Eugenia Colon

Unilabs · Department of Pathology Sweden

Humanin (HN) is a 24 amino acids peptide with potent neuro-survival properties that protects against damage associated with Alzheimer's disease. In the present report, we have demonstrated by immunohistochemical analysis and Western blotting the pattern of expression of rat humanin (HNr) in the testis of 10- to 60-day-old rats. The Leydig cells of...

The cytokine IL-1alpha is produced constitutively by the intact testis, but its function in this organ remains largely unknown. In this study we examined cooperation between IL-1alpha and GH and IGFs with regard to stimulation of steroidogenesis by Leydig cells from 40-d-old rats in vitro. IL-1alpha alone stimulated testosterone (T) and dihydrotest...

It is uncommon for extramammary tumors to metastasize to the breast, and very few cases describing metastasis of primary uterine leiomyosarcoma to the breast have been reported. We present the case of a 51-year-old woman diagnosed with metastasis of uterine leiomyosarcoma to the breast diagnosed 10 years ago after hysterectomy. Ultrasonography, mam...

Background: The most common type of testicular cancer (TC) is the germ cell tumor, which occurs disproportionately in young men. Although most patients with TC undergo unilateral orchiectomy, contralateral testicular biopsy is still not routinely performed. A predictor of this tumor is germ cell neoplasia in situ (GCNIS), which can be detected by h...

Background Adoptive natural killer (NK) cell transfer is being increasingly used as cancer treatment. However, clinical responses have so far been limited to patients with hematological malignancies. A potential limiting factor in patients with solid tumors is defective homing of the infused NK cells to the tumor site. Chemokines regulate the migra...

The secretory insulin-like growth factor-binding protein-3 (IGFBP-3) induces apoptosis via both insulin-like growth factor-I (IGF-I)-dependent and -independent mechanisms. Here, we have examined the effects of IGFBP-3 on Leydig cell apoptosis, proliferation and steroidogenesis. Immunohistochemical analysis of testes of rats at different ages reveal...

Aim: Published Growth studies from Latin America are limited to growth references from Argentina and Venezuela. The aim of this study was to construct reference growth curves for height, weight, body mass index (BMI) and head circumference of Colombian children in a format that is useful for following the growth of the individual child and as a to...

The origin of pelvic serous carcinoma continues to be controversial. Recent studies of patients undergoing primary surgery for ovarian, primary peritoneal, and uterine serous carcinomas have indicated the value of complete fimbrial sampling for detecting occult serous tubal intraepithelial carcinoma (STIC). Evidence suggests that a significant prop...

Our understanding of the biology and clinical behavior of serous neoplasms of the ovary has changed enormously over the past decade. It is now clear that although all serous tumors share a cell type reflecting tubal epithelium in various levels of differentiation, they appear to have different origins and distinct behaviors. Benign and borderline s...

Background: Germ cells are unique cells that possess the ability to transmit genetic information between generations. Detailed knowledge about the molecular and cellular mechanisms determining the fate of human male germ cells still remains sparse. This is partially due to ethical issues limiting the access to research material. Therefore, the mec...

Background: Tumor size is crucial for clinical management and prognosis of breast malignancies. Materials and methods: The gold standard-size of 12 tumor phantoms was assessed at The Department of Production Engineering. Subsequently, with a conventional ruler, seven experienced mammographers measured the largest diameter of the 12 devices in tw...

Resumen Antecedentes El crecimiento infantil está condicionado por factores genéticos, ambientales, sociales y económicos, por lo que es útil elaborar gráficas de crecimiento locales. La Fundación Cardio-Infantil, Instituto de Cardiología, y la Asociación Colombiana de Endocrinología Pediátrica, con el apoyo del Karolinska Institutet en Suecia y d...

Functional gonads are mandatory for sexual reproduction and survival of higher animal species. However, at the level of the individual subject, acquired or inherited gonadal dysfunction and infertility are not commonly associated with severe life-threatening phenotypes. Medical progress and increased societal interest have led to more prioritized a...

