCA) were analyzed in patients with sleep apnea/hypopnea syndrome (SAHS) and controls. Occurrence and severity of NCA were compared in 33 SAHS patients and 16 control subjects, matched for cardiovascular risk factors. Continuous overnight polysomnography provided ECG, respiratory and sleep parameters for a comparative...
Diabetes mellitus is a civilizational disease with an incidence that has achieved character of the pandemia nowadays. It is estimated that there will be approximately 333 millions diabetics in the world in 2025. Diabetics are in higher risk of the development of the serious cardiovascular complications compared to the non-diabetic population. One o...
Cardiovascular morbidity and mortality of patients with obstructive sleep apnoe-hypopnoe syndrome (OSAHS) is higher than in matched population. The aim of the study was to analyse, whether high prevalence of risk factors of atherosclerosis in patients with OSAHS can explaine their higher cardiovascular morbidity.
2 groups of 33 males with moderate...
The intima-media thickness (IMT) of carotid arteries as a marker of preclinical atherosclerosis was measured by ultrasonography in 49 subjects to determine, how strongly the obstructive sleep apnoea (OSA) syndrome is associated with atherosclerosis. Maximal IMT was higher in patients with cardiovascular diseases and with or without risk factors of...
The occurrence of cardiac dysrhythmias have been analysed in 16 adult patients suffering from obstructive sleep apnea syndrome of various severity randomly selected from more than 300 persons examined in our sleep laboratory from 1996 with a complex polysomnography Alice 3 (Healthdyne). The number of apneic episodes emerging in the first, second an...
Dyslipidemia in type 2 diabetes has been shown to be related to the incidence of macrovascular events. Increased carotid intima-media thickness is considered to be a marker of macrovascular disease.
To investigate a possible relationship between lipoprotein levels and carotid intima-media thickness as a marker of early atherosclerosis in patients w...
Increased carotid intima-media thickness is regarded as a marker of atherosclerosis. Type 2 diabetes mellitus is associated with a high prevalence of macrovascular disease.
The present study aimed to examine the relationship between carotid intima-media thickness and the presence of macrovascular disease in patients with type 2 diabetes.
71 patient...
Obstructive sleep apnoea may be accompanied by various cardiovascular consequences resulting from alteration of the activity of the autonomous nervous system. These changes are mediated by: a--hypoxemia developing during the apnoea, b--severe hypoxemia, hypercapnia and acidosis in postapnoea, c--powerful but ineffective ventilatory efforts causing...
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In the group of patients investigated in our sleep laboratory and successfully treated by positive pressure applied in to the upper airways through nasal mask (nCPAP) some interesting cases appeared. These cases show beneficial effect of nCPAP therapy, unfortunately not widely spread and recognized in our country. These patients were u...
Sleep disordered breathing (SDB), particularly their clinically most serious and at the same time common form-sleep apnoea syndrome-caused by structural or functional abnormalities in the area of upper airways, are frequently linked with other diseases. The accompanying respiratory, cardiovascular, neuropsychic, sympathoadrenal and endocrine-metabo...
The authors describe a case of a 48-year old man living more than 9 years with a transplanted heart. Beside chronic complications (repeated rejection, gradual progression of renal and hepatic insufficiency, osteoporosis, marrow suppression), deterioration of cardiac insufficiency and angiographically documented coronary disease of the graft, there...
Sleep apnoea is often accompanied by severe disturbances in heart rate and cardiac rhythm.
Various respiratory parameters were continuously recorded 6-9 hours during sleep in ten patients with sleep apnoea syndrome, paralley with direct ECG recording (8 cases) or Holter monitoring (2 cases). The rate, development and reversibility of various dysrrh...
The reciprocal effect of 3 principal regulatory systems (neurogenic, endocrine and local) influences the arising of arterial hypertension in patients with obstructive sleep apnoea. Firstly, the hypertension is present only during the sleep apnoea event, later it persists also in the morning, and after years the intermittent elevation of blood press...
Dissecting aneurysms of the aorta are among the most dangerous acute conditions in medicine. Their incidence is rising in recent years. The pathogenesis of vascular aneurysms is not completely clear. In the submitted paper the authors discuss the most important factors (atherosclerosis, hereditary, metabolic, mechanical, haemodynamic, nutritional)...