Sex steroids are crucial regulators of sexual differentiation and the proper development of secondary sex characteristics and patterns of sexual behavior. Since Leydig cells are the primary major producers of these steroid hormones, maintenance of the normal functions of these cells determines the reproductive capacity and fertility of males. The p...

The present investigation examines the influence of IGF-I and the role of IGF-I receptor (IGF-IR) in the apoptosis/survival of Leydig cells. Immunohistochemical analysis of the rat testis at different ages revealed that the level of the phosphorylated IGF-IR increases from birth to d 20 of postnatal life, remaining high in the adult testis. Western...

Interleukin-1alpha (IL-1alpha) plays an important role(s) in the regulation of immune and inflammatory responses. The testis is an immunologically privileged organ and the variety of effects exerted by IL-1alpha on this organ have yet to be explored in detail. The aim of the present review is to describe our current view of the paracrine role playe...

Interleukin-1α (IL-1α) plays an important role(s) in the regulation of immune and inflammatory responses. The testis is an immunologically privileged organ and the variety of effects exerted by IL-1α on this organ have yet to be explored in detail. The aim of the present review is to describe our current view of the paracrine role played by IL-1α i...

Previous studies have demonstrated that the administration of the cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF)(20 micrograms/kg) to rats in a fasting state can produce many and perhaps most of the metabolic alterations found in patients with sepsis and injury. The purposes of the present study were 1) to define the metabolic effe...

In this study, 20 micrograms.kg.-1.h-1 of recombinant human insulin-like growth factor I (IGF-I) was infused into normal healthy rats to examine the effects of IGF-I on glucose, protein, and energy metabolism in either overnight-fasting or parenteral-feeding states. The fed state was maintained by continuous intravenous feeding of a complete diet c...

Auditory cortical evoked responses (ACRs) were recorded in 65 preterm infants, at least on 3 occasions in 48 of them. The infants were divided into 5 groups according to their gestational age (GA). The recording sessions were performed at 8 conceptional age (CA) levels, defined as the gestational age added to the chronological age. The last recordi...

Somatosensory chronotopography of a limited number of components gives a simple representation of the potential distribution of evoked potentials over the skull. Components of individual somatosensory evoked potentials over 16 equally distributed electrodes were analysed in 10 healthy volunteers. The distribution of some specific and non-specific c...

The aim of this study was to describe the EEGs, brainstem auditory evoked potentials and somatosensory evoked potentials obtained in eleven children with the Zellweger syndrome. In six out of the eleven patients BAEPs and in five of them SSEPs were performed. Severe abnormalities could be demonstrated, reflecting diffuse cerebral dysfunction as wel...

Die somatosensorische Chronotopographie einer begrenzten Zahl von Komponenten bietet eine einfache Repräsentation der Potentialverteilung der evozierten Potentiale über dem Schädel. Bei zehn gesunden Versuchspersonen wurden über 16 gleichverteilte Elektroden die Komponenten der individuellen somatosensorisch evozierten Potentiale analysiert. Die Ve...

Somatosensory and brainstem auditory evoked potentials (SSEPs and BAEPs) provide sensitive measures of the central conduction functions of the auditory and somatosensory input systems at different levels of the central nervous system. The contribution of SSEPs and BAEPs in the primary diagnosis and follow-up of 26 children with infra- and supratent...

In 7 patients with symptoms of cerebrovascular diseases a somatosensory evoked potential (SSEP) chronotopogram was constructed after median nerve stimulation of seven different EP components: N20, P25, P45, P100, N140, P200 and P300. We examined only a limited number of patients (and controls) because the methodology is very time-consuming. We anal...

Using vertebral artery sonography, we investigated the influence of the position of the head on the vertebral artery bloodflow in five children, who were admitted because of NSIDS (near sudden infant death syndrome) episodes. Three out of the five children showed blocking of vertebral bloodflow determined by position of the head. This was not obser...

A nonparoxysmal nonprogressive autosomal dominant choreatic disorder of early onset is described in two families. Laboratory investigations of blood, urine and cerebrospinal fluid were normal. Extensive electroneurophysiological examinations did not reveal evident abnormalities. The contingent negative variation was also normal, except for a P500....

We are investigating the maturation of auditory evoked responses, as a potential diagnostic tool for the neurological examination of premature infants at the Intensive Care Unit for Prematures. In this communication we report the group composite averages of the BMC-ARs in a group of 25 mature and healthy newborns with a follow-up at 3 months of age...

In 10 patients with definite MS, an SSEP chronotopogram was constructed of 7 different, well-defined components: N20, P25, P45, P100, N140, P200 and P300. Chronotopographical maps were constructed on the basis of the localization of maximal amplitudes of the different components and their dipolar counterparts (when present). Most patients showed a...

Two brothers with 'pure' spastic paraplegia are presented. Inheritance of their condition probably was autosomal recessive. Clinical onset was in the first decade. Peripheral nerve conduction, visual and brain stem auditory evoked potentials were normal. Somatosensory evoked potentials suggested involvement of the cuneate tract. The relevance of ne...

The neurological manifestations of idiopathic hypoparathyroidism in a father, his son, and his daughter are reported. In all three epilepsy was the first manifestation of the disease. Father and son also showed mental deterioration and striocerebellar symptoms; their CT scans revealed symmetrical calcification in the basal ganglia and dentate nucle...

A disability-scoring and an EEG-spectral analysis was performed in patients suffering from clinically and biochemically (oligoclonal aspect in cerebro-spinal fluid) proven multiple sclerosis at two stages of their illness, that are before and after a short intensive immuno suppressive therapy. In both stages a relationship is found between the degr...

In the search for methods which might increase the discrimination of the EEG, the power density spectra of a random sample of patients during different conditions were analysed. Power density spectra were made during eyes closed, eyes open, after hyperventilation, during photic stimulation, and during auditory stimulation. It proved that the spectr...

In a group of normal children aged 8, 9 and 10 years power density spectra of a 100-second EEG period were made over four different brain regions. All children had to undergo medical and psychological examinations prior to this EEG and the criteria for normality were based on these examinations. Reference values of the power density distribution fo...

Off-responses to repetitive photic stimulation may be of various shapes. In particular, very young children with respiratory distress showed a typical off-response. This reaction is rather peculiar; it consists of a triphasic, very sharp wave followed by a depolarization of longer duration. The latency is about 200 msec. This off-response seems to...

In contrast to the distal sensory response, the somatosensory evoked response (SSER) is detectable in patients with A-alpha sensory fiber diseases such as Friedreich's ataxia. In four patients with this disease a combined histological and electrophysiological investigation of sensory propagation was performed. The sural nerve was analyzed in terms...

This is a report of changes in blood flow velocity in the carotid system induced by lumbar puncture in five patients who had clinical and neuroradiological signs of normal pressure hydrocephalus. After lowering cerebrospinal fluid pressure an increase of carotid flow velocity was found on Doppler hematotachography. These changes of carotid blood fl...

In six patients suffering from a multifocal neurological disease of the demyelinating type, a somatosensory evoked response was analyzed in the cortical and cervical are after stimulating the right index finger and the right nervus suralis. The results of the investigation with this method indicate that localization of the central nervous system pa...

Quantitative percutaneous flow velocity measurements are possible in carotid arteries. The results of the direct percutaneous angiography were measured by means of a Doppler directional flow velocity device and registered on a polygraphy. The results indicate an increase in the flow velocity of the injected as well as the non-injected carotid syste...

Quantitative percutaneous flow velocity measurements are possible in carotid arteries by means of a directional Doppler flow velocity device and registration on a polygraph. Carotid flow velocity changes were recorded during catheterization of the ascending aorta and common carotid artery and after infusion of 20 cc contrast medium in the ascending...